Article
Oncology
Shiqiang Su, Lizhe Liu, Chao Sun, Yanhua Nie, Hong Guo, Yang Hu, Shunli Guo, Shujian Pang
Summary: In patients with bladder cancer treated by radical cystectomy, elevated serum GGT levels were associated with lower overall survival, cancer-specific survival, and disease-free survival rates. Preoperative serum GGT was identified as an independent predictor of prognosis for these patients, along with other factors such as age, diabetes history, and cancer stage.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Shiyu Zhang, Jiajia Du, Xin Zhong, Ping Tan, Hang Xu, Jiapeng Zhang, Di Jin, Yifan Li, Weizhen Le, Xingyu Xiong, Tianhai Lin, Qiang Wei
Summary: This study aimed to evaluate the association of preoperative systemic immune-inflammation index (SII) with the clinical outcomes of patients diagnosed with bladder cancer and who underwent radical cystectomy (RC). The study found that a high SII level was associated with worse overall survival and recurrence-free survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Stefano Tappero, Andrea Panunzio, Lukas Hohenhorst, Cristina Cano Garcia, Francesco Barletta, Mattia Piccinelli, Zhe Tian, Stefano Parodi, Alessandro Antonelli, Markus Graefen, Felix K. H. Chun, Alberto Briganti, Ottavio De Cobelli, Fred Saad, Shahrokh F. Shariat, Nazareno Suardi, Marco Borghesi, Carlo Terrone, Pierre I. Karakiewicz
Summary: The effect of radical cystectomy (RC) on cancer-specific mortality (CSM) is uncertain in non-metastatic sarcomatoid bladder cancer (SBC) patients. This study aimed to evaluate the benefit of RC in SBC patients and compare it with urothelial bladder cancer (UCB).
Article
Urology & Nephrology
Francesco Claps, Maaike W. van de Kamp, Roman Mayr, Peter J. Bostrom, Shahrokh F. Shariat, Katrin Hippe, Simone Bertz, Yann Neuzillet, Joyce Sanders, Wolfgang Otto, Michiel S. van Der Heijden, Michael A. S. Jewett, Robert Stoehr, Alexandre R. Zlotta, Carlo Trombetta, Markus Eckstein, Laura S. Mertens, Maximilian Burger, Yanish Soorojebally, Bernd Wullich, Riccardo Bartoletti, Francois Radvanyi, Nicola Pavan, Nanour Sirab, M. Carmen Mir, Damien Pouessel, Theo H. van Der Kwast, Arndt Hartmann, Yair Lotan, Rossana Bussani, Yves Allory, Bas W. G. van Rhijn
Summary: The study aims to evaluate variant histologies (VHs) for disease-specific survival (DSS) in patients with invasive urothelial bladder cancer (BCa) undergoing radical cystectomy (RC). The results showed that compared to pure urothelial carcinoma, clear-cell, plasmacytoid, small-cell, and sarcomatoid VHs were associated with worse DSS, while lymphoepithelioma-like VH showed a DSS benefit. Accurate pathological diagnosis can ensure tailored counselling for patients who require more intensive management.
Article
Urology & Nephrology
Francesco Soria, Peter C. Black, Adrian S. Fairey, Michael S. Cookson, Evan Y. Yu, Wassim Kassouf, Marc A. Dall'Era, Srikala S. Sridhar, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Siamak Daneshmand, Jeff M. Holzbeierlein, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Jay B. Shah, Bas W. van Rhijn, Philippe E. Spiess, Shahrokh F. Shariat, Paolo Gontero
Summary: In patients with cT2N0 bladder cancer and no preoperative hydronephrosis, neoadjuvant chemotherapy (NAC) increased the rate of pathological complete response and downstaging, showing a positive impact on overall survival.
