Article
Chemistry, Analytical
Carla Silva-Batista, Graham Harker, Rodrigo Vitorio, Fay B. Horak, Patricia Carlson-Kuhta, Sean Pearson, Jess VanDerwalker, Mahmoud El-Gohary, Martina Mancini
Summary: This study tested the feasibility of using a physical therapist assisted system (Mobility Rehab) with wearable sensors for one session of treadmill training in 10 people with Parkinson's disease (PD). The training significantly improved foot-strike angle, trunk coronal range-of-motion (RoM), and arm swing RoM during overground walking. Participants perceived moderate to excellent effects on their gait. One session of treadmill training with Mobility Rehab is feasible for people with mild-to-moderate PD.
Article
Engineering, Biomedical
Kate McMaster, Michael H. Cole, Daniel Chalkley, Mark W. Creaby
Summary: This study suggests that real-time visual biofeedback can effectively modify specific gait characteristics associated with falls in PD patients, such as reducing mediolateral trunk lean, step length and gait velocity.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Neurosciences
Dione Y. L. Quek, Kristin Economou, Hamish MacDougall, Simon J. G. Lewis, Kaylena A. Ehgoetz Martens
Summary: This study evaluated the consistent improvement of freezing of gait (FOG) using body-related visual feedback (VF) under low and high threat conditions. The results revealed that providing VF significantly reduced FOG occurrence in the low threat condition, whereas there were no differences in FOG occurrence regardless of providing VF in the high threat condition. These findings suggest that anxiety may interfere with the ability of patients to utilize sensory feedback and improve FOG.
Article
Clinical Neurology
Nora Vanegas-Arroyave, Denise F. Chen, Peter M. Lauro, Gina Norato, Codrin Lungu, Mark Hallett
Summary: This study found that Parkinson's disease patients with freezing of gait tend to fixate more on proximal areas of the ground, indicating increased dependence on nearby visual feedback.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Femke Hulzinga, Jana Seuthe, Nicholas D'Cruz, Pieter Ginis, Alice Nieuwboer, Christian Schlenstedt
Summary: This study investigated the effects of split-belt treadmill (SBT) training versus tied-belt treadmill (TBT) training on gait adaptation in people with Parkinson's disease (PD). The results showed that SBT training improved gait adaptation compared to TBT training, and these improvements were sustained during follow-up and dual tasking. However, better gait adaptation did not transfer to over-ground turning speed. Additionally, both SBT and TBT training led to improvements in over-ground walking and Movement Disorder Society-Unified Parkinson's Disease Rating Scale III scores, with clinically meaningful effects observed only in the SBT group.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
E. C. Klaver, J. P. P. van Vugt, B. R. Bloem, R. J. A. van Wezel, J. Nonnekes, M. C. Tjepkema-Cloostermans
Summary: This study evaluates the effect of tactile cueing delivered via vibrating socks versus auditory cueing on freezing of gait (FOG) in individuals with Parkinson's disease (PD). The results show that the impact of tactile and auditory cueing on FOG varies among individuals, highlighting the importance of a personalized approach in treating FOG.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Sarah A. Brinkerhoff, Patrick G. Monaghan, Jaimie A. Roper
Summary: Split-belt treadmill walking allows researchers to understand the acquisition of new gait patterns through adaptation, deadaptation, and readaptation processes. Visual feedback may be useful in promoting step timing or position adaptation to understand gait impairments. Research indicates that walking with temporal or spatial visual feedback does not interfere with gait adaptation, and future work should explore the effects of asymmetric feedback on populations with altered step control.
Article
Behavioral Sciences
Jeremy Cosgrove, Mark R. Hinder, Rebecca J. St George, Chiara Picardi, Stephen L. Smith, Michael A. Lones, Stuart Jamieson, Jane E. Alty
Summary: In Parkinson's disease, individuals exhibit increased reliance on visual feedback during upper limb reaching movements, especially in the presence of cognitive decline, indicating a greater need for visual guidance in motor planning and execution.
