Interleukin-23 Mediates the Intestinal Response to Microbial β-1,3-Glucan and the Development of Spondyloarthritis Pathology in SKG Mice

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

(2013) Iain B McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation

(2013) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

(2013) Lucille C Rankin et al.   NATURE IMMUNOLOGY

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

(2012) Mark C Genovese et al.   ANNALS OF THE RHEUMATIC DISEASES

Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model

(2012) Liesbet Van Praet et al.   ANNALS OF THE RHEUMATIC DISEASES

β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice

(2012) Merja Ruutu et al.   ARTHRITIS AND RHEUMATISM

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Distinct requirements for T-bet in gut innate lymphoid cells

(2012) Giuseppe Sciumé et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytokine Secretion by Pathogen Recognition Receptor-stimulated Dendritic Cells in Rheumatoid Arthritis and Ankylosing Spondylitis

(2012) C. PREVOSTO et al.   JOURNAL OF RHEUMATOLOGY

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional role of IL-22 in psoriatic arthritis

(2012) Anupam Mitra et al.   ARTHRITIS RESEARCH & THERAPY

Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response

(2011) Ling Zeng et al.   ARTHRITIS AND RHEUMATISM

Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis

(2011) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

(2010) Tetsuro Takayama et al.   GASTROENTEROLOGY

Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene

(2010) J J Pointon et al.   GENES AND IMMUNITY

Endogenous PGE2 promotes the induction of human Th17 responses by fungal β-glucan

(2010) Maria Cristina Gagliardi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

(2010) R D Eri et al.   Mucosal Immunology

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease

(2010) Patrick Danoy et al.   PLoS Genetics

The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis

(2009) J Sieper et al.   ANNALS OF THE RHEUMATIC DISEASES

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

(2009) Hui Shen et al.   ARTHRITIS AND RHEUMATISM

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

(2009) Monica L. DeLay et al.   ARTHRITIS AND RHEUMATISM

Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis

(2009) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial

(2009) Alice Gottlieb et al.   LANCET

IL-23 and IL-17 in ankylosing spondylitis

(2009) Daniel Wendling   RHEUMATOLOGY INTERNATIONAL

Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis

(2009) Xinwei Wang et al.   RHEUMATOLOGY INTERNATIONAL

Association of interleukin-23 receptor variants with ankylosing spondylitis

(2008) Proton Rahman et al.   ARTHRITIS AND RHEUMATISM

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides

(2008) Camilla Jandus et al.   ARTHRITIS AND RHEUMATISM

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

IL-23/IL-17 immunity as a hallmark of Crohnʼs disease

(2008) Veera Hölttä et al.   INFLAMMATORY BOWEL DISEASES

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE