Article
Chemistry, Physical
Dillon R. McCarthy, Jacob M. Remington, Jonathon B. Ferrell, Severin T. Schneebeli, Jianing Li
Summary: DNA nanostructures are promising nanomedical tools due to their biocompatibility and adjustability. Recent research focuses on the interaction between DNA nanocages decorated with organic dendrimers and human serum albumin (HSA). The study reveals the fuzzy interactions between these structures and provides insights for the design of next-generation DNA nanomedicines.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Review
Chemistry, Multidisciplinary
Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed, Aleksandr Kakinen, Sijie Lin, Tian Xia, Yang Song, Thomas P. Davis, Iseult Lynch, Wolfgang J. Parak, David Tai Leong, Pu Chun Ke, Chunying Chen, Yuliang Zhao
Summary: Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology that focus on nano-bio interface, with shared goals and challenges. In recent years, the relationship between the two fields has become closer, and their joint development can bring greater benefits to human health and environmental safety.
Article
Chemistry, Multidisciplinary
Axel Gomes, Jose M. Carnerero, Aila Jimenez-Ruiz, Elia Grueso, Rosa M. Giraldez-Perez, Rafael Prado-Gotor
Summary: This study investigated the adsorption of lysozyme onto gold nanoparticles and obtained the free energy of binding of the system for the first time. The interactions between lysozyme and AuNPs induce aggregation of citrate-stabilized AuNPs at low concentrations. The study also found that 10 nm AuNPs were the most appropriate for this interaction.
Review
Chemistry, Multidisciplinary
Saima Hameed, Didar Baimanov, Xiumin Li, Ke Liu, Liming Wang
Summary: Studying nano-bio interactions is crucial for nanosafety evaluation and nanomedicine development. However, there is limited information available on nano-bio interfacial interactions and their underlying mechanisms. Advanced synchrotron radiation-based techniques can help us understand the detailed mechanism of nano-bio interactions and provide insight into the behavior and fate of nanomaterials in a biological system.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Review
Chemistry, Physical
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review provides a guideline for physicist/chemist/biologist/physician in the introduction of metallic nanocluster applications in biomedicine. It introduces the physicochemical properties of metallic nanoclusters and the potential biomedical opportunities, guiding researchers in developing new scaffolds for biomedical engineering.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2022)
Article
Engineering, Biomedical
Chenyang Yin, Yuqing Li, Ziyu Liao, Zekun Wang, Chunxue Dai, Weiyun Wang, Endong Yang, Feng Guo, India R. Wright, Lisandra L. Martin, Dongdong Sun
Summary: A functionalized, smart nanosonosensitizer, Bac@ARS, based on Au-RuO2 nanoparticles and selenium nanoparticles, was developed. Bac@ARS exhibited highly efficient ROS-producing activity and optimized sonosensitivity. It was able to remodel the tumor microenvironment and generate excess reactive oxygen species (ROS) for improved tumor treatment.
ACTA BIOMATERIALIA
(2023)
Review
Materials Science, Biomaterials
Boyang Hu, Ruijie Liu, Qingyue Liu, Zi'an Lin, Yiwei Shi, Jun Li, Lijun Wang, Longjie Li, Xianjin Xiao, Yuzhou Wu
Summary: This review summarizes the role of nanoparticle surface patterns in modulating biological effects. The article discusses the interactions between nanoparticle surface patterns and cell membranes, virus recognition, and protein adsorption. The reasonable design of surface microstructure can enhance the application of artificial nanoparticles in biomedicine and improve the design of nano-drug carriers.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Environmental Sciences
Nelofer Jan, Neelofar Majeed, Muneeb Ahmad, Waseem Ahmad Lone, Riffat John
Summary: Nanoparticles are highly diverse in quality and sources of emission. The lack of rules and regulations has led to severe impacts on the environment and human health, with only a few studies assessing their toxic effects. Further research is needed to determine the actual impacts of nanoparticles on the environment and human health.
Review
Chemistry, Multidisciplinary
Yuan Liu, Junqing Wang, Qingqing Xiong, Daniel Hornburg, Wei Tao, Omid C. Farokhzad
Summary: Understanding the interactions between nanomaterials and biological systems is crucial for improving the efficacy of nanomedicine and advancing disease diagnosis. The nanoparticle-protein corona has a decisive effect on the in vivo fate of nanomedicine and can be used to enrich low-abundance proteins for biomarker discovery.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Alexander Al-Zubeidi, Frederic Stein, Charlotte Flatebo, Christoph Rehbock, Seyyed Ali Hosseini Jebeli, Christy F. Landes, Stephan Barcikowski, Stephan Link
Summary: Gold-silver alloy nanoparticles are utilized for various applications, with gold acting as a stabilizer for silver to prevent corrosion and control the release of antimicrobial ions. The kinetics of silver ion leaching from these nanoparticles is characterized by two stages, with a reduction in leaching rate due to alloying with gold and a dependence on silver content. Individual nanoparticles show diverse silver ion leaching yields, with some nanoparticles completely releasing silver while others exhibit arrested leaching. Scalable production methods and kinetic studies provide insights for designing the durability and bioactivity of alloy nanoparticles.
Article
Materials Science, Multidisciplinary
Anran Zhang, Yangping Zhang, Zhangmeng Liu, Gangan Huang, Lihua Wu, Yunzhi Fu, Xiaomei Wang, Yukou Du
Summary: This article reviews the development of anisotropic gold nanostructures, the properties of gold, and its potential for solar energy applications. It provides a detailed introduction to the stability, optical properties, and hot carrier states of gold. The characteristics of anisotropic gold nanostructures in different morphologies are summarized, and the maximum efficiency of solar light utilization is analyzed.
APPLIED MATERIALS TODAY
(2022)
Review
Chemistry, Analytical
Chenghua Zong, Xiaoting Jin, Juewen Liu
Summary: This article critically reviews the recent advances in arsenic detection using biomolecules and nanomaterials, discussing interactions between arsenic and gold, thiol, and DNA aptamers. It suggests that bio/nano systems show promise for arsenic detection and future research directions may include fundamental studies, searching for more specific arsenic binding materials and aptamers, incorporation of sensors into portable devices, and more systematic testing of sensors in real samples.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Sheng-Hann Wang, Chia-Wen Kuo, Shu-Cheng Lo, Wing Kiu Yeung, Ting-Wei Chang, Pei-Kuen Wei
Summary: In this study, a spectral image contrast-based flow digital nanoplasmon-metry method was developed to amplify and quickly detect the peak shift signal of gold nanoparticles (AuNPs) by comparing the scattering image brightness in two neighboring wavelength bands near the local surface plasmon resonance (LSPR) peak. The method provides an ultrahigh signal-to-noise ratio and has a lower sample volume requirement compared to conventional LSPR immunoassays. It demonstrates high sensitivity, selectivity, and a broad dynamic detection range.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Erem Ujah, Meimei Lai, Gymama Slaughter
Summary: A highly sensitive refractive index sensor for glucose detection is developed using a tapered optical fiber coated with gold nanoparticles. The sensor shows improved performance compared to a larger-sized tapered optical fiber, with a sensitivity enhancement of nearly 4 times. The fabricated sensor demonstrates ultrasensitive glucose detection with good stability and fast response, showing potential for real-world applications such as disease diagnosis.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Heba F. F. Salem, Marwa Mohamed Abd El-Maboud, Amira S. A. Said, Mohamed Nabil Salem, Dina Sabry, Nadia Hussain, Omnia A. M. Abd El-Ghafar, Raghda R. S. Hussein
Summary: Nanomedicine is an important approach for targeting RA medication. The combination of methotrexate with gold nanoparticles can overcome the restrictions of methotrexate and improve its anti-arthritic effects.
Article
Multidisciplinary Sciences
Liezl Rae Balaoing, Allison Davis Post, Adam Yuh Lin, Hubert Tseng, Joel L. Moake, K. Jane Grande-Allen
Article
Nanoscience & Nanotechnology
Allen L. Chen, Meredith A. Jackson, Adam Y. Lin, Elizabeth R. Figueroa, Ying S. Hu, Emily R. Evans, Vishwaratn Asthana, Joseph K. Young, Rebekah A. Drezek
NANOSCALE RESEARCH LETTERS
(2016)
Article
Biotechnology & Applied Microbiology
Elizabeth R. Figueroa, J. Stephen Yan, Nicolette K. Chamberlain-Simon, Adam Y. Lin, Aaron E. Foster, Rebekah A. Drezek
JOURNAL OF NANOBIOTECHNOLOGY
(2016)
Article
Nanoscience & Nanotechnology
Allen L. Chen, Meredith A. Jackson, Adam Y. Lin, Elizabeth R. Figueroa, Ying S. Hu, Emily R. Evans, Vishwaratn Asthana, Joseph K. Young, Rebekah A. Drezek
NANOSCALE RESEARCH LETTERS
(2016)
Article
Multidisciplinary Sciences
Amirali Aghazadeh, Adam Y. Lin, Mona A. Sheikh, Allen L. Chen, Lisa M. Atkins, Coreen L. Johnson, Joseph F. Petrosino, Rebekah A. Drezek, Richard G. Baraniuk
Article
Chemistry, Multidisciplinary
Adam Y. Lin, Joseph K. Young, Ariel V. Nixon, Rebekah A. Drezek
Article
Chemistry, Multidisciplinary
Joao Paulo Mattos Almeida, Adam Yuh Lin, Robert James Langsner, Phillip Eckels, Aaron Edward Foster, Rebekah Anna Drezek
Article
Chemistry, Multidisciplinary
Adam Y. Lin, Joseph K. Young, Ariel V. Nixon, Rebekah A. Drezek
Article
Chemistry, Multidisciplinary
Joao Paulo Mattos Almeida, Adam Yuh Lin, Elizabeth Raquel Figueroa, Aaron Edward Foster, Rebekah Anna Drezek
Editorial Material
Oncology
Adam Yuh Lin, Sheetal Kircher
Article
Nanoscience & Nanotechnology
Adam Yuh Lin, Jonathan Scott Rink, Reem Karmali, Jiahui Xu, Masha Kocherginsky, Colby Shad Thaxton, Leo I. Gordon
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Hematology
Adam Yuh Lin, Bongseo Choi, Taehoon Sim, Eva Yang, Hyunjun Choi, Amir Behdad, Dong-Hyun Kim, Leo I. Gordon
Summary: This study investigates a novel mechanism of in situ vaccination in lymphoma. By combining cytosine guanine dinucleotide (CpG) deoxynucleotides with radiation therapy (RT) or photothermal therapy (PTT), an enhanced abscopal response and immune stimulation could be achieved. The results show that the combination of CpG deoxynucleotides with PTT significantly reduces tumor growth and increases CD8/CD4 and cytotoxic T-cell/regulatory T-cell ratios in the tumor microenvironment, as well as promoting effector memory T cells in lymph nodes and spleen.
Review
Immunology
Adam Yuh Lin, Joseph Michael Schnitter, Leo Gordon
Summary: Classical Hodgkin lymphoma differs biologically from other lymphomas, with cancer cells occupying only a small portion of the lymph node and evading the immune system through amplification of PD-L1 and PD-L2. Checkpoint inhibitors, such as pembrolizumab and nivolumab, have shown high response rates in clinical trials and are approved by the FDA as third-line therapy. There is a growing interest in combining checkpoint inhibitors with chemotherapy or targeted agents in earlier stages of treatment. This review highlights the clinical trials that led to the approval of checkpoint inhibitors for Hodgkin lymphoma.
IMMUNOTARGETS AND THERAPY
(2022)
Article
Hematology
Adam Yuh Lin, Shira Naomi Dinner
Article
Biochemistry & Molecular Biology
Jonathan S. Rink, Adam Yuh Lin, Kaylin M. McMahon, Andrea E. Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton, Leo Gordon
Summary: Recent research suggests that malignant cells dependent on cholesterol uptake from lipoproteins are susceptible to ferroptosis, a type of cell death triggered by accumulation of oxidized lipids in cell membranes. Treatment of these cells with HDL NPs activates a compensatory metabolic response, leading to increased de novo cholesterol synthesis and downregulation of GPX4 expression, resulting in ferroptosis-mediated cell death. In vivo studies in mouse lymphoma xenografts and patient samples further support the potential of targeting SCARB1 with HDL NPs for cholesterol uptake-addicted lymphoma cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)