Article
Chemistry, Multidisciplinary
Mei-Hsiu Chen, Tse-Ying Liu, Yu-Chiao Chen, Ming-Hong Chen
Summary: The study synthesized a complex Au-OMV, combining with radiotherapy to successfully suppress glioblastoma growth and improve survival in mice. Mechanistic studies revealed that Au-OMV increased intracellular ROS levels in glioma cells and influenced macrophage chemotaxis and TNF-alpha production.
Review
Microbiology
Jianwei Chen, Hongfang Zhang, Siqi Wang, Yujie Du, Bin Wei, Qiang Wu, Hong Wang
Summary: Bacterial extracellular vesicles (EVs) play a significant role in bacterial infections by influencing the infection process through various mechanisms. With the increasing problem of antibiotic resistance, researching and developing novel therapeutic approaches is of high importance.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Engineering, Biomedical
Wenlong Huang, Lingxi Meng, Yuan Chen, Zaiquan Dong, Qiang Peng
Summary: Antibiotic therapy is important, but its improper use and emergence of drug resistance have reduced its effectiveness. Therefore, developing more potent antimicrobial therapies is crucial. Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria have been used as active agents, drug carriers, and vaccine adjuvants, showing great potential.
ACTA BIOMATERIALIA
(2022)
Review
Microbiology
Rokas Juodeikis, Simon R. Carding
Summary: This review focuses on nonlytic outer membrane vesicles (OMVs), a subtype of bacterial extracellular vesicles (BEVs) produced by Gram-negative organisms, emphasizing on the mechanisms of their biogenesis, cargo, and function. Throughout, the issues concerning the characterization of OMVs and distinguishing them from other types of BEVs are highlighted. The review also addresses the shortcomings of commonly used methodologies for BEVs study and proposes solutions to standardize protocols for OMV studies.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2022)
Article
Biology
Daniel A. Phillips, Lori A. Zacharoff, Cheri M. Hampton, Grace W. Chong, Anthony P. Malanoski, Lauren Ann Metskas, Shuai Xu, Lina J. Bird, Brian J. Eddie, Aleksandr E. Miklos, Grant J. Jensen, Lawrence F. Drummy, Mohamed Y. El-Naggar, Sarah M. Glaven
Summary: BAR domain proteins are a superfamily of coiled-coil proteins that influence membrane curvature in eukaryotes, and a bacterial protein BdpA with BAR domain-like activity has been discovered to impact the formation of membrane vesicles and outer membrane extensions. BdpA is essential for the uniform size distribution of membrane vesicles and the scaffolding of consistent diameter and curvature in OMEs, influencing the morphology of these structures. Overexpression of BdpA can promote the formation of OMEs in bacterial species where it is not typically observed, suggesting a new class of bacterial BAR domain-like proteins.
Article
Engineering, Environmental
Qingtong Zhang, Mingfu Li, Bin Luo, Yuying Luo, Hongrui Jiang, Changzhou Chen, Shuangfei Wang, Douyong Min
Summary: This work utilized gold nanoparticles decorated sugarcane membrane for efficient flow catalytical and antibacterial applications. The superior catalytic and antibacterial performance of the Au NPs/sugarcane membrane shows promising potential for designing flow catalytical membrane reactors to purify microbial contaminated water.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Multidisciplinary Sciences
Rasha A. Abo-Elmagd, Ragaa A. Hamouda, Mervat H. Hussein
Summary: This study investigated the phycotoxicity of OG-AgNPs on freshwater microalgae and revealed a significant inhibitory effect on cell growth and photosynthetic pigments. It also showed that OG-AgNPs have catalytic activity in reducing hydrogen peroxide, which could be useful in various domains such as medical and industrial processes.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Atanu Naskar, Hyejin Cho, Sohee Lee, Kwang-sun Kim
Summary: Biomimetic nanoparticles fabricated with natural cellular materials are utilized in biomedical applications, utilizing the original biological functions of the cellular materials. Bacterial outer membrane vesicles are considered important molecules for coating nanoparticles and have potential applications in immune response activation, cancer therapeutics, and bacterial infection treatment with photothermal activity.
