Homing endonucleases from mobile group I introns: discovery to genome engineering

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Gene Correction of a Duchenne Muscular Dystrophy Mutation by Meganuclease-Enhanced Exon Knock-In

(2013) Linda Popplewell et al.   HUMAN GENE THERAPY

Targeted molecular trait stacking in cotton through targeted double-strand break induction

(2013) Kathleen D'Halluin et al.   PLANT BIOTECHNOLOGY JOURNAL

Male-sterile maize plants produced by targeted mutagenesis of the cytochrome P450-like gene (MS26) using a re-designed I-CreI homing endonuclease

(2013) Vesna Djukanovic et al.   PLANT JOURNAL

High Frequency Targeted Mutagenesis Using Engineered Endonucleases and DNA-End Processing Enzymes

(2013) Fabien Delacôte et al.   PLoS One

The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive

(2013) Yuk-Sang Chan et al.   PLoS One

Targeted Gene Therapy of Xeroderma Pigmentosum Cells Using Meganuclease and TALEN™

(2013) Aurélie Dupuy et al.   PLoS One

TALE-PvuII Fusion Proteins – Novel Tools for Gene Targeting

(2013) Mert Yanik et al.   PLoS One

The CRISPR Craze

(2013) E. Pennisi   SCIENCE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease

(2012) Mauricio S Antunes et al.   BMC BIOTECHNOLOGY

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases

(2012) Séverine Ménoret et al.   FASEB JOURNAL

Coupling endonucleases with DNA end–processing enzymes to drive gene disruption

(2012) Michael T Certo et al.   NATURE METHODS

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

(2012) Sarah Baxter et al.   NUCLEIC ACIDS RESEARCH

Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases

(2012) Fayza Daboussi et al.   NUCLEIC ACIDS RESEARCH

Monomeric site-specific nucleases for genome editing

(2012) B. P. Kleinstiver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells

(2011) Stéphanie Grosse et al.   MOLECULAR THERAPY

Tracking genome engineering outcome at individual DNA breakpoints

(2011) Michael T Certo et al.   NATURE METHODS

A novel zinc-finger nuclease platform with a sequence-specific cleavage module

(2011) Benno Schierling et al.   NUCLEIC ACIDS RESEARCH

Native homing endonucleases can target conserved genes in humans and in animal models

(2011) Adi Barzel et al.   NUCLEIC ACIDS RESEARCH

Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

(2011) Barry L. Stoddard   STRUCTURE

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Frequent Endonuclease Cleavage at Off-target Locations In Vivo

(2010) Lisa M Petek et al.   MOLECULAR THERAPY

Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus

(2010) Inés G. Muñoz et al.   NUCLEIC ACIDS RESEARCH

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

(2010) Justin Ashworth et al.   NUCLEIC ACIDS RESEARCH

Mobile DNA elements in T4 and related phages

(2010) David R Edgell et al.   Virology Journal

Exploitation of binding energy for catalysis and design

(2009) Summer B. Thyme et al.   NATURE

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

(2009) Hui Li et al.   NUCLEIC ACIDS RESEARCH

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

(2009) Jordan Jarjour et al.   NUCLEIC ACIDS RESEARCH

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

Heritable targeted mutagenesis in maize using a designed endonuclease

(2009) Huirong Gao et al.   PLANT JOURNAL

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

(2009) A. McConnell Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

(2008) Pilar Redondo et al.   NATURE

Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His–Cys box homing endonucleases

(2008) Norimichi Nomura et al.   NUCLEIC ACIDS RESEARCH