Article
Medicine, General & Internal
Hae Won Jung, Moni Ra, Han Joon Bae, Seung-Pyo Hong
Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
Article
Cardiac & Cardiovascular Systems
Nicole M. A. White-Al Habeeb, Victoria Higgins, Allison A. Venner, Dana Bailey, Daniel R. Beriault, Christine Collier, Khosrow Adeli
Summary: There is limited guidance on laboratory reporting and interpretation of lipids and lipoproteins used in cardiovascular risk stratification, leading to inconsistencies in lipid reporting across clinical laboratories. The Canadian Cardiovascular Society has published guidelines aligned with harmonized lipid reporting recommendations for improving standardization of lipid assessment and clinical decision-making.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xing Shui, Zheqi Wen, Ruimin Dong, Zefeng Chen, Leile Tang, Wenyu Tang, Zhen Wu, Lin Chen
Summary: This study found that apolipoprotein B (apoB) was associated with angiographic progression of coronary artery disease (CAD). Baseline apoB levels had a better predictive efficacy for angiographic progression compared to lipoprotein cholesterol. Therefore, apoB can be used as an accurate indicator of angiographic progression in patients with CAD.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Liu Shi, Dongmei Zhang, Jianqing Ju, Anlu Wang, Tianyi Du, Xuanye Chen, Yewen Song, Zhuye Gao, Hao Xu
Summary: In the general US adult population, remnant cholesterol (RC) is associated with hypertension beyond LDL-C levels. Elevated RC levels are linked to a higher prevalence of hypertension, independent of BMI, LDL-C, HDL-C, or triglycerides.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Hiroki Nishiyama, Takehiro Funamizu, Hiroshi Iwata, Hirohisa Endo, Yuichi Chikata, Shinichiro Doi, Hideki Wada, Ryo Naito, Manabu Ogita, Yoshiteru Kato, Iwao Okai, Tomotaka Dohi, Takatoshi Kasai, Kikuo Isoda, Shinya Okazaki, Katsumi Miyauchi, Tohru Minamino
Summary: This study aimed to evaluate the prognostic impact of preprocedural ApoA1 on cancer mortality in patients undergoing PCI. The results showed that patients with lower levels of ApoA1 had higher mortality rates for total, gastrointestinal, and lung cancer, while HDL-C levels had no significant impact on any type of cancer mortality. Multivariable analysis confirmed that elevated ApoA1 levels independently predicted a lower risk of total and gastrointestinal cancer. Therefore, preprocedural ApoA1 levels have prognostic implications for predicting cancer mortality in PCI patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Federica Galimberti, Manuela Casula, Elena Olmastroni
Summary: The retention of apoB-containing lipoproteins in the subendothelial layer is crucial for the development of atherosclerotic processes. Recent evidence suggests that the number of atherogenic particles trapped in the arterial lumen, rather than their lipid content, plays a key role in this process. Hence, apoB level is proposed as a better indicator than LDL-cholesterol for assessing cardiovascular disease risk, particularly in specific patient subgroups. Routine measurement of both LDL-cholesterol and apoB is essential for estimating overall cardiovascular risk, evaluating residual risk, and monitoring therapeutic effectiveness.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu
Summary: Despite advancements in pharmacotherapy and intervention devices, residual cardiovascular risks remain a significant burden on public health. Molecular modifications of lipid and lipoprotein components play a critical role in atherogenicity, with levels of certain lipids and proteins closely associated with atherosclerotic cardiovascular disease. Therapies targeting these modifications are showing promising results in trials for reducing risks and enhancing cardiovascular health.
Article
Cardiac & Cardiovascular Systems
Tianci Chai, Zhisheng Wang, Xiaojie Yang, Zhihuang Qiu, Liangwan Chen
Summary: By analyzing the associations between gene expression levels and circulating protein levels with LDL-C and CAD, this study found that regulatory SNPs in PSRC1 may affect CAD risk by altering CELSR2, PSRC1, and SORT1 gene expression in liver cells and circulating granulins and apolipoprotein B proteins.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Martin Jansenid, Christine Contini
Summary: This study examines the interrelationship of LDL mass, its composition, and other lipoproteins, and uses a mathematical model to estimate LDL's retention time in plasma.
Article
Medicine, General & Internal
Mohsen Mazidi, Richard J. Webb, Gregory Y. H. Lip, Andre P. Kengne, Maciej Banach, Ian G. Davies
Summary: Low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) are markers of atherosclerotic cardiovascular disease (ASCVD), and ApoB is a better predictor than LDL-C. The association between ApoB and chronic kidney disease (CKD) is debated. This study found that high levels of ApoB, compared to LDL-C, were independently associated with an increased likelihood of CKD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Justine Cole, James Dorian Otvos, Alan Thomas Remaley
Summary: Despite recent studies showing better correlation between atherosclerotic cardiovascular disease (ASCVD) risk and apolipoprotein B (apoB) than with low-density lipoprotein cholesterol (LDL-C), treatment decisions in the United States still rely on LDL-C. This study developed a method to convert apoB values into LDL-C units, allowing the use of LDL-C targets for apoB-based treatment decisions.
CLINICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Tsui-Yen Chang, Jong-Dar Chen
Summary: The study found that the low-density lipoprotein cholesterol (LDL-C) to apolipoprotein B (ApoB) ratio is superior to ApoB in diagnosing subjects with coronary artery calcification (CAC). The LDL-C/ApoB ratio can be conveniently used to enhance the diagnostic ability of ApoB for CAC.
CORONARY ARTERY DISEASE
(2021)
Review
Pharmacology & Pharmacy
Bahare Salehi, Cristina Quispe, Javad Sharifi-Rad, Natalia Cruz-Martins, Manisha Nigam, Abhay Prakash Mishra, Dmitryi Alexeevich Konovalov, Valeriya Orobinskaya, Ibrahim M. Abu-Reidah, Wissam Zam, Farukh Sharopov, Tommaso Venneri, Raffaele Capasso, Wirginia Kukula-Koch, Anna Wawruszak, Wojciech Koch
Summary: Phytosterols are plant-originated steroids with significant pharmacological effects, but their bioavailability is influenced by various factors and more research is needed to fully understand their therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Akshyaya Pradhan, Ravninder Kuka, Pravesh Vishwakarma, Wahid Ali, Marco Alfonso Perrone, Ferdinando Iellamo, Gaurav Chaudhary, Sharad Chandra, Rishi Sethi, Sudhanshu Dwivedi, Varun Narain, R. K. Saran
Summary: In ACS patients, age, sex, diabetes, smoking, and the severity of coronary artery disease did not significantly affect sd-LDL levels. However, prior statin usage was associated with lower sd-LDL levels, and diabetic patients had higher sd-LDL/lb-LDL ratios.
JOURNAL OF CLINICAL MEDICINE
(2022)