Article
Biochemistry & Molecular Biology
Blaze M. Pharoah, Vinayak S. Khodade, Alexander Eremiev, Eric Bao, Ting Liu, Brian O'Rourke, Nazareno Paolocci, John P. Toscano
Summary: Hydrogen sulfide (H2S) has protective effects in cardiovascular disease, but its mechanism of action is still unclear. Recent studies have found that H2S can modulate protein activity through redox-based post-translational modifications. Other reactive sulfur species also exhibit cardioprotective action. Exogenous hydropersulfide donation is a superior approach compared to other reactive sulfur species and mechanical post-conditioning in protecting cardiac function and limiting infarct size.
Article
Pharmacology & Pharmacy
Tianwei Cui, Weiyu Liu, Chenghao Yu, Jianxun Ren, Yikui Li, Xiaolu Shi, Qiuyan Li, Jinyan Zhang
Summary: Allicin has protective effects on acute myocardial infarction by inducing H2S production, resulting in effective coronary artery dilation and regulation of Ca2+ homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tamas Gall, Peter Nagy, Dorottya Garai, Laszlo Potor, Gyorgy Jazon Balla, Gyorgy Balla, Jozsef Balla
Summary: Vulnerable atherosclerotic plaques with hemorrhage significantly contribute to cardiovascular morbidity and mortality, and calcification is their main characteristic. Hydrogen sulfide may play beneficial effects in the progression of atherosclerosis and can suppress the oxidation of Hb/heme.
Article
Chemistry, Multidisciplinary
Rynne A. Hankins, Molly E. Carter, Changlei Zhu, Chen Chen, John C. Lukesh
Summary: This study reports a useful platform for H2Se donation using gamma-keto selenides and demonstrates their significant anticancer activity. These findings are of great importance for understanding the biological activity and therapeutic potential of H2Se.
Article
Medicine, Research & Experimental
Ting Yang, Qi Yang, Qi Lai, Junxiong Zhao, Liangui Nie, Shengquan Liu, Jun Yang, Chun Chu
Summary: This study investigates whether the mitochondrial-targeted H2S donor AP39 inhibits mitochondrial autophagy and counteracts cardiac cell iron death through the PINK1/Parkin pathway, improving myocardial fibrosis in rats with myocardial infarction. The results show that there is a significant accumulation of collagen fibers in the hearts of rats with myocardial infarction, accompanied by downregulation of CSE protein expression, activation of the PINK1/Parkin signaling pathway, and activation of mitochondrial autophagy. Intervention with AP39 improves these changes and can be reversed by the addition of PAG.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Yu Li, Yuanyue Wang, Xiaoqing Feng, Yanying Zhao
Summary: Excited-state intramolecular proton transfer (ESIPT) reaction plays a significant role in biology, materials, and related fields. A solvatochromic benzoxazole-based probe exhibited dual fluorescence phenomenon via the ESIPT reaction, and the inhibition of ESIPT reaction by solvent polarity and intermolecular hydrogen bonding was confirmed. The study provides insights into designing potential ESIPT + AIE fluorescent sensors.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Cell Biology
Nian-Hua Deng, Wen Luo, Dan-Dan Gui, Bin-Jie Yan, Kun Zhou, Kai-Jiang Tian, Zhong Ren, Wen-Hao Xiong, Zhi-Sheng Jiang
Summary: Diabetic cardiomyopathy is a cardiovascular complication related to diabetes, obesity, or insulin resistance, characterized by metabolic disorders in cardiac tissues leading to heart dysfunction. Studies suggest that hydrogen sulfide may have therapeutic effects on diabetic cardiomyopathy by regulating cell metabolism and protecting cardiomyocytes.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ying Li, Yan Feng, Li Liu, Xue Li, Xin-yu Li, Xun Sun, Ke-xin Li, Rong-rong Zha, Hong-dan Wang, Meng-di Zhang, Xiong-xiong Fan, Di Wu, Yao Fan, Hao-cheng Zhang, Guo-fen Qiao, Bai-yan Li
Summary: The study showed that H2S improves the autonomic control of blood pressure regulation by increasing K-ATP channel expression in the baroreflex afferent pathway, suggesting a crucial role of H2S in cardiovascular disorders.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Weirun Li, Peier Chen, Yuxuan Pan, Ling Lu, Xiaodong Ning, Jiamin Liu, Jintao Wei, Minsheng Chen, Peng Zhao, Caiwen Ou
Summary: By using a complex scaffold and nanocomposite scaffold, a band-aid like patch can slowly release H2S and attach to the myocardium, relieving inflammation and promoting angiogenesis after myocardial infarction and recovering heart function.
