Article
Urology & Nephrology
Jacqueline Zillioux, Blayne Welk, Anne M. Suskind, E. Ann Gormley, Howard B. Goldman
Summary: There is a likely small but significant increased risk of dementia with chronic exposure to overactive bladder (OAB) anticholinergic medications. Short-term use of most OAB anticholinergic medications is likely safe in most individuals. Clinicians should consider potential cognitive risks when prescribing OAB anticholinergics for chronic use, and advanced therapy should be considered earlier in the OAB treatment paradigm.
NEUROUROLOGY AND URODYNAMICS
(2022)
Review
Food Science & Technology
Ju-Chuan Hu, Lin-Nei Hsu, Wei-Chia Lee, Yao-Chi Chuang, Hung-Jen Wang
Summary: This study aims to explore the safety and efficacy of BoNT-A injection in treating bladder and voiding dysfunction in PD and post-stroke patients. Currently, intradetrusor injection of BoNT-A is approved as a third-line therapy for nDO and idiopathic OAB by the FDA. However, the clinical use of BoNT-A for post-stroke patients is limited due to the development of urinary retention in about one-fifth of patients.
Article
Multidisciplinary Sciences
Lingfeng Meng, Zijian Tian, Yaoguang Zhang, Jianye Wang, Limin Liao, Guoqing Chen, Xiaojun Tian, Lulin Ma, Yan Li, Benkang Shi, Yong Zhang, Qing Ling, Peng Zhang, Zhongqing Wei, Tie Zhong, Zhihui Xu, Jiayi Li, Deyi Luo
Summary: This study evaluated the clinical outcomes of different sacral neuromodulation systems (InterStim and BetterStim) in the treatment of overactive bladder. The results showed that both systems were effective in improving voiding frequency, urinary leakage, and quality of life. However, the InterStim system may be more beneficial for patients with dry overactive bladder, while the BetterStim system may be more suitable for patients with wet overactive bladder.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Samuel Gomes Cardoso, Beatriz Paixao Argollo, Ana Aparecida Nascimento Martinelli Braga, Ubirajara Barroso
Summary: This study compared the clinical, psychological, and sociodemographic features of children with overactive bladder (OAB) and voiding postponement (VP), finding that children with OAB had more behavioral problems, especially hyperactivity, and a strong association between urge incontinence and lower MVV/EBC. No significant differences were found in sociodemographic characteristics between the two groups.
JOURNAL OF PEDIATRIC UROLOGY
(2021)
Article
Urology & Nephrology
Teppei Okamoto, Shingo Hatakeyama, Atsushi Imai, Hayato Yamamoto, Tohru Yoneyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, Shigeyuki Nakaji, Chikara Ohyama
Summary: The study found that individuals reporting daily urinary urgency had lower bacterial diversity in their gut microbiome, lower abundance of Bifidobacterium, and higher abundance of Faecalibacterium compared to non-OAB individuals.
WORLD JOURNAL OF UROLOGY
(2021)
Review
Physiology
Kylie J. Mansfield, Zhuoran Chen, Kate H. Moore, Luke Grundy
Summary: Overactive bladder (OAB) is a clinical syndrome defined by urinary urgency, increased daytime urinary frequency and/or nocturia, with or without urinary incontinence. Despite being clinically characterized in the absence of other organic diseases, including urinary tract infection, research shows that a significant proportion of OAB patients have active bladder infection, with increased pathogenic bacteria and bladder inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Food Science & Technology
Fan-Ching Hung, Hann-Chorng Kuo
Summary: Botulinum toxin A (BoNT-A) intravesical injections have been used to treat refractory functional bladder disorders. Liposomes, as drug delivery vehicles, can transport BoNT-A into cells. Liposomal BoNT-A can reduce frequency and urgency of urination, improve bladder pain and may have a promising role in treating bladder oversensitivity.
Article
Pharmacology & Pharmacy
Katja S. Just, Karen A. Schultze, Harald Dormann, Thomas Seufferlein, Ingo Graeff, Catharina Scholl, Matthias Schwab, Julia C. Stingl
Summary: This study aims to analyze the association between the individual anticholinergic load of older adults, particularly the use of overactive bladder anticholinergic medications, and falls in multi-medicated patients. The results show that the use of overactive bladder anticholinergic medications and fall-risk increasing drugs is associated with falls, while the anticholinergic burden itself is not.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Hsueh-Yu Mu, Ming-Ping Wu, I-Te Wang, Jeng-Cheng Wu, Hung-Yen Chin
Summary: Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are two lower urinary tract disorders with overlapping symptoms, making it difficult to accurately differentiate between them. This study identified a subgroup of OAB patients with bladder pain (OAB-BP) that could be distinguished from those with OAB alone through urodynamic study (UDS) findings. The clinical presentations and urodynamic parameters of OAB-BP and IC/PBS were found to be more similar than those of OAB alone.
Review
Food Science & Technology
Hsiang-Ying Lee, Hann-Chorng Kuo
Summary: This article reviewed the use of botulinum toxin type A (BTX-A) injections into the bladder wall for men with small prostates without bladder outlet obstruction (BOO). The results showed that BTX-A injections were effective and safe for treating overactive bladders (OAB) in men, particularly in those without prior prostate surgery. Patients with prior radical prostatectomy (RP) also had better efficacy and lower risk of side effects. However, the pathophysiology mechanism of OAB in men may differ from that in women, which could affect the efficacy of BTX-A injection.
