Article
Plant Sciences
Hazwani Mat Saad, Syarifah Nur Syed Abdul Rahman, Suerialoasan Navanesan, Chun Hoe Tan, Sugumaran Manickam, Sri Nurestri Abd Malek, Kae Shin Sim
Summary: Plant extracts such as essential oils, specifically from Baeckea frutescens and Leptospermum javanicum, were found to exhibit appreciable antioxidant activity in various radical scavenging assays, with BF essential oil demonstrating higher overall antioxidant capacity than LJ. Compounds 1-5 in the essential oils were identified as potent antioxidants that significantly contributed to their antioxidant capacity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Joana L. C. Sousa, Cristiana Goncalves, Ricardo M. Ferreira, Susana M. Cardoso, Carmen S. R. Freire, Armando J. D. Silvestre, Artur M. S. Silva
Summary: This study focused on valorizing biomass derived compounds by transforming them into new added-value compounds with enhanced antioxidant properties. Through the design of specific substitution patterns, a derivative was found to exhibit the highest scavenging ability against free radicals. Additionally, analogues were designed and tested, with one showing an increased scavenging effect due to the presence of an extended pi-conjugated system at a particular position.
Article
Chemistry, Applied
Iftikhar Ali Khan, Ji Luo, Haibo Shi, Ye Zou, Asad Khan, Zongshuai Zhu, Weimin Xu, Daoying Wang, Ming Huang
Summary: The study found that a combination of allspice and perilla frutescens seed extract had the best effect in reducing the formation of HCAs in pan-fried chicken meat patties, with phenolic compounds showing the greatest inhibitory effect on the formation of IQ.
Article
Biochemistry & Molecular Biology
Marko R. Antonijevic, Edina H. Avdovic, Dusica M. Simijonovic, Ziko B. Milanovic, Ana D. Amic, Zoran S. Markovic
Summary: This paper investigated the antioxidative properties and radical scavenging abilities of five different coumarin derivatives. The results showed that these compounds have good antioxidative potential and radical scavenging abilities, and they meet the criteria of drug-likeness tests. In addition, three additional mechanisms of radical scavenging activity were discovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Horticulture
Nana Millicent Duduzile Buthelezi, Sechene Stanley Gololo, Liziwe Lizbeth Mugivhisa
Summary: In this study, the biostimulant effect of moringa seed extract (MSE) on cancer bush plants under deficit irrigation was investigated. The results showed that the foliar application of 2% MSE effectively enhanced the growth, yield, and physiological and biochemical attributes of the plants. This study highlights the potential of MSE as a cost-effective and environmentally friendly alternative for mitigating the negative impact of drought stress on cancer bush plants.
Article
Nutrition & Dietetics
Saulo Victor e Silva, Maria Celeste Gallia, Jefferson Romaryo Duarte da Luz, Adriana Augusto de Rezende, Guillermina Azucena Bongiovanni, Gabriel Araujo-Silva, Maria das Gracas Almeida
Summary: CoQ10 exhibits antioxidant properties and can protect cells from oxidative stress and cytotoxicity induced by pro-oxidant compounds, especially arsenic. Even in combination with Zn, CoQ10 is still able to maintain cellular activity, while higher concentrations of Zn may have detrimental effects on cells.
Article
Food Science & Technology
Pedro Ferreira-Santos, Raquel Ibarz, Jean-Michel Fernandes, Ana Cristina Pinheiro, Claudia Botelho, Cristina M. R. Rocha, Jose Antonio Teixeira, Olga Martin-Belloso
Summary: The study achieved effective protection and enhanced antioxidant and antimicrobial activity of compound from pine bark extract through microencapsulation, enabling controlled release during gastrointestinal digestion. This encapsulation system could also be useful for nutritional enrichment and antimicrobial protection of fermented foods.
Article
Nutrition & Dietetics
Heba Nageh Gad El-Hak, Hany Salah Mahmoud, Eman A. Ahmed, Heba M. Elnegris, Tahany Saleh Aldayel, Heba M. A. Abdelrazek, Mohamed T. A. Soliman, Menna Allah I. El-Menyawy
Summary: This study found that methanolic date flesh extract (MDFE) has the potential to alleviate cisplatin-induced hepatic injury. In a rat model, pretreatment with MDFE reduced liver damage caused by cisplatin, improved liver function, and reduced inflammation.
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Food Science & Technology
Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Arachchige Maheshika Kumari Jayasinghe, Eui-Jeong Han, Mawalle Kankanamge Hasitha Madhawa Dias, Kyung-Pil Kang, Sung-Ig Moon, Tai-Sun Shin, Ayeong Ma, Ginnae Ahn
Summary: The present study identified phenolic compounds in Moringa oleifera hot water extract (MOH) and evaluated its antioxidant activity on H2O2-induced oxidative stress in Vero cells. Results showed that MOH exhibited strong radical scavenging and antioxidant properties, reduced ROS generation, increased cell viability, suppressed mitochondrial depolarization and apoptosis, and activated the Nrf2/HO-1 signaling pathway.
