Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Atorvastatin Added to Interferon Beta for Relapsing Multiple Sclerosis: 12-Month Treatment Extension of the Randomized Multicenter SWABIMS Trial

(2014) Christian P. Kamm et al.   PLoS One

Simvastatin Inhibits Proliferation and Induces Apoptosis in Human Lung Cancer Cells

(2013) Xiaofeng Yu et al.   ONCOLOGY RESEARCH

Interference with RhoA–ROCK Signaling Mechanism in Autoreactive CD4+ T Cells Enhances the Bioavailability of 1,25-Dihydroxyvitamin D3 in Experimental Autoimmune Encephalomyelitis

(2012) Ajaib S. Paintlia et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased levels of IL-23 and osteopontin in serum and cerebrospinal fluid of multiple sclerosis patients

(2012) Shi-Rong Wen et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunomodulatory synergy by combining atorvastatin and rapamycin in the treatment of experimental autoimmune encephalomyelitis (EAE)

(2012) Zhenfei Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Atorvastatin added to interferon beta for relapsing multiple sclerosis: a randomized controlled trial

(2012) Christian Philipp Kamm et al.   JOURNAL OF NEUROLOGY

Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung

(2011) Songen Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Simvastatin as add-on therapy to interferon beta-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial

(2011) Per Soelberg Sorensen et al.   LANCET NEUROLOGY

Simvastatin improves final visual outcome in acute optic neuritis: a randomized study

(2011) Anna Tsakiri et al.   Multiple Sclerosis Journal

Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trial

(2010) Mansoureh Togha et al.   Multiple Sclerosis Journal

Atorvastatin Combined To Interferon to Verify the Efficacy (ACTIVE) in relapsing— remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy

(2010) Roberta Lanzillo et al.   Multiple Sclerosis Journal

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Atorvastatin attenuates murine anti-glomerular basement membrane glomerulonephritis

(2009) Philipp Eller et al.   KIDNEY INTERNATIONAL

Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells

(2009) Akira Saito et al.   MELANOMA RESEARCH

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

The pathological spectrum of CNS inflammatory demyelinating diseases

(2009) Wei Hu et al.   Seminars in Immunopathology

Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients

(2008) Desmond M. Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Combined treatment with atorvastatin and minocycline suppresses severity of EAE

(2008) Ilaria Luccarini et al.   EXPERIMENTAL NEUROLOGY

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

(2008) Mark A. Kroenke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis

(2008) G. Birnbaum et al.   NEUROLOGY

Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung

(2008) M Imamura et al.   THORAX

Simvastatin exerts its anti-inflammatory effect in hypercholesterolaemic patients by decreasing the serum levels of monocyte chemoattractant protein-1

(2007) Loukianos S. Rallidis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY