Article
Allergy
Jiayu Bao, Lei Tian, Yifan Meng, Binge Wu, Jingyi Wang, Jing He, Qiyan Shao, Chengshuo Wang, Ying Jie, Luo Zhang
Summary: Measuring the total IgE level in tears can accurately assess the severity and predict the prognosis of seasonal allergic conjunctivitis (SAC).
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Ophthalmology
Yasuo Yamana, Satoshi Yamana, Eiichi Uchio
Summary: The study found a positive correlation between t-tIgE, s-sIgE, and t-sIgE levels in patients with pollen-induced AC. Pollen-induced AC is caused by sensitization of the conjunctiva to pollen, while food-induced AC may be induced by different pathological mechanisms.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Immunology
Zhan Zhao, Yuqin Deng, Lei Xiang, Jin Chen, Jing Wan, Jinli Sun, Yonggang Kong, Qingquan Hua
Summary: This study aimed to evaluate the clinical efficacy of omalizumab in patients with allergic rhinitis by analyzing the ratio of total IgE level at week 16 to baseline. Retrospective analysis of 62 patients showed that 48 patients demonstrated significant improvement after 16 weeks of treatment, while 14 patients did not show significant improvements. The ratio of total IgE levels at week 16 to baseline was higher in responders compared to non-responders. In conclusion, the ratio of total IgE level at week 16 to baseline correlated with the clinical response to omalizumab in moderate to severe allergic rhinitis patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Ting Shen, Zijian Yang
Summary: The study demonstrated that the pemirolast potassium ocular in situ gels have good stability and sustained release ability, effectively suppressing inflammatory symptoms and improving drug bioavailability in the therapy of allergic conjunctivitis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Kathryn A. A. Recto, Tianxiao Huan, Dong Heon Lee, Gha Young Lee, Jessica Gereige, Chen Yao, Shih-Jen Hwang, Roby Joehanes, Rachel S. S. Kelly, Jessica Lasky-Su, George O'Connor, Daniel Levy
Summary: Measurement of circulating immunoglobulin E (IgE) concentration is helpful for diagnosing and treating asthma and allergic diseases. Identifying gene expression signatures associated with IgE might elucidate novel pathways for IgE regulation. Our findings build upon prior knowledge of IgE regulation and provide a deeper understanding of underlying molecular mechanisms, offering promising therapeutic targets for asthma and IgE-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Boyu Yang, Kuiyao Wen, Jing Li, Shiyao Zhang, Zixin Fan, Xiaoling Liang, Lingyi Liang
Summary: LLT is thinner in pediatric patients with AC, especially in those with VKC/AKC, who also have shorter TBUT and increased partial blinking rate. AC group shows significant deterioration in meibomian gland parameters compared to control group, with worse severity in the severe type of AC. Thinner LLT is significantly correlated with decreased TBUT and severity of upper MGL.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Allergy
Mukesh Kumar, Karthi Duraisamy, Rajasekar Reddy Annapureddy, Chi Bun Chan, Billy K. C. Chow
Summary: The research team designed and synthesized a series of novel small molecule antagonists for the treatment of MRGPRX2-mediated allergies and inflammation. These small molecules showed high binding affinity and inhibitory activity in both in vitro and in vivo experiments, effectively inhibiting mast cell activation and related signaling pathways. Therefore, these small molecules may hold significant therapeutic promise for MRGPRX2-mediated allergies and inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Ophthalmology
Hongmei Wang, Xiaodan Jiang, Pei Zhang, Yingyu Li, Yiren Wang, Xuemin Li
Summary: In this study, the positive rates of allergen-specific IgE in the tear fluid of Chinese patients with common allergic conjunctivitis in autumn and winter were determined. The most common allergen was found to be house dust mites. Measuring specific IgE in tears may be a non-invasive method to diagnose and evaluate the severity of conjunctivitis, which is more suitable to reflect the local conditions of ocular surface inflammation.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Allergy
Stanislaw J. Gabryszewski, Xiao Chang, Jesse W. Dudley, Frank Mentch, Michael March, John H. Holmes, Jason Moore, Robert W. Grundmeier, Hakon Hakonarson, David A. Hill
Summary: The study identified associations between race and progression along different allergic trajectories, with ancestral genetic differences potentially contributing to these associations. These findings uncover important health disparities and represent a step towards developing personalized medical approaches for allergic conditions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Engineering, Mechanical
Jun Wu, Hao Ye, Guang Yu, Tian Huang
Summary: This paper proposes a method to evaluate the dynamic performance of a robot by considering the specified velocity and acceleration limits of the end-effector in task space, and obtaining the required torque along joint-space directions. The method presents global dynamic performance indices reflecting the minimum range of actuator torque and the ratio of the required torque range to the actual torque range in the entire workspace, making it useful for robotic design and dynamic performance evaluation.
MECHANISM AND MACHINE THEORY
(2022)
Article
Engineering, Multidisciplinary
Chi Zhang, Yujie Zhu, Yongchuan Yu, Dong Wu, Massoud Rezavand, Songdong Shao, Xiangyu Hu
Summary: This paper presents a simple stabilization procedure to enhance the numerical stability of the SPH method by introducing an artificial damping term into the second Piola-Kirchhoff stress. By adding a Kelvin-Voigt type damper to the constitutive equation, the spurious oscillation near sharp spatial gradients can be alleviated. After validation and testing, the proposed method shows great potential in the field of biomechanics.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2022)
Article
Virology
Keren Kang, Lingfang Huang, Chaolin Ouyang, Jiaming Du, Bin Yang, Yaqin Chi, Shuyu He, Le Ying, Guoling Chen, Jihua Wang
Summary: A Rapid Antibody Test Kit was developed for the sensitive, accurate, and automated detection of IgM and IgG antibodies against SARS-CoV-2 in human samples, showing good performance in sensitivity, specificity, precision, and stability. The combined use of IgM and IgG as an alternative detection method for COVID-19 patients achieved high sensitivity and specificity, making it of great public health significance for the prevention and control of the pandemic.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Vladimira Datinska, Pantea Gheibi, Keynttisha Jefferson, Jaeyoung Yang, Sri Paladugu, Carolina Dallett, Ivona Voracova, Frantisek Foret, Yann Astier
Summary: Epitachophoresis is a versatile extraction system capable of isolating DNA and RNA from a wide range of nucleic acids, and the quality of extracted miRNA, mRNA, and gDNA was confirmed by downstream Next-Generation Sequencing.
SCIENTIFIC REPORTS
(2021)
Article
Green & Sustainable Science & Technology
Xiaofei Li, Zhao Wang, Yinnan Liu, Haifeng Wang, Liusheng Pei, An Wu, Shuang Sun, Yongjun Lian, Honglu Zhu
Summary: This study proposes a method to select the reference state and perform a grading evaluation of PV strings using the TOPSIS algorithm. A probability distribution model of PV string conversion efficiency is built to describe the operating state, and the reference state is determined based on the operating characteristic indicator. The effectiveness of the method is verified using actual data from a PV power station.
