Article
Rheumatology
Ju-Yeun Lee, So-Yeon Park, Seo Young Sohn
Summary: This study aimed to investigate the relationship between hyperthyroidism and the risk of developing gout. The results showed that hyperthyroidism was associated with an increased risk of incident gout, particularly in younger age groups and males.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Christine Gyldenkerne, Jakob S. Knudsen, Kevin K. W. Olesen, Henrik T. Sorensen, Hans E. Botker, Reimar W. Thomsen, Michael Maeng
Summary: From 1996 to 2011, Danish patients with incident type 2 diabetes and no prior cardiovascular disease experienced significant reductions in cardiac risk and mortality. These risk reductions coincided with increased use of prophylactic cardiovascular medications.
Article
Medicine, General & Internal
Ping-Han Tsai, Chang-Fu Kuo, Lai-Chu See, Pei-Ru Li, Jung-Sheng Chen, Wen-Yi Tseng
Summary: This study estimates the risk of stroke in Taiwanese patients with gout. The results show that gout patients have a higher risk of ischemic and hemorrhagic stroke after 3 years.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ziyad Alshehri, Anuradhaa Subramanian, Nicola J. Adderley, Krishna M. Gokhale, Muhammad Ali Karamat, Clare J. Ray, Prem Kumar, Krishnarajah Nirantharakumar, Abd A. Tahrani
Summary: Individuals with type 1 diabetes are at an increased risk of obstructive sleep apnoea compared with people without diabetes. Clinicians should suspect obstructive sleep apnoea in patients with type 1 diabetes if they are old, have obesity, are male, have atrial fibrillation or depression, or if they are taking lipid-lowering or antihypertensive drugs.
Article
Immunology
Zhiyong Chen, Yiwen Xu, Miao Chen, Ran Cui, Yu-Hsun Wang, Sheng-Ming Dai, James Cheng-Chung Wei
Summary: The risk of cardiovascular diseases is significantly higher in patients with both psoriasis and gout, and gout independently increases the risk of CVD in psoriasis patients, regardless of traditional risk factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jing-Wen Chen, Qiang Xu, Pei-Dan Yang, Jing-Yang Huang, James Cheng-Chung Wei
Summary: This retrospective cohort study aimed to analyze the association between thalassemia and gout arthritis. The results indicated that thalassemia did not significantly increase the risk of gout arthritis.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Chun-Chao Chen, Chun-Chih Chiu, Nai-Hsuan Chen, Tsung-Yeh Yang, Cheng-Hsin Lin, Yu-Ann Fang, William Jian, Meng-Huan Lei, Hsien-Tang Yeh, Min-Huei Hsu, Wen-Rui Hao, Ju-Chi Liu
Summary: This study found that influenza vaccination is associated with a lower risk of atrial fibrillation in patients with gout, and the protective effect seems to depend on the number of vaccine doses given.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Jenny Riley, Christina Antza, Punith Kempegowda, Anuradhaa Subramanian, Joht Singh Chandan, Krishna Gokhale, Neil Thomas, Christopher Sainsbury, Abd A. Tahrani, Krishnarajah Nirantharakumar
Summary: Social deprivation is an independent risk factor for the development of DFD, PN, FU, PVD, LLA, and gangrene in newly diagnosed patients with type 2 diabetes. Strategies targeting patients in socially deprived areas are needed to reduce health inequalities considering the high individual and economic burdens of DFD.
Article
Medicine, General & Internal
Mats Dehlin, Tatiana Zverkova Sandstroem, Lennart T. H. Jacobsson
Summary: This study evaluated the overall mortality and causes of death in patients with gout. It found that gout patients have an increased risk of cardiovascular diseases, renal diseases, and digestive system diseases, but a decreased risk of dementia, cancer, and lung diseases. This highlights the importance of addressing cardiovascular disease risk factors in gout management.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ching-Han Liu, Shih-Chung Huang, Chun-Hao Yin, Wei-Chun Huang, Jin-Shuen Chen, Yao-Shen Chen, Su-Ting Gan, Shiow-Jyu Tzou, Ching-Tsai Hsu, Hao-Ming Wu, Wen-Hwa Wang
Summary: Individuals of Asian descent have a higher risk of developing hyperuricemia and gout compared to Western populations. Urate-lowering therapy is effective in treating hyperuricemia and gout. However, the association between febuxostat, a type of urate-lowering therapy, and atrial fibrillation (AF) in Asian populations has not been properly investigated.
