Article
Oncology
Jie Wan, Yinqiu Wu, Lan Huang, Yu Tian, Xiaoyun Ji, Mohamed Hamed Abdelaziz, Wei Cai, Kesavan Dineshkumar, Yuqing Lei, Shun Yao, Caixia Sun, Zhaoliang Su, Shengjun Wang, Huaxi Xu
Summary: ILC2s, characterized by secretion of type 2 cytokines, are abundant in colorectal cancer tissue and mainly secrete IL-9, which activates CD8(+) T cells to inhibit tumor growth. The study showed that ILC2-derived IL-9 can promote anti-tumor effects in CRC.
Article
Biochemistry & Molecular Biology
Ming Chang, Yu He, Cong Liu, Risheng Lin, Xin Huang, Dongcuan Liang, Jian Zhang, Yi Lu
Summary: This study found that SEPT5 is overexpressed in prostate cancer and is associated with prognosis. Downregulation of SEPT5 inhibits the progression of prostate cancer and increases immune cell infiltration, especially CD8+ T cells. This may be achieved by promoting the production of chemokines and cytokines associated with immune cell infiltration. SEPT5 may serve as a prognostic biomarker for prostate cancer and a potential target for enhancing the efficacy of immunotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Cell Biology
David A. Lewis, Tony Ly
Summary: CD8(+) T cells are crucial in immunity and immuno-oncology, as they undergo complex cellular growth, cell cycle entry, and differentiation to produce antigen-specific cytotoxic T lymphocytes. Some activated T cells will differentiate into memory T cells which are essential in adaptive immunity. This review explores the control of cell cycle entry in CD8(+) T cells and the interaction between these mechanisms and pathways regulating immunological phenotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jianru Chen, Weinan Guo, Pengran Du, Tingting Cui, Yuqi Yang, Yinghan Wang, Pan Kang, Zhe Zhang, Qi Wang, Zhubiao Ye, Ling Liu, Zhe Jian, Tianwen Gao, Huijie Bian, Shuli Li, Chunying Li
Summary: This study found that MIF is overabundant in vitiligo patients and a mouse model for human vitiligo. Inhibiting MIF can ameliorate vitiligo progression by suppressing the infiltration of CD8(+) T cells and protecting epidermal melanocytes. This suggests that MIF may be a potential target for vitiligo treatment.
JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Hongkai Zhuang, Zixuan Zhou, Zedan Zhang, Xinming Chen, Zuyi Ma, Shanzhou Huang, Yuanfeng Gong, Chuanzhao Zhang, Baohua Hou
Summary: B3GNT3 overexpression in pancreatic cancer is associated with tumor progression, poor clinical outcomes, and immunosuppression, making it a potential therapeutic target.
Article
Endocrinology & Metabolism
J. N. Rashida Gnanaprakasam, Bhavana Kushwaha, Lingling Liu, Xuyong Chen, Siwen Kang, Tingting Wang, Teresa A. Cassel, Christopher M. Adams, Richard M. Higashi, David A. Scott, Gang Xin, Zihai Li, Jun Yang, Andrew N. Lane, Teresa W. -M. Fan, Ji Zhang, Ruoning Wang
Summary: The study shows that asparagine restriction has opposing effects on different phases of T cell activation, mediated by NRF2-dependent mechanism. Restricting asparagine suppresses early phase activation and cell cycle entry, but promotes proliferation and effector function in the differentiation phase. This research suggests that asparagine restriction could enhance cancer immunotherapy.
Review
Immunology
Jaeoh Park, Pei -Chun Hsueh, Zhiyu Li, Ping-Chih Ho
Summary: Metabolic stress in the tumor microenvironment inhibits T cell anti-tumor immunity. Recent studies have identified strategies to activate T cell activities by targeting T cell metabolism, improving immune checkpoint blockade and adoptive cell transfer therapies. However, different treatment outcomes across cancers raise the question of universal understanding of CD8+ T cells in the tumor microenvironment, regardless of tissue origin.
Review
Immunology
Joseph S. Dolina, Natalija Van Braeckel-Budimir, Graham D. Thomas, Shahram Salek-Ardakani
Summary: Recent research has revealed the heterogeneity within the exhausted CD8(+) T cell lineage, which consists of multiple interconnected subpopulations with distinct characteristics and locations. This understanding calls for a re-focusing of cancer immunotherapies on targeting the driver mechanisms underlying CD8(+) T(ex) development to stabilize functional subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Summary: Cancer immunotherapy is more effective against hematological malignancies than solid tumors due to metabolic challenges in the tumor microenvironment. Mitochondria play a key role in CD8(+) T cell activation and effector function. Enhanced mitochondrial function is associated with improved T cell migration and effector function, highlighting the importance of mitochondrial metabolism in T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Angela Castoldi, Jennifer Lee, Daniel de Siqueira Carvalho, Fabricio Oliveira Souto
Summary: Immunometabolism has advanced our understanding of how cellular environment and nutrient availability regulate immune cell fate. Dysregulation of immune cell metabolism plays an essential role in the progression of diseases including breast cancer. CD8(+) T cells are crucial in the tumor microenvironment and their metabolic changes are important for tumor progression. However, identifying specific CD8(+) T cell subtypes in breast cancer remains challenging.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cell Biology
Samrat T. Kundu, B. Leticia Rodriguez, Laura A. Gibson, Amanda N. Warner, Mabel G. Perez, Rakhee Bajaj, Jared J. Fradette, Caleb A. Class, Luisa M. Solis, Frank R. Rojas Alvarez, Ignacio I. Wistuba, Lixia Diao, Fengju Chen, Mohit Sachdeva, Jing Wang, David G. Kirsch, Chad J. Creighton, Don L. Gibbons
Summary: m96cl suppresses lung cancer growth and metastasis by inducing an IL2-mediated systemic CD8(+) CTL immune response.
GENES & DEVELOPMENT
(2022)
Review
Immunology
Duojiao Wu, Yuwen Chen
Summary: Lipids and lipid metabolism play important roles in regulating T cell function and immune memory. Tumor-infiltrating CD8(+) T lymphocytes restore their impaired function by burning fats, while fatty acids and cholesterol in the tumor microenvironment contribute to CD8(+) TILs dysfunction. Understanding the interplay between cellular lipid metabolism and CD8(+) TILs dysfunction is crucial for improving cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee, Matthew J. Riese
Summary: Studies have shown that mice deficient in DGK zeta exhibit better control of tumors, and deficiency of DGK zeta acts additively with anti-PD1 in tumor control. Additionally, DGK zeta imparts greater regulation in human T cells compared to DGK alpha.
Review
Cell Biology
Wai Ki Wong, Bohan Yin, Ching Ying Katherine Lam, Yingying Huang, Jiaxiang Yan, Zhiwu Tan, Siu Hong Dexter Wong
Summary: This article discusses the importance of epigenetic regulation of T-cell function in cancer immunotherapy and how to restore their function by modulating the epigenetic switches of T-cells, providing new therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dragan Copic, Martin Direder, Katharina Klas, Daniel Bormann, Maria Laggner, Hendrik Jan Ankersmit, Michael Mildner
Summary: This study reveals a novel mode of action of ATG in regulating T cell activity and effector functions through the secretion of cytokines and chemokines, as well as the modulation of cell surface ligands and receptors.