期刊
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
卷 94, 期 5, 页码 918-929出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02772248.2012.675156
关键词
copper; Anodonta anatina; thiobarbituric acid-reactive substances; glutathione; metallothionein; antioxidative enzymes
资金
- Directorate General of Higher Education, Ministry of National Education of the Republic of Indonesia
Copper is an essential element to all animals. At elevated concentrations, it is toxic and can participate in the formation of reactive oxygen species, leading to cellular damage. In this study, the ecotoxicological relevance of copper was investigated with freshwater mussels, Anodonta anatina. When the mussels were exposed to copper at environmentally realistic concentrations, either via the water (0.3 mu mol L-1 Cu) or fed with Cu-loaded algae (equivalent to 0.06 mu mol L-1 Cu), the level of thiobarbituric acid-reactive substances rose and glutathione decreased. This was associated with the induction of metallothionein and, relative to total protein, of glutathione reductase and the antioxidative enzymes superoxide dismutase, catalase, and glutathione peroxidase. But, since the overall protein-synthetic capacity was hampered by the copper insult, the activities of the enzymes relative to tissue weight and copper concentrations were depressed. During depuration, most parameters started to normalize although not returning to control values within 12 days.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据