期刊
CURRENT UROLOGY REPORTS
卷 16, 期 1, 页码 -出版社
SPRINGER
DOI: 10.1007/s11934-014-0468-4
关键词
Reprogramming; Prostate cancer; Cell transcriptome; Principal components analysis; LuCaP xenografts
资金
- CNPq-Conselho Nacional de Desenvolvimento Cientifico e Tecnologico for research at the University of Washington
- NCI
Prostate cancer progression is characterized by tumor dedifferentiation. Cancer cells of less differentiated tumors have a gene expression/transcriptome more similar to that of stem cells. In dedifferentiation, cancer cells may follow a specific program of gene expression changes to a stem-like state. In order to treat cancer effectively, the stem-like cancer cells and cancer differentiation pathway need to be identified and studied. Due to the very low abundance of stem-like cancer cells, their isolation from fresh human tumors is technically challenging. Induced pluripotent stem cell technology can reprogram differentiated cells into stem-like, and this may be a tool to generate sufficient stem-like cancer cells.
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