Article
Genetics & Heredity
Nancy W. Lin, Cuining Liu, Ivana Yang, Lisa A. Maier, Dawn L. DeMeo, Cheyret Wood, Shuyu Ye, Margaret H. Cruse, Vong L. Smith, Carrie A. Vyhlidal, Katerina Kechris, Sunita Sharma
Summary: This study identified sex-specific differences in miRNA expression during human fetal lung development, which may impact susceptibility to pulmonary diseases later in life.
FRONTIERS IN GENETICS
(2022)
Article
Physiology
Mahmoud Abdelbary, Riyaz Mohamed, Ellen E. Gillis, Karl Diaz-Sanders, Babak Baban, Michael W. Brands, Jennifer C. Sullivan
Summary: Apoptosis was measured in various tissues of spontaneously hypertensive rats (SHR) to investigate its role in hypertension and T cell profile. The results showed that female SHR had higher renal and aortic apoptosis compared to males, but spleen apoptosis was comparable. However, treatment with the caspase inhibitor did not alter blood pressure or renal T cells in male or female SHR. This suggests that apoptosis does not contribute to hypertension or sex differences in renal T cells in SHR.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Lindsay Ferguson, Christopher C. Giza, Rebecka O. Serpa, Tiffany Greco, Hannah Robert, Michael Folkerts, Mayumi L. Prins
Summary: Adolescence is a period marked by puberty onset, cognitive and social developments, and physical changes, with sex differences impacting athletic performance. Results from a study on adolescent rats engaging in 10 days of exercise show changes in physiological functions, with females exhibiting greater running distances and durations.
FRONTIERS IN NEUROLOGY
(2021)
Article
Microbiology
Adeline Ribeiro E Silva, Alix Sausset, Francoise Bussiere, Fabrice Laurent, Sonia Lacroix-Lamande, Anne Silvestre
Summary: This study analyzed and characterized the ROPK gene family in the parasite responsible for avian coccidiosis, Eimeria tenella, revealing transcription in various life-cycle stages with higher intensity in extracellular stages. Specifically, 7-9 ROPK genes were found to be specifically transcribed in merozoites compared to sporozoites. The transcriptional profiles of intracellular stages were closely related, suggesting a common role of ROPKs in hijacking signaling pathways and immune responses in infected cells. These findings lay a solid foundation for future functional analysis of ROPK from E. tenella.
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Article
Urology & Nephrology
Lihe Chen, Chung-Lin Chou, Chin-Rang Yang, Mark A. Knepper
Summary: This study investigated sex differences in kidney physiology and pathophysiology using RNA-seq, ATAC-seq, and protein mass spectrometry methods. The results revealed significant differences in gene expression and chromatin accessibility in the proximal tubules between males and females. Many of the differentially expressed genes are involved in metabolic processes and transport functions. The study also identified several transcription factors and proteins that contribute to sex differences. The findings provide valuable insights into the regulatory mechanisms underlying sex differences in kidney function.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Peripheral Vascular Disease
Reham H. Soliman, Chunhua Jin, Crystal M. Taylor, Emile Moura Coelho da Silva, David M. Pollock
Summary: This study found that diet-induced obesity impairs renal handling of an acute salt load in male rats, leading to reduced natriuretic response and lower renal endothelin function. Female rats, on the other hand, were not salt sensitive and did not show changes in renal endothelin excretion. Obesity in males also resulted in higher blood pressure, which was further exacerbated by high salt intake.
Article
Endocrinology & Metabolism
Yiting Wang, Jue Zhang, Junlin Zhang, Yucheng Wu, Rui Zhang, Honghong Ren, Mark E. Cooper, Fang Liu
Summary: The study found that female patients with DKD had higher levels of certain indicators (such as blood pressure, cholesterol levels) compared to male patients, but there was no significant association observed between sex differences and ESKD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Kimberly C. Olney, Seema B. Plaisier, Tanya N. Phung, Michelle Silasi, Lauren Perley, Jane O'Bryan, Lucia Ramirez, Harvey J. Kliman, Melissa A. Wilson
Summary: The study shows that there are sex differences in gene expression during pregnancy, which are conserved in adult tissues. These sex differences are mainly driven by gene expression on the sex chromosomes.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xinyu Guo, Yuzhu Sha, Weibing Lv, Xiaoning Pu, Xiu Liu, Yuzhu Luo, Jiang Hu, Jiqing Wang, Shaobin Li, Zhidong Zhao
Summary: Sex has a significant impact on the composition and function of rumen microbiota in Tibetan goats, with differences observed in rumen fermentation parameters, microbiota composition, and gene expression.