Article
Urology & Nephrology
Maria Carmen Mir, Michele Marchioni, Homi Zargar, K. Zargar-Shoshtari, A. S. Fairey, Laura S. Mertens, C. P. Dinney, L. M. Krabbe, M. S. Cookson, N. E. Jacobsen, J. Griffin, J. S. Montgomery, N. Vasdev, E. Y. Yu, E. Xylinas, J. S. McGrath, W. Kassouf, M. A. Dall'Era, S. S. Sridhar, J. Aning, S. F. Shariat, J. L. Wright, A. C. Thorpe, T. M. Morgan, J. M. Holzbeierlein, T. J. Bivalacqua, S. North, D. A. Barocas, Y. Lotan, P. Grivas, A. J. Stephenson, J. B. Shah, B. W. van Rhijn, P. E. Spiess, D. Daneshmand, P. C. Black
Summary: A postoperative nomogram for predicting bladder cancer-specific mortality (BCSM) in MIBC patients was developed using international consortium data, with pathological stage, lymph node metastasis, and positive surgical margins identified as significant factors associated with BCSM. The model showed modest net benefit and clinical utility, providing key insights for patient counseling and high-risk patient identification for clinical trials.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Urology & Nephrology
Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G. Schultz, Chiara Lonati, Agostino Mattei, R. Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F. Shariat, Marco Moschini
Summary: The study found that patients with variant histology bladder cancer have a higher risk of recurrence, requiring extended surveillance time, and different histological types have different risks of recurrence and metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Jinliang Ni, Keyi Wang, Houliang Zhang, Jinbo Xie, Jun Xie, Changxiu Tian, Yifan Zhang, Weiyi Li, Bin Su, Chaozhao Liang, Xinran Song, Bo Peng
Summary: The study aimed to evaluate the prognostic significance of the systemic inflammatory response index (SIRI) in bladder cancer (BCa) patients treated with radical cystectomy (RC), and develop a survival predictive model through establishing a nomogram. Results showed that higher SIRI grade was significantly associated with poor prognosis, and the nomogram based on SIRI had better predictive performance compared to TNM stage. ROC analysis demonstrated that nomograms could better predict the 3- and 5-year OS and DFS, with calibration curves showing significant agreement between the nomogram and the actual observation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Hang Xu, Tianhai Lin, Jianzhong Ai, Jiapeng Zhang, Shiyu Zhang, Yifan Li, Xiaonan Zheng, Peng Zhang, Qiang Wei, Ping Tan, Lu Yang
Summary: This study aimed to determine the prognostic value of the preoperative lactate dehydrogenase-to-albumin ratio (LAR) in patients with urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC). The results showed that preoperative low LAR was associated with decreased overall survival (OS) and recurrence-free survival (RFS), and LAR was an independent prognostic factor. Incorporating LAR into the nomograms improved the predictive performance.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Aleksander Slusarczyk, Piotr Zapala, Tomasz Piecha, Lukasz Zapala, Tomasz Borkowski, Piotr Radziszewski
Summary: The study found that patients who underwent radical nephroureterectomy for upper urinary tract urothelial cancer after radical cystectomy experienced poor overall survival and cancer-specific survival, with most surgeries being performed for locally advanced tumors. Independent risk factors for worse survival included UTUC T stage, presence of metastasis, and male gender.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Houliang Zhang, Yidi Wang, Jinliang Ni, Huajuan Shi, Tao Zhang, Yifan Zhang, Jing Guo, Keyi Wang, Weipu Mao, Bo Peng
Summary: The study found that LCR is a prognostic indicator for BCa patients after RC, with the high LCR group significantly associated with better prognosis. The nomogram showed better predictive capability compared to TNM stage, confirming the usefulness of LCR in clinical decision-making and personalized therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Francesco Claps, Samarpit Rai, Maria Carmen Mir, Bas W. G. van Rhijn, Giorgio Mazzon, Laura Elizabeth Davis, Crystal Lynn Valadon, Tommaso Silvestri, Michele Rizzo, Murali Ankem, Giovanni Liguori, Antonio Celia, Carlo Trombetta, Nicola Pavan
Summary: The study evaluated the prognostic role of albumin-to-fibrinogen ratio (AFR) in bladder cancer patients undergoing radical cystectomy (RC), with preoperative low AFR independently associated with worse outcomes. These results suggest that patients with low AFR may benefit from neoadjuvant treatment.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
Carl J. Wijburg, Charlotte T. J. Michels, Gerjon Hannink, Janneke P. C. Grutters, Maroeska M. Rovers, J. Alfred Witjes
Summary: This study did not find significant differences in complications and health-related quality of life between robot-assisted radical cystectomy and open radical cystectomy. However, there were some differences in secondary outcomes, with the main limitation being residual confounding.
Review
Medicine, General & Internal
Vincent D. D'Andrea, Kevin Melnick, Kendrick Yim, John Ernandez, Nnamdi Onochie, Timothy N. Clinton, Graeme S. Steele, Mark A. Preston, Adam S. Kibel, Matthew Mossanen
Summary: The study analyzed and reviewed the critical steps of open radical cystectomy and developed a concise guide. Through evidence-based assessment, valuable information for optimizing surgical techniques and patient outcomes is provided.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Francois-Xavier Nouhaud, Marouene Chakroun, Claire Lenormand, Idir Ouzaid, Benoit Peyronnet, Alexandre Gryn, Thomas Prudhomme, Vivien Grafeille, Michel Soulie, Mathieu Roumiguie, Gregory Verhoest, Evanguelos Xylinas, Abderrazak Bouzouita, Mohamed Chebil, Christian Pfister
Summary: The study aimed to assess the prognosis differences between primary and progressive muscle invasive bladder cancer (MIBC) after radical cystectomy. Results showed that patients with progressive MIBC had worse overall survival, cancer specific survival, and recurrence-free survival. Pathological stage, positive surgical margins, and positive lymph nodes status were also found to be predictors of prognosis.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)