Article
Toxicology
Ulrike Kogel, Ee Tsin Wong, Justyna Szostak, Wei Teck Tan, Francesco Lucci, Patrice Leroy, Bjoern Titz, Yang Xiang, Tiffany Low, Sin Kei Wong, Emmanuel Guedj, Nikolai V. Ivanov, Walter K. Schlage, Manuel C. Peitsch, Arkadiusz Kuczaj, Patrick Vanscheeuwijck, Julia Hoeng
Summary: Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease and cardiovascular disease. Mice exposed to cigarette smoke in both whole-body and nose-only exposure systems showed respiratory and cardiovascular effects, with more severe outcomes observed in the nose-only exposure group.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Respiratory System
Jef Serre, Ajime Tom Tanjeko, Carolien Mathyssen, An-Sofie Vanherwegen, Tobias Heigl, Rob Janssen, Eric Verbeken, Karen Maes, Bart Vanaudenaerde, Wim Janssens, Ghislaine Gayan-Ramirez
Summary: In this study, a standardized CS exposure protocol resulted in higher serum cotinine levels and more severe inflammation in the whole-body exposure system compared to the nose-only system. Both exposure systems showed similar lung function impairment, but differences were observed in lung inflammation and remodeling, indicating potential sensitization to CS. Researchers should consider these differences when designing future studies for early intervention in COPD.
RESPIRATORY RESEARCH
(2021)
Article
Food Science & Technology
Shu-Chieh Hu, Seonggi Min, Hyun-Ki Kang, Dong-Jin Yang, Mallikarjuna Basavarajappa, Sherry M. Lewis, Kelly J. Davis, Ralph E. Patton, Matthew S. Bryant, Estatira Sepehr, Raul Trbojevich, Mason G. Pearce, Michelle E. Bishop, Wei Ding, Robert H. Heflich, MacKean P. Maisha, Robert Felton, Susan Chemerynski, Steven B. Yee, Melis Coraggio, Hans Rosenfeldt, R. Philip Yeager, Paul C. Howard, Yunan Tang
Summary: In this study, the subchronic inhalation toxicity of NNK (a key substance in tobacco) was evaluated in rats. The results showed that NNK exposure caused multiple adverse effects, with non-neoplastic lesions in the nose being the most sensitive endpoint. Additionally, although a genotoxic biomarker was detected, genotoxicity from NNK exposure was negative in the micronucleus and comet assays.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Toxicology
Shu-Chieh Hu, Seonggi Min, Hyun-Ki Kang, Dong-Jin Yang, Sherry M. Lewis, Kelly J. Davis, Ralph E. Patton, Matthew S. Bryant, Estatira Sepehr, Raul Trbojevich, Mason G. Pearce, Michelle E. Bishop, Robert H. Heflich, MacKean P. Maisha, Robert Felton, Susan Chemerynski, Steven B. Yee, Melis Coraggio, Hans Rosenfeldt, R. Philip Yeager, Paul C. Howard, Yunan Tang
Summary: The subacute inhalation toxicity of NNK in Sprague Dawley rats led to multiple adverse effects, with the most sensitive endpoint being non-neoplastic histopathological lesions in the nose. The lowest-observed-adverse-effect level (LOAEL) was determined to be 0.8mg/kg BW/day or 0.03mg/L air for 1h/day for both sexes. Additionally, the assessment of Haber's Rule showed that longer exposure to a lower dose of NNK aerosol resulted in greater adverse effects than shorter exposure to a higher concentration.
TOXICOLOGICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Hongin Jeong, Jhongryul Yoo, Seokyung Park, Jiling Lu, Sungho Park, Jeseung Lee
Summary: A non-enzymatic glucose sensor using TiO2 nanoparticles and chitosan-polypyrrole conductive polymer films was successfully fabricated, showing high sensitivity and low detection limit, with excellent selectivity and reactivity.
Article
Chemistry, Analytical
Jhongryul Yoo, Hongin Jeong, Seo Kyung Park, Sungho Park, Je Seung Lee
Summary: This study synthesized high-purity TiO2 nanoparticles and deposited them on an electrode to fabricate a DNA biosensor. The structural and chemical properties of the nanoparticles were analyzed, and the concentration of target DNA was quantitatively analyzed using a picoammeter. Specificity experiments confirmed the ability of the biosensor to discriminate between different nucleotide sequences.
