Article
Multidisciplinary Sciences
Gloria Pascual, Diana Dominguez, Marc Elosua-Bayes, Felipe Beckedorff, Carmelo Laudanna, Claudia Bigas, Delphine Douillet, Carolina Greco, Aikaterini Symeonidi, Inmaculada Hernandez, Sara Ruiz Gil, Neus Prats, Coro Bescos, Ramin Shiekhattar, Moran Amit, Holger Heyn, Ali Shilatifard, Salvador Aznar Benitah
Summary: The study suggests that dietary palmitic acid (PA), but not oleic acid or linoleic acid, may promote metastasis in oral carcinomas and melanoma in mice. The PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with stable deposition of histone H3 lysine 4 trimethylation by methyltransferase Set1A. Furthermore, the proregenerative state of tumor-activated Schwann cells induced by PA may play a role in long-term stimulation of metastasis.
Article
Medicine, Research & Experimental
Toru Hirozane, Mari Masuda, Teppei Sugano, Tetsuya Sekita, Naoko Goto, Toru Aoyama, Takato Sakagami, Yuko Uno, Hideki Moriyama, Masaaki Sawa, Naofumi Asano, Masaya Nakamura, Morio Matsumoto, Robert Nakayama, Tadashi Kondo, Akira Kawai, Eisuke Kobayashi, Tesshi Yamada
Summary: The study demonstrated that TNIK could be a potential therapeutic target in osteosarcoma, as its inhibition suppressed cell proliferation, altered metabolic network direction, and converted cell phenotype. These findings offer a new direction for osteosarcoma treatment.
Article
Oncology
Antonin Marchais, Maria Eugenia Marques da Costa, Bastien Job, Rachid Abbas, Damien Drubay, Sophie Piperno-Neumann, Olivia Fromigue, Anne Gomez-Brouchet, Francoise Redini, Robin Droit, Cyril Lervat, Natacha Entze-Werle, Helene Pacquement, Catherine Devoldere, Didier Cupissol, Damien Bodet, Virginie Gandemer, Marc Berger, Perrine Marec-Berard, Marta Jimenez, Gilles Vassal, Birgit Geoerger, Laurence Brugieres, Nathalie Gaspar
Summary: This study suggests that the composition of the osteosarcoma microenvironment is a significant characteristic for identifying hard-to-treat tumors in patients at the time of diagnosis, and it also defines the biological pathways and potential therapeutic targets associated with these tumors.
Review
Endocrinology & Metabolism
Shohei Otani, Mizuho Ohnuma, Kosei Ito, Yuki Matsushita
Summary: This mini-review discusses the cellular diversity and dynamics of multiple skeletal cell types and the origin of osteosarcoma (OS). It has been found that skeletal stem cells (SSCs) in the bone marrow endoskeletal region efficiently generate OS and are the cells of origin under p53 deletion conditions. The study also highlights future challenges in the research of skeletal cells and OS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Qingxin Fan, Jing Zuo, Hailong Tian, Canhua Huang, Edouard C. Nice, Zheng Shi, Qingquan Kong
Summary: In this study, a novel nanoparticle (HA/ZIF-8@Gem/D-1-MT NPs) was synthesized, which improves the tumor microenvironment and enhances the treatment of osteosarcoma by depriving myeloid-derived suppressor cells of nourishment. The results showed that the nanoparticles effectively inhibited the growth and invasion of osteosarcoma cells, and reactivated anti-tumor immunity. Animal experiments also confirmed the inhibitory effect of the nanoparticles on tumor growth.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Nicole Bodmer, Stefanie Hecker-Nolting, Godehard Friedel, Claudia Blattmann, Leo Kager, Torsten Kessler, Matthias Kevric Dok, Thomas Kuhne, Vanessa Mettmann, Peter Mueller-Abt, Benjamin Sorg, Matthias Theobald, Stefan S. Bielack
Summary: This study analyzed the clinical characteristics and optimal therapeutic strategies for primary rib osteosarcoma. The results showed that surgery and chemotherapy played a key role in treatment, but negative prognostic factors included incomplete tumor surgery, osteoblastic histology, and poor response to chemotherapy. Early diagnosis and effective local control are crucial for better outcomes.
Review
Biochemistry & Molecular Biology
Boren Tian, Xiaoyun Du, Shiyu Zheng, Yan Zhang
Summary: Osteosarcoma, an increasingly common malignancy in adolescents, is associated with the presence of osteosarcoma stem cells (OSCs) that contribute to malignant progression and therapy resistance. The unique properties of OSCs, such as self-renewal, multilineage differentiation, and metastatic potential, are closely regulated by the tumor microenvironment. Novel strategies targeting OSC plasticity and modulation of the tumor microenvironment are being explored for the treatment of osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Louise Marchandet, Morgane Lallier, Celine Charrier, Marc Baud'huin, Benjamin Ory, Francois Lamoureux
Summary: Osteosarcoma is the most common primary bone tumor affecting children and adolescents, with resistance being one of the reasons for treatment failure. Understanding the molecular mechanisms of resistance is key to developing new strategies to improve patient outcomes.
