Complement anaphylatoxins as immune regulators in cancer

Genetic and Pharmacologic Inhibition of Complement Impairs Endothelial Cell Function and Ablates Ovarian Cancer Neovascularization

(2015) Selene Nunez-Cruz et al.   NEOPLASIA

Generation of Anaphylatoxins by Human β-Tryptase from C3, C4, and C5

(2014) Yoshihiro Fukuoka et al.   JOURNAL OF IMMUNOLOGY

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

(2014) Paulo Ornellas et al.   International Braz J Urol

Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88)

(2013) H. Nitta et al.   CLINICAL CANCER RESEARCH

Prevalence of human papillomavirus and Epstein-Barr virus DNA in penile cancer cases from Brazil

(2013) Larissa Alves Afonso et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Complement inhibition in cancer therapy

(2013) Ruben Pio et al.   SEMINARS IN IMMUNOLOGY

Anaphylatoxin C5a Creates a Favorable Microenvironment for Lung Cancer Progression

(2012) Leticia Corrales et al.   JOURNAL OF IMMUNOLOGY

Opposing Roles for Complement Component C5a in Tumor Progression and the Tumor Microenvironment

(2012) L. Gunn et al.   JOURNAL OF IMMUNOLOGY

Complement in Cancer and Cancer Immunotherapy

(2011) Martin Kolev et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Novel roles of complement in T effector cell regulation

(2011) Peter S. Heeger et al.   IMMUNOBIOLOGY

The new face of anaphylatoxins in immune regulation

(2011) Wuding Zhou   IMMUNOBIOLOGY

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

(2010) Claire E. Bamberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

(2010) Motomu Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer and the Complement Cascade

(2010) M. J. Rutkowski et al.   MOLECULAR CANCER RESEARCH

Decreased Survival of Human Breast Cancer Cells Expressing HER2/neuonIn vitroIncubation with an Anti-HER2/neuAntibody Fused to C5a or C5adesArg

(2010) Jaheli Fuenmayor et al.   MOLECULAR CANCER THERAPEUTICS

Role and mechanism of action of complement in regulating T cell immunity

(2010) Jason R. Dunkelberger et al.   MOLECULAR IMMUNOLOGY

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells

(2010) M.S. Campo et al.   VIROLOGY

Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

(2009) C. Fang et al.   BLOOD

C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells

(2009) Donald J. Weaver et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells and immune tolerance to tumors

(2009) Xuefang Cao   IMMUNOLOGIC RESEARCH

Dendritic Cell Function in Allostimulation Is Modulated by C5aR Signaling

(2009) Q. Peng et al.   JOURNAL OF IMMUNOLOGY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Immune infiltration in human tumors: a prognostic factor that should not be ignored

(2009) F Pagès et al.   ONCOGENE

Is complement good or bad for cancer patients? A new perspective on an old dilemma

(2009) Maciej M. Markiewski et al.   TRENDS IN IMMUNOLOGY

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

(2008) K. Li et al.   BLOOD

Modulation of Protective T Cell Immunity by Complement Inhibitor Expression on Tumor Cells

(2008) J. C. Varela et al.   CANCER RESEARCH

Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells

(2008) S. Nagaraj et al.   CANCER RESEARCH

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

Cancer and complement

(2008) Suzanne Ostrand-Rosenberg   NATURE BIOTECHNOLOGY

Cancer exploiting complement: a clue or an exception?

(2008) Bruce E Loveland et al.   NATURE IMMUNOLOGY

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE