Article
Neurosciences
Miriam Steines, Arne Nagels, Tilo Kircher, Benjamin Straube
Summary: This study systematically compared abstract related, concrete unrelated, and concrete related gestures, finding that abstract related and concrete unrelated stimuli elicited stronger activation of the bilateral IFG. Laterality effects indicate a left hemispheric dominance for metaphoric gestures and a right hemispheric dominance for unrelated gestures.
Article
Geriatrics & Gerontology
Hakuei Fujiyama, Jane Tan, Rohan Puri, Mark R. Hinder
Summary: Research suggests that transcranial direct current stimulation can improve executive function in healthy older adults, including decision-making speed and inhibitory control. Anodal tDCS appears to enhance perceptual decision-making and inhibitory control performance in both younger and older adults.
NEUROBIOLOGY OF AGING
(2022)
Article
Multidisciplinary Sciences
Miguel Angel Rivas-Fernandez, Benxamin Varela-Lopez, Susana Cid-Fernandez, Santiago Galdo-Alvarez
Summary: The study explored the functional activation and connectivity of the left inferior frontal gyrus using functional magnetic resonance imaging, revealing differences in activation and connectivity for objects and letters in a naming task. The results highlight the different roles played by this brain region in lexical, syntactic, and phonological retrieval during speech production.
Review
Neurosciences
Redmond G. O'Connell, Simon P. Kelly
Summary: Recent methodological advances have enabled the study of human brain signals that trace the dynamics of decision formation, revealing key elements of decision-making processes and algorithms in the brain.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 44, 2021
(2021)
Article
Neurosciences
Kenneth I. Vaden, Susan Teubner-Rhodes, Jayne B. Ahlstrom, Judy R. Dubno, Mark A. Eckert
Summary: Extensive increases in cingulo-opercular frontal activity during speech recognition in noise tasks have been linked to a word recognition benefit on the next trial, but the mechanisms behind this effect have been unclear. This study suggests that pre-stimulus cingulo-opercular activity reflects criterion adjustments that determine how much information to collect for word recognition in subsequent trials. These findings provide insight into the role of cingulo-opercular cortex in optimizing speech recognition performance.
Article
Neurosciences
Kazuma Mori, Masahiko Haruno
Summary: This study used behavioral data and functional magnetic resonance imaging (fMRI) to explore the brain connectivity associated with the size of an individual's active social network. The results showed that individuals with a larger social network size exhibited higher fMRI connectivity between the left inferior frontal gyrus and the dorsomedial prefrontal cortex and temporoparietal junction, which are core regions of the theory of mind network.
HUMAN BRAIN MAPPING
(2022)
Article
Geriatrics & Gerontology
Ping Ren, Guozhi Luo, Jiayin Huang, Meiling Tan, Donghui Wu, Han Rong
Summary: Aging is often accompanied by cognitive decline and altered decision making. This study found that older adults have difficulty in processing reward/risk information, leading to suboptimal decision strategy. It also investigated the neural substrates of risky decision-making under ambiguity in aging and found that older adults are more sensitive to high punishment frequency.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Yusuke Morito, Tsutomu Murata
Summary: This study investigates the neural substrates of evidence accumulation during decision-making tasks using functional magnetic resonance imaging (fMRI). The findings suggest the existence of different types of accumulators in various brain regions, which are involved in decision timing and competition among alternative choices.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Xiaoyu Liu, Jing Qu, Huiling Li, Rui Yang, Leilei Mei
Summary: This study investigated the neural mechanisms of language production in bilinguals, revealing that bilinguals exhibit similar neural activation patterns in the production of the non-dominant language in both monolingual and bilingual contexts.
Article
Neurosciences
Wanying Zhao, Yanchang Li, Yi Du
Summary: The study investigates how the frontal control region interacts with temporal representation in semantic integration by using inhibitory transcranial magnetic stimulation. The results suggest a two-stage gesture-speech integration circuit with sequential involvement of pMTG and IFG, providing new insights into the dynamic brain network of multimodal semantic processing.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Yoojeong Choo, Dora Matzke, Mark D. Bowren, Daniel Tranel, Jan R. Wessel
Summary: Inhibitory control is an important function in the human brain. Lesions in the right inferior frontal gyrus can impair inhibitory control and lead to an increase in trigger failures. However, once triggered, patients' ability to implement inhibitory control remains intact.
