Article
Orthopedics
Elise Naufal, Cade Shadbolt, Yassin Elsiwy, Sharmala Thuraisingam, Yves S. Poy Lorenzo, Jonathan Darby, Sina Babazadeh, Peter F. M. Choong, Michelle M. Dowsey, Jarrad M. Stevens
Summary: This study evaluated the prevalence of antibiotic dispensation before and after total knee arthroplasty (TKA) and total hip arthroplasty (THA) and identified factors associated with antibiotic dispensation in the month following the surgical procedure. A high rate of antibiotic dispensation in the first month after THA and TKA was observed. Poor preoperative health status, older age, undergoing TKA rather than THA, obesity, inflammatory arthritis, and experiencing in-hospital wound-related or other infectious complications were associated with increased antibiotic dispensation in the first 30 days after discharge.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Yang Wang, Yu Zhang, Yicun Wang, Hedong Han, Jianning Zhao, Jun Wang
Summary: This study provides a nationally representative perspective on the characteristics, trends, and outcomes of chronic thrombocytopenia (cTCP) in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). Patients with cTCP had a higher risk of mortality and complications postoperatively, as well as increased cost and length of stay. Further research is needed to improve preoperative management and prevent worse outcomes associated with cTCP.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Heather E. Van Brug, Rob G. H. H. Nelissen, Willem M. Lijfering, Liza N. Van Steenbergen, Frits R. Rosendaal, Eveline L. A. Van Dorp, Marcel L. Bouvy, Albert Dahan, Maaike G. J. Gademan
Summary: The annual opioid prescribing rate in patients who underwent hip/knee arthroplasty in the Netherlands increased between 2013 and 2018, mainly due to increased oxycodone prescriptions.
Article
Geriatrics & Gerontology
Michael J. Cook, Mark Lunt, Timothy Board, Terence W. O'Neill
Summary: The study found that short-term mortality following THA/TKA increased with increasing frailty. Among surgical patients, mortality also increased with increasing frailty. In contrast, all-cause 30-day mortality following THA/TKA did not increase when comparing cases with controls in the same frailty category.
Article
Orthopedics
Zhantao Deng, Jiewen Jin, Mengyuan Li, Shuai Wang, Yuanchen Ma, Qiujian Zheng
Summary: Alcohol withdrawal is associated with increased risk of in-hospital mortality, medical and surgical complications in patients undergoing total knee or total hip arthroplasty procedures.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Medicine, General & Internal
Yonghan Cha, Suk-Yong Jang, Jun-Il Yoo, Hyo-Gil Choi, Jeong Won Hwang, Wonsik Choy
Summary: This study using Korean nationwide cohort data found that opioid use before and after total hip arthroplasty (THA) does not impact postoperative mortality, but a history of past opioid use is a risk factor for sustained opioid use. Additionally, the use of strong opioids tends to increase after THA compared to before surgery.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Orthopedics
Tetsu Ohnuma, Karthik Raghunathan, Matthew Fuller, Alan R. Ellis, Eric A. JohnBull, Raquel R. Bartz, Mihaela S. Stefan, Peter K. Lindenauer, Maggie E. Horn, Vijay Krishnamoorthy
Summary: The study found that the transition from ICD-9 to ICD-10 coding system resulted in relatively small discontinuities for most comorbidities among patients who underwent primary THA or TKA. Medical complications generally showed a decreasing trend over the quarters studied.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Orthopedics
Nishad N. Mysore, Jesus M. Villa, Robert B. Eysler, Tejbir S. Pannu, Vivek Singh, Carlos A. Higuera
Summary: This study aimed to determine whether patients who undergo multiple total hip arthroplasty (THA) and/or knee arthroplasty (TKA) revisions have decreased survival. The results showed that the number of revisions per patient did not significantly impact mortality. Age and ASA were positively associated with mortality, while BMI was negatively associated.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Zunhan Liu, Wei-Nan Zeng, Zhenyu Luo, Enze Zhao, Hao Li, Zongke Zhou
Summary: The study aimed to compare the outcomes of patients who underwent different sequences of ipsilateral total hip arthroplasty (THA) and total knee arthroplasty (TKA). Results showed that patients achieved similar favorable outcomes in clinical scores and survivorship regardless of the sequence of surgeries. Total joint arthroplasty can be performed safely with excellent outcomes in patients with a history of prior ipsilateral THA or TKA.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Cameron K. Ledford, Michael R. Wolverton, Luke S. Spencer-Gardner, Mark W. Pagnano, Daniel J. Berry, Matthew P. Abdel
Summary: The outcomes of total hip arthroplasty (THA) and total knee arthroplasty (TKA) for patients with a history of cerebrovascular accident (CVA) and neurological sequelae are similar to those without CVA. However, there is a higher risk of mortality for CVA patients.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Medicine, General & Internal
Yikai Liu, Chenkai Li, Zian Zhang, Xinzhe Lu, Haining Zhang
Summary: This case report describes the diagnosis and treatment of ochronotic arthropathy in a patient who underwent total hip arthroplasty (THA) and total knee arthroplasty (TKA). The patient experienced significant improvement in quality of life postoperatively.
