Review
Biotechnology & Applied Microbiology
Steven L. Daniel, Luke Moradi, Henry Paiste, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Lama Nazzal, Marguerite Hatch, John Knight
Summary: Oxalobacter formigenes is a unique anaerobic bacterium crucial in degrading oxalate in the gut, potentially reducing the risk of calcium oxalate kidney stone disease. However, further research is needed to fully understand the role of this bacterium in human health.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
John A. Chmiel, Charles Carr, Gerrit A. Stuivenberg, Robertson Venema, Ryan M. Chanyi, Kait F. Al, Daniel Giguere, Henry Say, Polycronis P. Akouris, Sergio Ari Dominguez Romero, Aaron Kwong, Vera Tai, Susan F. Koval, Hassan Razvi, Jennifer Bjazevic, Jeremy P. Burton
Summary: In this study, the authors performed genomic analysis on multiple strains of Oxalobacter formigenes and identified three new species. They also found that the Oxalobacter aliiformigenes strains are capable of thriving within the human gut microbiota. These findings have implications for identifying strains better suited to mitigate calcium oxalate-based urolithiasis in the future.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Energy & Fuels
Mohamed Donia, Mohamed Zeineldin, Naglaa Gomaa, Midhat Nassif, Yamen Hegazy, Jose Cedillo Monroy, Edson Brodeli Figueroa Pacheco, Raymundo Rene Rivas-Caceres, Rabiha Seboussi, Mohamed Abdelmegeid
Summary: This study aimed to investigate the association between the colonization of Oxalobacter formigenes and the occurrence of calcium oxalate urolithiasis in cats. The results suggest a protective role of O. formigenes against calcium oxalate urolithiasis only in static chronic kidney disease (CKD) cats.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Review
Urology & Nephrology
Aaron W. Miller, Kristina L. Penniston, Kate Fitzpatrick, Jose Agudelo, Gregory Tasian, Dirk Lange
Summary: Kidney stone disease affects around 10% of the global population and its incidence is increasing due to the rise in medical conditions associated with the disease. The intestinal microbiome and the presence of commensal bacterial species in urine could influence the development of kidney stone disease.
NATURE REVIEWS UROLOGY
(2022)
Review
Nutrition & Dietetics
Roswitha Siener
Summary: The prevalence of kidney stone disease is increasing globally, with a high recurrence rate for urinary stones. Dietary composition plays a crucial role, and inadequate fluid intake is a major risk factor for urolithiasis. Other nutritional factors like protein, carbohydrates, oxalate, calcium, and sodium chloride also influence the risk of kidney stone formation.
Article
Transplantation
Bernd Hoppe, Patricia A. Pellikka, Bastian Dehmel, Ana Banos, Elisabeth Lindner, Ulrike Herberg
Summary: In PH1 ESRD patients, long-term administration of OC5 was found to significantly reduce Pox concentrations, improve or stabilize cardiac function and clinical status, without increasing dialysis frequency. OC5 was safe and well-tolerated, showing promising results for potential clinical impact.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Immunology
Zhenzhen Xu, Xiangyang Yao, Chen Duan, Haoran Liu, Hua Xu
Summary: Kidney stone disease is still not well understood in terms of its formation mechanism and metabolic changes. This manuscript summarizes the progress in research on metabolic changes in kidney stone disease and proposes new potential targets. The influence of metabolism of various substances on stone formation is discussed, including oxalate regulation, reactive oxygen species release, macrophage polarization, hormone levels, and other substance alteration. Understanding these metabolic changes and utilizing emerging research techniques will provide new directions in the treatment of kidney stones.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Physiology
Hao Li, Yingjian Zhou, Wenchao Xu, Jihong Liu, Shaogang Wang, Hongyang Jiang
Summary: This systematic review discusses the role of autophagy in the pathogenesis of kidney stone and suggests that upregulation of autophagy may be a future research direction for kidney stone treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Tao Chen, Biao Qian, Junrong Zou, Peiyue Luo, Jun Zou, Wei Li, Qi Chen, Liying Zheng
Summary: Kidney stones are a common urological disease, and current treatment methods are limited in reducing their occurrence and recurrence. Therefore, studying the relationship between oxalate metabolism and kidney stones can provide new insights into the role of oxalate in stone formation and suggestions for reducing their incidence and recurrence rate.
FRONTIERS IN MEDICINE
(2023)
Article
Pediatrics
Gema Ariceta, Laure Collard, Saoussen Abroug, Shabbir H. Moochhala, Edward Gould, Abir Boussetta, Mohamed Ben Hmida, Sudarsana De, Tracy E. Hunley, Faical Jarraya, Gloria Fraga, Ana Banos, Elisabeth Lindner, Bastian Dehmel, Gesa Schalk
Summary: This study investigated the effectiveness of orally administered Oxabact in reducing plasma oxalate levels in patients with primary hyperoxalurias. The results suggest that Oxabact treatment may stabilize/reduce plasma oxalate levels compared to placebo, but the difference over 12 months was not statistically significant.