Article
Chemistry, Analytical
Hyeonjong Kim, Ji-Won Kim, Junghyuk Ko
Summary: Parkinson's disease is a common neurodegenerative disorder characterized by gait disorders. Recent advancements in numerical modeling and algorithms for gait detection and classification, along with augmented feedback training, have shown promise in effective physical rehabilitation. The GDC method can distinguish between normal individuals and those with gait disorders, providing potential applications in rehabilitation and gait evaluation.
Article
Computer Science, Information Systems
Luca Pietrosanti, Alexandre Calado, Cristiano Maria Verrelli, Antonio Pisani, Antonio Suppa, Francesco Fattapposta, Alessandro Zampogna, Martina Patera, Viviana Rosati, Franco Giannini, Giovanni Saggio
Summary: Parkinson's disease (PD) causes a range of symptoms, including motor impairments. Recent studies have utilized technology-based systems, particularly wearable devices, to objectively measure gait capabilities and differences between PD patients and healthy individuals. This study focused on the harmonic content of upper limb swing during walking, which had not been previously studied. Using IMU sensors, the walking capabilities of PD patients (both newly diagnosed and those under chronic dopaminergic treatment in an off-therapy state) and healthy individuals were measured. The collected data were FFT transformed and analyzed for frequency content. The results showed objectively evidenced upper limb rigidity in PD patients, which was correlated to lower harmonic contents.
Article
Biotechnology & Applied Microbiology
Federico Arippa, Bruno Leban, Marco Monticone, Giovanni Cossu, Carlo Casula, Massimiliano Pau
Summary: The unilaterality of motor symptoms in Parkinson's disease is associated with motor deficits and limitations in functional abilities. This study investigated gait alterations and interlimb asymmetry in a cohort of Parkinson's disease patients using 3D gait analysis. The results showed significant differences in gait patterns and interlimb coordination compared to unaffected individuals. These findings could be useful for early diagnosis and disease progression evaluation.
BIOENGINEERING-BASEL
(2022)
Article
Clinical Neurology
Martina Putzolu, Virginia Manzini, Matteo Gambaro, Carola Cosentino, Gaia Bonassi, Alessandro Botta, Elisa Ravizzotti, Laura Avanzino, Elisa Pelosin, Susanna Mezzarobba
Summary: This study tested the feasibility, usability, and training effects of a home-based exercise program using a customized version of Parkinson Rehab application. The results showed that the home-based training had positive effects on symptoms, mobility, and cognition in patients with mild to moderate stage of PD disease. The use of a mobile app might increase the amount of daily physical activity in the study population. Further studies are needed to confirm these findings in a large cohort of PD participants at different disease stages.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Thurmon Lockhart, Chris Frames, Markey Olson, Seong H. Moon, Dan Peterson, Abraham Lieberman
Summary: The aim of this study was to investigate the effects of PD on walking ability and the ability to respond to balance perturbations, as well as the short-term effects of a training session to improve compensatory reactions and walking stability. The results suggest that individuals with PD can benefit from perturbation training to reduce falls and improve balance control during rehabilitation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Elisa Pelosin, Chiara Ponte, Martina Putzolu, Giovanna Lagravinese, Jeffrey M. Hausdorff, Alice Nieuwboer, Pieter Ginis, Lynn Rochester, Lisa Alcock, Bastiaan R. Bloem, Freek Nieuwhof, Andrea Cereatti, Ugo Della Croce, Anat Mirelman, Laura Avanzino
Summary: The study showed that longer TT + VR training leads to greater improvements in cognitive functions, especially those directly addressed by the virtual environment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Eui Jin An, Woo-Sob Sim, Seung Min Kim, Jun Yup Kim
Summary: This study investigated the differences in characteristics of patients with idiopathic Parkinson's disease (IPD) who exhibit freezing of gait (FOG) and examined the effectiveness of visual cueing using laser shoes. The results showed that patients with lower self-reported FOG severity scores, higher dopamine active transporter availability in specific regions of the brain, and shorter duration of FOG episodes without cueing responded better to visual cueing. These findings have important implications for identifying patients who may benefit from visual cueing and the early diagnosis of FOG in IPD patients.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
