Review
Biotechnology & Applied Microbiology
Mansour Poorebrahim, Niloufar Mohammadkhani, Reza Mahmoudi, Monireh Gholizadeh, Elham Fakhr, Angel Cid-Arregui
Summary: Neoepitopes or neoantigens are unique mutations in a patient's tumor that can be used for tumor treatment. Adoptive therapies based on T cell receptor engineering or CARs show promise in eradicating tumors while minimizing damage to normal tissues. The focus is on neoepitopes and addressing current limitations in harnessing this approach for effective and specific anti-tumor therapy.
CANCER GENE THERAPY
(2021)
Article
Thermodynamics
Daniel Rohacs
Summary: This paper presents a methodology for assessing the sustainability of energy management in buildings, taking into account the life cycle costs and externalities of various energy sources. The results indicate that an optimized energy mix consisting of locally available sources is most effective, and real-time energy support and a centralized management system are crucial for efficient energy use. Additionally, the development of local microgrids can significantly improve energy supply efficiency.
Review
Food Science & Technology
Marta Gallardo-Fernandez, Marina Gonzalez-Ramirez, Ana B. Cerezo, Ana M. Troncoso, M. Carmen Garcia-Parrilla
Summary: This study evaluated the dietary intake of hydroxytyrosol (HT) in the European population by compiling scattered literature data. Olives, olive oil, and wine were identified as the main sources of HT. The estimated average intake varied among EU countries, with Greece showing the highest intake and Austria the lowest. The low estimated intake suggests that the use of HT as a food ingredient is feasible and offers new possibilities for utilizing waste products from olive oil and olive production.
Correction
Biotechnology & Applied Microbiology
Mansour Poorebrahim, Niloufar Mohammadkhani, Reza Mahmoudi, Monireh Gholizadeh, Elham Fakhr, Angel Cid-Arregui
Summary: An erratum has been published for this paper, which can be found at https://doi.org/10.1038/s41417-021-00323-7.
CANCER GENE THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Deepak Kulkarni, Rushikesh Sherkar, Chaitali Shirsathe, Rushikesh Sonwane, Nikita Varpe, Santosh Shelke, Mahesh P. More, Sagar R. Pardeshi, Gargee Dhaneshwar, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly
Summary: Nanotechnology is an important emerging field in applied science that offers various possibilities for human interventions. Biogenic nanoparticles derived from natural sources have gained attention due to their positive effects on health and the environment. Different microorganisms, plants, and marine sources can be utilized to produce these nanoparticles through the bioreduction mechanism. The nanoparticles are characterized using physical and chemical analysis techniques, and various process parameters can affect their production. Biogenic nanoparticles have wide-ranging applications in biomedical fields, including drug delivery and biosensing. However, there is a need for more research on degradation pathways, kinetics, and biodistribution to facilitate their translation from laboratory studies to clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Frank Mnthambala, Elizabeth Tilley, Sean Tyrrel, Ruben Sakrabani
Summary: Population growth and changing dietary needs in Malawi have led to a high demand for phosphorus (P) fertilisers, with most soils in the country having low P levels. A phosphorus flow analysis (PFA) revealed a large amount of recyclable organic P sources, but only 16% is currently being recycled, resulting in a negative P balance in Malawian soils. Adopting organic P recycling practices could reduce the country's reliance on imported chemical P fertilisers, but regulations on organic fertiliser quality are needed to ensure effectiveness.
RESOURCES CONSERVATION AND RECYCLING
(2021)
Article
Thermodynamics
Tianqi Shi, Ge Han, Xin Ma, Zhipeng Pei, Weibo Chen, Jiqiao Liu, Xingying Zhang, Siwei Li, Wei Gong
Summary: Accurate reporting of CO2 point source emissions is crucial for addressing climate change. Satellite remote sensing, specifically spaceborne LiDAR, has shown promise as a cost-effective global-scale verification method. A novel emission inversion method using genetic algorithms and trust-region techniques was proposed to estimate CO2 emissions from point sources using spaceborne LiDAR observations. The results demonstrate that this approach provides affordable and accurate carbon verification services.
ENERGY CONVERSION AND MANAGEMENT
(2023)
Article
Pharmacology & Pharmacy
Joana Torres, Jose Miguel Pereira, Rita Marques-Oliveira, Ines Costa, Eva Gil-Martins, Renata Silva, Fernando Remiao, Andreia Filipa Peixoto, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: This study investigated the use of lipid nanoparticles, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), for intranasal delivery of astaxanthin. The formulations loaded with astaxanthin from different sources (algae Haematococcus pluvialis extract (AE) and fungi Blakeslea trispora extract (PA)) were evaluated for biocompatibility with nasal (RPMI 2650) and neuronal (SH-SY5Y) cells, antioxidant activity, and cellular uptake. The PA-loaded NLC formulation showed promising neuroprotective effects, suggesting its potential for improving the treatment of neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Eric Woith, Gea Guerriero, Jean-Francois Hausman, Jenny Renaut, Celine C. Leclercq, Christoph Weise, Sylvain Legay, Alexander Weng, Matthias F. Melzig
Summary: While human EVs have been extensively studied, plant-derived EVs have received less attention. This study introduces plant cell suspension culture as a new source for plant EVs and nanovesicles, revealing properties and mechanisms similar to animal cell-derived exosomes and microvesicles. Proteins present in plant EVs indicate potential mechanisms for cell wall passage and suggest similarities in EV secretion mechanisms between plant and animal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Transportation Science & Technology
Milad Ghasri, Akshay Vij
Summary: This study investigates consumers' consideration to adopt AVs, with a focus on the impact of informational cues from different communication channels. Results show that social media sentiment has the highest effect on AV consideration for 90% of the sample, while 3.8% of the sample never consider adopting AVs regardless of the informational cues.
TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES
(2021)
Article
Green & Sustainable Science & Technology
Grzegorz Przydatek, Andrzej Ryniewicz, Oana Irimia, Claudia Tomozei, Emilian Mosnegutu, Marcin Bodziony
Summary: Passenger cars vary in noise emissions and mileage, which negatively impact the environment and humans. Findings confirm that even among passenger cars with the same parameters or of the same type, there are differences in noise levels. The combustion engine compartment was found to be the loudest area in the tested vehicles, with an average noise level exceeding 90 dB and showing a significant increase with higher mileage. This noise intensity level is classified as dangerous for human health. The study suggests that using an engine cover and an aluminum heat shield can help mitigate the noise emitted by internal combustion engines. Encouraging the use of quieter electric vehicles could be a solution to the environmental issue of noise emissions from cars.
Article
Chemistry, Multidisciplinary
Grace Brennan, Sally Ryan, Tewfik Soulimane, Syed A. M. Tofail, Christophe Silien
Summary: Magnetic-plasmonic Fe3O4-Au core-shell nanoparticles are widely used in therapeutics and diagnostics. By exploring their nonlinear optical properties in biological imaging, nanoparticles coated with gold nanoseeds and thinner gold shells showed the highest contrast agent potential.
Article
Environmental Sciences
Ulla Makkonen, Mika Vestenius, L. N. Huy, N. T. N. Anh, P. T. V. Linh, P. T. Thuy, H. T. M. Phuong, Huyen Nguyen, L. T. Thuy, Minna Aurela, Heidi Hell, Katja Loven, Rostislav Kouznetsov, Katriina Kyllo, Kimmo Teinila, N. T. Kim Oanh
Summary: The chemical composition of PM2.5 was monitored in Hanoi, Vietnam from August 2019 to July 2020. The annual average PM2.5 concentrations exceeded national and WHO limit values. Winter had the highest daily PM2.5 concentrations due to stagnant meteorological conditions. Organic matter, biomass burning, secondary inorganic aerosol, and coal combustion were identified as significant sources of PM2.5 pollution. Zinc was the most common trace element and often appeared with Cd, Cl-, and Pb, indicating industrial sources and/or coal combustion. Positive matrix factorization identified six main source factors: traffic, local secondary inorganic aerosol, biomass burning, industry, long-range transported SIA, and dust.
ATMOSPHERIC ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Charlotte U. Zajc, Benjamin Salzer, Joseph M. Taft, Sai T. Reddy, Manfred Lehner, Michael W. Traxlmayr
Summary: CAR T cells, genetically engineered T cells expressing chimeric antigen receptors, have shown impressive clinical efficacy against B-cell malignancies. However, there are limitations with CAR T cells directed against other tumor entities and antigens, leading to the discussion of alternative engineered binding scaffolds and natural ligands/receptors for CAR design in recent studies. The risk of immunogenicity is also critically discussed, showing that engineered binding scaffolds based on nonhuman proteins can be more similar to humanized scFvs than expected.
Article
Environmental Sciences
Marc Muselli, Danilo Carvajal, Daniel A. Beysens
Summary: This study investigates the radiative cooling and dew formation on cars, comparing the data obtained on different car parts with that on a thermally isolated planar film. The results show that cars can be used to estimate the dew yields in a given site.
Article
Environmental Sciences
Salim Ahmadi, Doris Klingelhoefer, Christina Erbe, Fabian Holzgreve, David A. Groneberg, Daniela Ohlendorf
Summary: This study reveals that key players in oral hygiene research are concentrated in high-income countries, with minimal participation from lower income economies. The burden situations are shifting towards low-income countries, calling for an expansion of international network to address future global oral health challenges. The USA and Western European nations are leading in research output on oral hygiene, with Brazil emerging as a significant player.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Doerthe Brueggmann, Kathrin Quinkert-Schmolke, Jenny M. Jaque, David Quarcoo, Michael K. Bohlmann, Doris Klingelhoefer, David A. Groneberg
Summary: Cervical cancer has caused significant morbidity and mortality worldwide, especially in low-income countries. This study investigated the global scientific output related to cervical cancer and found imbalances in research activity, with European Nordic countries leading the field.