Article
Endocrinology & Metabolism
Justin B. Echouffo-Tcheugui, Jun Guan, Ravi Retnakaran, Baiju R. Shah
Summary: In a large observational study, it was found that gestational diabetes mellitus (GDM) is associated with an increased risk of heart failure (HF), even after adjusting for relevant cardiometabolic risk factors. Additionally, GDM was also found to increase the odds of peripartum cardiomyopathy.
Article
Medicine, General & Internal
Yeonghee Eun, Kyungdo Han, Seung Woo Lee, Kyunga Kim, Seonyoung Kang, Seulkee Lee, Hoon-Suk Cha, Eun-Mi Koh, Hyungjin Kim, Jaejoon Lee
Summary: The study found that metabolic syndrome is an important risk factor for gout in young men, especially in the association between MetS and gout in young and non-obese males. Management of MetS in young men will be crucial for future gout prevention.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Guan-Ling Lin, Hsiu-Chen Lin, Hsiu-Li Lin, Joseph Jordan Keller, Li-Hsuan Wang
Summary: This study investigated the association between statin use and gout risk in patients with hyperlipidemia. It was found that regular statin use was associated with a non-significant reduction in gout risk compared to irregular statin use and other lipid-lowering agent use. However, a protective effect was observed for higher cumulative doses and longer therapy durations.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
James Cheng-Chung Wei, Yi-Jung Chang, Yu-Hsun Wang, Chih-Jung Yeh
Summary: This study found an association between psoriasis and the risk of developing gout. Patients with psoriasis should be evaluated for the occurrence of gout.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ching-Lung Cheung, Chor-Wing Sing, Wallis C. Y. Lau, Gloria H. Y. Li, Gregory Y. H. Lip, Kathryn C. B. Tan, Bernard M. Y. Cheung, Esther W. Y. Chan, Ian C. K. Wong
Summary: The study found that among adults with AF receiving OACs, the use of dabigatran was associated with the lowest risk of diabetes compared to warfarin use, while the risk of diabetes with apixaban and rivaroxaban use was not statistically significant.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Rheumatology
Chandrasekar Gopalakrishnan, Rishi J. Desai, Jessica M. Franklin, Yinzhu Jin, Joyce Lii, Daniel H. Solomon, Jeffrey N. Katz, Yvonne C. Lee, Patricia D. Franklin, Seoyoung C. Kim
Summary: This study aimed to develop a claims-based model for predicting persistent high-dose opioid use among patients who underwent total knee replacement (TKR). The study utilized Medicare claims data and employed group-based trajectory modeling to identify different patterns of opioid use. The findings revealed that approximately 10.6% of older patients became persistent high-dose opioid users after TKR.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Rishi J. Desai, Ajinkya Pawar, Farzin Khosrow-Khavar, Michael E. Weinblatt, Seoyoung C. Kim
Summary: There was no significant difference in the risk of venous thromboembolism between patients with rheumatoid arthritis treated with tofacitinib and those treated with TNFα inhibitors.
