Article
Chemistry, Physical
Giovanni Loureiro Raspantini, Marcela Tavares Luiz, Juliana Palma Abriata, Josimar de Oliveira Eloy, Miguel Menezes Vaidergorn, Flavio da Silva Emery, Juliana Maldonado Marchetti
Summary: This study developed polymeric nanoparticles based on PCL-block-TPGS containing docetaxel for prostate cancer therapy. The nanoparticles showed suitable characteristics for the proposed objectives and demonstrated high efficacy in cell death and internalization in vitro and in vivo studies. The docetaxel-loaded PCL-block-TPGS polymeric nanoparticle system is a potential treatment for prostate cancer.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Ying-Ying Guan, Shao-Qi Zeng, Yin Qin, Yan Mu, Hong Liu
Summary: The development of a TPGS-decorated drug delivery system showed enhanced intracellular drug accumulation, induction of apoptosis in drug resistant tumor cells, and significant inhibitory effects on tumor development and metastasis.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Evelyn Osehontue Uroro, Richard Bright, Andrew Hayles, Krasimir Vasilev
Summary: This report describes the encapsulation of amphotericin B into lipase-sensitive polycaprolactone as a nanocomposite for targeted and controlled drug delivery, reducing cytotoxicity and enhancing antifungal activity against Candida albicans.
Article
Biochemistry & Molecular Biology
Radka Boyuklieva, Asya Hristozova, Bissera Pilicheva
Summary: The study aimed to prepare an optimal model of poly-e-caprolactone nanoparticles for nasal administration of idebenone. A solvent/evaporation technique was used for nanoparticle preparation, and different molecular weights of poly-e-caprolactone were utilized. The emulsifiers Polysorbate 20 and Poloxamer 407, both alone and in combination, were used to obtain a stable formulation. The nanoparticles were characterized and their size distribution depended on the type of emulsifier. The effect of molecular weight and type of emulsifier was established, and optimal models for nasal administration were selected.
Article
Chemistry, Inorganic & Nuclear
Ruth Stephanie, Bo Bae Kim, Ping Xu, Yoojin Choi, Chan Yeong Park, Tae Jung Park
Summary: The biosynthesis of FeSe nanoparticles in vitro demonstrated unique fluorescence properties, making them promising for imageable drug-delivery applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Sepideh Khoee, Samaneh Moayeri, Mohammad A. Charsooghi
Summary: This paper synthesized functionalized nanoparticles and investigated their diffusion coefficients and velocities in different solutions, as well as the effects of an external magnetic field and NaCl concentration on their movement direction.
Article
Pharmacology & Pharmacy
Supriti Ghosh, Pradyumna Jayaram, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy
Summary: Cervical cancer is a prevalent cancer among women worldwide, but it can be preventable. Nanotechnology has provided a solution for targeted drug delivery due to the limitations of conventional chemotherapeutics. This review summarizes various drug delivery approaches and nanocarriers, their advantages, limitations, and potential applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Mohamed Ahmed Mohamady Hussein, Ece Guler, Erkan Rayaman, Muhammet Emin Cam, Ali Sahin, Mariusz Grinholc, Demet Sezgin Mansuroglu, Yesim Muge Sahin, Oguzhan Gunduz, Mamoun Muhammed, Ibrahim M. El-Sherbiny, Mosaad Megahed
Summary: Dual-drug delivery systems were constructed using coaxial techniques, showing controlled drug release and improved performance of nanofibrous membranes, which have promising applications in tissue regeneration and wound healing.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Liang Qiao, Fuhua Deng, Xulin Hu, Tianfang Huang, Junlin An, Dong Pan, Junqiang Yan, Gaofeng Liang, Jian He
Summary: This study presents a microsphere delivery system with efficient drug loading and controlled release. The system achieves dual sustained release, maintaining blood drug concentration for a longer time and reducing drug side effects.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Inorganic & Nuclear
Hossein Danafar, Amir Hossein Taromchi, Akram Rakhshbahar, Ali Sharafi, Vesal Hasani, Saeedeh Tafvizi, Mina Rostami
Summary: Nanocarrier-based chemotherapy has been widely used in the treatment of cancer. This study synthesized a biodegradable mPEG-PCL copolymer for effective and targeted drug delivery of curcumin and methotrexate to breast cancer cells. The results show that the nanoparticles have good physicochemical properties, high drug loading, and degradation rate, and exhibit strong cytotoxicity against cancer cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Fazlollah Heshmatnezhad, Ali Reza Solaimany Nazar, Halimeh Aghaei, Jaleh Varshosaz
Summary: This study demonstrated a simple method for producing DOX-loaded PCL nanoparticles with uniform size distribution and high EE through a microfluidic device. The release analysis showed sustained release of the nanoparticles for 10 days at pH 7.4, indicating good sustained-release performance.
