Article
Clinical Neurology
Kay-Cheong Teo, Sze-Man Fong, William C. Y. Leung, Ian Y. H. Leung, Yuen-Kwun Wong, Olivia M. Y. Choi, Ka-Keung Yam, Rachel C. N. Lo, Raymond T. F. Cheung, Shu-Leong Ho, Anderson C. O. Tsang, Gilberto K. K. Leung, Koon-Ho Chan, Kui-Kai Lau
Summary: This study aimed to determine the ideal hematoma volume cutoff for different intracerebral hemorrhage (ICH) locations in predicting ICH outcomes. The results showed that location-specific volume cutoff should be considered in patient selection for ICH trials, as the outcomes differed based on the size of the hematoma in different locations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Li, Zhuangzhuang Zhang, Jieyu Li, Weiping Sun, Zhaoxia Wang, Yining Huang
Summary: This study investigated the relationship between hematoma morphology and intraventricular hemorrhage (IVH) in patients with supratentorial deep intracerebral hemorrhage (ICH). The results showed that sphericity index and largest diameter-midline angle (LMA) were significantly associated with the presence of IVH in these patients.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Medicine, General & Internal
Daniel Woo, Mary E. Comeau, Simone Uniken Venema, Christopher D. Anderson, Matthew Flaherty, Fernando Testai, Steven Kittner, Michael Frankel, Michael L. James, Gene Sung, Mitchell Elkind, Bradford Worrall, Chelsea Kidwell, Nicole Gonzales, Sebastian Koch, Christiana Hall, Lee Birnbaum, Douglas Mayson, Bruce Coull, Marc Malkoff, Kevin N. Sheth, Jacob L. McCauley, Jennifer Osborne, Misty Morgan, Lee Gilkerson, Tyler Behymer, Elisheva R. Coleman, Jonathan Rosand, Padmini Sekar, Charles J. Moomaw, Carl D. Langefeld
Summary: This cohort study validates the elements of the ICH score and suggests that additional baseline and interim patient characteristics are associated with variation in the 3-month outcome.
Article
Clinical Neurology
Lei Song, Xiao-Ming Qiu, Ting-Ting Guo, Hang Zhou, Dong-Fang Tang, Long-Sheng Wang, Yu-Fei Fu, Hui Chen, Hua-Qing Mao, Hai-Bao Wang, Yong-Qiang Yu
Summary: The involvement of the posterior limb of the internal capsule in deep intracerebral hemorrhage is associated with hematoma expansion and may serve as a promising predictor.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: The study found that hematoma expansion is common in patients with unclear symptom onset of intracerebral hemorrhage and independently associated with worse outcome. These findings suggest that patients with unclear symptom onset may benefit from clinical trials of medical treatments targeting hematoma expansion.
Article
Cardiac & Cardiovascular Systems
Wen-Song Yang, Shu-Qiang Zhang, Yi-Qing Shen, Xiao Wei, Li-Bo Zhao, Xiong-Fei Xie, Lan Deng, Xin-Hui Li, Xin-Ni Lv, Fa-Jin Lv, Dar Dowlatshahi, Qi Li, Peng Xie
Summary: The study revealed that NCCT markers are independently associated with IVH growth and RHE, with the expansion-prone hematoma showing higher predictive accuracy. These findings can aid in risk stratification based on NCCT markers for predicting active bleeding.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Clinical Neurology
Xin-Ni Lv, Lan Deng, Wen-Song Yang, Xiao Wei, Qi Li
Summary: The review discusses the importance of predicting hematoma expansion after intracerebral hemorrhage using non-contrast computed tomography (NCCT) markers, such as swirl sign, blend sign, black hole sign, island sign, satellite sign, and subarachnoid extension, which have been shown to be significantly associated with hematoma expansion and poor outcome in small sample studies. It emphasizes the urgent need for using these markers to identify high-risk patients and guide anti-hematoma expansion treatments in acute intracerebral hemorrhage.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Clinical Neurology