MICROBIAL CELL FACTORIES
(2022)
Article
Cardiac & Cardiovascular Systems
Denise Borzsei, Daniel Priksz, Renata Szabo, Mariann Bombicz, Zoltan Karacsonyi, Laszlo G. Puskas, Liliana Z. Feher, Zsolt Radak, Krisztina Kupai, Aniko Magyarine Berko, Csaba Varga, Bela Juhasz, Aniko Posa
Summary: Voluntary exercise has been shown to improve cardiac function in aged rats, with gender differences in key protein expression. Long-term exercise is associated with decreased Ogn and Comt expression, and enhanced presence of Pcp4 and Esm1 genes. Sex-dependent changes were observed in the expression of cardiovascular key proteins. Fundamental alterations in gene and protein expression may contribute to the improvement of cardiac performance.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Xiaoqing Pan, Xuemei Geng, Yong Liu, Mengqian Yu, Manoj K. Mishra, Xialian Xu, Xiaoqiang Ding, Pengyuan Liu, Mingyu Liang
Summary: This study is the first to characterize tRFs in hypertension, revealing the abundant expression of tRFs in human and rat kidneys, which may play important roles in the development of hypertension and renal injury.
Review
Endocrinology & Metabolism
Ionel Sandovici, Denise S. Fernandez-Twinn, Antonia Hufnagel, Miguel Constancia, Susan E. Ozanne
Summary: Early-life exposures can affect long-term metabolic health, and male and female fetuses have different responses to these exposures, which may contribute to sex differences in metabolic health in adulthood.
Article
Clinical Neurology
Sarina Falcione, Elena Spronk, Danielle Munsterman, Twinkle Joy, Roobina Boghozian, Glen C. Jickling
Summary: Sex differences exist in stroke risk and outcome, and these differences may be related to variations in thrombin generation. Females and males have similar overall capacity for thrombin generation, but there are differences in genes associated with promoting thrombin generation. Females may have increased thrombin signaling and platelet activation, while males may have decreased thrombus degradation.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Ryan W. Logan, Xiangning Xue, Kyle D. Ketchesin, Gabriel Hoffman, Panos Roussos, George Tseng, Colleen A. McClung, Marianne L. Seney
Summary: The study found similar amplitude and phase of diurnal rhythms in canonical circadian genes in both sexes, but significant sex differences in transcriptional rhythms when the analyses were expanded to the entire transcriptome. There were nearly twice as many rhythmic transcripts in the DLPFC in males and nearly 4 times as many in the ACC in females, suggesting a sex-specific diurnal rhythm in synaptic transmission in the ACC.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Oncology
Yanira Gonzalez, Kaytee L. Pokrzywinski, Elliot T. Rosen, Steven Mog, Baikuntha Aryal, Leena M. Chehab, Vikrant Vijay, Carrie L. Moland, Varsha G. Desai, Jennifer S. Dickey, V. Ashutosh Rao
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2015)
Article
Endocrinology & Metabolism
Joshua C. Kwekel, Vikrant Vijay, Varsha G. Desai, Carrie L. Moland, James C. Fuscoe
BIOLOGY OF SEX DIFFERENCES
(2015)
Article
Toxicology
Laura K. Schnackenberg, Lisa Pence, Vikrant Vijay, Carrie L. Moland, Nysia George, Zhijun Cao, Li-Rong Yu, James C. Fuscoe, Richard D. Beger, Varsha G. Desai
JOURNAL OF APPLIED TOXICOLOGY
(2016)
Article
Pharmacology & Pharmacy