Article
Neurosciences
Sreenivasan Meyyappan, Abhijit Rajan, George R. Mangun, Mingzhou Ding
Summary: Feature-based visual attention relies on the inferior frontal junction (IFJ) for control, while the debate continues regarding its role in spatial attention control. Functional connectivity between the right IFJ and visual cortex (V4) is associated with subsequent attentional selection of targets and behavioral performance during feature attention, but not during spatial attention.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Yuan Chang Leong, Roma Dziembaj, Mark D'Esposito
Summary: People's perceptual reports are biased toward percepts they are motivated to see. The arousal system coordinates the body's response to motivationally significant events and is well positioned to regulate motivational effects on perceptual judgments. Heightened arousal biases people toward what they want to see and away from an objective representation of the environment.
PSYCHOLOGICAL SCIENCE
(2021)
Article
Psychology, Multidisciplinary
Keita Umejima, Isso Nakamura, Naoki Fukui, Mihoko Zushi, Hiroki Narita, Kuniyoshi L. Sakai
Summary: Left-to-right surface linear arrangements of human languages are a combination of the core language system and systems unrelated to language. Merge-generable dependencies, characterized by hierarchically structured linguistic expressions, were tested using a Subject-Predicate matching task. Functional magnetic resonance imaging (fMRI) revealed separate cortical networks involved in Merge-generable and memory-based ordering dependencies. The findings provide insights into the neural mechanisms underlying syntactic processing and support the notion of distinct brain regions for different linguistic processes.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Ren Calabro, Yizhou Lyu, Yuan Chang Leong
Summary: People are biased towards perceiving outcomes that align with their motivations. This study found that such motivational biases in perceptual decision-making are associated with amygdala activity, rather than frontoparietal regions commonly associated with biases in perceptual decision-making.
Article
Psychology, Clinical
Antje Riepenhausen, Ilya M. Veer, Carolin Wackerhagen, Zala C. Reppmann, Goeran Koeber, Jose Luis Ayuso-Mateos, Sophie A. Bogemann, Giovanni Corrao, Mireia Felez-Nobrega, Josep Maria Haro Abad, Erno Hermans, Judith van Leeuwen, Klaus Lieb, Vincent Lorant, Murielle Mary-Krause, Roberto Mediavilla, Maria Melchior, Ellenor Mittendorfer-Rutz, Matteo Monzio Compagnoni, Kuan-Yu Pan, Lara Puhlmann, Karin Roelofs, Marit Sijbrandij, Pierre Smith, Oliver Tuescher, Anke Witteveen, Matthias Zerban, Raffael Kalisch, Hannes Kroeger, Henrik Walter
Summary: This study identified several psychological risk and protective factors related to psychological distress outcomes during the COVID-19 pandemic. The relevance of longitudinal assessments and the implications for targeted prevention and intervention programs during highly stressful times were discussed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Yan Sun, Tianye Jia, Edward D. Barker, Di Chen, Zuo Zhang, Jiayuan Xu, Suhua Chang, Guangdong Zhou, Yun Liu, Nicole Tay, Qiang Luo, Xiao Chang, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Lin Lu, Jie Shi, Gunter Schumann, Sylvane Desrivieres
Summary: Negative life events (NLEs) increase the risk for externalizing behaviors (EBs) and internalizing behaviors (IBs). DNA methylation associated with behavioral problems may reflect this risk and long-lasting effects of NLEs.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Helene Vulser, Herve S. Lemaitre, Stella Guldner, Pauline Bezivin-Frere, Martin Loffler, Anna S. Sarvasmaa, Jessica Massicotte-Marquez, Eric Artiges, Marie-Laure Paillere Martinot, Irina Filippi, Ruben Miranda, Argyris Stringaris, Betteke Maria van Noort, Jani Penttila, Yvonne Grimmer, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Juliane H. Frohner, Hugh Garavan, Antoine Grigis, Penny A. Gowland, Andreas Heinz, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Philip A. Spechler, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Jean-Luc Martinot, Frauke Nees
Summary: Adolescence is a critical period for circadian rhythm, with a shift toward eveningness. Eveningness in adolescence predicts later onset of depressive symptoms. This study investigates the structural variations associated with chronotype in early adolescence and its contribution to the development of depressive symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Hasan Cagin Lenk, Robert Lovsletten Smith, Kevin S. O'Connell, Marin M. Jukic, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman-Sundberg, Espen Molden
Summary: This study found that genetic variants in CYP1A and NFIB have a significant impact on the dose requirements and clinical response of clozapine, especially in smokers. Smokers carrying these genetic variants may require higher doses to achieve therapeutic effects.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Psychiatry
Raka Maitra, Charlotte M. Horne, Owen O'Daly, Evangelos Papanastasiou, Christian Gaser, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne M. Winterer, Robert Whelan, Erin Burke Quinlan, Alex Ing, Gunter Schumann, Sukhi Shergill
Summary: The study found that Psychotic Like Experiences (PLEs) in adolescents are associated with changes in cortical gyrification, indicating abnormal neurodevelopment. Adolescents with higher PLEs had lower cortical gyrification in the fronto-temporal regions in the left hemisphere, and higher cortical gyrification in the right parietal cortex during late adolescence. The study also revealed that adolescents with high PLEs were 5.6 times more likely to develop psychosis by age 23.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Nora R. Bakken, Laurie J. Hannigan, Alexey Shadrin, Guy Hindley, Helga Ask, Ted Reichborn-Kjennerud, Martin Tesli, Ole A. Andreassen, Alexandra Havdahl
Summary: This study examines the association between childhood temperamental traits, emotional and behavioral problems, and adolescent mood and anxiety disorders. The findings show a consistent and increasing relationship between negative emotionality, behavioral and emotional problems in early to middle childhood, and mood and anxiety disorders in adolescence.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Roberto Pagano, Ahmad Salamian, Janusz Zielinski, Anna Beroun, Maria Nalberczak-Skora, Edyta Skonieczna, Anna Caly, Nicole Tay, Tobias Banaschewski, Sylvane Desrivieres, Antoine Grigis, Hugh Garavan, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Katarzyna Kalita, Haruhiko Bito, Christian P. Mueller, Gunter Schumann, Hiroyuki Okuno, Kasia Radwanska
Summary: Alcohol use disorder (AUD) is a chronic and fatal disease with a high likelihood of relapse. This study identifies a mechanism involving the activity-regulated cytoskeleton-associated protein (Arc)/ARG3.1-dependent plasticity of amygdala synapses that selectively controls cue-induced alcohol relapse and AUD symptoms. In humans, single nucleotide polymorphisms and methylation in the ARC gene were associated with amygdala size and frequency of alcohol use, even at the onset of regular consumption. Targeting Arc during alcohol cue exposure may provide a new approach for relapse prevention.
MOLECULAR PSYCHIATRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Harshvardhan Gazula, Kelly Rootes-Murdy, Bharath Holla, Sunitha Basodi, Zuo Zhang, Eric Verner, Ross Kelly, Pratima Murthy, Amit Chakrabarti, Debasish Basu, Subodh Bhagyalakshmi Nanjayya, Rajkumar Lenin Singh, Roshan Lourembam Singh, Kartik Kalyanram, Kamakshi Kartik, Kumaran Kalyanaraman, Krishnaveni Ghattu, Rebecca Kuriyan, Sunita Simon Kurpad, Gareth J. Barker, Rose Dawn Bharath, Sylvane Desrivieres, Meera Purushottam, Dimitri Papadopoulos Orfanos, Eesha Sharma, Matthew Hickman, Mireille Toledano, Nilakshi Vaidya, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruhl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Tomas Paus, Luise Poustka, Juliane H. Frohner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Robert Whelan, Jessica A. Turner, Anand D. Sarwate, Sergey M. Plis, Vivek Benegal, Gunter Schumann, Vince D. Calhoun
Summary: With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks.
Article
Substance Abuse
Rene Freichel, Janine Pfirrmann, Janna Cousjin, Peter de Jong, Ingmar Franken, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah H. Hohmann, Juliane N. Froehner, Michael Smolka, Nilakshi Vaidya, Robert Whelan, Gunter Schumann, Henrik M. Walter, Ilya W. Veer, Reinout Wiers
Summary: This study aims to examine the dynamic associations between distal and proximal risk factors (personality traits, life stressors, and drinking motives) and their relationship with alcohol use in adolescence and early adulthood. The findings suggest that heavy and frequent alcohol use, along with social drinking motives, are key targets for preventing alcohol-related problems during late adolescence. However, there was no evidence found for personality traits and life stressors predisposing towards distinct drinking motives over time.
