Article
Psychology, Developmental
Martha L. Cervantes-Henriquez, Johan E. Acosta-Lopez, Ariel F. Martinez, Mauricio Arcos-Burgos, Pedro J. Puentes-Rozo, Jorge I. Velez
Summary: The study found that genes DRD4, SNAP25, and ADGRL3 are associated with ADHD severity and can be used to predict different domains of severe and non-severe ADHD symptoms.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Nicole A. Perry-Hauser, Max W. VanDyck, Kuo Hao Lee, Lei Shi, Jonathan A. Javitch
Summary: ADGRL3 is a cell adhesion molecule highly expressed in the central nervous system and involved in synapse formation through interactions with ligands. This study identified a construct that disrupts specific functions of ADGRL3 while retaining others, providing a tool to further investigate its adhesion and G protein signaling functions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Clinical Neurology
Charlotte Tye, Fiona S. McEwen, Holan Liang, Emma Woodhouse, Lisa Underwood, Elizabeth Shephard, Edward D. Barker, Fintan Sheerin, Nicholas Higgins, Juul Steenbruggen, Patrick Bolton
Summary: This study found an association between attention-deficit/hyperactivity disorder (ADHD) and tuberous sclerosis complex (TSC), which may be mediated by epilepsy. The researchers also identified a developmental pathway from genetic mutation to cortical tuber load to epileptic spasm severity in infancy, ultimately leading to ADHD symptoms in middle childhood and adolescence.
Article
Endocrinology & Metabolism
Dennis Boyle, Orit Levi-Shachar, Hila Z. Gvirts, Orna Zagoory-Sharon, Ruth Feldman, Yuval Bloch, Uriel Nitzan, Hagai Maoz
Summary: This study did not find a statistical correlation between the severity of ADHD symptoms and salivary OT levels in children. It suggests that impairments in the reactivity of the OT system, associated with interpersonal difficulties, may be a distinct aspect of the clinical presentation of ADHD, different from other symptoms.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Ana Moreno-Alcazar, Josep A. Ramos-Quiroga, Marta Ribases, Cristina Sanchez-Mora, Gloria Palomar, Rosa Bosch, Josep Salavert, Lydia Fortea, Gemma C. Monte-Rubio, Erick J. Canales-Rodriguez, Michael P. Milham, F. Xavier Castellanos, Miquel Casas, Edith Pomarol-Clotet, Joaquim Radua
Summary: The study found that both risk and protective ADGRL3 haplotypes are associated with significant hypo-activation in the brain during working memory tasks. However, there were no brain effects of the interactions between adult ADHD and ADGRL3 haplotypes.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Rhiannon V. McNeill, Viola Stella Palladino, Nathalie Brunkhorst-Kanaan, Oliver Grimm, Andreas Reif, Sarah Kittel-Schneider
Summary: The study found that starvation significantly decreased ADGRL3 expression, while nicotine exposure significantly increased expression. Certain ADGRL3 gene polymorphisms interacted with the environment to modulate ADGRL3 transcription. ADGRL3 SNPs were able to predict its transcription levels under baseline and starvation conditions.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Maria Addolorata Mariggio, Roberto Palumbi, Angela Vinella, Riccardo Laterza, Maria Giuseppina Petruzzelli, Antonia Peschechera, Alessandra Gabellone, Ottavio Gentile, Alessandra Vincenti, Lucia Margari
Summary: The dopaminergic system may play a role in both ASD and ADHD, with DRD1 and DRD2 dopamine receptor SNPs potentially being risk factors for these disorders. Specifically, DRD2-12 was found to be significantly associated with the ASD/ADHD overlap, supporting the hypothesis of genetic neuromodulation in the neurobiology of these conditions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychology, Developmental
Astri J. Lundervold, Henna Vartiainen, Daniel Jensen, Jan Haavik
Summary: This study examined the test-retest reliability of WURS-25 and factors influencing adults with ADHD retrospective reports of childhood behavior. The results showed a strong correlation between WURS-25 scores at two time points and highlighted the significant impact of current ADHD symptoms on the WURS scores.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Toxicology
Satoru Aoki, Asuka Kaizaki-Mitsumoto, Natsumi Hattori, Satoshi Numazawa
Summary: This study investigated the effects of fetal exposure to methylphenidate on infant development and behavior in mice. The research found that this exposure might lead to ADHD-like phenotypes in offspring, which were alleviated by treatment with methylphenidate and atomoxetine. The study suggests that continuous use of methylphenidate during pregnancy could induce ADHD phenotypes in the offspring.
