Review
Immunology
Fabrice Cognasse, Anne Claire Duchez, Estelle Audoux, Theo Ebermeyer, Charles Antoine Arthaud, Amelie Prier, Marie Ange Eyraud, Patrick Mismetti, Olivier Garraud, Laurent Bertoletti, Hind Hamzeh-Cognasse
Summary: Platelets are anucleate cytoplasmic fragments derived from medullary megakaryocytes. They form platelet plugs by adhering to damaged endothelium and secrete growth factors that contribute to platelet aggregation and vascular repair. Platelets also play a major role in inflammation and immune defense through receptors and lectins. Additionally, platelet activation leads to the release of inflammatory mediators and direct activation of immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Annette Ives, Didier Le Roy, Charlotte Theroude, Juergen Bernhagen, Thierry Roger, Thierry Calandra
Summary: The cytokine MIF plays a chemokine-like role in promoting the migration of dendritic cells (DCs) by activating the Src/PI3K signaling pathway and myosin II complexes. MIF contributes to the recruitment of DCs to draining lymph nodes through autocrine and paracrine activities acting via CD74. These findings indicate that MIF is crucial for DC motility and trafficking.
Article
Medicine, Research & Experimental
Gabsik Yang, Hye Eun Lee, Magdalena Trzeciak, Tadeusz Pawelczyk, Osamu Takeuchi, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: Regnase-1 downregulation is observed in both atopic dermatitis patients and mice. Regnase-1 deficiency leads to global changes in gene expression related to innate immune and inflammatory responses, particularly chemokines. The levels of Regnase-1 in the skin are inversely related to chemokine expression in both atopic dermatitis patients and Regnase-1-deficient mice, indicating that enhanced chemokine production contributes to increased inflammation at lesion sites. Subcutaneous administration of recombinant Regnase-1 significantly improves atopic dermatitis-like skin inflammation with reduced chemokine production in a mouse model. These findings suggest that Regnase-1 plays a crucial role in maintaining skin immune homeostasis and regulating chemokine expression, making it a potential therapeutic target for chronic inflammatory diseases like atopic dermatitis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Saswati Banerjee, Winston E. Thompson, Indrajit Chowdhury
Summary: Toll-like receptors (TLRs) are molecules that recognize molecular patterns and regulate the immune system, sustained immune activation can disrupt immune homeostasis leading to inflammatory diseases. MicroRNAs (miRNAs) can affect the immune regulatory network by regulating the expression of TLRs and TLR signaling components.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Immunology
Mohamed L. Sobah, Aimee C. Scott, Miranda Laird, Cassandra Koole, Clifford Liongue, Alister C. Ward
Summary: By investigating the zebrafish socs3b gene, it was found that socs3b gene plays a critical role in regulating neutrophil production and macrophage activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Fisheries
Tan Phat Nguyen, Bao Trung Nguyen, Fan-Hua Nan, Meng-Chou Lee, Po-Tsang Lee
Summary: Nile tilapia (Oreochromis niloticus) is an important food fish species mainly cultivated in tropical and subtropical countries. This study focuses on Toll-like receptors (TLRs) and the clonation of OnTLR23 in fish cells. The study also explores the interaction of OnTLR23 with other molecules and its potential role in immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Spela Knez, Mojca Narat, Jernej Ogorevc
Summary: Toll-like receptor 10 (TLR10) is a member of TLR family with unclear function and ligand. Its role as an immunomodulator appears to be cell type, pathogen, and TLR10 expression level-dependent. In this study, we overexpressed TLR10 in A549 lung epithelial cells and observed differential expression of TLR signaling genes activated by various TLR ligands. The overexpression of TLR10 suppressed proinflammatory cytokine expression and increased anti-inflammatory cytokine and antimicrobial peptide expression, suggesting its potential as an anti-inflammatory molecule in A549 cells.
Review
Pharmacology & Pharmacy
Elias Rawish, Manuela Sauter, Reinhard Sauter, Henry Nording, Harald F. Langer
Summary: This review explores the mutual relationship between immune activation and thrombus formation mechanisms, particularly focusing on how the complement system can modulate platelet activation. While some components of the complement system have been associated with platelets and shown to be functionally active in the micromilieu of platelet activation, the exact regulatory mechanisms and the consequences on tissue inflammation, damage, or recovery are still to be fully understood.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Virology
Hind Hamzeh-Cognasse, Alexandre Mansour, Florian Reizine, Patrick Mismetti, Isabelle Gouin-Thibault, Fabrice Cognasse
Summary: The study identified that plasma levels of platelet soluble (s)CD40L are elevated in the early stages of COVID-19, then decrease over time while sCD62P levels increase significantly. These platelet markers could serve as monitoring biomarkers of patient inflammatory state during the disease course.
Article
Biochemistry & Molecular Biology
Nuri Choi, Gabsik Yang, Joo Hyeon Jang, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: The study found that loganin can prevent gout inflammation by inhibiting the NLRP3 inflammasome and reducing neutrophil recruitment. Additionally, loganin blocks mitochondrial DNA synthesis and inhibits mitochondrial damage, thus preventing the occurrence of gout inflammation.
Review
Immunology
Ewa Oleszycka, Kamila Kwiecien, Patrycja Kwiecinska, Agnieszka Morytko, Natalia Pocalun, Michelle Camacho, Piotr Brzoza, Brian A. A. Zabel, Joanna Cichy
Summary: The skin, as the largest organ exposed to the environment, plays a critical role in integrating signals and defending against external threats. The interactions between the epidermis, immune system, and nervous system are now recognized for their importance in regulating and maintaining the skin barrier function in relation to skin pathophysiology. Dysregulation of these connections can lead to chronic inflammatory diseases and conditions associated with chronic pain or itch.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Daniel Prantner, Shreeram Nallar, Katharina Richard, David Spiegel, Kim D. Collins, Stefanie N. Vogel
Summary: MG, a highly reactive compound, may be produced by M1 macrophages during sepsis, contributing to over-exuberant inflammation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
John T. Schroeder, Anja P. Bieneman
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic with significant health and socioeconomic consequences. Infection with SARS-CoV-2 can lead to lung injury and acute respiratory distress syndrome (ARDS), possibly due to a dysregulated innate immune response or cytokine release syndrome (CRS). The spike protein of SARS-CoV-2 plays a crucial role in the infection process, and recent research has shown that the S1 subunit can activate monocytes to produce cytokines associated with CRS in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lige Wu, Weiqing Zhao, Shuxian Tang, Rui Chen, Mei Ji, Xin Yang
Summary: This review examines the role of ILC2s in solid tumors and highlights their crucial regulatory role in tumor immunity. ILC2s may serve as an important predictor for tumor prognosis and a new therapeutic target after immunotherapy resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Daniela E. Kirwan, Deborah L. W. Chong, Jon S. Friedland
Summary: In 2019, 10 million people developed symptomatic tuberculosis (TB) disease, resulting in 1.2 million deaths. The tissue destruction in TB is mainly mediated by enzymes, particularly matrix metalloproteinases (MMPs) secreted by leukocytes and stromal cells. Platelets are implicated in TB immunopathology, with high platelet counts in TB patients correlating with disease severity and a hypercoagulable profile. Platelets likely drive TB immunopathology by influencing other immune cells, such as monocytes, leading to increased activation markers, MMP secretion, and enhanced phagocytosis. Targeted anti-platelet agents are being considered for the treatment of TB as part of host-directed therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Fabrice Cognasse, Sofiane Tariket, Hind Hamzeh-Cognasse, Charles-Antoine Arthaud, Marie-Ange Eyraud, Thomas Bourlet, Philippe Berthelot, Sandrine Laradi, Sebastien Fauteux-Daniel, Olivier Garraud
Article
Dentistry, Oral Surgery & Medicine
Youssouf Sereme, Tabata Larissa S. Polvora, Nicolas Rochereau, Lucas Ribeiro Teixeira, Rodrigo Carvalho Santana, Stephane Paul, Benedito Antonio Lopes da Fonseca, Thomas Bourlet, Bruno Pozzetto, Alan Grupioni Lourenco, Ana Carolina F. Motta
Summary: This study found the presence of HIV-1 p24 antigen in the gingival tissue of HIV-1 and CP patients undergoing cART treatment, suggesting the existence of a reservoir for the virus in gingival tissue.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Virology
Hind Hamzeh-Cognasse, Alexandre Mansour, Florian Reizine, Patrick Mismetti, Isabelle Gouin-Thibault, Fabrice Cognasse
Summary: The study identified that plasma levels of platelet soluble (s)CD40L are elevated in the early stages of COVID-19, then decrease over time while sCD62P levels increase significantly. These platelet markers could serve as monitoring biomarkers of patient inflammatory state during the disease course.