Stefan P. Haider, Adnan I. Qureshi, Abhi Jain, Hishan Tharmaseelan, Elisa R. Berson, Tal Zeevi, Shahram Majidi, Christopher G. Filippi, Simon Iseke, Moritz Gross, Julian N. Acosta, Ajay Malhotra, Jennifer A. Kim, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth, Seyedmehdi Payabvash
Summary: This study aimed to determine radiomics signature correlates of clinical severity and medium-term outcome in patients with intracerebral hemorrhage (ICH) using the ATACH-2 trial dataset. The radiomics signatures were found to have a stronger association with admission clinical scores and 3-month outcome compared to hematoma volume, suggesting potential for improving prognostication and treatment triage of ICH patients using imaging biomarkers.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Paul Martin Putora, Goncalo G. Almeida, Simon Wildermuth, Johannes Weber, Tobias Dietrich, Meike W. W. Vernooij, Pieter Jan van Doormaal, Lucas Smagge, Kamil Zelenak, Alexandre Krainik, Fabrice Bonneville, Luc van den Hauwe, Markus Moehlenbruch, Federico Bruno, Birgitta Ramgren, Ana Ramos-Gonzalez, Till Schellhorn, Stephan Waelti, Tim Fischer
Summary: The purpose of this study was to evaluate and compare the factors relevant to the diagnostic decision-making and imaging workup of intracerebral hemorrhages in large, specialized European centers. Expert neuroradiologists from ten centers in nine European countries were selected, and their descriptions of investigation methods were collected and compared. The findings showed that although all centers considered clinical guidelines important, there were still variations in imaging workup.
Article
Clinical Neurology
Christopher J. Love, Daniel Kirschenbaum, Magdy Selim, Eng H. Lo, Elisabeth Rushing, Myron Spector, Adriano Aguzzi
Summary: The study found that chronic hemorrhagic stroke lesions contain abundant collagenous material, primarily consisting of collagen 3. The collagenase rat model successfully reproduced the morphology and composition of chronic human hemorrhagic stroke lesions. By identifying new pathological features of hemorrhagic stroke lesions, these results are important for treatment and recovery strategies.
Article
Clinical Neurology
Yu-Jia Jin, Jia-Wen Li, Jian Wu, Yu-Hui Huang, Kai-Cheng Yang, Hong-Na An, Chang-Zheng Yuan, Feng Gao, Lu-Sha Tong
Summary: This study aimed to determine whether a large hematoma volume was the essential factor contributing to worse outcomes of cortical superficial siderosis (cSS). The results showed that cSS was associated with larger hematoma volume, and large hematoma volume was the major factor leading to worse outcomes in patients with cSS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Lindsey R. Kuohn, Jens Witsch, Thorsten Steiner, Kevin N. Sheth, Hooman Kamel, Babak B. Navi, Alexander E. Merkler, Santosh B. Murthy, Stephan A. Mayer
Summary: This study examined the relationship between different locations (deep versus lobar) of intracerebral hemorrhage (ICH) and early neurological deterioration, hematoma expansion (HE), and outcome. The results showed that lobar ICH location was associated with more common HE and early neurological deterioration, while deep ICH location was associated with smaller hematoma size. However, after adjusting for prognostic variables, deep ICH was associated with worse outcome.
Article
Clinical Neurology
Sanjula D. Singh, Marco Pasi, Floris H. B. M. Schreuder, Andrea Morotti, Jasper R. Senff, Andrew D. Warren, Brenna N. McKaig, Kristin Schwab, M. Edip Gurol, Jonathan Rosand, Steven M. Greenberg, Anand Viswanathan, Catharina J. M. Klijn, Gabriel J. E. Rinkel, Joshua N. Goldstein, H. Bart Brouwers
Summary: In patients with spontaneous cerebellar ICH treated conservatively, the spot sign is associated with speed of hematoma expansion, case fatality, and poor functional outcome. In surgically treated patients, the spot sign is associated with 90-day case fatality.
