Article
Genetics & Heredity
Dominique Talabot-Ayer, Alejandro Diaz -Barreiro, Ali Modarressi, Gaby Palmer
Summary: IL-38, encoded by the IL1F10 gene, is closely correlated with keratinocyte differentiation in human epidermis. This study characterized the regulation of IL1F10 expression and identified downstream enhancer regions that play a role in IL1F10 transcription. Overexpression of the transcription factors KLF4 and TAp63 beta promoted the expression of IL1F10 and differentiation markers in keratinocytes, indicating their involvement in regulating IL1F10 transcription. These findings provide insights into the coordinated transcription and epigenetic remodeling of IL1F10 in differentiated keratinocytes.
Article
Food Science & Technology
Yu Wu, Qiuhua Li, Junxi Cao, Fenling Fan, Lishe Gan, Rihui Wu, Jingwei Jin, Ruohong Chen, Lingli Sun, Zhenbiao Zhang, Xingfei Lai, Wing-Leung Wong, Shili Sun, Dongli Li
Summary: The study showed that black tea extracts can relieve constipation symptoms by improving defecation weight, fecal water content, and gastrointestinal transit rate. Black tea extracts can also protect colon tissue, regulate serum neurotransmitters levels. Aged black tea has a better relief effect, possibly due to the role of active ingredients.
FOOD & NUTRITION RESEARCH
(2023)
Article
Food Science & Technology
Manxue Mei, Ruhang Cai, Qihua Yu, Renkui Tian, Wei Zhu, Jianping Song, Dinghong Wu
Summary: This study investigated the protective effect of Salidroside (SAL) on UVB-induced skin damage and repair of skin barrier function. Both in vitro and in vivo experiments showed that SAL significantly alleviated UVB-induced photodamage by inhibiting the activation of AQP3/ROS/GSDMD-N in damaged skin tissues and keratinocytes. This led to a reduction in skin lesions, IL-18 and IL-1β levels, oxidative stress, and downregulation of necroptosis-related proteins.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Paula Montero, Javier Milara, Martin Perez-Leal, Cristina Estornut, Ines Roger, Alejandro Perez-Fidalgo, Celia Sanz, Julio Cortijo
Summary: This study demonstrated that paclitaxel affects healthy human epidermal cells, impairing various cellular processes such as inflammation, oxidative stress, apoptosis, and reduced vascular tube formation. Toll-like receptor 4 activation is involved in mediating some of these adverse effects on skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dermatology
Mitsuhiro Denda, Shinobu Nakanishi
Summary: Keratinocytes were traditionally believed to only construct a protective barrier in the skin, but recent research has shown that they also have sensory systems capable of detecting environmental changes and expressing neurotransmitters and receptors. Activation of keratinocytes has been found to influence sensory perception in the brain, suggesting they may represent an early stage in brain development during vertebrate evolution.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biology
Oscar Urtatiz, Amanda Haage, Guy Tanentzapf, Catherine D. Van Raamsdonk
Summary: Different melanoma subtypes have specific and non-overlapping sets of gene mutations, originating from melanocytes. The epidermal microenvironment may actively affect the initiation and survival of melanoma, but the exact mechanisms are unclear.
Review
Cell Biology
Hanxiao Yin, Mingzheng Hu, Dengwen Li
Summary: The epidermis is a barrier in the outermost layer of the skin that protects against pathogens. Basal keratinocytes, acting as stem cells, are crucial for epidermal development and skin damage recovery. Understanding the molecular mechanism of basal keratinocytes in epidermal development and stratification is important for preventing and treating skin lesions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Anna Domaszewska-Szostek, Magdalena Gewartowska, Marek Stanczyk, Beata Narowska, Maria Moscicka-Wesolowska, Waldemar Lech Olszewski
Summary: Research shows that skin preserved in anhydrous sodium chloride can serve as a source for keratinocyte transplantation for treating extensive skin wounds. Transplanted keratinocytes maintained their morphology and functionality.
Article
Biochemistry & Molecular Biology
Nan-Hyung Kim, Ha Jung Kim, Ai-Young Lee
Summary: AQP3 downregulation in vitiligo leads to oxidative stress and subsequent melanocyte death.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Vivek Choudhary, Ismail Kaddour-Djebbar, Victoria E. Custer, Rawipan Uaratanawong, Xunsheng Chen, Elyssa Cohen, Rong Yang, Etsubdenk Ajebo, Sarah Hossack, Wendy B. Bollag
Summary: Research has shown that both topical and oral glycerol can improve psoriasis-like skin lesions in mice, with the beneficial effects of oral glycerol possibly requiring PLD2-mediated conversion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chenliang Gou, Wenkai Ni, Panpan Ma, Fengbo Zhao, Zhou Wang, Rong Sun, Yingcheng Wu, Yuanyuan Wu, Miaomiao Chen, Hao Chen, Jie Zhang, Yu Shen, Mingbing Xiao, Cuihua Lu, Renfang Mao, Yihui Fan
Summary: N4BP1 is a key regulator in the development of psoriasis, controlling the proper function of keratinocytes and neutrophils by negatively regulating JunB, FosB, and CXCL1, respectively.
CELL DEATH & DISEASE
(2021)
Article
Dermatology
Jie Zhou, Gaopeng Liang, Lu Liu, Shujing Feng, Zhengni Zheng, Yaguang Wu, Xiaoling Chen, Xiangqian Li, Lina Wang, Li Wang, Zhiqiang Song
Summary: This study conducted an in-depth transcriptome analysis of atopic dermatitis (AD) in the Chinese population, revealing heterogeneity and highly expressed keratinocyte activation and pro-inflammatory genes. The study also identified an increased IL19(+)IGFL1(+) subpopulation in AD lesions, which may be associated with disruption of the skin barrier, amplified Th2 and Th17 inflammatory responses, and mediation of skin pruritus. Additionally, progressive activation of multiple immune axes dominated by Type 2 inflammatory reaction occurred in AD chronic lesions.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Multidisciplinary Sciences
Marielle Moreau, Christophe Capallere, Laurent Chavatte, Christelle Plaza, Celine Meyrignac, Karl Pays, Bruno Bavouzet, Jean-Marie Botto, Carine Nizard, Anne-Laure Bulteau
Summary: This study found that treatment with plant extracts enriched with compounds known to protect mitochondria can improve mitochondrial defects in keratinocytes derived from older donors and enable the generation of high-quality reconstructed human epidermis equivalents (RHE).
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Monika Mlinaric, Ivan Lucic, Lidija Milkovic, Ines V. da Silva, Ivana Tartaro Bujak, Vesna Musani, Graca Soveral, Ana Cipak Gasparovic
Summary: Aquaporin 3 (AQP3) is a membrane protein that transports hydrogen peroxide, water, and glycerol. It is implicated in tumor progression and malignancy in breast cancer and may be a target for therapy. This study examined the relationship between AQP3 expression, disruption of lipid raft harboring EGFR, and the EGFR/PI3K/Akt signaling pathway in breast cancer cell lines. The results indicate that AQP3 may not directly affect the PI3K/Akt pathway but rather its role is cell-line specific.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yutaka Shindo, Keigo Fujita, Mari Tanaka, Hiroki Fujio, Kohji Hotta, Kotaro Oka
Summary: Recent studies have shown that keratinocytes play crucial roles in nociception and ATP is a key mediator in signal transduction from keratinocytes to sensory neurons. Sensory dorsal root ganglion (DRG) neurons are more sensitive to ATP than keratinocytes, and signals from moderate mechanical stimulation of keratinocytes are predominantly transmitted to DRG neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)