Article
Engineering, Chemical
Ariel J. Atkinson, Mikayla D. Armstrong, John T. Eskew, Orlando Coronell
Summary: Biofouling is a challenge in membrane applications, particularly in the purification of natural waters. The study found that the 2-AI membrane effectively inhibited biofilm formation, resulting in weaker biofouling that was easier to remove. Despite initially lower water permeance, the 2-AI membranes outperformed controls after biofilm formation, fouling less without compromising water productivity and solute rejection.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Microbiology
K. B. Arun, Aravind Madhavan, Billu Abraham, M. Balaji, K. C. Sivakumar, P. Nisha, R. Ajay Kumar
Summary: Isoniazid (INH) is activated by the KatG enzyme of Mycobacterium tuberculosis and inhibits cell wall biosynthesis. INH-resistant strains often have mutations in specific genes, but some strains may use alternative mechanisms. A study found that Rv2170 acetylates INH, potentially contributing to drug resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Tsung-Lun Li, Tai-Hua Chan, Cheng-Hui Wang, Ruwen Jou, Ming-Chih Yu, Denise Utami Putri, Chih-Hsin Lee, Yi-Hsien Lin
Summary: This case report highlights the importance of appropriate treatment and prompt diagnosis in eliminating tuberculosis. The patient initially diagnosed with latent tuberculosis infection later developed active TB disease with drug resistance, but showed improvement and no recurrence after individualized anti-TB treatment for 20 months. The study suggests that traditional diagnostic methods may not be sufficient to differentiate different stages of TB or LTBI.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Vanessa B. Vogensen, Mathieu S. Bolhuis, Marieke G. G. Sturkenboom, Tjip S. van der Werf, Wiel C. M. de Lange, Richard M. Anthony, Dick van Soolingen, Jan-Willem Alffenaar, Huib A. M. Kerstjens, Onno W. Akkerman
Summary: This retrospective study in a Dutch TB center investigated the impact of rifampicin on moxifloxacin exposure in patients with isoniazid-resistant or -intolerant TB. The study found a clinically significant 39% decrease in moxifloxacin exposure when rifampicin was co-administered, but moxifloxacin dose adjustment may compensate for this drug-drug interaction.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Juliana Maira Watanabe Pinhata, Lucilaine Ferrazoli, Flavia de Freitas Mendes, Maria Gisele Goncalves, Michelle Christiane da Silva Rabello, Kelen Teixeira Ghisi, Vera Simonsen, Roberta Figueiredo Cavalin, Ana Angelica Bulcao Portela Lindoso, Rosangela Siqueira de Oliveira
Summary: This study investigated the mutations, clinical characteristics, treatment outcomes, and clustering of drug-resistant tuberculosis (TB) in southeast Brazil. The results showed that katG and inhA mutations were not equally distributed between isoniazid-monoresistant and multidrug-resistant (MDR) isolates. In addition, isolates with inhA mutations were found to have a higher frequency of clustering. Unfavorable treatment outcomes of TB were associated with specific factors such as age, drug resistance status, and treatment history.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Marwa Bachir, Lorenzo Guglielmetti, Simone Tunesi, Typhaine Billard-Pomares, Sheila Chiesi, Jeremy Jaffre, Hugo Langris, Valerie Pourcher, Frederic Schramm, Nadine Lemaitre, Jerome Robert
Summary: This study assessed the impact of rapid diagnostic tests on the treatment of HR-TB in France and found that early implementation of molecular detection can shorten the time to adequate treatment.