Review
Medicine, General & Internal
Xin-Ni Lv, Zuo-Qiao Li, Qi Li
Summary: Intracerebral hemorrhage is a dangerous subtype of stroke with high rates of morbidity and mortality. Targeting prevention of hematoma growth and perihematomal edema expansion shows promise as a therapeutic approach. Blood-based biomarkers are being studied as potential diagnostic, predictive, and prognostic markers due to their accessibility and acceptance in clinical practice. Validation studies are needed to determine the usefulness of these biomarkers in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Lei Song, Hang Zhou, Tingting Guo, Xiaoming Qiu, Dongfang Tang, Liwei Zou, Yu Ye, Yufei Fu, Rujia Wang, Longsheng Wang, Huaqing Mao, Yongqiang Yu
Summary: This study found that a clinical-radiomics model based on clinical and radiographic variables can better predict the progression of deep intracerebral hemorrhage compared to a routine noncontrast computed tomography signs model. It has potential clinical value in risk stratification.
WORLD NEUROSURGERY
(2023)
Meeting Abstract
Clinical Neurology
Audrey C. Leasure, Julian Acosta, Richa Sharma, Harlan M. Krumholz, Adam de Havenon, Guido J. Falcone, Kevin N. Sheth
Meeting Abstract
Clinical Neurology
Adam H. de Havenon, Richa Sharma, Guido J. Falcone, Kevin N. Sheth
Meeting Abstract
Clinical Neurology
Daniela Renedo, Julian Acosta, Kevin N. Sheth, Charles Matouk, Guido J. Falcone
Article
Medicine, General & Internal
Julian N. Acosta, Cameron P. Both, Cyprien Rivier, Natalia Szejko, Audrey C. Leasure, Thomas M. Gill, Seyedmehdi Payabvash, Kevin N. Sheth, Guido J. Falcone
Summary: This study examines the association between the Life’s Simple 7 (LS7) score and brain health in individuals without stroke or dementia, finding that healthier LS7 profiles are associated with significant brain health benefits. It also explores the role of genomic information in recapitulating this association.
Review
Clinical Neurology
Isha R. Chavva, Anna L. Crawford, Mercy H. Mazurek, Matthew M. Yuen, Anjali M. Prabhat, Sam Payabvash, Gordon Sze, Guido J. Falcone, Charles C. Matouk, Adam de Havenon, Jennifer A. Kim, Richa Sharma, Steven J. Schiff, Matthew S. Rosen, Jayashree Kalpathy-Cramer, Juan E. Iglesias Gonzalez, W. Taylor Kimberly, Kevin N. Sheth
Summary: Brain imaging is crucial for the clinical care of stroke patients, but there are challenges in applying advanced neuroimaging techniques due to time delays, inter-clinician variability, and lack of systematic integration of clinical information. Recent advancements in deep machine learning provide new strategies for using computational medical image analysis to assist in acute stroke decision making. This article examines the current state of using deep learning models in stroke triage and evaluates their ability to automatically select clinical features, reduce inter-rater variability, and integrate neuroimaging with electronic medical record data.
ANNALS OF NEUROLOGY
(2022)
Article
Peripheral Vascular Disease
Ka-Ho Wong, Varsha Muddasani, Cecilia Peterson, Nazanin Sheibani, Cameron Arkin, Irene Cheong, Jennifer J. Majersik, Alessandro Biffi, Nils Petersen, Guido J. Falcone, Lauren H. Sansing, Adam H. de Havenon
Summary: This study found that baseline serum IL-6 is associated with increased subsequent BPV. Further investigation is needed to better understand the relationship between chronic inflammation and BPV.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Alvin S. Das, Elif Gokcal, Robert W. Regenhardt, Mitchell J. Horn, Kristin Schwab, Nader Daoud, Anand Viswanathan, W. Taylor Kimberly, Joshua N. Goldstein, Alessandro Biffi, Natalia Rost, Jonathan Rosand, Lee H. Schwamm, Steven M. Greenberg, M. Edip Gurol
Summary: This study aimed to evaluate whether non-haemorrhagic imaging markers (NHIM) can discriminate cerebral amyloid angiopathy (CAA) from hypertensive cerebral small vessel disease (HTN-cSVD) among patients with isolated lobar intracerebral haemorrhage (isolated-LICH). The study found that NHIM can differentiate HTN-cSVD from CAA using left ventricular hypertrophy (LVH) as a marker for HTN-cSVD.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Jason D. Hinman, Fanny Elahi, Davis Chong, Hannah Radabaugh, Adam Ferguson, Pauline Maillard, Jeffrey F. Thompson, Gary A. Rosenberg, Abhay Sagare, Abhay Moghekar, Hanzhang Lu, Tiffany Lee, Donna Wilcock, Claudia L. Satizabal, Russell Tracy, Sudha Seshadri, Kristin Schwab, Karl Helmer, Herpreet Singh, Pia Kivisakk, Steve Greenberg, Charlie DeCarli, Joel Kramer
Summary: This study found that plasma PlGF levels are associated with cognitive impairment and white matter injury, and can serve as a stable and reliable diagnostic biomarker.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Abdalla A. Ammar, Aladine A. Elsamadicy, Mahmoud A. Ammar, Benjamin C. Reeves, Andrew B. Koo, Guido J. Falcone, David Y. Hwang, Nils Petersen, Jennifer A. Kim, Rachel Beekman, Morgan Prust, Jessica Magid-Bernstein, Julian N. Acosta, Ryan Herbert, Kevin N. Sheth, Charles C. Matouk, Emily J. Gilmore
Summary: This study compared the safety of immediate EVD placement after the bolus administration of a factor Xa-inhibitor reversal agent versus after the infusion of the agent in patients with intracerebral hemorrhage. The results showed no significant differences in the incidence of hemorrhage, mortality, length of hospital stay, and discharge modified Rankin Score between the two groups. Therefore, it may be considered to perform EVD placement immediately after the infusion of the reversal agent to shorten the treatment time.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Review
Clinical Neurology
Shubham Misra, Terence J. Quinn, Guido J. Falcone, Vijay K. Sharma, Adam de Havenon, Yize Zhao, Ece Eldem, Jacqueline A. French, Clarissa Lin Yasuda, Jesse Dawson, David S. Liebeskind, Patrick Kwan, Nishant K. Mishra
Summary: We conducted a systematic review to investigate the association of single-nucleotide polymorphisms (SNPs) with the risk of post-traumatic epilepsy (PTE) and post-stroke epilepsy (PSE). Our findings showed that 11 SNPs were significantly associated with an increased risk of PTE, while 3 SNPs were significantly associated with an increased risk of PSE, and 2 SNPs were associated with a reduced risk. The association between APOE e4 and PTE was not significant.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yuhan Xie, Julian N. Acosta, Yixuan Ye, Zachariah S. Demarais, Carolyn J. Conlon, Ming Chen, Hongyu Zhao, Guido J. Falcone
Summary: This study used whole-exome sequencing data from 152,058 UK Biobank participants and identified a significant association between a rare genetic variant at CYP2R1 and the risk of ischemic stroke (IS). Validation analyses further confirmed this association in other cohorts and neuroimaging traits.
Article
Clinical Neurology
Julian N. Acosta, Stefan P. Haider, Cyprien Rivier, Audrey C. Leasure, Kevin N. Sheth, Guido J. Falcone, Seyedmehdi Payabvash
Summary: In this study, the relationship between higher systolic blood pressure (SBP) and white matter (WM) microstructural/cytostructural disintegrity patterns was investigated. It was found that higher SBP was associated with lower neurite density and higher mean diffusivity (MD). Among various WM tracts, the diffusion metrics of the internal capsule anterior limb, external capsule, superior and posterior corona radiata were most affected by higher SBP. The study also revealed that certain WM tracts mediated the effects of SBP on fluid intelligence.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Yixuan Ye, Rommell B. Noche, Natalia Szejko, Cameron P. Both, Julian N. Acosta, Audrey C. Leasure, Stacy C. Brown, Kevin N. Sheth, Thomas M. Gill, Hongyu Zhao, Guido J. Falcone
Summary: Frailty is an aging-related clinical phenotype characterized by increased vulnerability when exposed to stressors. A large-scale GWAS identified 37 novel loci associated with frailty, offering new insights into its genetic architecture and underlying mechanisms.
Letter
Dermatology
Audrey C. Leasure, Julian N. Acosta, Lauren H. Sansing, Kevin N. Sheth, Jeffrey M. Cohen, Guido J. Falcone
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Meeting Abstract
Clinical Neurology
Jessica Magid-Bernstein, Alison L. Herman, Conor Johnson, Hannah Beatty, Guido Falcone, Charles Matouk, Kevin Sheth, Lauren Sansing
ANNALS OF NEUROLOGY
(2022)