Editorial Material
Physics, Multidisciplinary
Aina Gallemi-Perez, Venecia Chavez-Medina
Summary: The Third Infinity conference, held in Gottingen, provides a platform for discussing complex systems physics and themes central to doctoral life and education. The organizing committee aims to raise awareness on the main issues faced by European interdisciplinary Ph.D. students.
COMMUNICATIONS PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Angela C. Evans, Kelly A. Martin, Manoj Saxena, Sandra Bicher, Elizabeth Wheeler, Emilio J. Cordova, Christopher D. Porada, Graca Almeida-Porada, Takamitsu A. Kato, Paul F. Wilson, Matthew A. Coleman
Summary: The bioavailability of curcumin, a natural polyphenol with antioxidant and anti-inflammatory properties, is improved by incorporating it into biomimetic nanolipoprotein particles. This formulation enhances water solubility and loading capacity, making it a potential method for drug delivery in various applications.
Review
Biochemistry & Molecular Biology
Nicola De Stefano, Alberto Calleri, Angelo Corso Faini, Victor Navarro-Tableros, Silvia Martini, Silvia Deaglio, Damiano Patrono, Renato Romagnoli
Summary: Extracellular vesicles (EVs) are small, membrane-bound vesicles that contain various bioactive molecules and play important roles in intercellular communication. In the field of liver disease research, EVs are emerging as a promising topic with potential applications in liver transplantation. This review provides an overview of the current understanding of the role of EVs in liver transplantation, including their potential as biomarkers and therapeutic agents, as well as their involvement in graft rejection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Arash Pezhouman, Ngoc B. Nguyen, Maryam Kay, Baishali Kanjilal, Iman Noshadi, Reza Ardehali
Summary: Cardiovascular disease is the leading cause of death and illness worldwide. Although there have been improvements in the treatment of heart diseases, there is still no effective method to prevent heart failure. Cardiac transplantation is the last option for severe heart failure patients, but there is a shortage of donors. Different strategies for cardiac regeneration have been explored, including cell-based therapeutics, gene therapy, and tissue engineering methods.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Chemistry, Analytical
Hojjatollah Nazari, Asieh Heirani-Tabasi, Sadegh Ghorbani, Hossein Eyni, Sajad Razavi Bazaz, Maryam Khayati, Fatemeh Gheidari, Keyvan Moradpour, Mousa Kehtari, Seyed Mohsen Ahmadi Tafti, Seyed Hossein Ahmadi Tafti, Majid Ebrahimi Warkiani
Summary: Microfluidics is a promising approach for the fabrication of monodispersed droplets, offering potential solutions to the limitations of regenerative medicine. This technology has been applied in various fields such as stem cell therapy, tissue engineering, reproductive biology, and gene therapy.
Article
Computer Science, Artificial Intelligence
Inigo Martinez, Elisabeth Viles, Igor G. Olaizola
Summary: Data science projects face challenges such as lack of vision and clear objectives, biased emphasis on technical issues, and ambiguity in roles, highlighting the need for a more holistic approach. Existing methodologies are often outdated and lack comprehensive guidance on team, project, and data & information management.
Review
Construction & Building Technology
Tareq Abuimara, Brodie W. Hobson, Burak Gunay, William O'Brien, Michael Kane
Summary: This paper provides recommendations for improving current building management practices in commercial and institutional buildings in North America. The recommendations are based on interviews with professionals, literature examples, and authors' experiences. The paper outlines current building management practices, barriers to improvement, and short- and long-term goals for enhancing building energy management practices.
JOURNAL OF BUILDING ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Richard Barker, Sylvain V. Costes, Jack Miller, Samrawit G. Gebre, Jonathan Lombardino, Simon Gilroy
Summary: Spaceflight exposes biology to unique radiation environments, and the Rad-Bio-App database helps users explore the impact of ionizing radiation on different biological systems in space experiments.
