Article
Polymer Science
Kadambari Bairagi, Jiang Tian Liu, Anna Thinphang-nga, Jung Kwon Oh
Summary: Stimuli-responsive degradable amphiphilic block copolymers (SRD-ABPs) have been extensively investigated for the construction of smart nanoassemblies with controlled release of encapsulated molecules. A new approach using conjugated benzoic imine chemistry was developed to achieve dual acidic pH/light responses with a single labile linkage. The synthesized SRD-ABP self-assembled into stable nanoassemblies which degraded upon dual responses to acidic pH and UV/visible light. This work demonstrates the versatility of the new approach for designing advanced nanoassemblies for intracellular drug delivery.
Article
Chemistry, Physical
Chaolei Hu, Yimeng Sun, Gil van Wissen, Yitong Peng, Andrij Pich
Summary: In this study, visible light- and temperature-responsive poly(N-vinylcaprolactam) microgels decorated by donor-acceptor Stenhouse adducts (DASAs) were synthesized for the first time using a robust and straightforward post-modification synthesis route. The microgels exhibited homogeneous distributions and temperature responsiveness in aqueous solutions. The photoswitching behaviors of the microgels in different solvents were systematically investigated, and their size in aqueous solutions could be modulated by visible light irradiation. Moreover, the microgels showed potential application in the photostimulated delivery of hydrophobic drugs.
CHEMISTRY OF MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Nurul Huda Kamsani, Muhammad Salahuddin Haris, Manisha Pandey, Muhammad Taher, Kamal Rullah
Summary: Electrospinning technique is a versatile method for producing continuous nanofibers, which has become cost-effective and drawn keen interests in the biomedical field. Smart electrospun pH-responsive nanofibers have various applications in emerging biomedical developments such as cancer drug targeting, wound healing, and vaginal drug delivery.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Materials Science, Multidisciplinary
Jun Xu, Tiantian Hao, Changlin Liu, Jingjing Bi, Jing Sun, Zheng Wen, Zhaosheng Hou, Jinjian Wei
Summary: A new type of pH-responsive block polyurethane (PMCU) was synthesized in this study, showing good tensile properties and pH responsiveness, making it a promising platform for targeted drug delivery in biomedical areas.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Polymer Science
Yuqing Qiu, Yuzhe Guo, Wang Yin, Anrong Mao, Yan Zhou, Meidong Lang
Summary: This study successfully synthesized a pH/GSH-stimulated responsive polycarbonate for smart drug delivery within the tumor microenvironment. The synthesized polymer exhibited extensive responsiveness to pH and GSH changes, effectively encapsulated the anticancer drug, and released the drug upon stimulation. The drug-loaded polymer demonstrated cytotoxicity towards cancer cells.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Review
Oncology
Shunli Chu, Xiaolu Shi, Ye Tian, Fengxiang Gao
Summary: The complexity of the tumor microenvironment can be overcome by using pH-responsive polymers for targeted drug delivery, improving treatment efficacy and reducing adverse reactions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Polymer Science
Zahn Stanvliet, Yiyi Deng, Dietmar Appelhans, Silvia Moreno, Susanne Boye, Jens Gaitzsch, Albena Lederer
Summary: This study investigates the temperature sensitivity of polymeric nanoparticles based on tertiary amine methacrylate block copolymers. The research shows that these nanoparticles can undergo a reversible morphological transformation in response to changes in pH and temperature. The findings also demonstrate the ability to lock their intermediate self-assembly structures through cross-linking and validate the morphology transition using analytical tools, which opens up new possibilities for responsive nanocarriers.
Review
Chemistry, Multidisciplinary
Xiao Dong, Rajeev K. Brahma, Chao Fang, Shao Q. Yao
Summary: This review summarizes the application of self-assembled prodrugs in cancer drug development. Self-assembled prodrugs can improve the physicochemical properties of drugs and achieve controlled release at tumor sites, thus showing potential for clinical applications.
Article
Biochemistry & Molecular Biology
Chloe Seyrig, Alexandre Poirier, Thomas Bizien, Niki Baccile
Summary: This study demonstrates the development of functional hydrogels with in situ responsivity of their elastic properties by external stimuli, using entirely sustainable materials. The elastic properties of the hydrogels can be modulated by selectively triggering the phase transition of the components.
Article
Pharmacology & Pharmacy
Robab Aslani, Hassan Namazi
Summary: In this study, Fe3O4 nanoparticles were encapsulated in hyperbranched poly L-lysine citramid (HBPLC) and modified with L-arginine and quantum dots (QDs) to obtain a new magnetic and luminescent nanocarrier for the targeted delivery of Doxorubicin (DOX). The prepared nanocarrier was characterized using various techniques and evaluated for its potential as a magnetic nanocarrier. The results showed that the nanocarrier exhibited pH-responsive behavior, good antioxidant properties, and excellent photoluminescence. Cell uptake studies revealed its high cell uptake in MCF-7 cells and its potential for bioimaging applications. In vitro studies also demonstrated the nanocarrier's non-toxicity, stability, and biodegradability, as well as its greater toxicity and cellular apoptosis against breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
S. Umesh, S. Sarkar, S. Bera, P. Moitra, S. Bhattacharya
Summary: A new hydrogel was developed by mixing 5'-guanosine monophosphate disodium salt and 1,4,5,8-naphthalene tetracarboxylic acid tetra potassium salt. The hydrogel showed excellent stability and pH-responsive properties. It was used for the encapsulation and delivery of an anticancer drug, and demonstrated high drug loading capacity and controlled release capabilities. In vivo studies showed significant regression of tumor volume after administration of the drug-loaded hydrogel.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Qiyi Feng, Junhuai Xu, Xinyi Liu, Haibo Wang, Junjie Xiong, Kai Xiao
Summary: Stimuli-responsive nanotherapeutics based on pH-responsive micelles showed great potential in precision oncology. The micelles efficiently encapsulated and released anti-cancer drugs, leading to cell death in cancer cells. They also prolonged blood circulation, reduced cardiac toxicity, and selectively delivered drugs to tumor tissues. Overall, these micelles significantly improved anti-tumor efficacy and reduced systemic toxicity, indicating their translational potential in precise drug delivery for cancer treatment.
Review
Biotechnology & Applied Microbiology
Udaykumar Vegad, Megha Patel, Dignesh Khunt, Ozbej Zupancic, Sanjay Chauhan, Amrit Paudel
Summary: In recent decades, there has been significant progress in the design and development of biomaterials based on non-cellulosic biological macromolecules. Stimuli-responsive hydrogels made from non-cellulosic biological macromolecules have gained attention due to their unique physicochemical properties, biological characteristics, and sustainability. pH-responsive hydrogels have the ability to release therapeutic substances in response to pH changes, leading to tailored drug administration, reduced side effects, and improved treatment efficacy. pH-sensitive biopolymers such as chitosan, alginate, hyaluronic acid, guar gum, and dextran have been widely used in various applications, including drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Zheng Wang, Xuewen Mu, Qian Yang, Jiajia Luo, Yanjun Zhao
Summary: This study utilizes hypoxia-responsive polymer micelles combined with an NQO1 inhibitor (dicoumarol) to enhance the sensitivity of ovarian cancer cells to the anticancer drug sorafenib under low oxygen conditions. Both drugs are encapsulated in nanoscale micelles and the degradation of HIF-1α is increased to improve apoptosis induced by the drug.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)