Ontogeny and Polarization of Macrophages in Inflammation: Blood Monocytes Versus Tissue Macrophages

Microglia: unique and common features with other tissue macrophages

(2014) Marco Prinz et al.   ACTA NEUROPATHOLOGICA

M2 Kupffer Cells Promote Hepatocyte Senescence

(2014) Jinghong Wan et al.   AMERICAN JOURNAL OF PATHOLOGY

Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia

(2014) Chittappen K. Prajeeth et al.   BRAIN BEHAVIOR AND IMMUNITY

Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms

(2014) F. Rohan Walker et al.   BRAIN BEHAVIOR AND IMMUNITY

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

(2014) Malay Haldar et al.   CELL

Exploring the activated adipogenic niche: Interactions of macrophages and adipocyte progenitors

(2014) Yun-Hee Lee et al.   CELL CYCLE

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

The multifaceted activity of VEGF in angiogenesis – Implications for therapy responses

(2014) Stijn Moens et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation

(2014) T. J. van Ham et al.   Disease Models & Mechanisms

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

(2014) I. D. Vainchtein et al.   GLIA

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Cardiac Macrophages: How to Mend a Broken Heart

(2014) Heather B. Cohen et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease

(2014) Gregory R Steinberg et al.   IMMUNOLOGY AND CELL BIOLOGY

Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis

(2014) Zhilong Jiang et al.   IMMUNOLOGY LETTERS

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

(2014) Charles D. Mills et al.   Journal of Innate Immunity

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation

(2014) Alexander R. Pinto et al.   Stem Cell Research

Langerhans Cell Homeostasis and Turnover After Nonmyeloablative and Myeloablative Allogeneic Hematopoietic Cell Transplantation

(2014) Marco Mielcarek et al.   TRANSPLANTATION

Macrophage: SHIP of Immunity

(2014) Charles D. Mills et al.   Frontiers in Immunology

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

(2014) Kai Sun et al.   Molecular Metabolism

Innate Immune System Cells in Atherosclerosis

(2013) Luis Chávez-Sánchez et al.   ARCHIVES OF MEDICAL RESEARCH

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury

(2013) Qiang You et al.   BIOCHEMICAL PHARMACOLOGY

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system

(2013) Laura B. Buckman et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut microbiota and non-alcoholic fatty liver disease: new insights

(2013) J. Aron-Wisnewsky et al.   CLINICAL MICROBIOLOGY AND INFECTION

Microglial Senescence

(2013) Wolfgang Streit et al.   CNS & Neurological Disorders-Drug Targets

Macrophages control innate inflammation

(2013) S. Akira et al.   DIABETES OBESITY & METABOLISM

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Macrophage plasticity and polarization in liver homeostasis and pathology

(2013) Antonio Sica et al.   HEPATOLOGY

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial Phenotype and Adaptation

(2013) B. J. L. Eggen et al.   Journal of Neuroimmune Pharmacology

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

(2013) Jessica M. Crain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

(2013) Takashi Satoh et al.   NATURE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

(2013) Noelia A-Gonzalez et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Microglia, seen from the CX3CR1 angle

(2013) Yochai Wolf et al.   Frontiers in Cellular Neuroscience

Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation

(2013) Sara Manteiga et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism

(2013) Elodie Luche et al.   Molecular Metabolism

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

(2012) I. Elias et al.   DIABETES

High-fat-diet exposure induces IgG accumulation in hypothalamic microglia

(2012) C.-X. Yi et al.   Disease Models & Mechanisms

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx

(2012) Bettina Linnartz et al.   GLIA

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

(2012) M. Shibuya   JOURNAL OF BIOCHEMISTRY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity, inflammation and the immune system

(2012) Fátima Pérez de Heredia et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

(2012) Giovanni Musso et al.   PROGRESS IN LIPID RESEARCH

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Characterization of Human Adipose Tissue-Resident Hematopoietic Cell Populations Reveals a Novel Macrophage Subpopulation with CD34 Expression and Mesenchymal Multipotency

(2012) Hitomi Eto et al.   STEM CELLS AND DEVELOPMENT

Adipose tissue-resident immune cells: key players in immunometabolism

(2012) Henk S. Schipper et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Non-Identical Twins – Microglia and Monocyte-Derived Macrophages in Acute Injury and Autoimmune Inflammation

(2012) Steffen Jung et al.   Frontiers in Immunology

Wound Macrophages as Key Regulators of Repair

(2011) Samielle K. Brancato et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia

(2011) Kate L. Lambertsen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages

(2011) D. J. Donnelly et al.   JOURNAL OF NEUROSCIENCE

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Novel Pathway of Adipogenesis through Cross-Talk between Adipose Tissue Macrophages, Adipose Stem Cells and Adipocytes: Evidence of Cell Plasticity

(2011) Gregorio Chazenbalk et al.   PLoS One

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR γ axis

(2010) Amir J. Guri et al.   CLINICAL NUTRITION

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

(2010) João-Bruno Soares et al.   Hepatology International

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

In obesity and weight loss, all roads lead to the mighty macrophage

(2010) Alex Red Eagle et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene Expression Profiling and Network Analysis Reveals Lipid and Steroid Metabolism to Be the Most Favored by TNFα in HepG2 Cells

(2010) Amit K. Pandey et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

(2010) Sandrine Poglio et al.   STEM CELLS

Adipose tissue is an extramedullary reservoir for functional hematopoietic stem and progenitor cells

(2009) J. Han et al.   BLOOD

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

PPAR γ is highly expressed in F4/80hi adipose tissue macrophages and dampens adipose-tissue inflammation

(2009) Josep Bassaganya-Riera et al.   CELLULAR IMMUNOLOGY

Hematopoietic stem cell origin of adipocytes

(2009) Yasuhiko Sera et al.   EXPERIMENTAL HEMATOLOGY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

(2009) Chen Varol et al.   IMMUNITY

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

(2009) Kavon Rezai-Zadeh et al.   Journal of Neuroimmune Pharmacology

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

(2008) L. Landsman et al.   BLOOD

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Liver Myofibroblasts Regulate Infiltration and Positioning of Lymphocytes in Human Liver

(2008) Andrew P. Holt et al.   GASTROENTEROLOGY

Peroxisome Proliferator-activated Receptor γ Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue

(2008) Rinke Stienstra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

(2008) S. Jimenez et al.   JOURNAL OF NEUROSCIENCE