Article
Oncology
Isabella Giacomini, Margherita Cortini, Mattia Tinazzi, Nicola Baldini, Veronica Cocetta, Eugenio Ragazzi, Sofia Avnet, Monica Montopoli
Summary: Osteosarcoma, the most common bone tumor in children and young adults, is also the second most fatal cancer. Despite the clinical benefit of chemotherapy, patients with osteosarcoma still face a poor prognosis due to drug resistance and frequent growth and metastasis of the disease. This study reveals a different mitochondrial phenotype in doxorubicin-resistant cancer cells and suggests targeting the altered pathway to reverse drug resistance. These findings contribute to understanding mitochondrial metabolism changes and developing strategies to overcome doxorubicin resistance in osteosarcoma.
Review
Biochemistry & Molecular Biology
Virinder Kaur Sarhadi, Ravindra Daddali, Riitta Seppanen-Kaijansinkko
Summary: Osteosarcoma is an aggressive bone tumor that predominantly affects children and adolescents, with a strong tendency to relapse and metastasize, posing challenges in identifying new therapeutic targets. Mesenchymal stem cells play a significant role in osteosarcoma development, contributing to tumor progression through intercellular signaling and communication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ming Li, Wei Ma
Summary: MiR-26a expression is negatively correlated with multidrug resistance (MDR) in human osteosarcoma, and its enforced expression can reverse MDR by directly targeting MCL1. This suggests a potential tactic of manipulating miR-26a for overcoming MDR in osteosarcoma chemotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Sung Han Kang, Wanlim Kim, Jong Seok Lee, Jin Kyung Suh, Hyery Kim, Dong Kwan Kim, Se Hoon Choi, Hee Won Cho, Hee Young Ju, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Sung Wook Seo, Ho Joon Im, Ji Won Lee, Kyung-Nam Koh
Summary: This study evaluated the role of high-dose chemotherapy with autologous stem cell transplantation (HDCT/ASCT) in treating relapsed osteosarcoma. The results showed that achieving complete remission was the most important factor for good survival outcomes, while HDCT/ASCT did not significantly improve survival rates.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Medicine, General & Internal
Hannah C. Beird, Stefan S. Bielack, Adrianne M. Flanagan, Jonathan Gill, Dominique Heymann, Katherine A. Janeway, J. Andrew Livingston, Ryan D. Roberts, Sandra J. Strauss, Richard Gorlick
Summary: Osteosarcoma is the most common primary malignant bone tumor with a bimodal incidence peaking at 18 and 60 years of age. It is more common in males and is driven by genetic factors related to bone formation leading to malignant progression and metastasis. Screening is currently focused on high-risk groups, and the prognosis for patients with metastatic disease remains poor.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Biochemistry & Molecular Biology
Pilar Baldominos, Alex Barbera-Mourelle, Olga Barreiro, Yu Huang, Andrew Wight, Jae-Won Cho, Xi Zhao, Guillem Estivill, Isam Adam, Xavier Sanchez, Shannon McCarthy, Julien Schaller, Zara Khan, Albert Ruzo, Ricardo Pastorello, Edward T. Richardson, Deborah Dillon, Paula Montero-Llopis, Romualdo Barroso-Sousa, Juliet Forman, Sachet A. Shukla, Sara M. Tolaney, Elizabeth A. Mittendorf, Ulrich H. von Andrian, Kai W. Wucherpfennig, Martin Hemberg, Judith Agudo
Summary: This study discovered that in primary breast cancer, tumor cells that resist T cell attack are quiescent and form clusters with reduced immune infiltration. These quiescent cancer cells show superior tumorigenic capacity and higher expression of chemotherapy resistance and stemness genes. Single-cell RNA sequencing revealed differential phenotypes in infiltrating cells based on their intra-tumor location, and uncovered hypoxia-induced immune-suppressive programs. The findings suggest that eliminating quiescent cancer cells holds the promise to counteract immunotherapy resistance and prevent disease recurrence in TNBC.
Article
Biotechnology & Applied Microbiology
Wenkai Chen, Zongguang Li, Naichun Yu, Linlin Zhang, Hongyu Li, Yongjie Chen, Fengqing Gong, Wenping Lin, Xu He, Siyuan Wang, Yue Wu, Guangrong Ji
Summary: In this study, a potential therapeutic nano platform was constructed by modifying BMSCs EXOs using the bone-targeting peptide SDSSD and encapsulating capreomycin (CAP) within a shell. These constructed nanoparticles (NPs) exhibited homologous targeting ability and significantly promoted cellular endocytosis in vitro and tumor accumulation in vivo. Furthermore, the NPs induced ferroptosis in OS cells by prompting excessive accumulation of reactive oxygen species (ROS), Fe2+ aggregation, and lipid peroxidation, and the potential anticancer molecular mechanism of ferroptosis was identified as transduced by the Keap1/Nrf2/GPX4 signaling pathway. Additionally, the NP-directed ferroptosis showed significant inhibition of tumor growth in vivo with no significant side effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)