Article
Polymer Science
Johanna Ludolph, Holger Rothe, Uwe Schirmer, Katharina Moebus, Christina Behrens, Henning Schliephake, Klaus Liefeith
Summary: This study investigates the use of polyelectrolyte multilayers (PEMs) with varying collagen content as drug carriers for human bone morphogenetic protein 2 (rhBMP-2). It is found that significant amounts of rhBMP-2 can be immobilized in all multilayer systems and its release can be specifically tuned through cross-linking. Furthermore, the immobilized rhBMP-2 in collagen-rich coatings has a higher influence on osteoprogenitor cell differentiation compared to unloaded layers.
Article
Polymer Science
Tilen Kopac, Ana Lisac, Rok Mravljak, Ales Rucigaj, Matjaz Krajnc, Ales Podgornik
Summary: The study presents an efficient polyHIPE/hydrogel system for targeted delivery of bacteriophages with rapid release at the target site. The system exhibits significant potential for targeted drug delivery in medicine and pharmacy.
Article
Biophysics
Ke Xu, Wangjie Shan, Neng Hu, Jiping Wang, Wenlong Zhou, Peter Muller-Buschbaum, Qi Zhong
Summary: High efficiency of in-situ cross-linking and acid triggered drug delivery is achieved by introducing tobramycin into the hydrogels. The hydrogels exhibit unique properties such as injectability, biodegradability, and self-healing, along with good biocompatibility and antibacterial performance.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Sjoerd J. Rijpkema, Rik van Egeraat, Wei Li, Daniela A. Wilson
Summary: This study reports a synthesis method for stable and catalytically active polymer vesicle nanoreactors. By cross-linking the polymer vesicle membranes, the stability and permeability issues are addressed, allowing the incorporation of functional handles. Additionally, co-assembly with specific ratios of polymers also results in the formation of pores, further expanding the application of this nanoreactor.
Article
Engineering, Multidisciplinary
Heun Young Seo, Dohyun Im, Young Je Kwon, Chae Yun Nam, Se Hun Kim, Taegu Nam, Changki Kim, E. Vivek, Kyong-Youl Baek, Kie Yong Cho, Ho Gyu Yoon
Summary: Epoxy composites (ECs) are improved in water absorption resistance and mechanical properties by adopting poly (methyl methacrylate)-b-(dimethyl aminoethyl methacrylate) (PMD) as a polymer compatibilizer. The as-prepared dual-networked epoxy composite system shows a high-water absorption suppression of about 166.78% and a high tensile modulus of 4.6 GPa.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Polymer Science
Amer Rashid Hameed, Hatem Majdoub, Fawzi Habeeb Jabrail
Summary: Cross-linked microspheres loaded with Favipiravir SARS-CoV-2 antiviral drug were prepared using different cross-linking techniques. Analysis revealed that one of the polysaccharides was pectin extracted from pomegranate peels. The surface morphology of the microspheres differed, with Glu microspheres having a rough surface and SHMP microspheres having a smooth surface. The loading percentage of the drug was higher in SHMP microspheres, and the release time depended on the pH of the release medium.
Article
Pharmacology & Pharmacy
Quanying Bao, Suraj Fanse, Xiaoyu (James) Lu, Diane J. Burgess
Summary: This study investigates the impact of drug loading on the release of Levonorgestrel intrauterine systems (LNG-IUSs) by preparing drug reservoirs with different drug loading and conducting release testing under accelerated conditions. The results show that the release rate of LNG-IUSs is inversely proportional to the drug loading. Low drug loading leads to incomplete drug release or even no drug release at all. Accelerated release testing methods are found to be representative of real-time release profiles, providing confidence in extending the duration of usage for these products as long as the device remains intact and the release rate is within the therapeutic window.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Yueqi An, Shanbai Xiong, Yanping Qian, Michael C. Qian
Summary: Transglutaminase-induced cross-linking can regulate the aroma release of surimi gels by affecting the concentrations and release rates of aroma compounds, with harder gels releasing fewer aroma compounds. Increasing cross-linking degrees first decrease, then significantly increase the release of aroma compounds, showing a negative correlation with the springiness and gel strength of surimi gels.