Review
Biochemistry & Molecular Biology
Wenjuan Ma, Yuxi Zhan, Yuxin Zhang, Chenchen Mao, Xueping Xie, Yunfeng Lin
Summary: DNA nanotechnology has been widely applied in various biological fields, showing great potential in altering cell behaviors and serving as drug carriers. The development of different DNA nanomaterials with diverse shapes and sizes has opened up new possibilities for innovative designs and biological applications. However, further research is needed to overcome current challenges and realize the full potential of DNA materials in real-life applications.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Immunology
Jeffrey A. Tomalka, Mehul S. Suthar, Michael S. Diamond, Rafick P. Sekaly
Summary: Innate immunity is an essential defense mechanism in cells, originating from bacteria and playing key roles in pathogen defense and immune response activation. Recent studies have shown that individual exposure histories, such as prior infections, vaccinations, and microbial metabolites, can modulate innate immunity and affect its effectiveness. Understanding how environmental factors regulate innate immune responses is crucial for pandemic preparedness.
TRENDS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Miguel de la Fuente, Laura Lombardero, Alfonso Gomez-Gonzalez, Cristina Solari, Inigo Angulo-Barturen, Arantxa Acera, Elena Vecino, Egoitz Astigarraga, Gabriel Barreda-Gomez
Summary: Enzymes have emerged as promising therapeutic tools for various pathologies, offering advantages such as specificity and affinity. However, challenges such as short in vivo half-life and immune system reactions need to be addressed. Monitoring serum immune response during treatment is crucial, with techniques like ELISA and microarrays being utilized. Research is ongoing, including the investigation of potential therapeutic alternatives like using ACE2 for treating COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
David Kis, Ilona Barbara Csordas, Eszter Persa, Balint Jezso, Rita Hargitai, Tuende Szatmari, Nikolett Sandor, Eniko Kis, Katalin Balazs, Geza Safrany, Katalin Lumniczky
Summary: This study investigated the role of bone marrow-derived extracellular vesicles (EVs) in mediating bystander effects induced by ionizing radiation (IR). The results showed that only EVs from an early stage of radiation damage were able to transmit IR-induced bystander effects.
Review
Neurosciences
Chao Zhou, Fating Zhou, Yarong He, Yan Liu, Yu Cao
Summary: Cerebral ischemia/reperfusion (I/R) injury leads to irreversible brain damage, and exosomes, as nanometre-scale membrane vesicles, have been found to play a role in intercellular communication during this process. Stem cell-derived exosomes show potential therapeutic effects for cerebral I/R injury.
Article
Oncology
Puja Upadhaya, Nathan Ryan, Peyton Roth, Travis Pero, Felipe Lamenza, Anna Springer, Pete Jordanides, Hasan Pracha, Darrion Mitchell, Steve Oghumu
Summary: This study demonstrates that tumor-targeted radiation therapy can generate tumor antigens that induce strong immune responses. These responses show comparable sensitivity but greater specificity for T cell activation compared to conventional antibodies. This information can be utilized to predict patient responses to radiation and immune therapy.
Review
Oncology
William A. Hall, Christina Small, Eric Paulson, Eugene J. Koay, Christopher Crane, Martijn Intven, Lois A. Daamen, Gert J. Meijer, Hanne D. Heerkens, Michael Bassetti, Stephen A. Rosenberg, Katharine Aitken, Sten Myrehaug, Laura A. Dawson, Percy Lee, Cihan Gani, Michael David Chuong, Parag J. Parikh, Beth A. Erickson
Summary: Pancreatic adenocarcinoma (PAC) has poor treatment outcomes, but MR-guided RT shows promise. Over 300 manuscripts were reviewed, with 6 clinical outcomes publications identified for PAC treated with MR guidance. Challenges and future directions for this technology were evident, showing potential benefits for PAC but requiring further evidence.
FRONTIERS IN ONCOLOGY
(2021)