Article
Rheumatology
Sicong Huang, Tianrun Cai, Brittany N. Weber, Zeling He, Kumar P. Dahal, Chuan Hong, Jue Hou, Thany Seyok, Andrew Cagan, Marcelo F. DiCarli, Jacob Joseph, Seoyoung C. Kim, Daniel H. Solomon, Tianxi Cai, Katherine P. Liao
Summary: This study found that elevated inflammation early in the diagnosis of rheumatoid arthritis (RA) was associated with heart failure, specifically heart failure with preserved ejection fraction (HFpEF). The association was not observed with heart failure with reduced ejection fraction (HFrEF). This finding suggests a window of opportunity for prevention of HFpEF in RA patients.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Min Zhuo, Seoyoung C. Kim, Elisabetta Patorno, Julie M. Paik
Summary: The study showed that the use of SGLT2i in patients with DKD is associated with reduced risks of MACE, kidney outcomes, HHF, and death. There is limited data on the associations between SGLT2i and safety outcomes, indicating the need for further research.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Pharmacology & Pharmacy
Andrei Barbulescu, Johan Askling, Saedis Saevarsdottir, Seoyoung C. Kim, Thomas Frisell
Summary: This study emulated a pragmatic trial using observational data and compared it with the results of a well-known trial. The findings showed that using a prespecified protocol in clinical registry data can replicate the results of the trial, favoring infliximab over SSZ + HCQ combination therapy at 9 months.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Min Zhuo, Seoyoung C. Kim, Elisabetta Patorno, Julie M. Paik
Summary: This study aimed to investigate whether there is a difference in the risk of hospitalization for heart failure (HHF) between the initiation of sodium zirconium cyclosilicate (SZC) and patiromer for the treatment of hyperkalemia. The results from the matched analysis showed that the use of SZC was associated with a numerically higher risk of HHF compared to patiromer, but this difference did not reach statistical significance.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Medicine, General & Internal
Rishi J. Desai, Vijay R. Varma, Tobias Gerhard, Jodi Segal, Mufaddal Mahesri, Kristyn Chin, Daniel B. Horton, Seoyoung C. Kim, Sebastian Schneeweiss, Madhav Thambisetty
Summary: This cohort study did not find any association of risk of ADRD in patients treated with tofacitinib, tocilizumab, or TNF inhibitors compared with abatacept.
Article
Oncology
Yinzhu Jin, Joan E. Landon, Whitney Krueger, Alexander Liede, Rishi J. Desai, Seoyoung C. Kim
Summary: This study used nationwide electronic health record (EHR) data in the USA to identify predictors of treatment changes among rheumatoid arthritis (RA) patients initiating a tumor necrosis factor inhibitor (TNFi). The study found that female patients and those who used glucocorticoids were more likely to experience TNFi cycling or switching. Conversely, inflammatory bowel disease, psoriasis, recent methotrexate use, and vitamin D intake were negatively associated with treatment changes.
Article
Rheumatology
Julie C. C. Lauffenburger, Zhigang Lu, Mufaddal Mahesri, Erin Kim, Angela Tong, Seoyoung C. C. Kim
Summary: This study used data-driven approach to classify and predict spending patterns in patients with gout. The study identified three distinct spending patterns: minimal spending, moderate spending, and high spending, and found that clinical predictors could help predict the spending groups. These findings are important for selecting appropriate interventions.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Hemin Lee, Jeffrey A. Sparks, Su Been Lee, Kazuki Yoshida, Joan E. Landon, Seoyoung C. Kim
Summary: This study aims to determine the accuracy of ICD-10 diagnosis codes for rheumatoid arthritis (RA) serostatus using a US claims database (Optum Clinformatics Data Mart) and compare the results to a previous study. The results showed that the PPVs for seropositive and seronegative RA in the Optum database were lower than those in MarketScan, but improved when more restricted definitions of M05 and M06 were used.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Rheumatology
H. Lee, S. K. Chen, N. Gautam, S. M. Vine, M. He, R. J. Desai, M. E. Weinblatt, R. J. Glynn, S. C. Kim
Summary: The objective of this study was to investigate the incidence rate of skin cancer associated with methotrexate and hydroxychloroquine in older adults with rheumatoid arthritis (RA). The results showed that there was no significant difference in the risk of skin cancer between methotrexate and hydroxychloroquine users. However, methotrexate initiators had a higher risk of basal cell carcinoma (BCC) but a lower risk of squamous cell carcinoma (SCC) compared to hydroxychloroquine initiators.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Letter
Allergy
Lily Li, Joan E. Landon, Seoyoung C. Kim
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Rheumatology
S. K. Tedeschi, Y. Jin, S. Vine, H. Lee, A. Pethoe-Schramm, V Yau, S. C. Kim
Summary: In these two U.S. GCA cohorts, high-dose glucocorticoids were the most common initial treatment. Over 25% of Medicare patients and 7% of MarketScan patients developed serious infections during follow-up. Older age and higher frailty score were associated with higher risk of serious infections.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Urology & Nephrology
Julie M. Paik, Min Zhuo, Cassandra York, Theodore Tsacogianis, Seoyoung C. Kim, Rishi J. Desai
Summary: A study on patients with ESRD on hemodialysis in the USA found a slight reduction in overall medication burden over time, accompanied by a decrease in prescribing of several classes of harmful medications, particularly non-benzodiazepine hypnotics, benzodiazepines, and opioids.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
