Article
Multidisciplinary Sciences
Chenggang Wu, Yi-Wei Chen, Matthew Scheible, Chungyu Chang, Manuel Wittchen, Ju Huck Lee, Truc T. Luong, Bethany L. Tiner, Andreas Tauch, Asis Das, Hung Ton-That
Summary: Fusobacterium nucleatum utilizes the two-component signal transduction system CarRS and environmental lysine to modulate interspecies interactions, virulence, and nutrient acquisition for survival in the adverse environment of oral biofilms and extraoral sites.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medical Laboratory Technology
Myungsook Kim, Shin Young Yun, Yunhee Lee, Hyukmin Lee, Dongeun Yong, Kyungwon Lee
Summary: This study investigated clinical differences among patients infected with Fusobacterium spp. and determined the antimicrobial susceptibility of the isolates. Despite clinical differences, there was no significant difference in mortality rates among patients infected with different species of Fusobacterium. Some Fusobacterium spp. exhibited resistance to certain commonly used antimicrobial agents.
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Microbiology
Orazio Palmieri, Stefano Castellana, Anna Latiano, Tiziana Latiano, Annamaria Gentile, Anna Panza, Marianna Nardella, Davide Ciardiello, Tiziana Pia Latiano, Giuseppe Corritore, Tommaso Mazza, Francesco Perri, Giuseppe Biscaglia
Summary: An increasing amount of evidence suggests the important role of gut microbiota in the development of colorectal cancer. This study analyzed the microbial communities in normal and neoplastic colonic mucosa using NGS and metagenomics analysis tools. The findings revealed weak differences in microbial diversity between CRC and control groups, with an increasing trend of Rikenellaceae, Pseudomonas, and Fusobacterium in CRC. Fusobacterium nucleatum was found to be significantly enriched in all tissues of subjects with synchronous colorectal neoplasia.
Article
Microbiology
Tingting Yu, Ling Ji, Liqin Lou, Shiqing Ye, Xiaoting Fang, Chen Li, Feizhao Jiang, Hongchang Gao, Yongliang Lou, Xiang Li
Summary: This study examined the composition of intestinal flora and their metabolites in CRC patients, and found that the alteration of intestinal flora can affect the concentrations of metabolites such as lactic acid and propionic acid, which in turn impact the apoptosis of CRC cells and the progression of CRC.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Cody A. Despins, Scott D. Brown, Avery Robinson, Andrew J. Mungall, Emma Allen-Vercoe, Robert A. Holt
Summary: The study found that F. nucleatum-induced host cell transcriptional modulation involves strong upregulation of genes related to immune migration and inflammatory processes, in addition to identifying genes strongly upregulated in a cell line-specific manner. Furthermore, extensive host cell epigenomic changes specific to host cell type were observed upon F. nucleatum exposure.
Article
Dentistry, Oral Surgery & Medicine
Hiroshi Haraga, Takenori Sato, Kiyoko Watanabe, Nobushiro Hamada, Nobuyuki Tani-Ishii
Summary: This study analyzed the effects of F. nucleatum on bacterial flora in the gut and surrounding organs in a rat model of apical periodontitis. The results showed the presence of F. nucleatum in the rat gut and kidney, and significant changes in the bacterial flora of the rat gut, heart, liver, and kidney. This suggests that apical periodontitis may lead to bacterial transmission from the oral cavity to the systemic circulation, affecting the gut and other organs.
JOURNAL OF ENDODONTICS
(2022)
Article
Microbiology
Merili Saar, Risto Vaikjarv, Ulle Parm, Priit Kasenomm, Siiri Koljalg, Epp Sepp, Madis Jaagura, Andres Salumets, Jelena Stsepetova, Reet Mandar
Summary: Based on next generation sequencing analysis, the most probable causative agents of peritonsillar abscess (PTA) include Streptococcus pyogenes, Fusobacterium necrophorum, and Fusobacterium nucleatum. Other streptococci and anaerobes may also contribute to the infection. Pus samples are more representative for microbiological examination than tonsil biopsies. These findings are important for optimizing the management of PTA patients.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Medicine, General & Internal
Shin Young Yun, Yunhee Lee, Juwon Hong, Dong-Chan Kim, Hyukmin Lee, Dongeun Yong, Yun Kyong Lim, Joong-Ki Kook, Kyungwon Lee
Summary: The aim of this study was to improve the accuracy and efficacy of identifying Fusobacterium species in clinical laboratories. Through the identification of 229 Fusobacterium isolates, the updated ASTA MicroIDSys system was found to be able to effectively identify nine species of Fusobacterium and four subspecies of F. nucleatum.
YONSEI MEDICAL JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Caitlin A. Brennan, Slater L. Clay, Sydney L. Lavoie, Sena Bae, Jessica K. Lang, Diogo Fonseca-Pereira, Kathryn G. Rosinski, Nora Ou, Jonathan N. Glickman, Wendy S. Garrett
Summary: Fusobacterium nucleatum influences intestinal immunity by shaping Th17 responses in an FFAR2-dependent manner. Further studies are necessary to clarify the precise role of FFAR2.