Article
Biotechnology & Applied Microbiology
Bowen Li, Daniel G. Anderson
Summary: A high-throughput platform has been developed to create lipid nanoparticles capable of delivering mRNA and CRISPR-Cas9 gene editing tools effectively to the lungs via intratracheal administration, expanding the potential clinical applications of gene editing and mRNA-based technologies.
NATURE BIOTECHNOLOGY
(2023)
Article
Toxicology
Shu-Chieh Hu, Matthew S. Bryant, Estatira Sepehr, Hyun-Ki Kang, Raul Trbojevich, Guy Lagaud, Darshan Mehta, Wei Ding, Roberta A. Mittelstaedt, Mason G. Pearce, Michelle E. Bishop, Kelly J. Davis, Sherry M. Lewis, Susan Chemerynski, Steven B. Yee, Melis Coraggio, Hans Rosenfeldt, R. Philip Yeager, Paul C. Howard, Yunan Tang
Summary: This study investigated the toxicokinetics and genotoxicity of NNK in vivo through three different routes of administration in rats. The results demonstrated that NNK was rapidly absorbed and extensively metabolized, with the intraperitoneal route showing the highest systemic exposure. Inhalation route exhibited more efficient metabolism to NNAL compared to intraperitoneal or oral routes. NNK induced significant DNA damage in tissues through all three routes of administration.
TOXICOLOGICAL SCIENCES
(2021)
Article
Chemistry, Physical
Larisa Sorokina, Andrey Savitskiy, Oleksandr Shtyka, Tomasz Maniecki, Malgorzata Szynkowska-Jozwik, Alexey Trifonov, Elena Pershina, Ivan Mikhaylov, Sergey Dubkov, Dmitry Gromov
Summary: This study investigates the photocatalytic activity of the Cu-Rh/TiO2 system in the ultraviolet and visible regions. By modifying the TiO2 layer with Cu-Rh nanoalloy, the photocatalytic activity is enhanced, especially in the visible range.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Physical
Yizheng Liu, Yandong He, Zhaorui Liu, Xuelan Cheng, Cangtao Zhou, Jidong Shi, Yan Li, Fang Xu
Summary: A one-step liquid phase precipitation method was developed to synthesize burr-like TiO2 nanostructures at room temperature. Different nanostructures such as nanotubes, nanorods, nanotetrapods, and nano-urchins with bur-surface were obtained. The growth mechanism was studied by comparing TiO2 obtained with different growth time. The method shows potential in commercial production of TiO2 nanostructures due to its room-temperature operation, mass production, low cost, and universality.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Chemistry, Physical
Lei Zhang, Xingxing Shi, Minghan Zhao, Zhen Yin, Jianping Zhang, Songbo Wang, Wei Du, Jun Xiang, Penggao Cheng, Na Tang
Summary: A novel approach using a combination of atomic layer deposition (ALD) and photodeposition was proposed to prepare stable and antibacterial organic-inorganic composited membranes. The as-prepared membranes exhibit similar mechanical stability and separation performance as pristine PVDF membranes, while also showing antibacterial and dye degradation capabilities. This method demonstrates great potential for controlled preparation of inorganic modifications on inert organic surfaces with different compositions and shapes for various applications.
SURFACES AND INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Armin Hadzic, Matic Moze, Klara Arhar, Matevz Zupancic, Iztok Golobi
Summary: This study investigates the possibility of enhancing pool boiling heat transfer by using TiO2-water nanofluid combined with laser-textured copper surfaces. The results show that the heat transfer coefficient (HTC) using nanofluids decreases compared to pure water, while the critical heat flux (CHF) is significantly improved at higher nanoparticle concentrations. The buildup of a highly wettable TiO2 layer on the surface is identified as the main reason for the observed performance. Multiple subsequent boiling experiments using nanofluids on the same surface exhibit a notable shift in boiling curves and instability at higher concentrations, attributed to the growth of the nanoparticle layer. Overall, the combination of nanofluids boiling on a laser-textured surface enhances the CHF after prolonged exposure to highly concentrated nanofluid, while the HTC is universally and significantly decreased in all cases.
Article
Health Care Sciences & Services
Roberto Bracaglia, Maria Servillo, Regina Fortunato, Anna Amelia Caretto, Stefano Gentileschi
Summary: This study evaluated the aesthetic value of bilateral double osteotomies in structural rhinoplasty and found that it is not only effective for deviated noses but also for non-deviated cases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Physical
Yuanting Tang, Xiangyu Ma, Xudong Du, Xiao Liu, Rong Chen, Bin Shan
Summary: We fabricated a depth-controlled TiO2 nanotrap via area-selective atomic layer deposition (ALD) method to balance the activity and anti-sintering properties of supported Au nanoparticles. The TiO2 nanotrapped Au catalyst showed enhanced sintering resistance and similar activity as pure Au catalyst. This strategy of exposing active sites and hindering Au migration-coalescence simultaneously provides a promising approach to design highly stable Au catalysts.
JOURNAL OF CATALYSIS
(2023)
Article
Thermodynamics
Tao Wen, Jielin Luo, Kai Jiao, Lin Lu
Summary: This study experimentally investigated the pool boiling performance of TiO2 nanofluid and compared it with Al2O3 and ZnO nanofluid. The results showed that a super-hydrophilic micro-porous deposition layer formed on the nanofluid boiling surface, leading to almost twice higher critical heat flux (CHF) than distilled water. Nanofluid type and concentration had limited influence on CHF, while increasing concentration of nanofluid resulted in unpredictable boiling performance.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Chemistry, Physical
Kenji Kawaguchi, Shuhei Kimura, Masatsugu Morimitsu
Summary: The nanoscale particle size of RuO2 in thermally prepared RuO2-coated Ti anodes affects the electrochemical kinetic parameters such as the active surface area and Tafel slope for oxygen evolution in sulfuric acid solutions. Decreasing RuO2 particle size leads to increased double-layer charge corresponding to the active surface area, higher oxygen evolution current density at a certain potential, and a decrease in Tafel slope, indicating changes in particle size influence both mass transfer and electron transfer processes during oxygen evolution in sulfuric acid solutions.
Article
Chemistry, Applied
Masaru Kubo, Takuya Sugahara, Manabu Shimada
Summary: A new spray-assisted process was used to fabricate HKUST-1 thin films in less than 3 minutes. This process involves the formation of nanoparticles from droplets attached to the substrate surface as seed particles, followed by the growth of seed particles to form thin films. Incorporating multi-walled carbon nanotubes into the spraying solution allows for the fabrication of MWCNT/HKUST-1 films, which have consistent porosities with HKUST-1 powders synthesized by conventional and spray-assisted methods.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Engineering, Chemical
Masaru Kubo, Motoyoshi Ishimura, Manabu Shimada
Summary: A new apparatus was designed for spray synthesis of metal-organic frameworks, significantly improving yield by optimizing the air flow and precursor solution conditions. Under the optimal conditions, the highest space-time yield was 45.7 kg/m(3)/day, the highest surface area was 1,872 m(2)/g, and the sample exhibited good hydrogen adsorption capacity.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shujun Zhou, Makoto Maeda, Masaru Kubo, Manabu Shimada
Summary: A one-step protocol for synthesizing Au@SiO2 yolk-shell nanoparticles (YSPs) from tetrachloroauric(III) acid (HAuCl4), tetramethyl orthosilicate (TMOS), and L-arginine in water is reported. The presence of arginine plays a dual role in reducing HAuCl4 to Au and catalyzing the formation of SiO2. The YSPs demonstrate good activity in reducing 4-nitrophenol.
Article
Toxicology
Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Toru Ishidao, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Shinichi Mochizuki, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto, Hidenori Higashi
Summary: Our study suggests that cross-linked polyacrylic acid (CL-PAA) potentially induces strong neutrophil inflammation and pulmonary fibrosis in rat and human lungs.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Chemistry, Physical
Kusdianto Kusdianto, Meditha Hudandini, Dianping Jiang, Masaru Kubo, Manabu Shimada
Summary: Ag-TiO2 nanocomposite films were fabricated using a one-step aerosol route, and the effects of different heating rates on photocatalytic performance were studied. Results showed that increasing the heating rate led to improved photocatalytic activity due to increased surface area and total pore volume.