JOURNAL OF INFECTION
(2022)
Article
Infectious Diseases
Getu Diriba, Ayinalem Alemu, Bazezew Yenew, Habteyes Hailu Tola, Dinka Fikadu Gamtesa, Hilina Mollalign, Kirubel Eshetu, Shewki Moga, Saro Abdella, Getachew Tollera, Abebaw Kebede, Mesay Hailu Dangisso
Summary: This study aimed to estimate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) in patients with multidrug-resistant TB (MDR-TB). A total of 64 studies involving 12,711 patients from 22 countries were included. The pooled proportion of pre-XDR-TB was 26%, while XDR-TB in MDR-TB cases was 9%. These findings highlight the substantial burden of pre-XDR-TB and XDR-TB in MDR-TB patients, emphasizing the importance of strengthening TB programs and drug resistance surveillance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Prabha Desikan, Nikita Panwalkar, Ram Prakash Punde, Zeba Khan, Ankur Pauranik, Shaina Beg Mirza, Manju Chourey, Sridhar Anand, K. S. Sachdeva
Summary: This study aimed to estimate the proportion of heteroresistance among Mycobacterium tuberculosis in clinical samples of drug-resistant tuberculosis patients in Central India. The results showed that 5.4% of the samples had heteroresistance, which may pose challenges in drug resistance testing and treatment outcomes.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Infectious Diseases
Marwa Bachir, Lorenzo Guglielmetti, Simone Tunesi, Typhaine Billard-Pomares, Sheila Chiesi, Jeremy Jaffre, Hugo Langris, Valerie Pourcher, Frederic Schramm, Nadine Lemaitre, Jerome Robert
Summary: Female sex, birth in the West-Pacific region, and resistance to streptomycin were independently associated with HR-TB, but treatment success rates did not significantly differ between HR-TB and DS-TB. Rapid molecular testing remains the only effective way to make early diagnosis of HR-TB and adapt treatment.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
Alessio Lanni, Angelo Iacobino, Lanfranco Fattorini, Federico Giannoni
Summary: The lungs of tuberculosis (TB) patients exhibit various types of granulomas, and the treatment for TB involves targeting different stages of the bacilli. However, non-replicating bacilli, known as persisters, are difficult to eradicate due to their drug tolerance and poor drug penetration. A comprehensive understanding of drug combinations that target both replicating and drug-tolerant bacilli is essential for developing new therapies and shortening the treatment duration for TB. Recent clinical trials have shown promising results, leading to the consideration of a 4-month regimen as an alternative to the current 6-month treatment.
Article
Materials Science, Multidisciplinary
Tianhang Xie, Yueming Song, Haitao Peng, Zhongqiu Dai, Yi Kang, Peng Xiu, Linnan Wang, Hong Li, Xi Yang
Summary: The study synthesized an implantable composite scaffold n-HP@ICG, which showed satisfactory anti-TB effects and bone regeneration activities. The scaffold could release INH for approximately 15 days in vitro and 28 days in vivo, demonstrating good biocompatibility and osteoconduction/integration.
MATERIALS & DESIGN
(2021)
Article
Pediatrics
Junfeng Zheng, Yongbin Xu, Jun Yang, Ke Cao, Guofang Deng, Peize Zhang
Summary: Hemophagocytic syndrome (HPS) is a severe disease characterized by an ineffective immune response that leads to infiltration of lymphocytes and histiocytes in various organs. HPS can be caused by genetic factors, malignancy, autoimmune disease, or infection. Tuberculosis of the bone marrow accompanied by HPS is rare and may be resistant to isoniazid. This case highlights the importance of testing for drug susceptibility in tuberculosis cases with uncommon manifestations.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Joaquim Trigo Marques, Catarina Frazao De Faria, Marina Reis, Diana Machado, Susana Santos, Maria da Soledade Santos, Miguel Viveiros, Filomena Martins, Rodrigo F. M. De Almeida
Summary: The increase in multidrug-resistant tuberculosis has made the challenge of ending this epidemic by 2030 even tougher. This has led to a search for more efficient antitubercular compounds, with a focus on isoniazid derivatives in this study. The study evaluates the cytotoxicity, binding to human serum albumin, and activity against resistant strains of Mycobacterium tuberculosis of these derivatives, showing promising results for their potential use as improved treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Adam Penn-Nicholson, Sophia B. Georghiou, Nelly Ciobanu, Mubin Kazi, Manpreet Bhalla, Anura David, Francesca Conradie, Morten Ruhwald, Valeriu Crudu, Camilla Rodrigues, Vithal Prasad Myneedu, Lesley Scott, Claudia M. Denkinger, Samuel G. Schumacher
Summary: The Xpert MTB/XDR assay demonstrated high diagnostic accuracy in detecting drug-resistant tuberculosis and has the potential to rapidly and accurately diagnose the disease, enabling proper treatment.