Article
Biology
Agnieszka Skalska-Kaminska, Weronika Wojciak, Magdalena Zuk, Roman Paduch, Magdalena Wojciak
Summary: Nettle extract, with its antioxidant properties, has a positive impact on human skin fibroblasts without affecting cell metabolism negatively. It can be a valuable and safe additive in skincare products.
Article
Biochemistry & Molecular Biology
Ewa Florek, Marta Szukalska, Katarzyna Markiewicz, Izabela Miechowicz, Justyna Gornowicz-Porowska, Anna Jelinska, Joanna Kasprzyk-Pochopien, Joanna Nawrot, Agnieszka Sobczak, Malgorzata Horoszkiewicz, Wojciech Piekoszewski, Gerard Nowak
Summary: The extract from the leaves of Cynara scolymus L. has been found to have a high antioxidative potential and exhibits protective and regenerative effects on the liver, making it beneficial for reducing hepatocellular damage caused by xenobiotics.
Article
Endocrinology & Metabolism
Larissa Menezes da Silveira, Nathalia Stark Pedra, Natalia Pontes Bona, Luiza Spohr, Francieli da Silva dos Santos, Juliane Torchelsen Saraiva, Fernando Lopez Alvez, Bernardo de Moraes Meine, Roselia Maria Spanevello, Francieli Moro Stefanello, Mayara Sandrielly Pereira Soares
Summary: Blueberry extract shows selective anticancer activity against C6 glioma cells by reducing cell viability and proliferation, decreasing colony size and cell migration, as well as enhancing antioxidant enzyme activities, while having minimal impact on normal cells.
METABOLIC BRAIN DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Giuseppe Annunziata, Xavier Capo, Maria Magdalena Quetglas-Llabres, Margalida Monserrat-Mesquida, Silvia Tejada, Josep A. Tur, Roberto Ciampaglia, Fabrizia Guerra, Maria Maisto, Gian Carlo Tenore, Ettore Novellino, Antoni Sureda
Summary: The study evaluated a novel nutraceutical formulation, Taurisolo(R), based on polyphenolic extract from Aglianico cultivar grape pomace, showing significant antioxidant activity and the ability to activate nuclear factors, reduce reactive oxygen species levels, decrease pro-inflammatory gene expression, and induce anti-inflammatory cytokine expression.
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Farrah Syazana Khattulanuar, Mahendran Sekar, Shivkanya Fuloria, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Subban Ravi, Kumarappan Chidambaram, M. Yasmin Begum, Abul Kalam Azad, Srikanth Jeyabalan, Arulmozhi Dhiravidamani, Lakshmi Thangavelu, Pei Teng Lum, Vetriselvan Subramaniyan, Yuan Seng Wu, Kathiresan V. Sathasivam, Neeraj Kumar Fuloria
Summary: This review summarizes the extensive research on tilianin as a treatment for cardiovascular disorders. Tilianin has cardioprotective properties and can be used in the therapy of diseases such as coronary heart disease, angina pectoris, hypertension, and myocardial ischemia. The cardioprotective actions of tilianin are believed to be achieved through mechanisms such as free radical scavenging, inflammation control, and mitochondrial function regulation.
Review
Biochemistry & Molecular Biology
Naurah Nabihah Nasir, Mahendran Sekar, Shivkanya Fuloria, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Subban Ravi, M. Yasmin Begum, Kumarappan Chidambaram, Kathiresan V. Sathasivam, Srikanth Jeyabalan, Arulmozhi Dhiravidamani, Lakshmi Thangavelu, Pei Teng Lum, Vetriselvan Subramaniyan, Yuan Seng Wu, Abul Kalam Azad, Neeraj Kumar Fuloria
Summary: Kirenol, a natural diterpenoid molecule found in Sigesbeckia species, has demonstrated significant potential in reducing inflammation. This review summarizes the efficacy and safety of kirenol in treating inflammation, its potential mechanisms of action, and opportunities for future drug development. Preclinical studies have shown that kirenol has therapeutic potential against various inflammatory diseases, including multiple sclerosis, inflammatory bowel disorders, and arthritis. Molecular mechanisms contributing to kirenol's anti-inflammatory actions include the inhibition of pro-inflammatory cytokines and the stimulation of heme-oxygenase-1 expression. The review also addresses the challenges and opportunities of drug delivery for kirenol in inflammation treatment.