TOXICOLOGY LETTERS
(2021)
Article
Psychology, Developmental
Weam Fageera, Natalie Grizenko, Sarojini M. Sengupta, Norbert Schmitz, Ridha Joober
Summary: The study found that the COMT and DRD3 genetic variants may have a combined effect in children with ADHD, with children with the COMT Met/Met genotype showing poorer performance at baseline and on placebo stages.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Psychiatry
Yunyu Xu, Shuangxiang Lin, Jiejie Tao, Xinmiao Liu, Ronghui Zhou, Shuangli Chen, Punit Vyas, Chuang Yang, Bicheng Chen, Andan Qian, Meihao Wang
Summary: This study analyzed the correlation between susceptibility single nucleotide polymorphisms (SNPs) and the severity of clinical symptoms in children with attention deficit hyperactivity disorder (ADHD). It identified 9 SNPs that are significantly correlated with the severity of clinical symptoms, including rs1410739 (OBI1-AS1 locus) which may provide a new direction for ADHD research.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biology
Lorenza Dall'Aglio, Hannah H. Kim, Sander Lamballais, Jeremy Labrecque, Ryan L. Muetzel, Henning Tiemeier
Summary: This study examined the associations between ADHD symptoms and brain morphology, and identified changes in these associations with adjustments for different confounders. The findings highlight the importance of careful confounder selection and control in psychiatric neuroimaging.
Article
Psychiatry
Chuqi Fu, Shuangli Chen, Andan Qian, Ronghui Zhou, Jiejie Zhou, Jiance Li, Jingliang Cheng, Chuang Yang, Ke Zhao, Meihao Wang
Summary: This study investigated brain structural abnormalities in ADHD patients without comorbidity, using MRI images. The results showed that ADHD patients had more regional gray matter in the bilateral thalamus compared to controls, with this change mainly linked to the iADHD subtype. Additionally, the volume of the right thalamus may be relevant to inattentive symptoms in iADHD.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Ali Kandeger, Murat Boysan, Gizem Karaoglan, Rukiye Tekdemir, Baris Sen, Ozge Tan, Bilal Sagliyan, Yavuz Selvi
Summary: Childhood trauma and dissociative experiences are suggested to be predisposing factors for ADHD and other psychiatric disorders. Trauma-related symptoms can mimic, trigger, or exacerbate ADHD symptoms. This study investigated the associations between dissociative experiences and attention deficits using mixture analysis and found three distinct subgroups with varying levels of dissociation and attention problems.
CURRENT PSYCHOLOGY
(2023)
Article
Environmental Sciences
Jesus Ibarluzea, Mikel Subiza-Perez, Ane Arregi, Amaia Molinuevo, Enrique Arranz-Freijo, Manuel Sanchez-de Miguel, Ana Jimenez, Ainara Andiarena, Loreto Santa-Marina, Aitana Lertxundi
Summary: This study investigated the association between prenatal maternal urinary fluoride levels and symptoms of attention-deficit/hyperactivity disorder (ADHD) in children aged 8 and 11 years. The results showed no association between maternal urinary fluoride levels during pregnancy and cognitive problems-inattention symptoms at 8 or 11 years old. However, at age 11, there was a significant inverse association between maternal urinary fluoride levels and being categorized as a cognitive problems-inattention case. These findings contradict previous studies and highlight the need for further population-based research to confirm or challenge these results.