Article
Environmental Sciences
Elise Verot, Paul Bonjean, Robin Chaux, Julie Gagnaire, Amandine Gagneux-Brunon, Bruno Pozzetto, Philippe Berthelot, Elisabeth Botelho-Nevers, Franck Chauvin
Summary: This study developed and validated a COVID-19 knowledge and behavior questionnaire for teenagers and adults in France. The questionnaire showed good psychometric properties and can be used by public health teams or caregivers for public health and research purposes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Microbiology
Abdelaye Keita, Josselin Rigaill, Sylvie Pillet, Youssouf Sereme, Souleymane Coulibaly, Fode Diallo, Paul Verhoeven, Bruno Pozzetto, Tenin Aoua Thiero, Thomas Bourlet
Summary: This study aimed to evaluate the efficacy of 1 year duration ART at blood and genital levels in females newly diagnosed with HIV-1 in Bamako, Mali. The results showed a significant reduction in HIV-1 RNA load in blood and cervicovaginal fluids after 12 months, with vaginal dysbiosis associated with HIV RNA shedding.
Article
Hematology
Yasmin E. S. de Wit, Hind Hamzeh-Cognasse, Fabrice Cognasse, Anja ten Brinke, Sacha S. Zeerleder
Summary: This study found that there is an association between HMGB1 and complement activation and the incidence of adverse reactions (AR) in patients receiving platelet transfusions. Additionally, the study demonstrated a correlation between HMGB1 and complement activation with platelet activation.
Article
Hematology
Fabrice Cognasse, Hind Hamzeh Cognasse, Marie Ange Eyraud, Amelie Prier, Charles Antoine Arthaud, Pierre Tiberghien, Stephane Begue, Dirk de Korte, Eric Gouwerok, Andreas Greinacher, Konstanze Aurich, Femke Noorman, Larry Dumont, Kathleen Kelly, Marc Cloutier, Renee Bazin, Rebecca Cardigan, Sian Huish, Peter Smethurst, Dana Devine, Peter Schubert, Lacey Johnson, Denese C. Marks
Summary: This international study investigates the effects of platelet collection and processing methods on the levels of HMGB1, sCD40L, and sCD62P proteins in platelet concentrate supernatants. The study found that the processing method and storage conditions have a greater impact on these parameters than storage duration.
Article
Virology
Alexandre Jentzer, Sebastien Fauteux-Daniel, Paul Verhoeven, Aymeric Cantais, Melyssa Yaugel Novoa, Fabienne Jospin, Blandine Chanut, Nicolas Rochereau, Thomas Bourlet, Xavier Roblin, Bruno Pozzetto, Sylvie Pillet
Summary: This study investigated the impact of chemically induced enteritis on cytomegalovirus reactivation using a mouse model. The results showed that chemically induced enteritis had no effect on the reactivation of cytomegalovirus in intestinal tissues.
Article
Virology
Sylvie Pillet, Julien Courtieux, Sylvie Gonzalo, Issam Bechri, Thomas Bourlet, Martine Valette, Antonin Bal, Bruno Pozzetto
Summary: This study evaluated the ability of four commercially available RLFTs in the French market to recognize different strains of SARS-CoV-2. Although all tests were able to recognize all tested variants, significant differences in sensitivity were observed among the four RLFTs.