PEDIATRIC NEPHROLOGY
(2023)
Review
Food Science & Technology
Chiara Favero, Laura Giordano, Silvia Maria Mihaila, Rosalinde Masereeuw, Alberto Ortiz, Maria Dolores Sanchez-Nino
Summary: Chronic kidney disease (CKD) is expected to become the fifth leading cause of death globally by 2040 due to limitations in current diagnostic and treatment methods. The holobiont concept, which considers the host and its microbial community, may improve our understanding of kidney disease. Postbiotics, which refer to preparations of inanimate microorganisms and/or their components that benefit the host, have potential clinical applications in kidney disease. This article reviews the revised concept of postbiotics and discusses various formulations being developed for kidney disease, providing a roadmap for future research.
Article
Multidisciplinary Sciences
Han-Na Kim, Jae Heon Kim, Yoosoo Chang, Dongmin Yang, Kwan Joong Joo, Young-Sam Cho, Heung Jae Park, Hyung-Lae Kim, Seungho Ryu
Summary: This study investigates the association between gut microbiome and renal stone diseases. The results show that prevalent nephrolithiasis is associated with reduced alpha diversity and abundance of key taxa involved in short-chain fatty acid production. Additionally, the gut microbiota composition is altered in patients with prevalent renal stones compared to the control group.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Yamuna Ravikumar, Rukaiah Fatma Begum, Ramaiyan Velmurugan
Summary: The study found that kidney stone patients had lower colonization of O. formigenes, reduced bone mineral density, low testosterone levels, higher urinary calcium and oxalate levels, and decreased serum testosterone and urinary citrate concentrations. Additionally, there was an association between O. formigenes and colon cancer.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhu Wang, Qiong Deng, Yanli Gu, Min Li, Ying Zhang, Qiyi Hu, Shenping Zhang, Xisheng Wang, Hui Liang
Summary: This study investigated the gene expression changes in the kidney of a rat model with kidney stones. The results showed dysregulated genes related to injury, apoptosis, immune response, solute carriers, transporters, and metabolic factors. These findings contribute to a better understanding of the pathogenesis of nephrolithiasis and could potentially lead to the development of new strategies for prevention and treatment.
Article
Urology & Nephrology
Megan Prochaska, John Asplin, Arlene Chapman, Elaine Worcester
Summary: The study found that men had higher calcium oxalate supersaturation in urine before RYGB, while women had higher urine calcium oxalate supersaturation and calcium phosphate supersaturation, as well as lower urine volumes after RYGB.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sonia Fargue, John Knight, Ross P. Holmes, Gill Rumsby, Christopher J. Danpure
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2016)
Article
Urology & Nephrology
Thanmaya G. Reddy, John Knight, Ross P. Holmes, Lisa M. Harvey, April L. E. Mitchem, Charles M. Wilcox, Klaus E. Monkemuller, Dean G. Assimos
JOURNAL OF ENDOUROLOGY
(2016)
Article
Urology & Nephrology
Abigail Liebow, Xingsheng Li, Timothy Racie, Julia Hettinger, Brian R. Bettencourt, Nader Najafian, Patrick Haslett, Kevin Fitzgerald, Ross P. Holmes, David Erbe, William Querbes, John Knight
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2017)
Article
Gastroenterology & Hepatology
Amber M. Moreland, Carol A. Santa Ana, John R. Asplin, Joseph A. Kuhn, Ross P. Holmes, Jason A. Cole, Elizabeth A. Odstrcil, Thomas G. Van Dinter, Juan G. Martinez, John S. Fordtran
Article
Urology & Nephrology
Sonia Fargue, Dawn S. Milliner, John Knight, Julie B. Olson, W. Todd Lowther, Ross P. Holmes
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Mikita Patel, Vidhush Yarlagadda, Oreoluwa Adedoyin, Vikram Saini, Dean G. Assimos, Ross P. Holmes, Tanecia Mitchell
Article
Biochemistry & Molecular Biology
Lingyun Wang, Ross P. Holmes, Ji-Bin Peng
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2019)
Article
Biochemistry & Molecular Biology
Kyle D. Wood, Ross P. Holmes, David Erbe, Abigail Liebow, Sonia Fargue, John Knight
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Medicine, Research & Experimental
Jacob A. Torres, Mina Rezaei, Caroline Broderick, Louis Lin, Xiaofang Wang, Bernd Hoppe, Benjamin D. Cowley, Vincenzo Savica, Vicente E. Torres, Saeed Khan, Ross P. Holmes, Michal Mrug, Thomas Weimbs
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Biochemistry & Molecular Biology
Brianna Buchalski, Kyle D. Wood, Anil Challa, Sonia Fargue, Ross P. Holmes, W. Todd Lowther, John Knight
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Review
Urology & Nephrology
Zachary Burns, John Knight, Sonia Fargue, Ross Holmes, Dean Assimos, Kyle Wood
CURRENT OPINION IN UROLOGY
(2020)
Article
Urology & Nephrology
Parveen Kumar, Mikita Patel, Vinoy Thomas, John Knight, Ross P. Holmes, Tanecia Mitchell
KIDNEY INTERNATIONAL REPORTS
(2020)
Review
Physiology
Tanecia Mitchell, Parveen Kumar, Thanmaya Reddy, Kyle D. Wood, John Knight, Dean G. Assimos, Ross P. Holmes
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Lingyun Wang, Ross P. Holmes, Ji-Bin Peng
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)