Article
Engineering, Biomedical
Kanika Suri, Anisha D'Souza, Di Huang, Aashray Bhavsar, Mansoor Amiji
Summary: Cancer therapy is shifting towards immunotherapy that activates the host immune system. Bacterial extracellular vesicles (BEVs) are being studied as a potential tool for controlling immune responses and for drug delivery. However, there are still unanswered questions regarding the use of BEVs, especially for long-term immunotherapies.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Seyedeh Roya Alizadeh, Pourya Biparva, Hamid Reza Goli, Barkat Ali Khan, Mohammad Ali Ebrahimzadeh
Summary: Biogenic methods offer an effective and eco-friendly approach to synthesizing nanoparticles. In this study, gold nanoparticles (CC-AuNPs) were synthesized using Crocus caspius extract in a green manner. The synthesized CC-AuNPs were characterized using various techniques and showed promising applications as green catalysts, as well as antibacterial, anticancer, and antileishmanial activities.
Article
Environmental Sciences
Thangavel Akkini Devi, Rajendran Muthukumar Sivaraman, Seth Sheeba Thavamani, Thomas Peter Amaladhas, Mohamad S. AlSalhi, Sandhanasamy Devanesan, Maruthamuthu Murali Kannan
Summary: In this study, a green synthetic method using Sargassum ilicifolium to prepare extremely stable silver nanoparticles and gold nanoparticles was demonstrated. The synthesized nanoparticles were characterized and found to have stability, bactericidal activity, and photocatalytic behavior, showing potential applications in wastewater treatment and water purification.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Gunasekaran Suriyakala, Sivaji Sathiyaraj, Ranganathan Babujanarthanam, Khaloud Mohammed Alarjani, Dina S. Hussein, Rabab Ahmed Rasheed, K. Kanimozhi
Summary: This study synthesized gold nanoparticles and tested their antibacterial effectiveness against human pathogens. The results showed that the synthesized gold nanoparticles exhibited antibacterial activity against selected bacteria, indicating their potential as alternative antibacterial agents.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ahmed Al Saqr, El-Sayed Khafagy, Ahmed Alalaiwe, Mohammed E. Aldawsari, Saad M. Alshahrani, Md Khalid Anwer, Salman Khan, Amr S. Abu Lila, Hany H. Arab, Wael A. H. Hegazy
Summary: This study demonstrates the efficient synthesis of gold nanoparticles (GNPs) using peel extracts of Benincasa hispida, which exhibited significant antibacterial and anticancer activities. The biosynthesized GNPs showed spherical shape with an average particle size of 22.18 +/- 2 nm, and exerted cytotoxic effects on human cervical cancer cells while sparing normal cells. Such cytotoxicity was attributed to the increased production of reactive oxygen species (ROS). Overall, B. hispida peel extracts can be a natural source of antimicrobial and anticancer agents through the synthesis of GNPs.
Article
Biotechnology & Applied Microbiology
Nouran Rezk, Abdallah S. Abdelsattar, Salsabil Makky, Assmaa H. Hussein, Azza G. Kamel, Ayman El-Shibiny
Summary: This study biosynthesized Au-Ag nanoparticles using propolis and examined their antibacterial activity against antibiotic-resistant bacteria as well as their anticancer activity. The results showed that these nanoparticles exhibited antibacterial activity against various bacteria and had a cytotoxic effect on HEPG2 cells.
Article
Medicine, Research & Experimental
Tomohiro Umezu, Masakatsu Takanashi, Yoshiki Murakami, Shin-ichiro Ohno, Kohsuke Kanekura, Katsuko Sudo, Kenichi Nagamine, Shin Takeuchi, Takahiro Ochiya, Masahiko Kuroda
Summary: Extracellular vesicles derived from mammalian cells have potential as carriers for drug delivery systems, but there are still challenges to be overcome for clinical applications. In this study, acerola exosome-like nanoparticles were explored for orally administered nucleic acid drug delivery, showing successful encapsulation of miRNA and downregulation of target genes. Oral delivery of AELNs was effective in transferring small RNA to the digestive system, with peak gene-suppressing effects observed in the small intestine and liver 1 day post-administration.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