Article
Cell Biology
Veronique Barateau, Loic Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, Mad-Helenie Elsensohn, Omran Allatif, Nicolas Guibert, Christelle Compagnon, Natacha Mariano, Julie Chaix, Sophia Djebali, Jean-Baptiste Fassier, Bruno Lina, Katia Lefsihane, Maxime Espi, Olivier Thaunat, Jacqueline Marvel, Manuel Rosa-Calatrava, Andres Pizzorno, Delphine Maucort-Boulch, Laetitia Henaff, Mitra Saadatian-Elahi, Philippe Vanhems, Stephane Paul, Thierry Walzer, Sophie Trouillet-Assant, Thierry Defrance
Summary: The history of infection and vaccination modality impact the immune memory of individuals vaccinated against SARS-CoV-2. A long-term follow-up study was conducted on unvaccinated and vaccinated COVID-19 convalescent individuals, as well as infection-naive vaccinated individuals, to understand how these factors affect immune memory. The study found that convalescent vaccinated individuals had the highest concentrations of spike protein-specific antibodies and increased frequencies of a specific memory B cell subset, suggesting enhanced protection at mucosal sites.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Carla Saade, Bruno Pozzetto, Melyssa Yaugel-Novoa, Guy Oriol, Laurence Josset, Bruno Lina, Stephane Paul, Antonin Bal, Sophie Trouillet-Assant
Summary: This study examines the humoral immune response in vaccinated patients who are simultaneously infected with Delta and Omicron BA.1 variants of SARS-CoV-2. The findings indicate that exposure to both Delta and BA.1 S proteins does not provide an additional immune advantage compared to exposure to BA.1 S protein alone.
Article
Biochemistry & Molecular Biology
Martin Fayolle, Amelie Epercieux, Cyrille H. Haddar, Sylvie Pillet, Philippe Berthelot, Bruno Pozzetto, Anne Carricajo, Florence Grattard, Paul O. Verhoeven
Summary: This study assessed the performance of the BD MAX StaphSR assay with liquid Amies elution swabs in routine care of intensive care unit patients. The results showed that the BD MAX StaphSR assay is reliable for S. aureus and MRSA detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Marc Cloutier, Fabrice Cognasse, Ana Paula Hitomi Yokoyama, Kelsey Hazegh, Olga Mykhailova, Mackenzie Brandon-Coatham, Hind Hamzeh-Cognasse, Jose Mauro Kutner, Jason P. Acker, Tamir Kanias
Summary: This study analyzed blood donors at the extremes of the age spectrum and found that teenage donors have higher red blood cell concentration, while older donors are more susceptible to oxidative hemolysis. These findings suggest that age-specific changes in red blood cell antioxidant capacity and physical characteristics may impact the storage and transfusion effectiveness of red blood cells.
Review
Neurosciences
Ming-Li Chou, Abdulkareem Olarewaju Babamale, Tara L. Walker, Fabrice Cognasse, David Blum, Thierry Burnouf
Summary: This review summarizes the roles of platelet-neutrophil interactions in neuroinflammatory diseases, emphasizing their importance and impact on pathological events in the brain. The study also highlights the activation of inflammasomes by damage-associated molecular patterns derived from platelets and neutrophils, and suggests the potential of interventions targeting platelets and neutrophils for treating neuroinflammatory diseases.
TRENDS IN NEUROSCIENCES
(2023)
Review
Virology
Bruno Pozzetto, Gilda Grard, Guillaume Durand, Marie-Claire Paty, Pierre Gallian, Sophie Lucas-Samuel, Stephanie Dieterle, Muriel Fromage, Marc Durand, Didier Lepelletier, Christian Chidiac, Bruno Hoen, Xavier Nicolas de Lamballerie
Summary: Diseases caused by arboviruses are increasing worldwide. Apart from arthropod bites, most arboviruses can be transmitted through other routes. Mainland France and its overseas territories face a complex environment with imported and endemic arboviral diseases, with risks varying by location. This review examines the risks of acquiring arboviral diseases from human products in the French context, focusing on solid organs and hematopoietic stem cells, and outlines the guidelines issued by the French High Council of Public Health.