Article
Biochemistry & Molecular Biology
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study aimed to evaluate the inhibitory effect of Antrodia camphorata (AC) administration on neuroinflammation and oxidative stress in a murine model of Parkinson's disease (PD). The results showed that AC treatment significantly reduced PD-related pathological changes, increased tyrosine hydroxylase expression, reduced alpha-synuclein-positive neurons, restored the myelination process of neurons associated with PD, and attenuated neuroinflammation. Furthermore, AC was able to reduce oxidative stress induced by MPTP injection. This study highlights AC as a potential therapeutic agent for neurodegenerative disorders such as PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nida Nehal, Bushra Nabi, Saleha Rehman, Ankita Pathak, Ashif Iqubal, Saif Ahmad Khan, M. Shahar Yar, Suhel Parvez, Sanjula Baboota, Javed Ali
Summary: The research developed a Ropinirole hydrochloride nanoemulsion for Parkinson's disease treatment, showing promising results in in vitro release and permeation studies. The formulation exhibited enhanced transmittance and stable pH, suggesting potential for improved management of PD symptoms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Christine N. Habib, Mohamed R. Mohamed, Mariane G. Tadros, Mai F. Tolba, Esther T. Menze, Somia Masoud
Summary: The study found that diosmin (DM) has neuroprotective effects in Parkinson's disease (PD) and can act through various mechanisms such as anti-inflammatory and antioxidative properties. These findings suggest that DM may be a promising candidate for managing the neuropathological course of PD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Eulla Keimili Fernandes Ferreira Cavalheiro, Larissa Espindola da Silva, Mariana Pacheco Oliveira, Marina Goulart Silva, Adriani Paganini Damiani, Catharina de Bem Ribeiro, Marina Lummertz Magenis, Luana Cucker, Monique Michels, Larissa Joaquim, Richard Simon Machado, Thais Cereser Vilela, Rafael M. Bitencourt, Vanessa M. Andrade, Felipe Dal-Pizzol, Fabricia Petronilho, Talita Tuon, Gislaine Tezza Rezin
Summary: The combination of obesity and Parkinson's disease leads to increased oxidative damage in the brain and peripheral tissues, as well as DNA damage. However, it does not increase inflammation, oxidative stress, or mitochondrial dysfunction.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Maanvi, Shilpa Kumari, Rahul Deshmukh
Summary: Parkinson's disease (PD) is the second most common age-related hypokinetic disorder characterized by dopaminergic degeneration and movement abnormalities. Therapeutic strategies aim to rescue dopaminergic degeneration and promote neuronal regeneration to halt disease progression. Repurposing DPP4 inhibitors, commonly used in treating diabetes, is being investigated for their efficacy in neurodegenerative pathologies such as PD, with reports of rescuing neuronal degeneration and improving motor functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Moises Rubio-Osornio, Carmen T. Gomez-De Leon, Sergio Montes, Carmen Rubio, Camilo Rios, Antonio Monroy, Jorge Morales-Montor
Summary: Parkinson's disease is characterized by oxidative stress and immune activation. Simvastatin, a cholesterol-regulating drug, can protect against atherosclerosis disease. Pretreatment with simvastatin reduced MPP+-induced damage in rats and decreased inflammation response proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Rafi Khezri, Morteza Ghasemnejad-Berenji
Summary: Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases worldwide, with no definitive treatment. Icariin, a natural compound with anti-inflammatory and anti-oxidant properties, may have potential in slowing the progression of neurodegenerative diseases.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Eun Ji Lee, Yoori Choi, Hong J. Lee, Do Won Hwang, Dong Soo Lee
Summary: The study shows that extracellular vesicles derived from human neural stem cells have the potential to protect neurons and prevent the pathology and progression of Parkinson's disease. The results demonstrate that these vesicles can reduce reactive oxygen species and pro-inflammatory cytokines, and decrease dopaminergic neuronal loss.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pablo Duarte, Patrycja Michalska, Enrique Crisman, Antonio Cuadrado, Rafael Leon
Summary: This study developed a promising family of compounds as a therapeutic strategy for Parkinson's disease. These compounds exhibited NRF2 induction activity and MAO-B inhibition activity, along with properties such as anti-inflammatory, antioxidant, and blood-brain barrier permeation. They also showed neuroprotective effects in vitro, reducing oxidative stress and toxicity.
Review
Biochemistry & Molecular Biology
Jana Tchekalarova, Rumiana Tzoneva
Summary: Aging and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are linked by common features like mitochondrial dysfunction and protein aggregation. The rising costs of caring for elderly patients with these diseases is a major issue in today's demographic crisis. Oxidative stress and imbalanced antioxidant defense system play crucial roles in age-related neurodegeneration, and diminished melatonin release with aging further increases susceptibility to these diseases. Understanding the underlying mechanisms and melatonin's role is important for developing precise treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Mohammad Yasin Zamanian, Maryam Golmohammadi, Rana Sherdil Amin, Ghadeer Sabah Bustani, Rosario Mireya Romero-Parra, Rahman S. Zabibah, Tuba Oz, Abduladheem Turki Jalil, Afsaneh Soltani, Malgorzata Kujawska
Summary: Kruppel-like factor 4 (KLF4) plays a crucial role in various neurophysiological and neuropathological processes in the brain, particularly in relation to Parkinson's disease. Further research on the regulatory mechanisms of KLF4 may provide potential therapeutic strategies for managing Parkinson's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi
Summary: The study demonstrated that DP can reduce elevated levels of acrolein in the basal ganglia of 6-OHDA rats, alleviate typical motor and sensory deficits of PD, and protect DA-like cells.
TRANSLATIONAL NEURODEGENERATION
(2021)
Review
Biochemistry & Molecular Biology
Ahsas Goyal, Kunal Solanki, Aanchal Verma
Summary: Neurodegenerative disorders are a group of diseases characterized by the slow loss of sensitive neurons. Despite extensive research, no cure exists for these conditions. However, natural substances such as flavonoids, particularly luteolin, have shown promising potential as therapeutic options. Luteolin possesses antioxidant and anti-inflammatory properties, making it a possible treatment for neurodegenerative diseases like Alzheimer's and Parkinson's.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adham Salah, Mokhtar Yousef, Maher Kamel, Ahmed Hussein
Summary: LPS is an important tool for inducing neuroinflammatory models and demonstrating the consequences of endotoxemia. Curcumin, in its native form, protects dopaminergic neurons against LPS-induced neurotoxicity but has poor bioavailability. This study explores the molecular mechanism of LPS-induced neurotoxicity and the protective effects of orally supplemented nanocurcumin. Nanocurcumin exhibits antioxidant and neuroprotective effects against LPS endotoxin.
Article
Biotechnology & Applied Microbiology
Xue Xue, Rui Duan, Guoyan Zheng, Hucheng Chen, Weiwei Zhang, Liang Shi
Summary: This study investigates the role of translocator protein (TSPO) in the phenotypic transformation of microglia in Parkinson's disease (PD) and suggests a potential therapeutic role for TSPO in PD treatment.