Article
Gastroenterology & Hepatology
Na Wu, Yu-Qing Feng, Na Lyu, Di Wang, Wei-Dong Yu, Yong-Fei Hu
Summary: In this study, it was demonstrated that F. nucleatum infection altered the colon mucosal microbiota by enriching pathogens related to the development of CRC, providing new insights into the role of F. nucleatum in the oncogenic microbial environment of the colon.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Hefei Zhang, Jiasan Zheng, Yue Sun, Chunxue Yang, Yang Yue
Summary: This study found that F. necrophorum causes foot rot in dairy cows by activating the NF-kB signaling pathway and increasing the expression of inflammatory factors such as TNF-a, IL-1b, and IL-8. The findings provide valuable insights for future clinical practice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Remberto Marcelo Argandona Valdez, Laurie Ann Ximenez-Fyvie, Karina Sampaio Caiaffa, Vanessa Rodrigues dos Santos, Rina Maria Gonzales Cervantes, Argelia Almaguer-Flores, Cristiane Duque
Summary: The study found that Bifidobacterium infantis and Bifidobacterium lactis alone or in double combinations have antagonist effects on periodontopathogens biofilms at different time points, with minimal influence on S. oralis growth.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Ruben Dyrhovden, Tomas Mikal Eagan, Oystein Flotten, William Siljan, Truls Michael Leegaard, Bjornar Bo, Hilde Fardal, Fredrik Grovan, Arne Kildahl-Andersen, Kjersti Wik Larssen, Rune Tilseth, Reidar Hjetland, Sigbjorn Loes, Frode Lindemark, Marit Tellevik, Rebecca Breistein, Oyvind Kommedal
Summary: This study provides a comprehensive microbiological and clinical characterization of oral-type pleural infections and highlights the importance of hematogenous seeding from dental infections as the underlying etiology.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Bhaskar Kumar, Stephen Lam, Mina Adam, Rachel Gilroy, Mark J. Pallen
Summary: This article discusses the potential importance of the oesophageal microbiome and introduces new research methods that offer hope for a comprehensive description of this microbial community.
TRENDS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yoav Charpak-Amikam, Tom Lapidus, Batya Isaacson, Alexandra Duev-Cohen, Tal Levinson, Adi Elbaz, Francesca Levi-Schaffer, Nir Osherov, Gilad Bachrach, Lois L. Hoyer, Maya Korem, Ronen Ben-Ami, Ofer Mandelboim
Summary: This study identifies how Candida albicans evades the immune response by manipulating the immune checkpoint receptor TIGIT. The results suggest that immunotherapy using a TIGIT-blocking antibody can restore anti-Candida immunity and serve as a potential therapeutic tool.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Gastroenterology & Hepatology
Pavel V. Pavlov, Andrey P. Kiryukhin, Alexander S. Tertychnyi, Yuri E. Kitsenko
Article
Medicine, General & Internal
Polina S. Lototskaya, Marina A. Manina, Aleksandr S. Tertychnyy, Andrey A. Zamyatnin, Svetlana Erdes
Article
Oncology
Ekaterina Blinova, Dmitry Enikeev, Dmitry Roshchin, Elena Samyshina, Olga Deryabina, Aleksander Tertychnyy, Dmitry Blinov, Evgenia Kogan, Marina Dudina, Haydar Barakat, Dmitrij Merinov, Aleksandr Kachmazov, Stanislav Serebrianyi, Natalia Potoldykova, Dmitrij Perepechin
Letter
Dermatology
Natalia P. Teplyuk, Purim M. Ruvinova, Vladimir A. Varshavsky, Alexander S. Tertychnyy, Anfisa A. Lepekhova
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Microbiology
Christine Landlinger, Lenka Tisakova, Vera Oberbauer, Timo Schwebs, Abbas Muhammad, Agnieszka Latka, Leen Van Simaey, Mario Vaneechoutte, Alexander Guschin, Gregory Resch, Sonja Swidsinski, Alexander Swidsinski, Lorenzo Corsini
Summary: The study found that using endolysins to treat Gardnerella can effectively eliminate the biofilms associated with bacterial vaginosis, while preserving beneficial bacteria, demonstrating high treatment selectivity and effectiveness.
Article
Environmental Sciences
Valery P. Kalinitchenko, Alexey P. Glinushkin, Alexander Swidsinski, Tatiana M. Minkina, Andrey G. Andreev, Saglara S. Mandzhieva, Svetlana N. Sushkova, Dmitry A. Makarenkov, Lyudmila P. Ilyina, Vladimir V. Chernenko, Inna Zamulina, George S. Larin, Alexey A. Zavalin, Sergey Gudkov
Summary: This study investigated the soil conditions and their impact on tree root growth in the Kastanozem complex in the dry steppe of southern Russia. The research found high soil density, a high content of aggregates impermeable to tree roots, and low water availability for tree growth. Modelling experiments revealed that salt components in the soil solution influenced the transfer of soil organic matter and heavy metals. An innovative methodology was applied to improve soil productivity and carbon sequestration.
ENVIRONMENTAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Christopher L. Bowlus, Michael R. Galambos, Richard J. Aspinall, Gideon M. Hirschfield, David E. J. Jones, Yvonne Doerffel, Stuart C. Gordon, Stephen A. Harrison, Andreas E. Kremer, Marlyn J. Mayo, Paul J. Thuluvath, Cynthia Levy, Mark G. Swain, Guy W. Neff, David A. Sheridan, Carmen M. Stanca, Christoph P. Berg, Aparna Goel, Mitchell L. Shiffman, John M. Vierling, Pol Boudes, Alexandra Steinberg, Yun-Jung Choi, Charles A. McWherter
Summary: This study examined the efficacy and safety of seladelpar in patients with primary biliary cholangitis (PBC). The results showed that seladelpar significantly improved biochemical markers of cholestasis and inflammation, and the improvements were maintained or improved after dose escalation at 52 weeks. The treatment was safe and not associated with worsening pruritus.
JOURNAL OF HEPATOLOGY
(2022)
Article
Immunology
Alexander Swidsinski, Vera Loening-Baucke, Sonja Swidsinski, Jack D. Sobel, Yvonne Doerffel, Alexander Guschin
Summary: This study investigated the adhesive and cohesive patterns of different bacteria in vaginal discharge of women diagnosed with bacterial vaginosis. The results showed that the bacteria in vaginal smears were not randomly assembled, but had specific distribution patterns based on their cohesiveness and adherence to epithelial cells. The study also identified two main types of bacterial vaginosis: biofilm vaginosis and bacterial excess vaginosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Alexander Swidsinski, Alexander Guschin, Lorenzo Corsini, Vera Loening-Baucke, Lenka Podpera Tisakova, Sonja Swidsinski, Jack D. Sobel, Yvonne Dorffel
Summary: FISH susceptibility testing allows for a unique evaluation of individually adjusted topical therapy without microbial isolation, facilitating the optimal choice of treatment.
Review
Engineering, Environmental
Valery P. Kalinitchenko, Alexander V. Swidsinski, Alexey P. Glinushkin, Valery P. Meshalkin, Sergey V. Gudkov, Tatiana M. Minkina, Vladimir V. Chernenko, Vishnu D. Rajput, Saglara S. Mandzhieva, Svetlana N. Sushkova, Alla A. Okolelova, Anna A. Shestakova
Summary: Soil plays a crucial role in regulating ecosphere and air quality. Outdated environmental technologies result in soil quality depletion and pollution of air, water, and land systems. The pedosphere and plants are closely intertwined with air quality. A biogeosystem technique (BGT*) methodology has been developed to enhance Earth's biogeochemical cycles and improve environmental quality through land use and air cleaning.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Obstetrics & Gynecology
Xinyi He, Qionglan Tang, Fengshu Zhan, Yiwen Mao, Fei Ye, Zeping Weng, Xuefeng Jiang, Alexander Swidsinski
Summary: This study investigated 144 human vaginal biopsy tissues and found that RVVC patients showed a large influx of neutrophils, lymphocytes, and plasma cells in the mucosa, basement membrane, and submucosa. Importantly, 29.2% of RVVC cases were found to have co-invasion of Gardnerella and fungi. Combining fluconazole with metronidazole resulted in higher treatment efficacy and lower recurrence rate.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Michael Kallenbach, Natalia Qvartskhava, Christian Weigel, Yvonne Doerffel, Jens Berger, Georg Kunze, Tom Luedde
Summary: With the increasing use of imaging and awareness among high-risk patients, gastroenterologists and hepatologists are frequently encountering patients with focal liver lesions. CT and MRI have become primary diagnostic tools in clinical practice, while contrast-enhanced sonography offers an effective and cost-efficient method for assessing these lesions. This article systematically presents the sonographic characteristics of common liver lesions, emphasizing the potential and importance of contrast-enhanced sonography in the future.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Nutrition & Dietetics
Nadine Rohwer, Racha El Hage, Christopher Smyl, Soeren Ocvirk, Tobias Goris, Tilman Grune, Alexander Swidsinski, Karsten-H. Weylandt
Summary: In this study, the effect of a 4-week ketogenic diet (KD) on the colonic microbiome of mice was examined. The results showed significant changes in the composition and quantity of gut bacteria, indicating possible anti-inflammatory effects of the KD. The findings suggest that the differential abundance of specific genera in the microbiota may be responsible for the health effects of the KD.
