Article
Engineering, Biomedical
Sarah Girardeau-Hubert, Barbara Lynch, Francesca Zuttion, Rabab Label, Chrystelle Rayee, Sebastien Brizion, Sylvie Ricois, Anthony Martinez, Eunhye Park, Changhwan Kim, Paulo Andre Marinho, Jin-Hyung Shim, Songwan Jin, Maite Rielland, Jeremie Soeur
Summary: This study focuses on the mechanical properties, extra-cellular matrix organization, and cell interactions in human skin samples reconstructed with pure collagen or dermal decellularized extra-cellular matrices (S-dECM). The results show that the S-dECM samples have higher stiffness compared to collagen samples and exhibit similarities to ex vivo human skin. The study demonstrates the importance of the microenvironment in influencing cell behaviors and mechanical properties.
ACTA BIOMATERIALIA
(2022)
Article
Cell Biology
Yahui Wang, Yong Xu, Guangdong Zhou, Yu Liu, Yilin Cao
Summary: In tissue engineering applications, an acellular dermal matrix (ADM) has been found to be more suitable for cartilage regeneration compared to an acellular cartilaginous matrix (ACM). ADM scaffolds exhibited better cell adhesion rate, more homogeneous chondrocyte distribution, and neocartilage formation. Subcutaneous implantation in a goat showed that ADM achieved more stable and matured cartilage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Jan Mihalecko, Martin Bohac, Lubos Danisovic, Jan Koller, Ivan Varga, Marcela Kuniakova
Summary: This article provides a brief review of the current literature assessing the clinical applications of ADM, a widely used material in plastic and reconstructive surgery, which promotes healing process and reduces scar tissue formation.
PHYSIOLOGICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Kangning Lv, Lei Wang, Xiaoli He, Wenjun Li, Lei Han, Song Qin
Summary: TADM is an extracellular matrix material that mimics the cell growth environment, promoting substantial acute wound healing. Primarily composed of type I collagen, it possesses excellent physical and chemical properties, biological activity, and cell adhesion, playing a crucial role in tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Dermatology
Linda Tognetti, Elisa Pianigiani, Francesca Ierardi, Guido Lorenzini, Donato Casella, Flavio Giulio Liso, Andrea De Pascalis, Elisa Cinotti, Pietro Rubegni
Summary: The use of human acellular dermal matrices (hADMs) at different body sites provides several advantages, including protection of deep structures, stimulation of functional new dermis, reduced wound closure time, and control of pain and exudate.
DERMATOLOGIC THERAPY
(2021)
Article
Anatomy & Morphology
M. L. Perez, C. Castells-Sala, P. Lopez-Chicon, N. Nieto-Nicolau, A. Aiti, O. Farinas, R. P. Casaroli-Marano, O. Porta, A. Vilarrodona
Summary: The study developed a decellularization protocol to obtain dermal matrix from human split-thickness skin from cadaveric donors. Evaluation of the absence of epidermis and dermal cells, as well as quantification of ECM biomolecules and residual genetic content, showed the efficacy of the decellularization process. Biomechanical tests confirmed the preservation of native properties in the acellular tissue.
Article
Nanoscience & Nanotechnology
My Thi Ngoc Nguyen, Ha Le Bao Tran
Summary: The study aimed to prepare injectable acellular adipose matrix (AAM) through delipidating and decellularizing, showing that mechanical disruption improved fat removal efficiency and the decellularization strategy was effective. AAM powder was non-toxic to human adipose derived stem cells and supported cell migration and proliferation.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2021)
Article
Engineering, Biomedical
Bin Wang, Qinglai Tang, Qian Yang, Mengmeng Li, Shiying Zeng, Xinming Yang, Zian Xiao, Xinying Tong, Lanjie Lei, Shisheng Li
Summary: Due to their unique properties such as low immunogenicity, biomimetic internal environment, tissue-and organ-like physicochemical properties, and functionalization potential, decellularized extracellular matrix (dECM) materials have gained considerable attention in tissue engineering. This review provides an overview of the composition of extracellular matrices and their role in stem-cell differentiation, discusses the advantages and disadvantages of existing decellularization techniques, and presents methods for the functionalization and characterization of decellularized scaffolds. Additionally, the review discusses the progress and shortcomings of using dECMs in cartilage, skin, nerve, and muscle repair, as well as the transplantation or regeneration of different whole organs, and examines the future prospects of refunctionalization in tissue and organ repair. It aims to systematize the application of functionalized dECMs in tissue/organ transplantation and keep researchers informed about the latest progress in dECM usage.
MATERIALS TODAY BIO
(2023)
Article
Cell Biology
Weidong Xia, Cai Lin, Zhuolong Tu, Yuan Li, Guoliang Shen
Summary: This study prepared a new type of porcine acellular dermis matrix (PADM) using the sequential combined decellularization method and laser microporous technique. The results showed that the PADM had a porcelain white, shiny, soft and elastic dermal matrix with low DNA residue and low cytotoxicity. The animal transplantation experiment demonstrated the effectiveness and safety of the novel PADM.
CELL AND TISSUE BANKING
(2023)
Review
Biochemistry & Molecular Biology
Marcin Gierek, Wojciech Labus, Diana Kitala, Andrzej Lorek, Gabriela Ochala-Gierek, Karolina Mikus Zagorska, Dariusz Waniczek, Karol Szyluk, Pawel Niemiec
Summary: Reconstructive surgery often deals with large tissue defects and requires materials that are both immunogenic but offer tissue filling. ADM, an acellular dermal matrix, is a commonly used biological collagen matrix without immunogenicity. This literature review examines the use of human ADM in reconstructive surgery across different fields, emphasizing the need for further research in this area.