Article
Environmental Sciences
Kim Sarah Blume, Fabian Holzgreve, Laura Fraeulin, Christina Erbe, Werner Betz, Eileen M. Wanke, Doerthe Brueggmann, Albert Nienhaus, Christian Maurer-Grubinger, David A. Groneberg, Daniela Ohlendorf
Summary: Despite their young age and short duration of practice, dental students are already experiencing musculoskeletal disorders (MSD). The study found that MSD in dental students is mainly related to poor posture during dental work, with the highest ergonomic risk observed in body parts such as the wrists, neck, and trunk. More focus on theoretical and practical ergonomics in dental education is necessary to reduce the occurrence of MSD.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Janis Droege, Ibrahim El Moussaoui, Doris Klingelhoefer, Hannelore Held, David A. Groneberg, Marcel A. Verhoff, Stefanie Plenzig
Summary: Particulate matter emitted during autopsies may act as a medium for the transmission of various viruses or bacteria, leading to infections. Thus, it is crucial to reduce the exposure to these particles in indoor working environments. In this study, particulate matter in the ambient air during autopsies was measured using an aerosol spectrometer. The particle emissions from using an ordinary oscillating saw and an adapted saw with a suction unit were compared to evaluate the effectiveness of technical adaptation in reducing particles. Additionally, the impact of wearing a face mask and variations in room background concentration were analyzed. The results showed high particle concentrations while using the ordinary saw, but the exposure could be mostly avoided by using the adapted saw or wearing a face mask. On most working days, an increase in background concentration was observed. Based on these findings, the use of a proper suction unit and face mask during autopsies is necessary, along with sufficient ventilation to prevent long-lasting high background concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pediatrics
Katja Boehme, Doris Klingelhoefer, David A. Groneberg, Michael H. K. Bendels
Summary: The proportion of women in medicine, especially in pediatrics, is increasing, but leadership positions are mostly occupied by men. This study found that women in pediatric research hold a relatively higher proportion of first-author and co-author positions, but are still underrepresented in prestigious first-author and last-author positions. Citation rates are not affected by the gender of the key authors. Pronounced gender-related differences were also found at the country-level. It is expected that career opportunities for women in pediatric research will improve in the coming years.
PEDIATRIC RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Doris Klingelhoefer, Markus Braun, Dorthe Brueggmann, David A. Groneberg
Summary: This study investigates the global research landscape on poverty and health, finding that the increasing poverty is attributed to the effects of climate change, COVID-19 pandemic, and armed conflict. Additionally, the study reveals a positive correlation between economic strength and publication numbers, as well as a negative correlation between article numbers and multidimensional poverty.
GLOBALIZATION AND HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Serafina Joachim, Doris Klingelhoefer, Markus Braun, Dorthe Brueggmann, David A. Groneberg, David Quarcoo
Summary: This article describes the progress towards a more comprehensive protection against the dangers of exposure to radon for the German population, aiming to minimize exposure risks through coordinated efforts and uniform rules.
ZENTRALBLATT FUR ARBEITSMEDIZIN ARBEITSSCHUTZ UND ERGONOMIE
(2022)
Review
Environmental Sciences
Doris Klingelhoefer, Markus Braun, Doerthe Brueggmann, David A. Groneberg
Summary: The use of neonicotinoid insecticides is widespread globally, but its negative ecological impact and effects on biodiversity are increasingly being recognized. This review article analyzes the global research landscape on neonicotinoids and reveals a growing interest in ecological issues. China leads in terms of published studies, while higher-economy countries show greater research output due to their scientific infrastructure and willingness to support research. There is a significant North-South divide in research performance, highlighting the need for sustainable solutions and greater involvement of developing countries.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Doris Klingelhoefer, Markus Braun, Janis Droege, Axel Fischer, Doerthe Brueggmann, David A. Groneberg
Summary: The global research on rare earth elements (REEs) mainly focuses on the environment and health, particularly in relation to medical applications and environmental issues. The major global players, such as China and the USA, show the highest interest in REE research, while regional research interests are driven by market demands.
GLOBALIZATION AND HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Doris Klingelhoefer, Markus Braun, Doerthe Brueggmann, David A. Groneberg
Summary: This bibliometric study assesses the global research on ticks and tick-borne diseases, providing insights into geographical and temporal patterns under epidemiological and socioeconomic aspects. The study aims to support targeted actions at scientific, societal, and policy levels to counter the growing threat associated with ticks.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Letter
Substance Abuse
Markus Braun, Doris Klingelhoeer, Janis Droee, David A. Groneberg
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Substance Abuse
Markus Braun, Laura Lian Marsidi, Doris Klingelhoefer, David A. Groneberg
Summary: This study reveals that PM emissions from Kretek cigarettes in Indonesia can be very high. It is important to inform and warn the Indonesian public, considering the prevalent smoking and SHS exposure. The implementation of a serious and effective tobacco control policy is overdue in Indonesia.
NICOTINE & TOBACCO RESEARCH
(2022)
Review
Rehabilitation
Laura Maltry, Daniela Ohlendorf, Michael Bendels, David A. Groneberg, Christoph Mickel
Summary: The impact of sleep on the consolidation of motor memory remains controversial, with publications presenting different views and highlighting methodological issues in research. Reasons for the difficulty in understanding include numerous influencing factors and complexity in terminology.