FRONTIERS IN MEDICINE
(2023)
Article
Orthopedics
Irfan A. Khan, Amer Haffar, Justin A. Magnuson, Christian Ong, Matthew S. Austin, Chad A. Krueger, Jess H. Lonner
Summary: The study found that surgeons experience significantly higher physiological strain and stress while performing THA compared to TKA, showing higher heart rate, energy expenditure, and minute ventilation during THA. Surgeons should take into consideration the higher physical demand associated with THAs and ensure adequate personal preparation and sequence of cases when scheduling THAs and TKAs.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Jesus M. Villa, Tejbir S. Pannu, Ibrahim Theeb, Martin A. Buttaro, Jose Onativia, Lisandro Carbo, Daniel H. Rienzi, Jose Fregeiro, Nikolai N. Kornilov, Svetlana A. Bozhkova, Nemandra A. Sandiford, Nicolas S. Piuzzi, Carlos A. Higuera, Daniel O. Kendoff
Summary: The most common pathogens for periprosthetic joint infections were Staphylococcus aureus and Staphylococcus epidermidis. The US and the UK had the lowest rates of resistant organisms, while Germany and Russia had the highest. The UK and Uruguay had the lowest rates of polymicrobial infections.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Hematology
Banne Nemeth, Rob Nelissen, Roopen Arya, Suzanne Cannegieter
Summary: VTE is a common complication following THA and TKA, despite available guidelines for prophylaxis, approximately 1.5% of patients still develop symptomatic VTE. This paper discusses an individualized approach to optimize the balance between VTE and bleeding risks by stratifying patients according to their risk levels.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Orthopedics
Mehdi S. Salimy, Amy Z. Blackburn, Kyle Alpaugh, Santiago A. Lozano-Calderon, Hany S. Bedair, Christopher M. Melnic
Summary: This study investigated the influence of preoperative factors on implant survivorship following total hip arthroplasty (THA) and total knee arthroplasty (TKA) in multiple myeloma patients. The results showed that multiple myeloma patients had a relatively high risk of revision, especially after THA. Radiotherapy was identified as a predictor for revision in THA patients.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Health Care Sciences & Services
Marielle Slikkerveer, Afke van de Plas, Johanna H. M. Driessen, Robin Wijngaard, Frank de Vries, Renske Olie, Nathalie Meertens, Patricia van den Bemt
Summary: This study aimed to determine the frequency and determinants of in-hospital LMWH-prescribing errors. The results showed a prescribing error rate of 34%, with the most common error being dose adjustment based on body weight and renal function. Prophylactic LMWH prescribing in medical wards was associated with a higher risk of error compared to surgical wards.
JOURNAL OF PATIENT SAFETY
(2021)
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Gastroenterology & Hepatology
Judith van Dalem, Johanna H. M. Driessen, Andrea M. Burden, Coen D. A. Stehouwer, Olaf H. Klungel, Frank de Vries, Martijn C. G. J. Brouwers
Summary: The study found that patients prescribed TZDs had a lower risk of NAFLD, while there was no significant difference in NAFLD risk between GLP-1 receptor agonist use and insulin use.
Article
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
Summary: Low-dose oral glucocorticoid therapy does not increase the overall risk of osteoporotic fractures in patients with RA, but is associated with an increased risk of clinical vertebral fractures.
Article
Endocrinology & Metabolism
Johan Roikjer, Nikki C. C. Werkman, Niels Ejskjaer, Joop P. W. van den Bergh, Peter Vestergaard, Nicolaas C. Schaper, Morten Hasselstrom Jensen, Olaf Klungel, Frank de Vries, Johannes T. H. Nielen, Johanna H. M. Driessen
Summary: The study found a decline in incidence rates, hospitalizations, and mortality for first diabetic foot ulcers in individuals with type 2 diabetes in the UK primary care setting. Conversely, no significant changes were observed for individuals with type 1 diabetes. This suggests improvements in prevention and care for type 2 diabetes patients with diabetic foot ulcers.
