Review
Biochemistry & Molecular Biology
Izabela Korczowska-Lacka, Bartosz Slowikowski, Thomas Piekut, Mikolaj Hurla, Natalia Banaszek, Oliwia Szymanowicz, Pawel P. Jagodzinski, Wojciech Kozubski, Agnieszka Permoda-Pachuta, Jolanta Dorszewska
Summary: In diseases of the central nervous system, oxidative stress load commonly exceeds the body's antioxidant capacity. Endogenous antioxidants such as enzymes and exogenous antioxidants like vitamins and polyphenols play a significant role in preventing oxidative damage. However, the clinical efficacy and effectiveness of these antioxidants in neurological diseases need further research and definition.
Article
Nanoscience & Nanotechnology
Heba Ghamry, Mustafa Shukry, Mohamed A. Kassab, Foad A. Farrag, Nagi M. El-Shafai, Enas Elgendy, Amany N. Ibrahim, Salwa A. Elgendy, Ali Behairy, Samah F. Ibrahim, Florin Imbrea, Florin Crista, Mohamed Abdo, Inas A. Ahmed, Marwa H. Muhammad, Hala Anwer, Ahmed Abdeen
Summary: The study found that Arthrospira platensis nanoparticles (NSP) can protect rats from aging injuries and alleviate oxidative changes caused by D-galactose (D-gal). This suggests that NSP may be a promising natural protective compound that can prevent aging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hiva Sharebiani, Shayan Keramat, Abdolali Chavoshan, Bahar Fazeli, Agata Stanek
Summary: Obesity is a global trend with a fast-growing incidence rate. The dysfunction of adipose tissue caused by obesity is associated with oxidative stress. Oxidative stress and inflammation caused by obesity play a crucial role in the development of vascular diseases, specifically vascular aging. This study aims to review the impact of antioxidants on obesity-induced vascular aging resulting from oxidative stress.
Article
Biochemistry & Molecular Biology
Bhavana Chhunchha, Eri Kubo, Ronald R. Krueger, Dhirendra P. Singh
Summary: A major feature of aging-related diseases is the inability to activate cellular defense responses. The transcriptional protein Nrf2 plays a crucial role in oxidative stress response, cellular homeostasis, and health span. The FDA-approved drug hydralazine has been found to activate the Nrf2/ARE pathway, reducing lens opacity and extending lens healthspan against aging and oxidative stress. This study provides evidence for the repurposing of hydralazine as a therapeutic agent.
Article
Biochemistry & Molecular Biology
Joanna Kochman, Karolina Jakubczyk, Piotr Bargiel, Katarzyna Janda-Milczarek
Summary: Thyroid diseases are increasingly associated with oxidative stress, and the oxidative profile can be used to evaluate patients' conditions. Oxidative stress appears to play a significant role in the development of thyroid dysfunction and diseases.
Article
Biochemistry & Molecular Biology
Sydney L. Lane, Jason C. Parks, Jennifer E. Russ, Shaihla A. Khan, William B. Schoolcraft, Ye Yuan, Mandy G. Katz-Jaffe
Summary: Ovarian aging is characterized by elevated oxidative stress and diminished oocyte competence, however, antioxidant treatment with acai in aged mice effectively improved blastocyst formation and implantation potential by upregulating NRF2 to enhance ovarian function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Elena Grossini, Diego Concina, Carmela Rinaldi, Sophia Russotto, Divya Garhwal, Patrizia Zeppegno, Carla Gramaglia, Seval Kul, Massimiliano Panella
Summary: The study found that the redox state of the elderly was relatively balanced, mitochondrial function was associated with patient outcomes, and elderly patients with symptoms suggestive of COVID-19 had lower mitochondrial membrane potential.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rosa Vona, Lucia Pallotta, Martina Cappelletti, Carola Severi, Paola Matarrese
Summary: Accumulating evidence suggests that oxidative stress plays a crucial role in the pathogenesis and progression of many diseases, with conflicting contributions in gastrointestinal disorders. Oxidative stress has been shown to impact gastrointestinal motility and muscle phenotype changes. Although potential therapeutic strategies using antioxidants for inflammatory gastrointestinal diseases are promising, further research is needed to clarify the involvement of oxidative stress in mucosal disorders of the gastrointestinal tract.
Article
Food Science & Technology
Julia Maria Alatorre-Cruz, Ricardo Carreno-Lopez, Graciela Catalina Alatorre-Cruz, Leslie Janiret Paredes-Esquivel, Yair Olovaldo Santiago-Saenz, Adriana Nieva-Vazquez
Summary: Phenolic compounds have a positive effect on obesity, diabetes, and cardiovascular diseases. The prevalence of these diseases has increased in the Mexican population, so the phenolic compound intake in the Mexican diet needs to be assessed. A survey conducted on 973 adults found that participants with healthier conditions had a higher intake of phenolic compounds compared to those with more diseases. The study also showed that traditional Mexican food, such as arroz con frijol or enchiladas, positively affected health status.
