Article
Multidisciplinary Sciences
Wenhan Luo, Di Yun, Yi Hu, Miaomiao Tian, Jiajun Yang, Yifan Xu, Yong Tang, Yang Zhan, Hong Xie, Ji-Song Guan
Summary: Hippocampal-lesioned mice can form new memories. The lateral entorhinal cortex modulates learning-induced cortical long-range gamma synchrony in a hippocampal-dependent manner, and artificially induced cortical gamma synchrony across cortical areas improves memory encoding in hippocampal-lesioned mice. These findings reveal the hippocampal-mediated organization of cortical memories and suggest brain-machine interface approaches to improve cognitive function.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xiaoping Fang, Benjamin Alsbury-Nealy, Ying Wang, Paul W. Frankland, Sheena A. Josselyn, Margaret L. Schlichting, Katherine D. Duncan
Summary: Humans navigate through similar environments by integrating commonalities or differentiating differences. This study investigated whether the temporal delay between experiences influences how humans integrate spatial memories. Results showed that memory integration and differentiation were not modulated by temporal delay.
Article
Multidisciplinary Sciences
Jessica D. Creery, David J. Brang, Jason D. Arndt, Adrianna Bassard, Vernon L. Towle, James X. Tao, Shasha Wu, Sandra Rose, Peter C. Warnke, Naoum P. Issa, Ken A. Paller
Summary: This study investigates the impact of sleep on memory by measuring electrical activity in the hippocampus, and finds that the presentation of sounds during sleep enhances corresponding spatial memories, which is associated with increased specific brainwave activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Behavioral Sciences
Shukun Jiang, Chuanfei Zheng, Gehua Wen, Bin Bu, Shuang Zhao, Xiaoming Xu
Summary: This study examined the effects of enriched environment (EE) on the expression of NR2B receptors in mice with inflammatory pain. The results showed that EE significantly reduced mechanical hypersensitivity and anxiety-related behavior, and decreased the expression of NR2B receptors. Additionally, EE increased the levels of 2-arachidonoylglycero (2-AG, an endocannabinoid) in the mice. The analgesic and anti-anxiety effects of EE were mediated by the CB1 receptor, and could be replicated by elevating 2-AG levels with a selective inhibitor of MAGL.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Brett S. East, Lauren R. Brady, Jennifer J. Quinn
Summary: The entorhinal cortex, with connections to the hippocampus, amygdala, and neocortex, plays a critical role in fear memory expression. This study manipulated the function of its subregions LEC and MEC to explore their potential roles. The results suggest that LEC may play a role in maintaining post-tone freezing.
Article
Biochemistry & Molecular Biology
Mi Kyoung Seo, Ah Jeong Choi, Dae-Hyun Seog, Jung Goo Lee, Sung Woo Park
Summary: Research indicates that an enriched environment in early life may enhance the ability to cope with adult stress through epigenetic modification, preventing depression-like behavior induced by chronic stress and preserving expression and modification of the p11 gene. These findings demonstrate the positive effects of early-life environments on adult mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Behavioral Sciences
Sara Borgomaneri, Simone Battaglia, Giuseppe Sciamanna, Francesco Tortora, Daniela Laricchiuta
Summary: The acquisition and extinction of fear associative memory rely on coordinated neural activity within specific brain regions, particularly the amygdala and prefrontal cortex. By comparing brain networks involved in fear processing in humans and other species, we can gain insights into fear mechanisms and potential treatments for fear-related disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Immunology
Shehong Zhang, Yonggang Zhang, He Liu, Fengfeng Wu, Zhihong Wang, Liqin Li, Huilian Huang, Sheng Qiu, Yuntao Li
Summary: With the aging of populations, cognitive and motor dysfunction caused by chronic cerebral ischemia and ischemic stroke have become a global problem. Enriched environment (EE) has shown great influence on the brain, and this study investigates its potential effect on cognitive and motor function in mice with chronic cerebral ischemia and secondary stroke (IS). The results show that EE improves behavior performance, reduces neuronal loss and white matter damage, promotes the expression of BDNF and p-CREB, inhibits inflammation, and improves cognitive and motor deficits caused by IS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Frederic Crevecoeur, James Mathew, Philippe Lefevre
Summary: The ability of humans to adapt reaching movements to different force fields in parallel remains a subject of active debates. Independent movement representations or goals enable dual adaptation. Independent cues delivered by means of background loads can support simultaneous adaptation to various velocity-dependent force fields. When the cue and force field are in the same direction but differ in magnitude, there are different motor representations observed but subject to increased interference.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Bethany J. Jones, Margaret E. Chen, Lindsey Simoncini, Rebecca M. C. Spencer