Vikrant Vijay, Carrie L. Moland, Tao Han, James C. Fuscoe, Taewon Lee, Eugene H. Herman, G. Ronald Jenkins, Sherry M. Lewis, Connie A. Cummings, Yuan Gao, Zhijun Cao, Li-Rong Yu, Varsha G. Desai
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
G. Ronald Jenkins, Taewon Lee, Carrie L. Moland, Vikrant Vijay, Eugene H. Herman, Sherry M. Lewis, Kelly J. Davis, Levan Muskhelishvili, Susan Kerr, James C. Fuscoe, Varsha G. Desai
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2016)
Article
Multidisciplinary Sciences
Kejian Wang, Vikrant Vijay, James C. Fuscoe
Article
Endocrinology & Metabolism
Joshua C. Kwekel, Vikrant Vijay, Tao Han, Carrie L. Moland, Varsha G. Desai, James C. Fuscoe
BIOLOGY OF SEX DIFFERENCES
(2017)
Article
Multidisciplinary Sciences
Ravi K. Sajja, Mohammad A. Kaisar, Vikrant Vijay, Varsha G. Desai, Shikha Prasad, Luca Cucullo
SCIENTIFIC REPORTS
(2018)
Article
Reproductive Biology
Noriko Nakamura, Vikrant Vijay, Varsha G. Desai, Deborah K. Hansen, Tao Han, Ching-Wei Chang, Yu-Chuan Chen, Wafa Harrouk, Barry McIntyre, Paul M. Foster, James C. Fuscoe, Amy L. Inselman
REPRODUCTIVE TOXICOLOGY
(2018)
Article
Pharmacology & Pharmacy
Varsha G. Desai, Taewon Lee, Carrie L. Moland, Vikrant Vijay, Tao Han, Sherry M. Lewis, Eugene H. Herman, James C. Fuscoe
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Letter
Reproductive Biology
Noriko Nakamura, Vikrant Vijay, Varsha G. Desai, Deborah K. Hansen, Tao Han, Ching-Wei Chang, Yu-Chuan Chen, Wafa Harrouk, Barry McIntyre, Paul M. Foster, James C. Fuscoe, Amy L. Inselman
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
James C. Fuscoe, Vikrant Vijay, Joseph P. Hanig, Tao Han, Lijun Ren, James J. Greenhaw, Richard D. Beger, Lisa M. Pence, Qiang Shi
DRUG METABOLISM AND DISPOSITION
(2020)
Article
Toxicology
Varsha G. Desai, Vikrant Vijay, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Taewon Lee, Kelly J. Davis, Levan Muskhelishvili, Kimo C. Stine, James C. Fuscoe
Summary: Research suggests that low doses of doxorubicin may lead to cardiotoxicity and subsequent cardiomyopathy. Experiments on mice showed that higher cumulative doses of DOX were associated with decreased cardiac function and increased cardiomyocyte apoptosis.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Editorial Material
Medicine, Legal
Joshua A. Harrill, Mark R. Viant, Carole L. Yauk, Magdalini Sachana, Timothy W. Gant, Scott S. Auerbach, Richard D. Beger, Mounir Bouhifd, Jason O'Brien, Lyle Burgoon, Florian Caiment, Donatella Carpi, Tao Chen, Brian N. Chorley, John Colbourne, Raffaella Corvi, Laurent Debrauwer, Claire O'Donovan, Timothy M. D. Ebbels, Drew R. Ekman, Frank Faulhammer, Laura Gribaldo, Gina M. Hilton, Stephanie P. Jones, Aniko Kende, Thomas N. Lawson, Sofia B. Leite, Pim E. G. Leonards, Mirjam Luijten, Alberto Martin, Laura Moussa, Serge Rudaz, Oliver Schmitz, Tomasz Sobanski, Volker Strauss, Monica Vaccari, Vikrant Vijay, Ralf J. M. Weber, Antony J. Williams, Andrew Williams, Russell S. Thomas, Maurice Whelan
Summary: Omics methodologies are widely used in toxicological research, but face challenges in gaining widespread regulatory acceptance due to lack of transparency in data processing methods and standardization in reporting. To foster further regulatory use of Omics data, the OECD's EAGMST launched a project to develop guidance for reporting Omics data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Toxicology
Noriko Nakamura, Vikrant Vijay, Daniel T. Sloper
JOURNAL OF TOXICOLOGICAL SCIENCES
(2020)