Article
Cell Biology
Sin-Mei Guo, Yen-Tze Liu, Sin-Ru He, Ming-Shiang Wu, Wei-Ting Tseng, Ray-Chin Wu, I-Chien Wu
Summary: The study found a J-shaped association between serum uric acid and the risk of all-cause mortality in older adults, primarily for those with low grip strength. Participants with low grip strength showed a non-linear association between serum uric acid levels and mortality risk. Those with both high serum uric acid and low grip strength, or low serum uric acid and low grip strength, exhibited greater risks of mortality and deviations in biomarkers of specific systems.
Review
Biochemistry & Molecular Biology
Yaqin Wei, Sergio Giunta, Shijin Xia
Summary: As the global aging process continues, aging-related diseases are becoming more prevalent among the elderly population. These diseases are influenced by various factors including aging itself, hypoxia, chronic inflammation, and oxidative stress. However, the role of hypoxia in inflammation and aging is often overlooked in advanced clinical research. Therefore, our study aims to investigate the specific effects of hypoxia in aging and aging-related diseases, as well as potential treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bruna Miglioranza Scavuzzi, Joseph Holoshitz
Summary: The review focuses on the contribution of endoplasmic reticulum (ER) stress to the pathogenesis of rheumatic diseases, particularly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It also discusses the interplay between protein folding and formation of reactive oxygen species (ROS), where ER stress induces oxidative stress (OS) and aggravates misfolded protein accumulation and oxidation. Intervention studies targeting ER stress and oxidative stress in these diseases have shown promising results and warrant further investigation.
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Gregory A. Shilovsky, Vasily V. Ashapkin
Summary: The transcription factor Nrf2 and mitochondria play important roles in regulating cellular antioxidant systems and the aging rate. Nrf2 affects mitochondrial quality control and dynamics through mechanisms such as regulation of mitochondrial proteins and ROS balance. Multiple regulatory proteins associated with mitochondria also influence Nrf2 activity and form regulatory loops. Additionally, mtDNA-encoded signal peptides have been found to interact with nuclear regulatory systems, including Nrf2, and may be involved in regulating the aging rate.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Nutrition & Dietetics
Visarut Buranasudja, Chawanphat Muangnoi, Kittipong Sanookpan, Hasseri Halim, Boonchoo Sritularak, Pornchai Rojsitthisak
Summary: The study found that eriodictyol can protect human dermal fibroblasts from the harmful effects of hydrogen peroxide by directly neutralizing reactive oxygen species, enhancing detoxifying enzyme activities, and regulating the expression of Nrf2 signaling system.
Article
Nutrition & Dietetics
Serena Fragiotta, Maria D. Pinazo-Duran, Gianluca Scuderi
Summary: Recent evidence suggests that neurodegeneration plays a crucial role in the development of diabetic retinopathy. The apoptosis of neuronal cells contributes to microvascular impairment and blood-retinal barrier breakdown. Targeting neurodegeneration represents an early intervention strategy to prevent the progression of microvascular alterations. Multimodal imaging and functional assessment can help identify neuronal damage before the onset of retinopathy. Clinical features of neurodegeneration are important in identifying high-risk patients and assessing treatment efficacy. Topical compounds acting on different elements of the pathological cascade show promise in targeting neurodegeneration, with brimonidine, somatostatin, and citicoline being tested in human clinical trials.
Article
Ophthalmology
Lihteh Wu, Dhariana Acon, Maria H. Berrocal, Roberto Gallego-Pinazo, Rosa Dolz-Marco, Jose A. Roca, Mauricio Maia, Sergio Rojas, Marcelo Zas, J. F. Arevalo, Jay Chhablani
Summary: The study concluded that after 5 years of treatment with an average of 10.6 injections, there was a mean gain in BCVA. Eyes with a better baseline BCVA and a shorter duration of symptoms were more likely to achieve better BCVA at 5 years, with more eyes achieving a BCVA of >= 20/40 and gaining >= 3 lines.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Jose Javier Garcia-Medina, Maria Dolores Pinazo-Duran
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Santiago Montolio-Marzo, Roberto Gallego-Pinazo, Rosa Dolz-Marco, Aitor Lanzagorta-Aresti, Marta Perez-Lopez
Summary: This case report describes a healthy female who developed NAION following in vitro fertilisation and uneventful cesarean section. The only risk factor identified was a small cup-to-disc ratio. Hemodynamic and hormonal changes during late pregnancy and uneventful cesarean section may have triggered this condition.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Ghazi Bou Ghanem, Piergiorgio Neri, Rosa Dolz-Marco, Thomas Albini, Amani Fawzi
Summary: Inflammatory choroidal neovascularization (iCNV) is a rare complication of uveitis and can cause vision compromise. Fluorescein angiography (FA) is the gold standard for diagnosis, but it can be difficult to distinguish iCNV from inflammatory lesions. Optical coherence tomography (OCT) is a noninvasive imaging modality that can assist in diagnosing iCNV. OCT angiography (OCTA) uses motion contrast to visualize flow and is useful in distinguishing iCNV from inflammatory lesions. However, further studies are needed to determine its role in evaluating iCNV activity and treatment response.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, General & Internal