Article
Engineering, Biomedical
Reyhaneh Nassiri Mansour, Ayoob Karimizade, Seyed Ehsan Enderami, Mozhgan Abasi, Fereshteh Talebpour Amiri, Abdolreza Jafarirad, Amir Mellati
Summary: This study investigated the effects of animal age, decellularization protocols, and sterilization methods on xenogeneic acellular dermal matrices (ADMs) for skin regeneration. The results show that fetal source and EO-sterilized samples performed better in terms of morphology, mechanical properties, and wound treatment. There was no added value in using enzymatic treatment during the decellularization process. The findings suggest that the selection of animal age, decellularization, and sterilization methods should be based on clinical requirements.
Article
Green & Sustainable Science & Technology
Qingxi Hu, Yiming Wang, Dongchao Yang, Haiguang Zhang, Zhicheng Song, Yan Gu
Summary: The study examined the feasibility and performance of ADM biological scaffolds fabricated by 3D printing, with findings indicating that factors influencing printability include printing parameters and ADM composition. Biocompatibility was evaluated through cytotoxicity, cell proliferation, and vivisection, demonstrating the potential applications of ADM scaffolds in tissue engineering.
JOURNAL OF RENEWABLE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yanan Luo, Fulin Tao, Jing Wang, Yandong Chai, Chaohua Ren, Yuanfei Wang, Tong Wu, Zhenyu Chen
Summary: In this study, we prepared a series of novel hemostatic sponges using tilapia skin, a marine biological resource, and found that the collagen sponge exhibited optimal hemostasis performance by accelerating clotting and enhancing blood absorption capability. These sponges provide a novel class of alternatives for hemostasis in acute wounds with broad application prospects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Danni Gong, Fei Yu, Meng Zhou, Wei Dong, Dan Yan, Siyi Zhang, Yan Yan, Huijing Wang, Yao Tan, Ying Chen, Bei Feng, Wei Fu, Yao Fu, Yang Lu
Summary: dcECM hydrogels derived from porcine ears through enzymatic digestion show good biocompatibility for delivering chondrocytes and forming subcutaneous cartilage in vivo. The structural and gelation kinetics of the hydrogels vary with ECM concentrations, with 10 mg/ml hydrogels supporting adhesion and proliferation of chondrocytes in vitro. In vivo, 10 mg/ml dcECM hydrogel grafts exhibit similar qualities to native cartilage, indicating their potential for tissue engineering applications in ear cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yanqi Li, Siyu An, Chengliang Deng, Shune Xiao
Summary: Human acellular amniotic membrane (HAAM) has emerged as a promising tool in regenerative medicine with low immunogenicity and good anti-infective and anti-scarring results. This review provides a comprehensive overview of HAAM, including its preparation, sterilization, preclinical research, and clinical applications. The review also discusses the potential of HAAM as a skin dressing and cell delivery system and the need for further research into its regenerative mechanisms.
Article
Surgery
Si-Fen Yang, Chun-Mei Wang, Shimpei Ono, Wei Xu, Kai-Yuan Xu, Lee L. Q. Pu
ANNALS OF PLASTIC SURGERY
(2016)
Article
Orthopedics
Shimpei Ono, Sandeep J. Sebastin, Hiroyuki Ohi, Kevin C. Chung
Article
Orthopedics
Matthew D. Chetta, Shimpei Ono, Kevin C. Chung
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2012)
Article
Orthopedics
Ian C. Sando, Shimpei Ono, Kevin C. Chung
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2012)
Article
Orthopedics
Jennifer F. Waljee, Bradley P. Larson, Kate Wan-Chu Chang, Shimpei Ono, Amy L. Holland, Steven C. Haase, Kevin C. Chung
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2012)
Letter
Surgery
Shimpei Ono, Rei Ogawa, Yoshihiro Takami, Hiko Hyakusoku
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2012)
Article
Surgery
Masahiro Murakami, Shimpei Ono, Nobuaki Ishii, Hiko Hyakusoku
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2012)
Article
Surgery
Shimpei Ono, Kevin C. Chung, Yoshihiro Takami, Takafumi Chin, Rei Ogawa, Jian-Hua Gao, Hiko Hyakusoku
PLASTIC AND RECONSTRUCTIVE SURGERY
(2012)
Letter
Surgery
Shimpei Ono, Rei Ogawa, Shigeyoshi Eura, Yoshihiro Takami, Hiko Hyakusoku
PLASTIC AND RECONSTRUCTIVE SURGERY
(2012)
Article
Surgery
Shimpei Ono, Sandeep J. Sebastin, Kevin C. Chung
PLASTIC AND RECONSTRUCTIVE SURGERY
(2013)
Article
Surgery
Shimpei Ono, Kevin C. Chung
CLINICS IN PLASTIC SURGERY
(2019)
Article
Cell Biology
Tomoko Shimura, Gojiro Nakagami, Rei Ogawa, Shimpei Ono, Toshiaki Takahashi, Misako Nagata, Kosuke Kashiwabara, Junko Sugama, Hiromi Sanada, Makoto Oe
Summary: This study aimed to determine the cumulative incidence of pressure injuries (PIs) and medical device-related pressure injuries (MDRPIs) in critically ill patients and identify corresponding risk factors. The results showed that there were common and unique risk factors for both PIs and MDRPIs, and preventive interventions should take these different risk factors into account.
WOUND REPAIR AND REGENERATION
(2022)
Article
Surgery
Shimpei Ono, Hiromitsu Hayashi, Hiroyuki Ohi, Rei Ogawa
CLINICS IN PLASTIC SURGERY
(2017)
Article
Surgery
Rei Ogawa, Shimpei Ono, Satoshi Akaishi, Teruyuki Dohi, Takeshi Iimura, Junichi Nakao
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2016)