LANCET INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Muluwork Getahun, Henry M. Blumberg, Gobena Ameni, Dereje Beyene, Russell R. Kempker
Summary: This study evaluated the minimum inhibitory concentrations (MICs) of multidrug resistant (MDR) and rifampin resistant (RR) as well as isoniazid (INH) resistant Mtb isolates to determine the level of drug resistance for key anti-tuberculosis drugs. It was found that a subset of INH resistant isolates had borderline rifampin resistance and a high proportion of MDR TB isolates had moderate level isoniazid resistance, indicating the potential benefit of high dose isoniazid treatment.
Article
Chemistry, Medicinal
Robert E. Furlani, Mike A. Richardson, Brendan K. Podell, David F. Ackart, Jessica D. Haugen, Roberta J. Melander, Randall J. Basaraba, Christian Melander
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Immunology
Susan L. Baldwin, Valerie A. Reese, Po-wei D. Huang, Elyse A. Beebe, Brendan K. Podell, Steven G. Reed, Rhea N. Coler
CLINICAL AND VACCINE IMMUNOLOGY
(2016)
Article
Cell Biology
Marcela I. Henao-Tamayo, Andres Obregon-Henao, Kimberly Arnett, Crystal A. Shanley, Brendan Podell, Ian M. Orme, Diane J. Ordway
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Review
Immunology
Dilara Kiran, Brendan K. Podell, Mark Chambers, Randall J. Basaraba
SEMINARS IN IMMUNOPATHOLOGY
(2016)
Article
Public, Environmental & Occupational Health
Barbara S. Drolet, Lindsey M. Reister-Hendricks, Brendan K. Podell, Jonathan E. Breitenbach, D. Scott McVey, Piet A. van Rijn, Richard A. Bowen
VECTOR-BORNE AND ZOONOTIC DISEASES
(2016)
Meeting Abstract
Endocrinology & Metabolism
James E. Dilisio, Noah Mishkin, Brendan Podell
Article
Veterinary Sciences
Bernard Seguin, Chris Pinard, Bertrand Lussier, Deanna Williams, Lynn Griffin, Brendan Podell, Sebastian Mejia, Anatolie Timercan, Yvan Petit, Vladimir Brailovski
VETERINARY AND COMPARATIVE ONCOLOGY
(2020)
Article
Microbiology
Firat Kaya, Jacqueline P. Ernest, Katherine LoMauro, Martin Gengenbacher, Abdeldjalil Madani, Wassihun Wedajo Aragaw, Matthew D. Zimmerman, Jansy P. Sarathy, Nadine Alvarez, Isaac Daudelin, Han Wang, Faye Lanni, Danielle M. Weiner, Laura E. Via, Clifton E. Barry, Kenneth N. Olivier, Thomas Dick, Brendan K. Podell, Radojka M. Savic, Veronique Dartois
Summary: This study found that the rabbit model of active tuberculosis reproduces key features of human NTM-PD and provides an acceptable surrogate model for studying antibiotic penetration and efficacy. The research also revealed that the clinical activity of clarithromycin is limited by pharmacodynamic factors.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Meeting Abstract
Endocrinology & Metabolism
James Dilisio, Andres Obregon-Henao, David Ackart, Alexandra Todd, Randall J. Basaraba, Brendan K. Podell
Meeting Abstract
Oncology
Molly Plehaty, Tara Srinivas, Wanida Stevens, Nema Sobhani, Tomoo Iwakuma, Brendan Podell, Farinaz Arbab, Tamara Terzian
Article
Cell Biology
Brendan K. Podell, David F. Ackart, Michael A. Richardson, James E. DiLisio, Bruce Pulford, Randall J. Basaraba
DISEASE MODELS & MECHANISMS
(2017)
Meeting Abstract
Endocrinology & Metabolism
James Dilisio, Liane Sehrt, Andres Obregon-Henao, David F. Ackart, Michael Mangalea, Randall J. Basaraba, Marcela Henao-Tamayo, Brendan K. Podell
Meeting Abstract
Immunology
Susan L. Baldwin, Valerie A. Reese, Po-wei D. Huang, Elyse A. Beebe, Brendan K. Podell, Steven G. Reed, Rhea N. Coler
JOURNAL OF IMMUNOLOGY
(2016)
Meeting Abstract
Endocrinology & Metabolism
Brendan K. Podell, David F. Ackart, Natalie Lakey, Randall J. Basaraba
Meeting Abstract
Endocrinology & Metabolism
Randall J. Basaraba, David Ackart, Natalie Lakey, Mike Richardson, Brendan K. Podell