Novel antimalarial drug targets: hope for new antimalarial drugs

Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria

(2009) Xuerong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones

(2009) Jeanne A. Geyer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials

(2009) Naresh Sunduru et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by ComprehensiveN-Methyl Scanning

(2009) Karen S. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Fatty Acid Biosynthesis Enzyme, β-Ketoacyl−Acyl Carrier Protein Synthase III (PfKASIII), in the Identification of Novel Antimalarial Agents

(2009) Patricia J. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

(2009) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for the inhibition of the essentialPlasmodium falciparumM1 neutral aminopeptidase

(2009) Sheena McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing Antibodies

(2009) Andrew V. Oleinikov et al.   PLoS Pathogens

Antimalarial Activity of Phenylthiazolyl-Bearing Hydroxamate-Based Histone Deacetylase Inhibitors

(2008) G. S. Dow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy

(2008) Prasenjit Mukherjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents

(2008) Mahama Ouattara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum

(2008) Karine G Le Roch et al.   BMC GENOMICS

Irreversible effect of cysteine protease inhibitors on the release of malaria parasites from infected erythrocytes

(2008) Svetlana Glushakova et al.   CELLULAR MICROBIOLOGY

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

The Fight Against Drug-Resistant Malaria: Novel Plasmodial Targets and Antimalarial Drugs

(2008) Mitchell Avery et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of Malaria Parasite Development by a Cyclic Peptide That Targets the Vital Parasite Protein SERA5

(2008) W. D. Fairlie et al.   INFECTION AND IMMUNITY

Mitochondria in malaria and related parasites: ancient, diverse and streamlined

(2008) Michael W. Mather et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Plasmodium falciparumPurine Nucleoside Phosphorylase Is Critical for Viability of Malaria Parasites

(2008) Dennis C. Madrid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent Antimalarial and Transmission‐Blocking Activities of Centanamycin, a Novel DNA‐Binding Agent

(2008) Stephanie K. Yanow et al.   JOURNAL OF INFECTIOUS DISEASES

Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines

(2008) Kimberly Yearick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target

(2008) Ingrid B. Müller et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

(2008) Shirin Arastu-Kapur et al.   Nature Chemical Biology

Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata

(2008) Anastasia Karioti et al.   PHYTOMEDICINE

Safety and Efficacy of Methylene Blue Combined with Artesunate or Amodiaquine for Uncomplicated Falciparum Malaria: A Randomized Controlled Trial from Burkina Faso

(2008) Augustin Zoungrana et al.   PLoS One

Evolutionary Patterning: A Novel Approach to the Identification of Potential Drug Target Sites in Plasmodium falciparum

(2008) Pierre M. Durand et al.   PLoS One

Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption

(2008) P. Ellekvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDP—A Novel Heme Detoxification Protein from the Malaria Parasite

(2008) Dewal Jani et al.   PLoS Pathogens

Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

(2007) L. Birkholtz et al.   ACTA TROPICA

Kinetic and biochemical characterization ofPlasmodium falciparumGMP synthetase

(2007) Javaid Yousuf Bhat et al.   BIOCHEMICAL JOURNAL

Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species

(2007) Sanjay Kumar et al.   FREE RADICAL BIOLOGY AND MEDICINE