ENVIRONMENTAL RESEARCH
(2023)
Letter
Psychiatry
Ma-Li Wong, Chuanhui Dong, Deborah L. Flores, Monika Ehrhart-Bornstein, Stefan Bornstein, Mauricio Arcos-Burgos, Julio Licinio
AMERICAN JOURNAL OF PSYCHIATRY
(2015)
Review
Immunology
Angad S. Johar, Juan-Manuel Maya, Dan Andrews, Hardip R. Patel, Matthew Field, Chris Goodnow, Mauricio Arcos-Burgos
AUTOIMMUNITY REVIEWS
(2015)
Article
Behavioral Sciences
E. M. Bruxel, A. Salatino-Oliveira, G. C. Akutagava-Martins, L. Tovo-Rodrigues, J. P. Genro, C. P. Zeni, G. V. Polanczyk, R. Chazan, M. Schmitz, M. Arcos-Burgos, L. A. Rohde, M. H. Hutz
GENES BRAIN AND BEHAVIOR
(2015)
Article
Medicine, Research & Experimental
Angad S. Johar, Claudio Mastronardi, Adriana Rojas-Villarraga, Hardip R. Patel, Aaron Chuah, Kaiman Peng, Angela Higgins, Peter Milburn, Stephanie Palmer, Maria Fernanda Silva-Lara, Jorge I. Velez, Dan Andrews, Matthew Field, Gavin Huttley, Chris Goodnow, Juan-Manuel Anaya, Mauricio Arcos-Burgos
JOURNAL OF TRANSLATIONAL MEDICINE
(2015)
Article
Endocrinology & Metabolism
Claudio Alberto Mastronardi, Gilberto Paz-Filho, Martina Zanoni, Nicolas Molano-Gonzalez, Mauricio Arcos-Burgos, Julio Licinio, Ma-Li Wong
NEUROIMMUNOMODULATION
(2015)
Article
Clinical Neurology
Marcelo Miranda, M. Leonor Bustamante, Francisco Mena, Andrew Lees
Article
Genetics & Heredity
Jorge I. Velez, Francisco Lopera, Hardip R. Patel, Angad S. Johar, Yeping Cai, Dora Rivera, Carlos Tobon, Andres Villegas, Diego Sepulveda-Falla, Shaun G. Lehmann, Simon Easteal, Claudio A. Mastronardi, Mauricio Arcos-Burgos
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2016)
Article
Rheumatology
Juan-Manuel Anaya, Adriana Rojas-Villarraga, Ruben D. Mantilla, Mauricio Arcos-Burgos, Juan Camilo Sarmiento-Monroy
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2016)
Editorial Material
Neurosciences
Mauricio Arcos-Burgos, Maria T. Acosta, Ariel F. Martinez, Maximilian Muenke, Pablo J. Enriori, Claudio A. Mastronardi
Editorial Material
Genetics & Heredity
Marcelo Miranda, Maria Leonor Bustamante
MOLECULAR GENETICS & GENOMIC MEDICINE
(2017)
Article
Medicine, General & Internal
Camila Vargas, Maria Leonor Bustamante, Trinidad Kahler, Fernanda Vargas, Ulises Rios, Angela Munoz, Francisca Opazo, Marcelo Arancibia
Summary: This article discusses the importance of genetic research in psychiatric disorders and its impact on clinical psychiatry. It introduces key genetic concepts and types of mutations and reviews genetic and genomic databases useful for clinical practice.
Article
Biology
Valeria Salinas, Juana Villarroel, Hernan Silva, Luisa Herrera, Sonia Jerez, Alejandra Zazueta, Cristian Montes, Rodrigo Nieto, M. Leonor Bustamante
BMC RESEARCH NOTES
(2020)
Review
Genetics & Heredity
M. Leonor Bustamante, Luisa Herrera, Pablo A. Gaspar, Rodrigo Nieto, Alejandro Maturana, Maria Jose Villar, Valeria Salinas, Hernan Silva
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2017)
Article
Psychiatry
Debjani Das, Jorge I. Velez, Maria T. Acosta, Maximilian Muenke, Mauricio Arcos-Burgos, Simon Easteal
ADHD-ATTENTION DEFICIT AND HYPERACTIVITY DISORDERS
(2016)
Meeting Abstract
Neurosciences
Ma-Li Wong, Chuanhui Dong, Deborah Flores, Monika Ehrhart-Bornstein, Stefan Bornstein, Mauricio Arcos-Burgos, Julio Licinio
NEUROPSYCHOPHARMACOLOGY
(2014)