Article
Cell Biology
Saije K. Morosin, Sarah J. Delforce, Celine Corbisier de Meaultsart, Eugenie R. Lumbers, Kirsty G. Pringle
Summary: The study suggests that FURIN may not be crucial for syncytialisation in human trophoblast cells, and there may be other proteases involved, especially in primary trophoblasts. The findings contradict previous research, indicating potential differences in the role of FURIN in syncytialisation among trophoblast cells from different gestational periods.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Xin Wu, Philip A. Gale
Summary: pH-dependent liposomal assays are commonly used to determine anion selectivity in transmembrane anion transport experiments. There are both validity and limitations to consider when using these assays, and guidelines are provided to ensure accurate results.
CHEMICAL COMMUNICATIONS
(2021)
Review
Oceanography
Thomas C. Wainwright
Summary: The study found that the predictive skill of climate and ecosystem indicators for forecasting marine population survival rates is often ephemeral, likely due to complex interactions between climate, ecosystems, and populations. Solutions to this issue may involve improving forecast models and climate, ecosystem indicators, but establishing management systems that are robust to forecast uncertainty would provide a more reliable response to expected rapid ecosystem changes due to climate.
PROGRESS IN OCEANOGRAPHY
(2021)
Article
Physics, Particles & Fields
Aishik Ghosh, Benjamin Nachman
Summary: This article discusses the techniques for training machine learning classifiers independent of a given feature and points out the caution needed when using decorrelation for uncertainties that do not have a statistical origin.
EUROPEAN PHYSICAL JOURNAL C
(2022)
Article
Sport Sciences
Andrea M. Brennan, Andrew G. Day, John Clarke, Robert Ross
Summary: This study used data from three randomized controlled trials to examine individual exercise response rates in cardiometabolic variables, cardiorespiratory fitness, and body composition. The findings suggest that the majority of participants' response falls within the uncertain range, except for MRI-derived variables which showed improvement beyond the uncertainty range.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Gastroenterology & Hepatology
Arielle E. Kanters, Sarah K. Evilsizer, Scott E. Regenbogen, Samantha Hendren, Darrell A. Campbell, Justin B. Dimick, John C. Byrn
Summary: This study demonstrates that video-based peer rating of minimally invasive colectomy was not correlated with postoperative complications among specialty surgeons. Therefore, caution should be exercised when adopting video review for use in credentialing.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Chemistry, Inorganic & Nuclear
Sriram Sundaresan, Sally Brooker
Summary: Two acyclic tetradentate Schiff base ligands, HLX-OH (X = H and Br), were synthesized and used to prepare six mononuclear complexes. The solution spin crossover switching temperature, T-1/2, of these complexes is influenced by factors such as substituent X, co-ligand E, solvent, and speciation effects. The polarity of the solvent and the coordination ability of the co-ligands are correlated with the T-1/2 values of the complexes.
INORGANIC CHEMISTRY
(2023)
Article
Physics, Fluids & Plasmas
W. Klein, Harvey Gould, Sakib Matin
Summary: Many natural systems are believed to exist at a critical point, characterized by a power law distribution of clusters. However, since power laws can also be produced by other mechanisms, it is important to use additional criteria to determine whether the observed power-law behavior indicates a critical point or an alternate mechanism. This study demonstrates how misinterpretation of cluster scaling data can lead to the incorrect conclusion that the measured critical exponents do not satisfy these criteria, emphasizing the significance of properly interpreting power-law cluster distributions in order to avoid abandoning promising research areas.
Article
Computer Science, Artificial Intelligence
Emilia Niemiec
Summary: A recent case of a flawed medical AI system, which was funded by public money, sheds light on the importance of government policies and regulations in the field of AI.
NATURE MACHINE INTELLIGENCE
(2023)
Review
Gastroenterology & Hepatology
Jesus Rivera-Esteban, Angelo Armandi, Salvador Augustin, Elisabetta Bugianesi
Summary: This paper discusses the challenges and opportunities in drug development for patients with non-alcoholic steatohepatitis cirrhosis, emphasizing the need for individualized therapeutic regimens based on specific cirrhosis substages and treatment mechanisms. Understanding the probabilistic expectations for different outcomes at each substage is crucial for selecting appropriate therapeutic strategies.
LIVER INTERNATIONAL
(2021)
Article
Mathematics
Rui Zhuang, Fan Xia, Yixin Wang, Ying-Qing Chen
Summary: Clinical trials with rare or distant outcomes are often large and long-term, which poses challenges in terms of resources and time. There is a motivation to replace these rare or distant clinical endpoints with reliable surrogate markers that can be collected earlier and more easily. However, there are still statistical challenges in evaluating and ranking potential surrogate markers.
Article
Chemistry, Physical
Scott Renken, Raj Pandya, Kyriacos Georgiou, Rahul Jayaprakash, Lizhi Gai, Zhen Shen, David G. Lidzey, Akshay Rao, Andrew J. Musser
Summary: Strong light-matter coupling to form exciton- and vibropolaritons can alter the fundamental properties of organic materials, with potential applications in catalysis and electronic devices. Optical complexity makes polaritonic systems prone to misleading optical signatures, necessitating high-time-resolution measurements for unique characterization of coherent polariton dynamics.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Economics
Indranil Dutta, Ricardo Nogales, Gaston Yalonetzky
Summary: Research shows that using endogenous weights to compute multidimensional poverty violates key properties of poverty indices, which could compromise poverty evaluation and policy targeting.
JOURNAL OF DEVELOPMENT ECONOMICS
(2021)
Article
Chemistry, Medicinal
Michael A. McCoy, Dominique Spicer, Neil Wells, Kurt Hoogewijs, Marc Fiedler, Matthias G. J. Baud
Summary: This article provides an account of the small-molecule ligands of ficatenin, a multifunctional protein involved in the canonical Wnt signaling pathway. In silico analysis reveals that most of these molecules possess promiscuous chemical substructures that interfere with screening assays. Biophysical techniques confirm that none of the examined small molecules bind at the surface of ficatenin. This study calls into question their reported mode of action, but also reaffirms ficatenin as a prominent target in drug discovery.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Mathematics, Interdisciplinary Applications
Michael R. Elliott
Summary: Surrogate markers are used in clinical trials for evaluating treatment effectiveness when obtaining final outcomes is time-consuming or costly. This review focuses on approaches using causal inference paradigm to define surrogate marker quality and efforts to evaluate the risk of surrogate paradox. Recent work in robust surrogate marker estimation is also discussed, with suggestions for future research.
ANNUAL REVIEW OF STATISTICS AND ITS APPLICATION
(2023)
Article
Psychiatry
Vajira Dharmawardene, David B. Menkes
AUSTRALASIAN PSYCHIATRY
(2015)
Editorial Material
Psychiatry
Susanna Every-Palmer, Sam McBride, Helen Berry, David B. Menkes
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2016)
Review
Behavioral Sciences
William Diprose, Frederick Sundram, David B. Menkes
EPILEPSY & BEHAVIOR
(2016)
Letter
Medicine, General & Internal
David B. Menkes, Joel Lexchin
BMJ-BRITISH MEDICAL JOURNAL
(2016)
Letter
Medicine, General & Internal
David B. Menkes
BMJ-BRITISH MEDICAL JOURNAL
(2016)
Letter
Medicine, General & Internal
David B. Menkes, Joel Lexchin
BMJ-BRITISH MEDICAL JOURNAL
(2016)
Letter
Medicine, General & Internal
David B. Menkes
BMJ-BRITISH MEDICAL JOURNAL
(2016)
Letter
Medicine, General & Internal
Alain Braillon, David B. Menkes
JAMA INTERNAL MEDICINE
(2016)
Article
Economics
Hanna Gyllensten, Anna K. Jonsson, Katja M. Hakkarainen, Staffan Svensson, Staffan Hagg, Clas Rehnberg
Article
Primary Health Care
Staffan A. Svensson, Tove M. Hedenrud, Susanna M. Wallerstedt
BMC FAMILY PRACTICE
(2019)
Article
Health Care Sciences & Services
Naldy Parodi Lopez, Staffan A. Svensson, Susanna M. Wallerstedt
Summary: The presence of a recorded medication review was not positively associated with adequate drug treatment management, but was associated with the age limit for remuneration, as well as some chronic diseases such as type 2 diabetes, hypertension, and depression.
SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
(2021)
Article
Pharmacology & Pharmacy
Carina Tukukino, Naldy Parodi Lopez, Staffan A. Svensson, Susanna M. Wallerstedt
Summary: This study described the interaction alerts in older patients and evaluated whether these alerts required further medical action or had already been addressed. The results showed that most alerts had already been addressed or were not relevant in the clinical setting, but some patients still needed medical action.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Naldy Parodi Lopez, Staffan A. Svensson, Susanna M. Wallerstedt
Summary: This study investigates the clinical relevance of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), and finds that a fraction of them are clinically relevant. The study shows that the number of PIMs/PPOs and the number of drugs are associated with inadequate drug treatment.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Naldy Parodi Lopez, Bjorn Belfrage, Anders Koldestam, Johan Lonnbro, Staffan A. Svensson, Susanna M. Wallerstedt
Summary: This study aimed to revisit the inter-rater reliability of drug treatment assessments according to the STOPP/START criteria. The findings showed issues with reliability and highlighted methodological factors that may contribute to inconsistency.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Susanna M. Wallerstedt, Staffan A. Svensson, Johan Lonnbro, Fredrik Hieronymus, Johan Fastbom, Mikael Hoffmann, Naldy Parodi Lopez
Summary: In this diagnostic study, the evaluated PIM/PPO sets had poor to fair performance as diagnostic tools to identify inadequate drug treatment, suggesting the need for reconsideration of using PIMs/PPOs as indicators of drug treatment quality.
