Review
Medicine, Research & Experimental
Hai Wang, Boda Guo, Zhongming Huang, Xin Zhao, Zhigang Ji
Summary: This study found that vardenafil showed significant efficacy in the treatment of erectile dysfunction in men, significantly improving multiple evaluation indicators. However, further research is needed to determine the optimal dosage and course of vardenafil.
ADVANCES IN THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Federico De Leonardis, Gaia Colalillo, Enrico Finazzi Agro, Roberto Miano, Andrea Fuschi, Anastasios D. Asimakopoulos
Summary: Erectile dysfunction is a common condition, mainly caused by vascular factors and endothelial dysfunction, which has a close connection with cardiovascular disease. Early detection of ED can help prevent cardiovascular risks. Therefore, patients presenting with ED should undergo cardiac assessment and treatment.
Article
Polymer Science
Soad A. Mohamed, Remon Roshdy Rofaeil, Hesham Salem, Mahmoud Elrehany, Yahya I. Asiri, Adel Al Fatease, Hamdy Abdelkader
Summary: Oral phosphodiesterase inhibitors have revolutionized the treatment of erectile dysfunction, and topical penile therapy could be a potential replacement for oral medication. This study focuses on developing proniosomal gels for selected members and evaluating their effectiveness on a rodent model. The results show that tadalafil-loaded proniosomal gel has superior skin permeability and improvement in sexual performance compared to the untreated control.
Review
Medicine, General & Internal
Nikolaos Pyrgidis, Ioannis Mykoniatis, Anna-Bettina Haidich, Maria Tirta, Persefoni Talimtzi, Dimitrios Kalyvianakis, Andreas Ouranidis, Dimitrios Hatzichristou
Summary: Phosphodiesterase-type 5 inhibitors are recommended first-line treatment for erectile dysfunction, being safe and effective in various patient groups. This overview aims to summarize the existing knowledge on the efficacy and safety of PDE5i in the general population and multiple patient subgroups.
Review
Cell Biology
Mohammad Sheibani, Mehdi Ghasemi, Ahmad Reza Dehpour
Summary: Lithium has been a main therapy for bipolar disorders, but it can cause adverse effects such as sexual and erectile dysfunction. The mechanisms underlying these side effects involve both central and peripheral pathways. Understanding these mechanisms may lead to improved therapies for sexual dysfunction and better patient adherence.
Review
Pharmacology & Pharmacy
Dengjianyi Xu, Yucong Zhang, Jian Bai, Huixing Yuan, Tao Wang, Jihong Liu, Wen Song, Delin Ma
Summary: Phosphodiesterase-5 inhibitors (PDE5-i) are widely used for treating erectile dysfunction (ED) but have suboptimal therapeutic effects and side effects. Therefore, there is a need for developing new ED drugs, and botanical drugs have shown promising therapeutic effects. This review summarizes 34 studies on botanical drugs, including those with PDE5 inhibitory activity, without PDE5 inhibitory activity, and mixed botanical drugs. It highlights the clinical studies, mechanisms, and the need for high-quality trials to verify dosage, targeted patients, therapeutic effects, and further pharmacology experiments to identify active compounds.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Andrea Crafa, Rossella Cannarella, Federica Barbagallo, Claudia Leanza, Roberto Palazzolo, Hunter Ausley Flores, Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero
Summary: Vitamin D deficiency and erectile dysfunction are common in males, especially in the elderly, suggesting a possible relationship between the two conditions. Studies indicate that vitamin D affects erectile function by regulating endothelial function and interfering with comorbidities associated with erectile dysfunction. Low levels of vitamin D may worsen erectile function through various mechanisms. However, the quality and heterogeneity of clinical trials evaluating the effects of vitamin D on erectile function and related comorbidities require further investigation.
Article
Chemistry, Analytical
Riham Kamal Ahmed, Engy M. Saad, Hussein M. Fahmy, Rasha M. El Nashar
Summary: The highly potent Vardenafil sensor was successfully fabricated using a unique approach to optimize seven factors, achieving low detection limits and high recoveries in pharmaceutical formulations, spiked urine and serum samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Song Yang, Yichun Zhang, Xiaohui Lyu, Yuanyuan Gu, Guodong Zhang, Pengcheng Liu, Yulu Zheng, Zheng Guo, Yanbo Zhang, Haifeng Hou
Summary: This study found a negative correlation between serum FGF21 levels and diabetes-induced erectile dysfunction (ED). Animal experiments also supported this association. The study suggests potential of FGF21 as a predictor for diabetic ED.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yu Chen, Hong-Chiang Chang, William J. J. Huang, Chii-Jye Wang, Thomas I-Sheng Hwang, Chun-Hou Liao, Chia-Chu Liu, See-Tong Pang, Eric Yi-Hsiu Huang, Chih-Wei Tsao, Kuo-Chiang Chen, Shih-Ping Liu, Chao-Yuan Huang, Cheng-Hsing Hsieh, Bang-Ping Jiann
Summary: According to the Taiwan Cancer Report, prostate cancer was one of the top five cancers reported in men in 2018. Erectile dysfunction is a common complication of radical prostatectomy therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Surojit Paul, Eduardo Candelario-Jalil
Summary: Stroke is a major cause of disability and death globally, with an increasing incidence particularly in younger age groups and low to middle-income countries. While treatment options are limited, advancements in recanalization therapy have shown promise in helping patients recover from ischemic stroke. Development of neuroprotective agents for acute ischemic stroke is urgently needed to protect the brain, extend the therapeutic time window, and improve outcomes.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Po-Yen Chen, Jai-Hong Cheng, Zong-Sheng Wu, Yao-Chi Chuang
Summary: Shock waves have been widely applied in various fields of medical science. Low energy extracorporeal shock wave (LESW) therapy has been used in urology to treat diseases such as chronic prostatitis, and it enhances the expression of growth factors and inhibits inflammatory molecules, showing promise as an effective treatment method for various diseases.
Review
Urology & Nephrology
Mohammad Amin Langarizadeh, Amirhossein Salary, Marziye Ranjbar Tavakoli, Behnam Ghorbani Nejad, Shirin Fadaei, Zahra Jahani, Hamid Forootanfar
Summary: Erectile dysfunction is a common urologic problem in men worldwide, significantly affecting their quality of life and their sexual partners. Preventing and treating this disorder is crucial for overall human health, as it is associated with essential diseases. New approaches are needed to curb this issue in the future.
SEXUAL MEDICINE REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Kurt Miller, Uwe May, Wolf-Dietrich Beecken, Georgios Hatzichristodoulou, Michael Boehm, Stefan Fink
Summary: This study evaluated the benefits and risks of reclassifying tadalafil, a phosphodiesterase type 5 inhibitor, as an over-the-counter medication. The expert panel concluded that the benefits outweighed the risks and considered the risk mitigation strategies of packaging label and patient information leaflet to be sufficient.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ruocong Yang, Chao Liu, Qianqian Li, Weilu Wang, Bingbing Wu, Aiping Chen, Bin Wang, Wei Li, Jianxin Chen
Summary: The main active ingredient hirudin in leeches was found to ameliorate the symptoms of diabetic erectile dysfunction by directly interacting with myeloperoxidase and inhibiting its activity, leading to decreased levels of oxidized low-density lipoprotein in the serum. This study provides insight into a potential therapeutic target for DED and the underlying mechanism of hirudin in regulating MPO activity.
PHARMACOLOGICAL RESEARCH
(2021)