Article
Chemistry, Medicinal
Samson A. Adeyemi, Yahya E. Choonara
Summary: This study investigated the use of LyP-1 as a homing peptide for p32 receptor targeting in a nanosystem loaded with endostatin for intracellular delivery and mitochondrial targeting in squamous cell carcinoma. The LyP-1-modified nanosystem showed reduced cell proliferation, increased receptor-mediated cellular uptake and internalization, and targeted mitochondrial and nuclear proteins. Additionally, the nanosystem inhibited cell migration and reduced the expression of angiogenic markers. The LyP-1-functionalized nanosystem also led to a significant reduction in tumor mass.
Review
Pharmacology & Pharmacy
Anne V. Yagolovich, Marine E. Gasparian, Dmitry A. Dolgikh
Summary: The TRAIL apoptotic pathway is widely studied in targeted antitumor therapy. Researchers focus on the design of novel nanodelivery systems to enhance apoptotic signaling and achieve a synergistic effect by encapsulating multiple therapeutic molecules. This review summarizes recent innovative developments in the design of nanodelivery systems modified with TRAIL pathway-targeting ligands.
Article
Chemistry, Multidisciplinary
M. J. Hernandez-Esparza, Ilaria Fratoddi, Sara Cerra, K. Juarez-Moreno, R. Huirache-Acuna
Summary: This research presents an evaluation of a hybrid material based on gold nanoparticles stabilized with 3-mercapto-propanesulfonate and loaded with methotrexate drug. The study demonstrates the effectiveness of the nanosystem in treating cervical cancer and melanoma, as well as its toxicity towards tumor cells.
NANOSCALE ADVANCES
(2023)
Article
Pharmacology & Pharmacy
Bin Jiang, Zhangkai Yang, Hangyu Shi, Abduladheem Turki Jalil, Marwan Mahmood Saleh, Weiyang Mi
Summary: Localized drug delivery vehicles based on implantable electrospun nanofibrous scaffolds have attracted interest in cancer cell eradication and tissue regeneration. In this study, zeolite Y nanoparticles were used to load Curcumin as an anticancer agent. The synthesized Curc@nZY was then integrated into a hybrid of PCL-gelatin electrospun nanofibers. The results showed successful loading of Curc@nZY into the nanofibers and a steady drug release over a long period.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qianqian Li, Zhaoqing Shi, Fan Zhang, Weiwei Zeng, Dunwan Zhu, Lin Mei
Summary: The immune system plays a critical role in cancer initiation and progression. Recent advancements in nanomaterials have expanded their applications in cancer immunotherapies, including drug carriers, inducers of immunogenic cell death, and immunomodulators. Nanomaterials can act as an integrated platform targeting multiple steps of the cancer-immunity cycle simultaneously, enhancing the effectiveness of anticancer immune response.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Li Yang, Yao Yang, Hongzhong Chen, Lin Mei, Xiaowei Zeng
Summary: Parenteral sustained release drug formulations have been widely used in clinical practice as preferable platforms for long-term exposure therapy. However, the requirement for hypodermic injection hinders their further applications due to issues such as needle-phobia, needle-stick injuries, and inappropriate needle reuse. Microneedles offer an alternative system that is minimally invasive and allows for self-administration.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Ting Chen, Weiwei Zeng, Changjun Tie, Mian Yu, Huisong Hao, Yang Deng, Qianqian Li, Hairong Zheng, Meiying Wu, Lin Mei
Summary: "Translation: The article introduces a new nanoplatform for sonodynamic therapy that uses ultrasound to induce the production of reactive oxygen species. The nanoplatform, Au/BP@MS, shows an increase in the efficiency of reactive oxygen species generation in tumor tissues, leading to significant inhibition of tumor growth. Furthermore, the nanoplatform exhibits responsiveness and degradability in the tumor microenvironment, enhancing its potential for clinical theranostics."
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Zhaoqing Shi, Jing Tang, Chuchu Lin, Ting Chen, Fan Zhang, Yuxing Huang, Ping Luan, Zhuo Xin, Qianqian Li, Lin Mei
Summary: This study developed an iron-mineralized black phosphorene nanosheet as a promising strategy for selective inhibition of tumor cells. The nanosheet showed enhanced cytotoxicity and excellent anti-tumor effects in combination with photothermal therapy.
Article
Gastroenterology & Hepatology
Hong-Zhong Zhou, Fan Li, Sheng-Tao Cheng, Yong Xu, Hai-Jun Deng, Da-Yong Gu, Jin Wang, Wei-Xian Chen, Yu-Jiao Zhou, Min-Li Yang, Ji-Hua Ren, Lu Zheng, Ai-Long Huang, Juan Chen
Summary: This study found a higher frequency of alternative splicing events in HCC tissues with extrahepatic metastasis compared to metastasis-free tissues. DDX17 and PXN-AS1-IR3 act as important metastatic promoters by modulating MYC signaling, suggesting they may be potential prognostic markers for metastatic HCC.
Review
Chemistry, Multidisciplinary
Chao Pan, Zhuo Mao, Xue Yuan, Hanjie Zhang, Lin Mei, Xiaoyuan Ji
Summary: This review summarizes the recent progress and applications of heterojunction nanomedicine, discusses the catalytic mechanisms and properties in relation to biomedical applications, and presents some challenges and future directions in research.
