Article
Dentistry, Oral Surgery & Medicine
Ciro Dantas Soares, Cinthia Veronica Bardalez Lopez de Caceres, Carla Isabelly Rodrigues-Fernandes, Thayna Melo de Lima Morais, Oslei Paes de Almeida, Maria Goretti Freire de Carvalho, Felipe Paiva Fonseca
Summary: The study investigated the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC). Results showed that nuclear RUNX1 expression was significantly associated with adverse clinicopathologic features and lower disease-free survival and disease-specific survival rates for head and neck ACC patients.
Article
Oncology
Laurie Saloner Dahan, Roch Giorgi, Sebastien Vergez, Ludovic Le Taillandier de Gabory, Valerie Costes-Martineau, Philippe Herman, Gilles Poissonnet, Olivier Mauvais, Olivier Malard, Renaud Garrel, Emmanuelle Uro-Coste, Beatrix Barry, Christine Bach, Dominique Chevalier, Francois Mouawad, Jean-Claude Merol, Vianney Bastit, Juliette Thariat, Laurent Gilain, Xavier Dufour, Christian-Adrien Righini, Antoine Moya-Plana, Caroline Even, Thomas Radulesco, Justin Michel, Bertrand Baujat, Nicolas Fakhry
Summary: This study described the characteristics of the largest European study on MEC of salivary glands and identified prognostic factors for overall and disease-free survival. The main prognostic factors included tumor grade, age, disease stage, and presence of diabetes. Advanced clinical stage, high-grade tumor, older age, inability to undergo complete surgical resection, and diabetes were found to have significant negative impacts on patient outcomes.
Article
Biochemistry & Molecular Biology
Cristina Stefania Dumitru, Amalia Raluca Ceausu, Nela Pusa Gaje, Cristian Silviu Suciu, Marius Raica
Summary: This study demonstrates the importance of double immunolabeling in assessing lymphangiogenesis and tumor proliferation in correlation with histopathological grades in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Otorhinolaryngology
Kosuke Terazawa, Toshimitsu Ohashi, Hirofumi Shibata, Takuma Ishihara, Takenori Ogawa
Summary: In this study, we investigated the prognostic role of immune-mGPS (imGPS) in patients with head and neck squamous cell carcinoma (HNSCC) and found that imGPS is a more accurate predictor compared to the conventional mGPS.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Multidisciplinary Sciences
Chih-Wei Luan, Yao-Te Tsai, Hsin-Yi Yang, Kuan-Yin Chen, Po-Hsien Chen, Hsin-Hsu Chou
Summary: The pretreatment prognostic nutritional index (PNI) has controversial predictive value for head and neck cancer (HNC) patients. Low pretreatment PNI is associated with poor overall survival (OS), progression-free survival (PFS), disease-specific survival (DSS), disease-free survival (DFS) and distant metastasis-free survival (DMFS) in HNC patients, regardless of variations in cancer site, sample size, PNI cut-off value, analysis method and treatment modality. Elevated pretreatment PNI is correlated with a better prognosis in HNC patients and could serve as a biomarker for prognosis prediction and treatment stratification in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Qigen Fang, Yao Wu, Wei Du, Xu Zhang, Defeng Chen
Summary: The expression of PD-L1 in high-grade salivary gland carcinomas was significantly associated with tumor stage, and a tumor proportion score (TPS) of >= 1% was common in 43.1% of patients, with significant differences in 5-year disease-free survival and overall survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hidenori Suzuki, Eiichi Sasaki, Gaku Takano, Seiya Goto, Daisuke Nishikawa, Shintaro Beppu, Hoshino Terada, Michi Sawabe, Nobuhiro Hanai
Summary: The study found that a higher lymph node ratio in minor salivary gland carcinoma patients is associated with shorter survival outcomes. A lymph node ratio ≥0.05 can predict shorter disease-specific, disease-free, and overall survival times.
Article
Genetics & Heredity
Yaodong He, Yunshan Li, Junwei Xiang, Xu Huang, Mingyu Zhao, Yuanyin Wang, Ran Chen
Summary: Tyrosine kinase 2 (TYK2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and is associated with tumor growth, prognosis, and immune infiltration. TYK2 can serve as a novel biomarker for assessing the prognosis of HNSCC patients and aiding in immunotherapy against HNSCC.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Paula Fatturi Moretz-sohn, Fernando Luiz Dias, Caroline Mafra de Carvalho Marques
Summary: The purpose of this study is to clarify the incidence, epidemiology, predictive factors, and outcome-based survival in a large cohort of patients with minor salivary gland carcinomas (MiSGC) of the head and neck treated at the Brazilian National Cancer Institute (BNCI) over a 20-year period by comparing and associating the results of current articles on the world stage.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Oncology
Ximena Terra, Victoria Ceperuelo-Mallafre, Carla Merma, Ester Benaiges, Ramon Bosch, Paola Castillo, Joan Carles Flores, Xavier Leon, Izaskun Valduvieco, Neus Baste, Marina Camara, Marylene Lejeune, Josep Guma, Joan Vendrell, Isabel Vilaseca, Sonia Fernandez-Veledo, Francesc Xavier Aviles-Jurado
Summary: Circulating succinate levels are increased in head and neck squamous cell carcinoma (HNSCC), with high expression of SUCNR1 and SDHA predicting poor locoregional control. This suggests that succinate could serve as a valuable noninvasive biomarker for diagnosis and prognosis in HNSCC.