Article
Biochemistry & Molecular Biology
Geethanjali Thayumanavan, Srikanth Jeyabalan, Shivkanya Fuloria, Mahendran Sekar, Monica Ravi, Logesh Kumar Selvaraj, Logeshwari Bala, Kumarappan Chidambaram, Siew Hua Gan, Nur Najihah Izzati Mat Rani, M. Yasmin Begum, Vetriselvan Subramaniyan, Kathiresan Sathasivam, Dhanalekshmi U. Meenakshi, Neeraj Kumar Fuloria
Summary: This study found that Bisphenol A (BPA) can cause neurotoxicity and behavioral abnormalities in zebrafish, and silibinin and naringenin have potential neuroprotective effects.
Review
Biochemistry & Molecular Biology
Md Rezaul Islam, Fahadul Islam, Mohamed H. Nafady, Muniya Akter, Saikat Mitra, Rajib Das, Humaira Urmee, Sheikh Shohag, Aklima Akter, Kumarappan Chidambaram, Fahad A. Alhumaydhi, Talha Bin Emran, Simona Cavalu
Summary: Breast cancer is a common malignancy in women and a significant cause of cancer-related death. The search for more effective and natural compounds for breast cancer prevention and treatment is ongoing. Natural compounds have shown potential in inhibiting breast cancer growth and promoting cell apoptosis, making them promising agents for breast cancer treatment.
Review
Public, Environmental & Occupational Health
Kumarappan Chidambaram, Taha Alqahtani, Yahia Alghazwani, Afaf Aldahish, Sivakumar Annadurai, Kumar Venkatesan, Kavitha Dhandapani, Ellappan Thilagam, Krishnaraju Venkatesan, Premalatha Paulsamy, Rajalakshimi Vasudevan, Geetha Kandasamy
Summary: Several medicinal plants, including species from the Solanum genus, have the potential to be effective and environmentally safe alternatives for mosquito control. This study systematically analyzed research publications on the insecticidal properties of Solanaceae plants and their phytoconstituents, providing valuable information on their activity and chemical diversity for the development of botanical repellents against disease-causing vectors.
JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Giriraj Pandey, Prashant Pandey, Dilip Kumar Arya, Shubham Kanaujiya, Deshraj Deepak Kapoor, Ravi Kr. Gupta, Shivendu Ranjan, Kumarappan Chidambaram, Balamurugan Manickam, P. S. Rajinikanth
Summary: This study aims to develop a nanofibrous wound dressing for topical drug delivery in wound healing applications. The electrospinning technique is used to fabricate bioabsorbable nanofiber scaffolds enriched with thrombin and vancomycin. The nanofibrous scaffolds demonstrate excellent biocompatibility, antimicrobial activity, and wound healing capability in both in vitro and in vivo studies. Based on the results, it can be concluded that the nanofibrous scaffolds loaded with thrombin and vancomycin have promising potential as a dressing material for hemostatic wound healing applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kumarappan Chidambaram
Summary: This study evaluated the hypoglycemic, α-amylase, DPP-IV, and free radical scavenging effects of a hydroalcoholic extract of Solanum incanum (HAE-SI) in various in-vitro and in-vivo models. The results showed that HAE-SI has a hypoglycemic effect on rats fed a high fructose diet and inhibits α-amylase and DPPIV, as well as exhibits antioxidant properties in in-vitro assays.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Muhamad Azrul Amir Yusri, Mahendran Sekar, Ling Shing Wong, Siew Hua Gan, Subban Ravi, Vetriselvan Subramaniyan, Nur Najihah Izzati Mat Rani, Kumarappan Chidambaram, M. Yasmin Begum, Mohankumar Ramar, Sher Zaman Safi, Siddharthan Selvaraj, Yuan Seng Wu, Palanisamy Revathy, Shivkanya Fuloria, Neeraj Kumar Fuloria, Pei Teng Lum, Sinouvassane Djearamane
Summary: This review focuses on the efficacy of celastrol, a naturally occurring chemical, in mitigating memory impairment. Preclinical studies have shown that celastrol is highly effective in enhancing cognitive performance in animal models of memory impairment. It achieves this through mechanisms such as reducing oxidative stress and attenuating neuro-inflammation. The review also discusses the challenges of medication delivery for treating memory impairment and explores potential structural alterations and derivatives of celastrol to improve its physicochemical and drug-like properties.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Chemistry, Medicinal
Naurah Nabihah Nasir, Mahendran Sekar, Subban Ravi, Ling Shing Wong, Sreenivas Patro Sisinthy, Siew Hua Gan, Vetriselvan Subramaniyan, Kumarappan Chidambaram, Nur Najihah Izzati Mat Rani, M. Yasmin Begum, Mohankumar Ramar, Sher Zaman Safi, Siddharthan Selvaraj, Senthil Kumar Chinna Maruthu, Shivkanya Fuloria, Neeraj Kumar Fuloria, Pei Teng Lum, Sinouvassane Djearamane
