期刊
INFECTIOUS DISEASES
卷 48, 期 2, 页码 152-155出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/23744235.2015.1087647
关键词
Carbapenemase-producing Enterobacteriaceae; Klebsiella pneumoniae carbapenemase; cancer; immunosuppression; children
Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.
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