Review
Endocrinology & Metabolism
Anderson Tadeu de Araujo-Ramos, Marcella Tapias Passoni, Marco Aurelio Romano, Renata Marino Romano, Anderson Joel Martino-Andrade
Summary: Glyphosate-based herbicides are widely used but controversial for their potential impacts on human health. While regulatory guideline studies suggest glyphosate lacks endocrine disrupting properties, in vivo and in vitro studies indicate GBHs may disrupt hormonal pathways.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Abdul Manan, Sittiruk Roytrakul, Sawanya Charoenlappanit, Toemthip Poolpak, Puey Ounjai, Maleeya Kruatrachue, Kwang Mo Yang, Prayad Pokethitiyook
Summary: This study investigated the effects of glyphosate on the proteomic aspects of Tetrahymena thermophila and its potential use as a bioindicator of freshwater ecosystems. The results showed that low and high doses of glyphosate caused changes in the proteome of T. thermophila. The study also revealed the multi-step process of glyphosate metabolism in T. thermophila.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Christelle Simasotchi, Audrey Chissey, Gerald Jungers, Thierry Fournier, Gilles-Eric Seralini, Sophie Gil
Summary: Glyphosate-based herbicidal formulations, such as Roundup, consist of glyphosate as the active principle and other undisclosed formulants. Studies show that these formulants are more toxic than glyphosate, affecting placental permeability and fetal blood flow. Formulants may disrupt fetal-placental circulation and integrity, potentially leading to adverse pregnancy outcomes.
Article
Agronomy
Waqas Mohy-Ud-Din, Muhammad Javed Akhtar, Safdar Bashir, Hafiz Naeem Asghar, Muhammad Farrakh Nawaz, Feng Chen
Summary: This study isolated 11 glyphosate-degrading bacteria from the rhizosphere of maize and wheat and tested their effects on the growth of maize and glyphosate degradation. E. ludwigii showed the highest improvement in shoot length (26%) and root length (34%) under 100 mg/kg glyphosate treatment. P. aeruginosa significantly improved the relative water content in leaves by 58% at 100 mg/kg glyphosate. The highest glyphosate degradation was observed in treatments inoculated with E. ludwigii (99 and 40%), P. aeruginosa (95 and 39%), K. variicola (91 and 38%), E. cloacae (92 and 38%), and S. liquefaciens (87 and 36%), respectively, at 100 and 200 mg/kg within 28 days. These five strains showed great potential for glyphosate degradation and promoting the growth of maize in vitro.
Article
Ecology
Eduarda Roberta Bordin, Renan Cesar Munhoz, Paloma Pucholobeck Panicio, Adriane Martins de Freitas, Wanessa Algarte Ramsdorf
Summary: This study evaluated the effects of atrazine and glyphosate on Daphnia magna. The results showed that these herbicides had significant effects on the survival, reproductive capacity, and antioxidant defense system of the microcrustacean. The commercial formulations of the herbicides had a greater impact on the second generation of organisms, while the analytical standards mainly affected sexual maturation in the first generation. The study also suggested that other components in the formulations could alter the toxicity of the products. Therefore, long-term studies are necessary to understand the potential impacts of these pesticides on multiple generations of organisms.
Review
Food Science & Technology
Diogo Soares, Liliana Silva, Sofia Duarte, Angelina Pena, Andre Pereira
Summary: Glyphosate is a widely used herbicide with controversial safety and health effects. Concerns about its presence in food due to its persistence in fields have raised awareness regarding public health.
Article
Multidisciplinary Sciences
Judit Hahn, Balazs Kriszt, Gergo Toth, Dongze Jiang, Marton Fekete, Istvan Szabo, Balazs Gobolos, Bela Urbanyi, Sandor Szoboszlay, Edit Kaszab
Summary: Glyphosate and glyphosate-based herbicides (GBHs) have an impact on the development of antibiotic resistance in Pseudomonas aeruginosa. Exposure to 0.5% GBHs resulted in decreased susceptibility to imipenem in P. aeruginosa strains, while the effectiveness of other carbapenems was not affected. The interactions between these chemicals may affect microbial communities.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Emily J. Eagles, Rachel Benstead, Susan MacDonald, Richard D. Handy, Thomas H. Hutchinson
Summary: This study investigated the acute toxicity of two common mycotoxins, deoxynivalenol (DON) and zearalenone (ZON), on a variety of freshwater organisms. The results showed that crustaceans were the most sensitive to DON, while cnidarians and molluscs were more sensitive to ZON. Combining these novel invertebrate toxicity results provides valuable information for the analysis of Species Sensitivity Distributions.
Article
Public, Environmental & Occupational Health
Francesca Truzzi, Daniele Mandrioli, Federica Gnudi, Paul T. J. Scheepers, Ellen K. Silbergeld, Fiorella Belpoggi, Giovanni Dinelli
Summary: The study found that glyphosate and its formulation Roundup Bioflow induced dose-related cytotoxic effects in in vitro human and murine models, while glycine itself did not show cytotoxicity. Similar to other organophosphate pesticides such as malathion, diazinon, and chlorpyriphos, glyphosate and Roundup Bioflow demonstrated cytotoxicity effects.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Robin Mesnage, Scarlett Ferguson, Inger Brandsma, Nynke Moelijker, Gaonan Zhang, Francesca Mazzacuva, Anna Caldwell, John Halket, Michael N. Antoniou
Summary: The co-formulant POE-15 tallow amine (POE-15) and the active ingredient glyphosate in herbicides have been found to be cytotoxic, causing cell necrosis and oxidative stress. The study highlights the importance of comprehensive testing of both co-formulants and active ingredients of commercial pesticides to ensure better regulation and protection of public health and the environment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Environmental Sciences
Germano A. B. Lanzarin, Luis M. Felix, Antonio Fontainhas-Fernandes, Sandra Mariza Monteiro, Carlos Venancio
Summary: A critical review was conducted to investigate the toxicity of glyphosate and glyphosate-based herbicides on zebrafish. The results showed that both substances can cause damage to zebrafish, compromising their survival, reproduction, and maintenance. These findings may be applicable to other fish species and aquatic ecosystems.
Article
Environmental Sciences
Jian Lu, Weiguo Wang, Cheng Zhang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Jiagao Cheng, Yang Zhang
Summary: Glyphosate, the most widely used herbicide, poses new hazards to human health, particularly cardiovascular toxicity. Research on zebrafish embryos exposed to glyphosate showed developmental abnormalities, including mortality, hatching issues, body length reduction, cardiac malformations, and impaired angiogenesis. Mechanistically, apoptosis occurred in the heart and vascular regions, with altered expression levels of apoptosis-related genes. This study provides evidence linking glyphosate exposure to cardiovascular developmental toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Zhihui Liu, Yingying Shangguan, Penglin Zhu, Yousef Sultan, Yiyi Feng, Xiaoyu Li, Junguo Ma
Summary: Glyphosate exposure in zebrafish larvae induces developmental toxicity, characterized by premature hatching, reduced heartbeats, and body deformities. This is likely due to disrupted thyroid function and abnormal expression of growth hormone/insulin-like growth factor axis-related genes. Additionally, glyphosate treatment leads to oxidative damage, endoplasmic reticulum stress, inflammatory reactions, and apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Chemistry, Multidisciplinary
Nikola Tresnakova, Alzbeta Stara, Josef Velisek
Summary: Glyphosate and its major metabolite AMPA are widely present in the aquatic environment, posing potential risks to aquatic organisms. The toxic effects of these compounds on aquatic organisms mainly include growth inhibition, developmental abnormalities, oxidative stress, and histopathological changes. Further research is needed to fully understand the impact of glyphosate and AMPA on aquatic ecosystems.
APPLIED SCIENCES-BASEL
(2021)
Review
Environmental Sciences
Lucas Battisti, Michele Potrich, Amanda Roberta Sampaio, Nedia de Castilhos Ghisi, Fabiana Martins Costa-Maia, Raiza Abati, Claudia Bueno dos Reis Martinez, Silvia Helena Sofia
Summary: Glyphosate, originally considered non-toxic to bees, has been shown to negatively impact their survival and behavior even at recommended doses. Meta-analysis of studies on GLY toxicity to bees revealed an increase in bee mortality rates, suggesting its toxic effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