Article
Urology & Nephrology
J. J. van Raaij, K. H. Hua, F. de Vries, Paddy K. C. Janssen
Summary: This study aimed to investigate the relationship between the His452Tyr polymorphism of the 5-HT2A receptor and the pathogenesis and intravaginal ejaculation latency time (IELT) differences in patients with lifelong premature ejaculation (LPE). The results showed no correlation between the polymorphism and IELT distribution in LPE patients.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Zohreh Safipour, Rogier van Der Zanden, Joop van den Bergh, Paddy Janssen, Peter Vestergaard, Frank de Vries, Johanna H. M. Driessen
Summary: This study found that the use of oral glucocorticoids in patients with myasthenia gravis did not increase the risk of major osteoporotic fractures based on both a case-control study and pooled analysis. Osteoporosis prevention in myasthenia gravis patients according to clinical guidelines is still recommended.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Oncology
Ard van Veelen, Shahab Abtahi, Patrick Souverein, Johanna H. M. Driessen, Olaf H. Klungel, Anne-Marie C. Dingemans, Robin van Geel, Frank de Vries, Sander Croes
Summary: This study compared the characteristics of lung cancer patients from phase III RCTs evaluating TKIs or ICIs with those in a real-world setting in the UK. The results showed that a considerable proportion of lung cancer patients in the real-world setting would have been ineligible for participation in RCTs, and these potentially ineligible patients had shorter overall survival.
CANCER EPIDEMIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sjoerd D. Meenks, Jos L. M. L. le Noble, Norbert A. Foudraine, Frank de Vries, Kees Neef (C Neef), Paddy K. C. Janssen
Summary: This study developed a reliable population PK model for unbound ceftriaxone in critically ill patients, and dosing simulations revealed that 1,000 mg twice daily, 2,000 mg once daily, or continuous infusion of 2,000 mg daily can achieve fT>4 mg/L>=60%.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Shirley Wang, Sushama Kattinakere Sreedhara, Sebastian Schneeweiss
Summary: Studies that analyze digital data collected in clinical practice provide important insights for healthcare decision-makers. In this study, the reproducibility of 150 peer-reviewed studies was tested, showing strong reproducibility. Future original studies could improve reproducibility by providing more complete reporting.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Eleni Domzaridou, Tjeerd Van Staa, Andrew G. Renehan, Natalie Cook, William Welfare, Darren M. Ashcroft, Victoria Palin
Summary: This study examines the association between antibiotic treatment and long-term mortality in cancer patients, finding that antibiotic use shortly before cancer diagnosis may reduce the effectiveness of chemotherapy and immunotherapy.
Meeting Abstract
Endocrinology & Metabolism
Shahab Abtahi, Rene Cordtz, Lene Dreyer, Johanna H. M. Driessen, Frank de Vries, Annelies Boonen, Andrea M. Burden
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Veerle van Hulten, Cindy Sarodnik, Johanna Driessen, Sandrine Bours, Frank de Vries, Caroll Webers, Geertjan Dinant, Hein de Vries, Patricia van Assema, Stef Kremers, Ramon Ottenheijm, Coen Stehouwer, Nicolaas Schaper, Piet Geusens, Joop van den Bergh
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Nicklas H. Rasmussen, Jakob Dal, Joop van den Bergh, Frank de Vries, Morten Hasselstrom Jensen, Peter Vestergaard
Summary: This study aimed to estimate the risk of falls in people with diabetes and identify related risk factors. Results showed that people with diabetes have a higher incidence of falls and specific risk factors such as age, sex, diabetic complications, alcohol abuse history, and medication use. Additionally, the incidence of fall-related injuries was higher in individuals with diabetes compared to the general population, with specific localized fractures showing increased risk in diabetes patients.
CURRENT DRUG SAFETY
(2021)
Article
Pharmacology & Pharmacy
Nikki C. C. Werkman, Johannes T. H. Nielen, Joop P. W. van den Bergh, Niels Ejskjaer, Johan Roikjer, Nicolaas C. Schaper, Bernardette Rossi, Olaf Klungel, Peter Vestergaard, Frank de Vries, Johanna H. M. Driessen
Summary: This study found that current use of SGLT2-Is was not associated with an increased risk of lower limb amputations compared to current use of sulphonylureas (SU). Concomitant use of diuretics and signs of hypovolemia were also not associated with an increased risk of lower limb amputations.
CURRENT DRUG SAFETY
(2021)