Summary: Streptonigrin, an aminoquinone alkaloid derived from Streptomyces flocculus, has potential antitumor and antibiotic effects. Despite its previous use as an anticancer drug being discontinued due to toxicity, recent studies have shown reduced toxicity of streptonigrin and its derivatives while maintaining pharmacological action at lower concentrations. This comprehensive review aims to discuss the prospects of streptonigrin and its derived compounds as interesting target molecules for new drug design, development, and therapy, providing a reference for their development and utilization as pharmaceuticals.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Rajapandi Raju, Kumarappan Chidambaram, Balakumar Chandrasekaran, Tapan Kumar Maity, Abdullah M. Alkahtani, Harish C. Chandramoorthy, Mohammad F. Bayan
Summary: A series of novel isatin hybrids 5a-g were designed, synthesized, and characterized spectroscopically. The synthesized compounds were evaluated for their cytotoxic activity against the human breast cancer cell line (MCF-7) using in vitro MTT assay. Compound 5e, bearing benzyl moiety at N4 piperazine, exhibited the most potent anticancer activity with an IC50 of 12.47 mM. Additionally, compounds 5e and 5g were evaluated for their antitumor activity against Dalton's ascitic lymphoma (DAL) cell line, and compound 5e showed the ability to normalize the blood picture compared to the standard drug. A molecular docking study using the crystal structure of Hsp90 protein provided insights into the protein-ligand interactions and binding mode. The drug-likeliness of the compounds was predicted based on Lipinski's rule of five and pharmacokinetic ADME parameters. Therefore, the synthesized isatin hybrids could serve as promising lead compounds for anticancer drug discovery due to their drug-like properties.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Nem Kumar Jain, Mukul Tailang, Hemant Kumar Jain, Balakumar Chandrasekaran, Biswa Mohan Sahoo, Anandhalakshmi Subramanian, Neelaveni Thangavel, Afaf Aldahish, Kumarappan Chidambaram, M. Alagusundaram, Santosh Kumar, Palani Selvam
Summary: Severe cases of COVID-19 are characterized by hyperinflammation and multiorgan failure. JAK-STAT signaling plays a role in the immunopathogenesis of COVID-19. Jakinibs, small molecules that target proinflammatory cytokines, are being investigated as potential treatments through clinical trials. Baricitinib is currently the only FDA-approved Jakinib for treating critical COVID-19 patients. Further studies are needed to understand the pathogenesis of COVID-19 and determine the optimal duration and combination therapy of Jakinibs. This review article provides important insights into the therapeutic implications of Jakinibs for COVID-19 treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Kumarappan Chidambaram
Summary: In this study, researchers used E-pharmacophore modeling to screen the eMolecules database and identified potential drug candidates against Alzheimer's disease with enhanced physicochemical and pharmacokinetic properties. Molecular dynamics simulation and MMPBSA analysis revealed the stability and binding free energy of these compounds. Furthermore, Qikprop analysis indicated that the selected compounds have good drug-likeness and pharmacokinetic properties.
Article
Polymer Science
Benedict Jose Chellathurai, Ramyadevi Anburose, Mohammad H. H. Alyami, Mohan Sellappan, Mohammad F. F. Bayan, Balakumar Chandrasekaran, Kumarappan Chidambaram, Mohamed Rahamathulla
Summary: The present study aimed to develop and evaluate a polyherbal gel for treating acne by formulating a mixture of Aloe barbadensis pulp and Vigna radiata extract using Carbopol 940, triethanolamine, and propylene glycol as gelling, viscosity modifying, and pH modifying agents respectively. The developed gel exhibited significant antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, with promising inhibition zones. The gel formulation also showed beneficial effects on acne, with the additional benefit of Aloe barbadensis on the skin.
Article
Medicine, General & Internal
Remya Radhakrishnan, Hemalatha Selvaraj, Kumarappan Chidambaram, Arshav Kv, Adona James, Sivakumar Thangavel
Summary: This observational study aimed at determining the prevalence of anxiety and depression in cancer patients and their correlation with various factors. The findings indicate that educational status and occupational status significantly contribute to the risk of anxiety and depression in cancer patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Rana Abutaima, Yousef Al-ebini, Ahmad Alkofahi, Anas Alshishani, Samar Thiab, Kumarappan C. Alagammai, Mohammad Khalid
Summary: This study investigated the effect of blackseed oil (BSO) on the pharmacokinetics of prednisolone. The results showed that a single dose of BSO decreased the maximum plasma concentration and area under the curve of prednisolone in rats, indicating a herb-drug interaction.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