Article
Engineering, Biomedical
Zimu Li, Zhidong Chen, Hongzhong Chen, Kebing Chen, Wei Tao, Xiao-kun Ouyang, Lin Mei, Xiaowei Zeng
Summary: Polyphenol-based hydrogels, as nature-derived bioactive materials, possess unique properties and have been widely used in biomedical fields. This review elaborates the evolution process of these hydrogels from crosslinking structures to biomedical applications and proposes efficient design considerations.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yan Zhang, Yuanchao Sun, Xia Dong, Qiang-Song Wang, Dunwan Zhu, Lin Mei, Husheng Yan, Feng Lv
Summary: In this study, a biomimetic platelet intelligent vehicle with navigation system was developed for controllable and visible drug delivery. The intelligent vehicle achieved efficient drug loading and controlled release by encapsulating photothermal-/pH-sensitive chemotherapeutic nanoparticles. It showed good tumor targeting and therapeutic efficacy in mouse models.
Article
Chemistry, Multidisciplinary
Meitong Ou, Chuchu Lin, Ying Wang, Yuting Lu, Wenyan Wang, Zimu Li, Weiwei Zeng, Xiaowei Zeng, Xiaoyuan Ji, Lin Mei
Summary: This study explores a new approach of utilizing active photosynthetic Chlorella functionalized with black phosphorus nanosheets for enhanced photodynamic therapy. The functionalized Chlorella improves tumor hypoxia and enhances immune cell activity and proliferation through photosynthesis. Additionally, the black phosphorus nanosheets improve the conversion efficiency of light and mediate chemodynamic therapy. The synergistic therapy shows high biocompatibility and potential biodegradability, suggesting promising clinical applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Chuchu Lin, Chenyi Huang, Zhaoqing Shi, Meitong Ou, Shengjie Sun, Mian Yu, Ting Chen, Yunfei Yi, Xiaoyuan Ji, Feng Lv, Meiying Wu, Lin Mei
Summary: Hydrogen sulfide (H2S) acts as a gasotransmitter molecule, activating intracellular signaling pathways and exerting concentration-dependent antitumor effects. By encapsulating calcium sulfide (CaS) and indocyanine green (ICG) into a biodegradable nanomodulator, researchers have achieved pH-responsive H2S release, enabling the suppression of catalase activity, abnormal Ca2?? retention, mitochondrial destruction, and oxidative stress amplification. This leads to blocked ATP synthesis and downregulated heat shock protein expression, effectively inhibiting tumor growth.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemical Research Methods
Yunfei Yi, Chan Feng, Mian Yu, Lin Mei, Meiying Wu, Wei Tao
Summary: Efficient gene delivery in an integrated drug delivery system is crucial for multimodal antitumor therapy. This study presents a protocol for constructing a peptide-based siRNA delivery system that achieves tumor vascular normalization and gene silencing in 4T1 cells. The system highlights four major steps and has the potential to silence gene expression and perform other treatments based on different peptide segments.
Review
Chemistry, Inorganic & Nuclear
Jun Li, Wang Liao, Dongqing Huang, Meitong Ou, Tongkai Chen, Xinlu Wang, Ruiyue Zhao, Lingyan Zhang, Lin Mei, Jun Liu, Ping Luan
Summary: Alzheimer's disease is a common central neurodegenerative disorder characterized by behavioral disturbance and progressive cognitive impairment. Accumulation of soluble oligomers and amyloid plaques outside nerve cells are crucial in its development. Advanced strategies for detecting and modulating amyloid beta (A beta) in diagnosis and treatment include the use of large-scale apparatus and novel devices, as well as therapeutic agents and nanomaterials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Jingzhe Wang, Tonggong Liu, Siyao Gu, Hui-hui Yang, Weidong Xie, Cheng Gao, Dayong Gu
Summary: This study introduces a novel cardiomyocyte sponge to trap and neutralize the virus causing viral myocarditis. The sponge effectively inhibits virus infection by maintaining cellular morphology. The most significant implication of this study is the development of a universal antivirus infection strategy for treating known and unknown virus outbreaks.
Article
Chemistry, Multidisciplinary
Guozheng Xing, Xuya Yu, Yan Zhang, Shupei Sheng, Limin Jin, Dunwan Zhu, Lin Mei, Xia Dong, Feng Lv
Summary: Pyroptosis-based immunotherapy using macrophage-based biohybrid microrobots shows promise in breast cancer treatment, as it can evade drug resistance, inhibit metastasis, and trigger an immune response. This novel strategy combines photothermal conversion, targeted drug delivery, and controlled drug release to achieve tumor-specific pyroptosis and enhance immunotherapy.
Article
Materials Science, Multidisciplinary
Hongzhong Chen, Tao Sun, Weiwei Zeng, Xiaowei Zeng, Lin Mei, Chen Jiang, Yanli Zhao
Summary: A hypoxia-activated prodrug has been developed in this study for combination therapy with photodynamic therapy (PDT), making the best use of the hypoxic tumor microenvironment. The combination of a hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer allows for effectively combined PDT and chemotherapy, providing a promising approach for cancer treatment.
ACS MATERIALS LETTERS
(2022)