Article
Urology & Nephrology
Blayne Welk, Khaled Etaby, Eric McArthur, Queena Chou
Summary: The study found that among older adults, continuous use of oxybutynin is associated with a significantly increased risk of fall/fracture compared to beta-3 agonists, while newer OAB anticholinergics are associated with a significantly increased risk of delirium.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Physiology
Yoshiyuki Akiyama, Jian-Rong Yao, Karl J. Kreder, Michael A. O'Donnell, Susan K. Lutgendorf, Dan Lyu, Daichi Maeda, Haruki Kume, Yukio Homma, Yi Luo
Summary: This study established a novel animal model for Hunner-type interstitial cystitis (HIC) using a transgenic mouse model (URO-OVA) through autoimmunity to the bladder urothelium. The model reproduced histological and clinical features of human HIC, providing a valuable tool for HIC research.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Urology & Nephrology
Yanping Zhang, Fengping Ji, Erpeng Liu, Jian Guo Wen
Summary: BoNT-A and SNM mainly act on the peripheral nervous system and central nervous system, respectively. But BoNT-A and SNM may partly act on the central and peripheral nervous systems, separately. SNM may be a better choice than BoNT-A in the long time. At the same time, BoNT-A and SNM can treat the ROAB as the first and next steps, and the sequence of both would not affect the effectiveness of each other.
UROLOGIA INTERNATIONALIS
(2021)
Article
Urology & Nephrology
Dongqing Pang, Limin Liao, Guoqing Chen, Yiming Wang
Summary: Our study provides novel neuroimaging evidence for the possible central pathogenesis of overactive bladder (OAB) and the possible central mechanism of action of sacral neuromodulation (SNM).
JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Blayne Welk
Summary: Large observational studies have found that anticholinergic overactive bladder medications may be associated with a higher risk of mortality. Among different populations of older adults, oxybutynin is found to have a significantly higher mortality risk (26-58%) compared to other anticholinergic medications or 63 agonists. Overall, anticholinergic medications for overactive bladder may increase the risk of mortality, while a multicountry study showed that users of 63 agonists had a 20% lower risk of mortality compared to anticholinergic users.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Urology & Nephrology
Craig E. Stauffer, Elizabeth Snyder, Tin C. Ngo, Christopher S. Elliott
Letter
Urology & Nephrology
Christopher S. Elliott, Craig V. Comiter
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2013)
Article
Obstetrics & Gynecology
Christopher S. Elliott, Kim F. Rhoads, Craig V. Comiter, Bertha Chen, Eric R. Sokol
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2013)
Article
Urology & Nephrology
Christopher S. Elliott, Judy Yeh, Craig V. Comiter, Bertha Chen, Eric R. Sokol
JOURNAL OF UROLOGY
(2013)
Article
Urology & Nephrology
Monica L. Richardson, Christopher S. Elliott, Jonathan G. Shaw, Craig V. Comiter, Bertha Chen, Eric R. Sokol
JOURNAL OF UROLOGY
(2013)
Article
Urology & Nephrology
Christopher S. Elliott, Craig V. Comiter
NEUROUROLOGY AND URODYNAMICS
(2014)
Article
Urology & Nephrology
Andrew J. Sun, Craig V. Comiter, Christopher S. Elliott
NEUROUROLOGY AND URODYNAMICS
(2018)
Article
Urology & Nephrology
Christopher S. Elliott, Dimitar Zlatev, James Crew, Kazuko Shem
NEUROUROLOGY AND URODYNAMICS
(2019)
Article
Rehabilitation
Christopher S. Elliott, John T. Stoffel, Jeremy B. Myers, Sara M. Lenherr, Blayne Welk, Sean P. Elliott, Kazuko Shem
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2019)
Article
Urology & Nephrology
Andrew J. Sun, Catherine R. Harris, Craig Comiter, Christopher S. Elliott
NEUROUROLOGY AND URODYNAMICS
(2019)
Article
Obstetrics & Gynecology
Kai Dallas, Lisa Rogo-Gupta, Raveen Syan, Ekene Enemchukwu, Christopher S. Elliott
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2020)
Article
Clinical Neurology
Christopher S. Elliott, Caleb Seufert, Dimitar Zlatev, Evgeniy Kreydin, James Crew, Kazuko Shem
Summary: In the first year after rehabilitation, more overall SCI patients transition away from CIC than convert to CIC. Significant improvements in UE motor function during the first year after rehabilitation discharge do not appear to affect bladder management decisions.
JOURNAL OF SPINAL CORD MEDICINE
(2021)
Article
Urology & Nephrology
Blayne Welk, Sara Lenherr, Yahir Santiago-Lastra, Holly S. Norman, Melanie G. Keiser, Christopher S. Elliott
Summary: This study aimed to measure the incidence and severity of urinary tract infections (UTI) in intermittent catheter (IC) users with neurogenic and non-neurogenic diagnoses. The study found that IC users had a higher incidence of UTIs compared to the general population, and IC users with neurogenic lower urinary tract dysfunction (NLUTD) had a higher hospitalization rate for UTIs.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Urology & Nephrology
Jacqueline Speed, Blayne Welk, Craig Comiter, Christopher Elliott
Summary: This study found that the frequency of future procedures, risk of catheterization, and the need for a device were the most important factors for patients when choosing third-line OAB therapy. Market simulation revealed that SNS was the preferred treatment option for all age groups, though external factors may influence the ultimate choice. Follow-up results showed that only a small percentage of patients were dissatisfied with all treatment options.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Christopher S. Elliott, Craig V. Comiter
CURRENT BLADDER DYSFUNCTION REPORTS
(2013)