Summary: Sleep has a positive effect on memory reconsolidation, enhancing the strengthening of episodic memories. The longer the sleep duration, the better the effect.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Anthony G. Mansour, Run Xiao, Stephen M. Bergin, Wei Huang, Logan A. Chrislip, Jianying Zhang, Seemaab Ali, Nicholas J. Queen, Michael A. Caligiuri, Lei Cao
Summary: The study demonstrates that an enriched environment (EE) can enhance NK cell maturation in mice, mediated by hypothalamic BDNF. This has important implications for cancer and obesity resistance.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Psychiatry
Mahmoud Harb, Justina Jagusch, Archana Durairaja, Thomas Endres, Volkmar Lessmann, Markus Fendt
Summary: BDNF is important for brain function, and low levels are associated with schizophrenia. A study on BDNF+/- mice showed deficits in attention, startle response, and sensorimotor gating, which were prevented by an enriched environment. These findings suggest a relationship between decreased BDNF levels and behavioral endophenotypes of schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Darryl C. Gidyk, Robert J. McDonald, Robert J. Sutherland
Summary: Results from experiments suggest that rats can maintain normal memory in adversarial learning and discrimination tasks even in the absence of the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychiatry
Yasmine Azza, Frank H. Wilhelm, Erich Seifritz, Klaus Junghanns, Birgit Kleim, Ines Wilhelm
Summary: Sleep supports adaptive reconsolidation of aversive autobiographical memories, as demonstrated by the reduction of distress and dysfunctional cognitions after imagery rescripting. Central sleep spindle density during the nap is correlated with the decrease in heart rate in response to the negative memory script.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Leonardo Lupori, Giulia Sagona, Claudia Fuchs, Raffaele Mazziotti, Antonia Stefanov, Elena Putignano, Debora Napoli, Enrica Strettoi, Elisabetta Ciani, Tommaso Pizzorusso
HUMAN MOLECULAR GENETICS
(2019)
Article
Neurosciences
Elie Baho, Bidisha Chattopadhyaya, Marisol Lavertu-Jolin, Raffaele Mazziotti, Patricia N. Awad, Pegah Chehrazi, Marianne Groleau, Celine Jahannault-Talignani, Elvire Vaucher, Fabrice Ango, Tommaso Pizzorusso, Laura Baroncelli, Graziella Di Cristo
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Laura Giusti, Angelo Molinaro, Maria Grazia Alessandri, Claudia Boldrini, Federica Ciregia, Serena Lacerenza, Maurizio Ronci, Andrea Urbani, Giovanni Cioni, Maria Rosa Mazzoni, Tommaso Pizzorusso, Antonio Lucacchini, Laura Baroncelli
Review
Neurosciences
Mariangela Gennaro, Alessandro Mattiello, Tommaso Pizzorusso
Article
Behavioral Sciences
Rodolfo Buselli, Antonello Veltri, Sigrid Baldanzi, Riccardo Marino, Alessandra Bonotti, Martina Chiumiento, Michelle Girardi, Luca Pellegrini, Giovanni Guglielmi, Liliana Dell'Osso, Alfonso Cristaudo
BRAIN AND BEHAVIOR
(2019)
Article
Biochemistry & Molecular Biology
Debora Napoli, Leonardo Lupori, Raffaele Mazziotti, Giulia Sagona, Sara Bagnoli, Muntaha Samad, Erika Kelmer Sacramento, Joanna Kirkpartick, Elena Putignano, Siwei Chen, Eva Terzibasi Tozzini, Paola Tognini, Pierre Baldi, Jessica C. F. Kwok, Alessandro Cellerino, Tommaso Pizzorusso
Article
Psychiatry
Rodolfo Buselli, Antonello Veltri, Martina Corsi, Riccardo Marino, Gabriele Necciari, Sigrid Baldanzi, Martina Chiumiento, Elena Del Lupo, Rudy Foddis, Fabrizio Caldi, Christian Lambiase, Andrea Pancetti, Santino Marchi, Giovanni Guglielmi, Massimo Bellini
Summary: Occupational stress is a significant factor in the development of diseases, including Irritable Bowel Syndrome (IBS). This study found a high prevalence of IBS among health workers, with IBS sufferers experiencing higher levels of psychiatric diagnoses and job strain, and lower work ability. The severity of IBS was positively correlated with occupational stress, and both were negatively associated with work ability.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sujeong Yang, Sylvain Gigout, Angelo Molinaro, Yuko Naito-Matsui, Sam Hilton, Simona Foscarin, Bart Nieuwenhuis, Chin Lik Tan, Joost Verhaagen, Tommaso Pizzorusso, Lisa M. Saksida, Timothy M. Bussey, Hiroshi Kitagawa, Jessica C. F. Kwok, James W. Fawcett
Summary: Perineuronal nets (PNNs), containing chondroitin sulphate proteoglycans on neuronal surfaces, play a role in neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) in PNNs leads to increased inhibition. Manipulating CS composition of PNNs can restore neuroplasticity and memory deficits in aged mice, with a focus on the importance of C6S in memory and neuroplasticity.