Article
Chemistry, Medicinal
Xiaokang Tang, Akiyuki Nishimura, Kohei Ariyoshi, Kazuhiro Nishiyama, Yuri Kato, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung-Kyu Kim, Jin Han, Yasunari Kanda, Keitaro Umezawa, Yasuteru Urano, Takaaki Akaike, Motohiro Nishida
Summary: Polyhydroxynaphtoquinone echinochrome A (Ech-A), a natural pigment of marine origin found in sea urchins, can prevent sulfide catabolism and improve chronic heart failure after myocardial infarction. Ech-A inhibits oxidative stress formation and improves heart function in cellular and animal experiments by suppressing the degradation of reactive sulfur species.
Article
Environmental Sciences
Yinai Liu, Qianqian Chen, Yaoqi Li, Liuliu Bi, Sue Lin, Hao Ji, Da Sun, Libo Jin, Renyi Peng
Summary: In this study, the researchers found that oxidative stress mediated H2S-induced apoptosis via the mitochondria pathway in the embryo-larval stages of zebrafish. H2S exposure increased intracellular ROS, Ca2+, NO and MDA contents while decreasing SOD activity. This led to oxidative stress and mitochondrial dysfunction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Jerzy Beltowski, Jolanta Kowalczyk-Boltuc
Summary: Hydrogen sulfide (H2S) is involved in the regulation of blood pressure and has potential therapeutic effects on hypertension and its associated organ injuries. Decreased H2S concentration and activity of H2S-producing enzymes have been observed in various animal models of hypertension, while administration of H2S donors can effectively reduce blood pressure and prevent end-organ damage. Modulating H2S signaling may be a promising approach for the management of hypertension, and more experimental and clinical studies are needed to explore the role of H2S in hypertension.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Junbin Li, Ying Zhou, Lifei Song, Sheng Yang, Qianqian Wang, Yibo Zhou, Xiao-Bing Zhang, Zhihe Qing, Ronghua Yang
Summary: In this study, a nanobeacon sensitive to hydrogen sulfide (H2S) was developed for monitoring in situ antioxidant fluctuation during epilepsy. The nanobeacon revealed that H2S levels were elevated during mild epilepsy but significantly suppressed during severe epilepsy. This research provides important insights into the pathology of epilepsy.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Nazmin Bithi, Christopher Link, Yoko O. Henderson, Suzie Kim, Jie Yang, Ling Li, Rui Wang, Belinda Willard, Christopher Hine
Summary: The study investigates the impact of dietary restriction (DR) on protein persulfidation, finding enrichment of persulfidation in liver, kidney, muscle, and brain, but decreased levels in the heart. Mice lacking cystathionine gamma-lyase (CGL) show an overall decrease in tissue protein persulfidation numbers under DR.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Petra Kleinbongard, Helmut Lieder, Andreas Skyschally, Gerd Heusch
Summary: This study compared the infarct size in female, castrated male, and male pigs undergoing ischemia/reperfusion (I/R) and ischemic preconditioning (IPC). The results showed no sex- or castration-related differences in infarct size, coronary microvascular injury, and cardioprotection by IPC.
CARDIOVASCULAR RESEARCH
(2023)
