期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00505
关键词
radiotherapy; abscopal effect; immune therapy; checkpoint inhibitors; PD-L1; DAMP; EGFR; anti-tumor immunity
类别
资金
- German Federal Ministry of Education and Research (BMBF) [16EX1021R, 02NUK017G]
- European Commission (DoReMi, European Atomic Energy Community's Seventh Framework Programme (FP7)) [249689]
- Bavarian Equal Opportunities Sponsorship - Forderung von Frauen in Forschung und Fare (FFL) - Promoting Equal Opportunities for Women in Research and Teaching
- German Research Foundation
- Friedrich-Alexander-Universitat Erlangen-Nurnberg
Radiotherapy (RI) primarily aims to locally destroy the tumor via the induction of DNA damage in the tumor cells. However, the so-called abscopal, namely systemic and immune mediated, effects of RI move over more and more in the focus of scientists and clinicians since combinations of local irradiation with immune therapy have been demonstrated to induce anti-tumor immunity. We here summarize changes of the phenotype and microenvironment of tumor cells after exposure to irradiation, chemotherapeutic agents, and immune modulating agents rendering the tumor more immunogenic. The impact of therapy-modified tumor cells and damage-associated molecular patterns on local and systemic control of the primary tumor, recurrent tumors, and metastases will be outlined. Finally, clinical studies affirming the bench-side findings of interactions and synergies of radiation therapy and immunotherapy will be discussed. Focus is set on combination of radio(chemo)therapy (RCT) with immune checkpoint inhibitors, growth factor inhibitors, and chimeric antigen receptor T-cell therapy. Well-deliberated combination of RCT with selected immune therapies and growth factor inhibitors bear the great potential to further improve anti-cancer therapies.
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