Article
Environmental Sciences
Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kaori Kato, Kazuhiro Yatera, Etsushi Kuroda, Yasuo Morimoto
Summary: This study evaluated the effectiveness of photocatalytic filters in suppressing allergic reactions in living organisms. It showed that photocatalysis of ovalbumin (OVA) using a titanium dioxide (TiO2) filter significantly decreased the number of eosinophils in bronchoalveolar lavage fluid and the concentration of OVA-specific IgE and IgG1 in serum.
Article
Chemistry, Physical
Jianghua Lang, Kazuma Takahashi, Masaru Kubo, Manabu Shimada
Summary: TiO2-Ag nanoparticle composite films were prepared by plasma-enhanced chemical vapor deposition (PECVD) method, which showed reduced bandgap and improved photocatalytic activity. The best photocatalytic activity was achieved for a 1 wt% Ag-loaded TiO2 composite film.
Article
Chemistry, Physical
Jianghua Lang, Kazuma Takahashi, Masaru Kubo, Manabu Shimada
Summary: The study successfully synthesized a TiO2-CNT-Ag ternary composite film and significantly improved the photocatalytic activity for the degradation of rhodamine 6G.
Article
Engineering, Chemical
Masaru Kubo, Tomoki Matsumoto, Manabu Shimada
Summary: In this study, Pd nanoparticles incorporated into HKUST-1 metal-organic framework (Pd/HKUST-1) were successfully synthesized using a spray synthesis method, and their catalytic activity was evaluated. The synthesized Pd/HKUST-1 exhibited well-dispersed Pd nanoparticles within the HKUST-1 framework and had a high BET surface area. As a catalyst, Pd/HKUST-1 demonstrated a high reaction rate constant for the reduction of 4-nitrophenol.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chinatsu Nishida, Hiroto Izumi, Taisuke Tomonaga, Ke-Yong Wang, Hidenori Higashi, Jun-Ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Yuki Hata, Kazuo Sakurai, Yasuyuki Higashi, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto
Summary: This study investigated the effects of polyacrylic acid (PAA) with different molecular weights on the lungs of rats. The results showed that high molecular weight PAA caused more persistent and severe lung responses compared to low molecular weight PAA. This suggests that molecular weight is an important factor in PAA-induced lung disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yuji Fujii, Shujun Zhou, Manabu Shimada, Masaru Kubo
Summary: A method was developed to synthesize hollow mesoporous nanoparticles with controllable size and shell thickness for drug-delivery applications. Monodispersed hollow mesoporous organosilica (HMOS) and hollow mesoporous silica (HMS) nanoparticles were successfully prepared using soft and hard templating methods. The hollow size of HMOS can be tuned by changing the size of the hard templates, and the shell thicknesses of HMOS and HMS can be adjusted by changing the amount of precursor used.
Article
Chemistry, Physical
Masaru Kubo, Tomoki Matsumoto, Manabu Shimada
Summary: HKUST-1 was prepared using spray synthesis method with Li doping and defect created via partial replacement of H3BTC with isophthalic acid (IP) to enhance H-2 adsorption capacity. Li-doping and defect creation significantly enhanced H-2 uptake to 3.03 wt% through the coordination of Li ions with carboxylic groups of the created defects via IP replacement.
Article
Public, Environmental & Occupational Health
Yasuyuki Higashi, Yasuo Morimoto, Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Hidenori Higashi, Ryohei Ono, Kazuki Sumiya, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera
Summary: This study investigated the effects of cross-linked polyacrylic acid (CL-PAA) on the lungs of rats, and found that intratracheal administration of CL-PAA induced persistent inflammation and fibrosis in the lungs.
JOURNAL OF OCCUPATIONAL HEALTH
(2023)
Article
Pathology
Toshio Kobayashi, Yutaka Oshima, Yasuhiro Tsubokura, Takako Muroi, Shozo Ajimi, Makoto Nakai, Kenji Kawaguchi, Takeshi Sasaki, Naohide Shinohara, Nobuya Imatanaka
Summary: The study found that the early toxic potential of NiO products is associated with their solubility, while the persistence of pulmonary inflammation is not determined by solubility.
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2021)