Article
Oncology
Stefan Stoiber, Faris F. Brkic, Tobias Maier, Julia Schnoell, Elisabeth Gurnhofer, Gregor Heiduschka, Lorenz Kadletz-Wanke, Lukas Kenner
Summary: This study evaluated the prognostic relevance of the Wnt/beta-CATENIN pathway in patients with HPV-positive HNSCC. High CTNNB1 expression was linked to better overall survival, and high beta-CATENIN expression was significantly associated with a better overall survival as well. Thus, beta-CATENIN expression may serve as a marker for better survival outcomes in patients with HPV-positive HNSCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Daniele Borsetto, Jerry Polesel, Giancarlo Tirelli, Anna Menegaldo, Vittorio Baggio, Alessandro Gava, Paul Nankivell, Paul Pracy, Jonathan Fussey, Paolo Boscolo-Rizzo
Summary: This study found that pretreatment anemia and macrocytosis are independent predictors of lower overall and progression-free survival in patients with head and neck squamous cell carcinoma undergoing organ preservation treatment.
Article
Oncology
Erik Haehl, Luisa Alvino, Alexander Ruhle, Jiadai Zou, Alexander Fabian, Anca-Ligia Grosu, Nils H. Nicolay
Summary: Sarcopenia, or the loss of muscle mass, is a risk factor for reduced survival and increased treatment-associated toxicities in many cancers, and it increases with age. In this study, we investigated sarcopenia and sarcopenia dynamics during treatment in elderly patients with head-and-neck cancers undergoing (chemo)radiotherapy. Pre-treatment sarcopenia in elderly patients correlated with decreased body weight, a higher level of comorbidities, larger tumor size, and increasing age. Additionally, patients who exhibited sarcopenia prior to radiotherapy had significantly reduced overall survival and an increased risk of higher-grade toxicities. However, during (chemo)radiotherapy, muscle mass in patients remained relatively stable, and post-therapeutic sarcopenia did not correlate with patient survival.
Article
Oncology
Florian Chatelet, Francois Regis Ferrand, Sarah Atallah, Juliette Thariat, Francois Mouawad, Nicolas Fakhry, Olivier Malard, Caroline Even, Erwan de Mones, Emmanuelle Uro-Coste, Nazim Benzerdjeb, Stephane Hans, Sylvie Testelin, Olivier Mauvais, Diane Evrard, Vianney Bastit, Sebastien Salas, Florent Espitalier, Marion Classe, Laurence Digue, Melanie Dore, Stephanie Wong, Charles Dupin, France Nguyen, Jeremie Bettoni, Ariane Lapierre, Emilien Colin, Pierre Philouze, Sebastien Vergez, Bertrand Baujat, Philippe Herman, Benjamin Verillaud
Summary: This study analyzed data from the national REFCOR multi-center cohort to investigate the prognostic factors in acinic cell carcinomas (AciCCs) and assess the impact of postoperative radiotherapy and prophylactic neck dissection. The results suggest the importance of long-term follow-up in AciCC patients and indicate that surgery alone may be an option for selected patients without high-grade transformation. Prophylactic neck dissection may be beneficial for patients with advanced stage or high-grade tumors.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Gregoire B. Morand, Antoine Eskander, Rui Fu, John de Almeida, David Goldstein, Hesameddin Noroozi, Ali Hosni, Hadi Seikaly, Paul Tabet, Justin M. Pyne, T. Wayne Matthews, Joseph Dort, Steve Nakoneshny, Apostolos Christopoulos, Houda Bahig, Stephanie Johnson-Obaseki, Nadia Hua, Marc Gaudet, Alborz Jooya, Anthony Nichols, Francisco Laxague, Matthew Cecchini, Jenny Du, Justin Shapiro, Irene Karam, Peter T. T. Dziegielewski, Krishna Hanubal, Boban Erovic, Stefan Grasl, Joel Davies, Eric Monteiro, Maru Gete, Ian Witterick, Nader Sadeghi, Keith Richardson, George Shenouda, Anastasios Maniakas, Vivianne Landry, Michael Gupta, Kelvin Zhou, Alex M. M. Mlynarek, Marc Pusztaszeri, Khalil Sultanem, Michael. P. Hier
Summary: This study analyzed the effectiveness of postoperative radiation therapy for low and intermediate grade cancers of the parotid and submandibular glands. The results indicated that postoperative radiation therapy can reduce locoregional recurrence in certain cases, but it has no benefit for early stage, low-grade cancers.