MOLECULAR PSYCHIATRY
(2021)
Review
Genetics & Heredity
Elsa Ghirardini, Francesco Calugi, Giulia Sagona, Federica Di Vetta, Martina Palma, Roberta Battini, Giovanni Cioni, Tommaso Pizzorusso, Laura Baroncelli
Summary: CTD is an X-linked metabolic disorder caused by mutations in the SLC6A8 gene, leading to intellectual disability, autistic behavior, and epilepsy. There is no effective treatment for CTD, making research on novel intervention strategies a major scientific challenge. Animal models are crucial for studying the disease mechanisms and developing therapeutics, with rodent models showing promise in recapitulating human CTD phenotypes.
Article
Public, Environmental & Occupational Health
Rodolfo Buselli, Antonello Veltri, Martina Corsi, Riccardo Marino, Gabriele Necciari, Sigrid Baldanzi, Martina Chiumiento, Elena Del Lupo, Rudy Foddis, Fabrizio Caldi, Michaela Kozakova, Giovanni Guglielmi, Carlo Palombo
Summary: This study investigated the effects of occupational stress on workers with adjustment disorders (AD), focusing on stress indices such as serum cortisol levels, heart rate variability (HRV), and affective temperaments. The findings showed that women had higher levels of occupational stress, higher HF-HRV, and lower LF-HRV compared to men. Serum cortisol levels were positively correlated with LF-HRV values and negatively correlated with HF-HRV values. The LF/HF ratio was inversely correlated with Harm Avoidance and directly correlated with Reward Dependence. In conclusion, high serum cortisol levels and reward dependence were associated with reduced mental health resilience in AD patients exposed to occupational stress.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Cell Biology
Leonardo Lupori, Sara Cornuti, Raffaele Mazziotti, Elisa Borghi, Emerenziana Ottaviano, Michele Dei Cas, Giulia Sagona, Tommaso Pizzorusso, Paola Tognini
Summary: Exposing animals to an enriched environment (EE) has significant effects on brain structure, function, and plasticity, which are believed to be mediated by signals from the gut microbiota. This study reveals differences in gut bacterial composition and higher levels of short-chain fatty acids (SCFA) in EE mice compared to standard rearing (ST) mice. Depletion of gut microbiota in EE mice reduces SCFA levels and prevents activation of brain plasticity. Treatment with SCFA in ST mice mimics the effects of EE on brain plasticity. Importantly, transferring the gut microbiota from EE mice to ST mice activates brain plasticity. Therefore, changes in gut microbiota due to environmental enrichment play a crucial role in regulating brain plasticity.
Article
Clinical Neurology
Rodolfo Buselli, Antonello Veltri, Martina Corsi, Riccardo Marino, Sigrid Baldanzi, Martina Chiumiento, Fabrizio Caldi, Rudy Foddis, Giovanni Guglielmi, Alfonso Cristaudo, Liliana Dell'Osso, Claudia Carmassi
Summary: This study aimed to investigate the distribution of temperaments and mood spectrum symptoms among workers exposed to occupational stress and suffering from different psychiatric disorders (AD, MDE). The results suggest that MDE patients had higher scores in psychopathological symptoms and mood spectrum compared to the AD group. The hyperthymic temperament was more frequent in the AD group and negatively correlated or unrelated to psychopathological symptoms severity and perceived stress levels.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Engineering, Biomedical
Daniela De Luca, Sara Moccia, Leonardo Lupori, Raffaele Mazziotti, Tommaso Pizzorusso, Silvestro Micera
Summary: This study aims to develop an algorithm that can automatically associate a cortical activation pattern with the visual stimulus that generated it. By conducting experiments on three mice using wide-field calcium imaging, a convolutional neural network (CNN) was trained to classify different visual stimuli. The results show that this method can be used to classify cortical responses to simple visual stimuli, offering a potential alternative to existing decoding methodologies.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Andrea Poli, Aurelia Viglione, Raffaele Mazziotti, Valentino Totaro, Silvia Morea, Riccardo Melani, Davide Silingardi, Elena Putignano, Nicoletta Berardi, Tommaso Pizzorusso
Summary: The ability to store, retrieve, and extinguish memories of adverse experiences is essential for animal survival. Recent studies suggest that the aggregation of CSPGs into PNNs regulates the boundaries of the critical period for fear extinction. The presence of PNNs in the adult brain may be responsible for the appearance of persistent fear memories.
MOLECULAR NEUROBIOLOGY
(2023)
Meeting Abstract
Clinical Neurology
F. Torri, E. Lai, S. Baldanzi, G. Ricci, G. Siciliano
EUROPEAN JOURNAL OF NEUROLOGY
(2019)