Carolina Garcia-Villanueva, Elena Milla, Jose M. Bolarin, Jose J. Garcia-Medina, Javier Cruz-Espinosa, Javier Benitez-del-Castillo, Jose Salgado-Borges, Francisco J. Hernandez-Martinez, Elena Bendala-Tufanisco, Irene Andres-Blasco, Alex Gallego-Martinez, Vicente C. Zanon-Moreno, Maria Dolores Pinazo-Duran
Summary: Open-angle glaucoma (OAG) is the most common cause of irreversible blindness worldwide. This study aimed to investigate the relationship between specific lifestyle habits, anthropometric and endocrine-metabolic, cardiovascular, and respiratory events, and commonly used psychochemicals with the presence of ocular hypertension (OHT) or OAG in a Spanish and Portuguese population. The results showed that overweight/obesity, migraine, asthma, and smoking are major risk factors for conversion from OHT to OAG in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Santiago Montolio-Marzo, Roberto Gallego-Pinazo, Elena Palacios-Pozo, Rosa Dolz-Marco
Summary: The purpose of this study was to use high dynamic range optical coherence tomography imaging to study subretinal hyperreflective material in patients with age-related macular degeneration. The study found that the disappearance rates, visual acuity improvement, and disruption of outer retinal layers varied among different types of subretinal hyperreflective material. This easily accessible tool may be helpful as a prognostic factor in age-related macular degeneration cases.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Irene Andres-Blasco, Alex Gallego-Martinez, Ximena Machado, Javier Cruz-Espinosa, Salvatore Di Lauro, Ricardo Casaroli-Marano, Victor Alegre-Ituarte, Jose Fernando Arevalo, Maria Dolores Pinazo-Duran
Summary: The study aimed to evaluate the molecules related to oxidative stress, inflammation, angiogenesis, and apoptosis in patients with proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME). By investigating their correlation in the plasma and vitreous body, as well as examining ophthalmological examination data, the study found that oxidative stress and inflammation were increased in the plasma and vitreous samples from patients with PDR/DME, while antioxidant capacity was decreased. The study suggests that exploring the relationship between these potential biomarkers in the plasma and vitreous may help detect early molecular changes in PDR/DME and monitor therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Prithvi Ramtohul, Maria Vittoria Cicinelli, Rosa Dolz-Marco, Orly Gal-Or, Sarah Mrejen, Jesus R. Garcia-Martinez, Alla Goldberg, Eduardo Cunha de Souza, Elisabetta Miserocchi, Emmett T. Cunningham, Lawrence A. Yannuzzi, K. Bailey Freund, Edmund Tsui
Summary: This study described a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions, characterized by grey-yellow chorioretinal lesions surrounded by smaller satellite dots, referred to as chrysanthemum lesions. The study retrospectively observed the multimodal imaging features of eyes with active iMFC and chrysanthemum lesions.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Medicine, General & Internal
Jose Javier Garcia-Medina, Nieves Bascunana-Mas, Paloma Sobrado-Calvo, Celia Gomez-Molina, Elena Rubio-Velazquez, Maravillas De-Paco-Matallana, Vicente Zanon-Moreno, Maria Dolores Pinazo-Duran, Monica Del-Rio-Vellosillo
Summary: In this study, the thickness of different segments of the macula was compared between dyslexic subjects and normal controls. The dyslexic group was found to have significantly thicker parafoveal sectors in both eyes, while no differences were observed in the outer retina or other layers of the retina.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Costanza Barresi, Jay Chhablani, Rosa Dolz-Marco, Robero Gallego-Pinazo, Alessandro Berni, Francesco Bandello, Enrico Borrelli
Summary: Age-related macular degeneration (AMD) is a complex and multifactorial disease that damages the unit comprising the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. While the outer retina is primarily affected, evidence suggests that the inner retina may also be impaired. Structural optical coherence tomography (OCT) technology has shown that both the inner and outer retina are impacted by AMD and that these impairments are associated. This review aims to describe the role of neurodegeneration in AMD to better understand the relationship between neuronal loss and outer retinal damage in this disease.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rosa Dolz-Marco, Javier Munoz-Solano, Jan F. Dechent, Roberto Gallego-Pinazo
Summary: This study aimed to compare treatment decisions by ophthalmologists with reading center fluid identification from optical coherence tomography. The results showed that treatment and reading center fluid determination agreed in the majority of visits, with more pronounced treatment response and smaller fluid areas contributing to discrepancies. Positive fluid discrepancy did not have a substantial impact on subsequent visual acuity.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