Article
Geriatrics & Gerontology
Ina S. Almdahl, Liva J. Martinussen, Olga Therese Ousdal, Miroslawa Kraus, Piotr Sowa, Ingrid Agartz, Maria S. Korsnes
Summary: This study aimed to compare the functional connectivity of large-scale brain networks during a cognitive control task with emotional stimuli in older adults with and without a history of late-life depression (LLD). The results revealed that LLD patients exhibited reduced functional connectivity between certain networks during the processing of incongruent emotional stimuli. The findings expand on the network-based LLD model and suggest the salience network as a potential target for future interventions.
AGING & MENTAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Stuart B. Murray, Jaroslav Rokicki, Alina M. Sartorius, Adriano Winterton, Ole A. Andreassen, Lars T. Westlye, Jason M. Nagata, Daniel S. Quintana
Summary: By analyzing the Allen Human Brain Atlas, researchers have found that genes associated with anorexia nervosa are highly expressed in the brain and have specific expression patterns, which are related to brain activity involved in processing appetitive and aversive cues.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Narges Chinichian, Johann D. Kruschwitz, Pablo Reinhardt, Maximilian Palm, Sarah A. Wellan, Susanne Erk, Andreas Heinz, Henrik Walter, Ilya M. Veer
Summary: We propose an intuitive and computationally efficient method to measure dynamic reconfiguration of brain regions, termed flexibility. Our method is based on a pre-defined set of biologically plausible brain modules and does not rely on data-driven module estimation, reducing computational burden. By measuring the change of affiliation of brain regions over time, we can assess the flexibility of brain networks. Our results demonstrate that our method produces similar patterns of whole-brain network reconfiguration compared to a more computationally expensive data-driven method, indicating its validity and efficiency in estimating whole-brain flexibility and analyzing biologically plausible brain networks at a finer scale.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Kristina Meyer, Catherine Hindi Attar, Jana Fiebig, Thomas Stamm, Tyler R. Bassett, Michael Bauer, Udo Dannlowski, Thomas Ethofer, Irina Falkenberg, Andreas Jansen, Georg Juckel, Tilo Kircher, Christoph Mulert, Gregor Leicht, Anne Rau, Jonas Rauh, Dirk Ritter, Philipp Ritter, Sarah Trost, Christoph Vogelbacher, Henrik Walter, Sarah Wolter, Martin Hautzinger, Felix Bermpohl
Summary: In this study, an emotion-centered psychotherapeutic intervention (FEST) was found to enhance amygdala activation and connectivity in patients with bipolar disorder (BD), and this increase was associated with a reduction in depressive symptoms.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Medicine, General & Internal
Nilakshi Vaidya, Bharath Holla, Jon Heron, Eesha Sharma, Yuning Zhang, Gwen Fernandes, Udita Iyengar, Alex Spiers, Anupa Yadav, Surajit Das, Sanjit Roy, Chirag K. Ahuja, Gareth J. Barker, Debasish Basu, Rose Dawn Bharath, Matthew Hickman, Sanjeev Jain, Kartik Kalyanram, Kamakshi Kartik, Murali Krishna, Ghattu Krishnaveni, Kalyanaraman Kumaran, Rebecca Kuriyan, Pratima Murthy, Dimitri Papadopoulos Orfanos, Meera Purushottam, Sunita Simon Kurpad, Lenin Singh, Roshan Singh, B. N. Subodh, Mireille Toledano, Henrik Walter, Sylvane Desrivieres, Amit Chakrabarti, Vivek Benegal, Gunter Schumann
Summary: This cohort study shows that low-level arsenic exposure is associated with impairments in executive function and has characterized the underlying brain mechanisms. These impairments are exacerbated by risk factors such as poor nutrition and poverty. The study calls for reexamination of safe levels of arsenic exposure and suggests improvements in nutrition and socioeconomic conditions as potential ways to mitigate the harmful consequences.
Article
Biochemistry & Molecular Biology
Olivia Wootton, Alexey A. Shadrin, Christine Mohn, Ezra Susser, Raj Ramesar, Ruben C. Gur, Ole A. Andreassen, Dan J. Stein, Shareefa Dalvie
Summary: This study conducted a large-scale genome-wide association study (GWAS) to identify genetic underpinnings of reaction time variability (RTV). The findings suggest that RTV is associated with genes involved in synaptic function and neural development. Additionally, RTV is genetically correlated with other neuropsychological traits. The study also demonstrated the predictive ability of a polygenic score for RTV.
MOLECULAR PSYCHIATRY
(2023)