Article
Biochemistry & Molecular Biology
Pengxiang Xu, Jiangfeng Song, Zhuqing Dai, Yayuan Xu, Dajing Li, Caie Wu
Summary: The study investigated the construction of nano-lutein hydrogels with sustained release properties by cross-linking with different concentrations of Ca2+. Results showed that the highest loading capacity for lutein reached 770.88 μg/g, with an encapsulation efficiency of 99.39%. The presence of lutein nanoparticles and increased Ca2+ concentration both affected the physical properties and swelling behavior of the hydrogel. The stability of cross-linked ionic bonds in the hydrogel was reduced by lutein nanoparticles and excessive Ca2+, impacting its thermodynamic stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Qiuli Cheng, Shuxiang Ding, Yan Zheng, Meng Wu, Yi-Yang Peng, Diana Diaz-Dussan, Zuosen Shi, Yang Liu, Hongbo Zeng, Zhanchen Cui, Ravin Narain
Summary: An injectable antibacterial hydrogel with self-healing property was developed in this study, utilizing a dual cross-linking network structure and quadruple hydrogen bonds. The hydrogel exhibited excellent mechanical properties, pH and sugar dual-responsiveness, and showed potential for cell and tissue engineering applications.
Review
Chemistry, Multidisciplinary
Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: Thiomers, such as thiolated hyaluronic acid and chitosan, are widely studied for their high reactivity in hydrogel synthesis. They exhibit in situ gelling properties and can undergo various click reactions, making them versatile materials for tissue engineering, regenerative medicine, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Monika Gosecka, Mateusz Gosecki, Malgorzata Urbaniak
Summary: A graphene oxide-filled composite hydrogel based on boronic ester cross-links has been constructed to achieve better thermoresponsiveness. Increasing the concentration of graphene oxide enhances the rate and amplitude of material response. The diffusion property of the hydrogel can be regulated by the length of the applied boronic acid-based cross-linking agent.
Review
Chemistry, Multidisciplinary
Wei-Hua Han, Qing-Yu Wang, Yuan-Yi Kang, Li-Rui Shi, Yu Long, Xin Zhou, Chun-Cheng Hao
Summary: This review comprehensively discusses the cross-linking electrospinning system for the first time, including cross-linking strategies, cross-linking mechanisms, and applications of cross-linked electrospun nanofibers. The significance of cross-linking electrospinning and the challenges in constructing this system are also highlighted.
Article
Chemistry, Applied
Yonghao Liu, Jiaqi Yu, Honghua Cao, Changhu Xue, Kai Chen, Ying Xu, Xun Sun
Summary: This study demonstrates that DAG is a highly reactive cross-linking agent even under undesirable Maillard reaction conditions and has good cross-linking ability in food processing. DAG treatment enhances the mechanical strength of foods and generates brown pigments during cross-linking. In addition, DAG outperforms GA in generating stronger chitosan hydrogels and more acid-resistant films.
Article
Chemistry, Multidisciplinary
Yu Jiang, Nikos Hadjichristidis
Summary: A novel synthetic strategy was used to create reversible cross-linked polymeric materials with tunable fluorescence properties. By adjusting the temperature, the fluorescence behavior of the materials can be controlled, showing potential applications in areas such as information security and transmission.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Manufacturing
Yu-Chao Shih, Mahmoud Mohamed, Jun Ge, Subhayu Sen, Selvum Pillay, Haibin Ning
Summary: Continuous fiber-reinforced plastic composite materials are increasingly used in additive manufacturing due to its ability to manufacture high-performance parts on demand. This study characterized the interlaminar shear strength of 3D-printed continuous fiber-reinforced plastic composites and found that it varies with fiber orientation. It is recommended to design with a balanced stiffness to fully utilize continuous fiber reinforcement.
PROGRESS IN ADDITIVE MANUFACTURING
(2023)
Article
Engineering, Biomedical
Hsia-Wei Liu, Jen-Ray Chaw, Yu-Chao Shih, Ching-Cheng Huang
BIO-MEDICAL MATERIALS AND ENGINEERING
(2014)
