Article
Immunology
Guanqun Chao, Zhaojun Wang, Shuo Zhang
Summary: The study revealed that patients with diarrheapredominant IBS exhibited more serious levels of anxiety and depression, down-regulated expression of neuropeptide S, neuropeptide Y, and NPY receptor 2. Additionally, there was a significant increase in total mast cells and tryptase-positive mast cells, along with an up-regulation of Protease-activated receptor 2 expression in the colon tissue of IBS-D patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Jian Song, Zhigang He, Muqing Yang, Tianyu Yu, Xiaodong Wang, Bin Liu, Jiyu Li
Summary: In hepatic ischemia reperfusion injury, tryptase is accumulated in the circulation and positively correlated with liver injury. Tryptase inhibition can down-regulate adhesion molecules expression and reduce neutrophil infiltration in the liver. The activation of tryptase/PAR-2 axis participates in liver injury through the regulation of neutrophil adhesion and inflammatory factor secretion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ewelina Wozniak, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Summary: Psoriasis vulgaris is a common inflammatory skin disease with complex pathogenesis involving genetic, environmental factors, and mental health. Chronic stress may influence hormonal changes, promoting autoimmunity. Mast cells play an important role in the pathophysiology of psoriasis by responding to environmental stimuli and emotional stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Bing Qin, Yucong Peng, Chen Zhong, Yong Cai, Shengjun Zhou, Huaijun Chen, Jianfeng Zhuang, Hanhai Zeng, Chaoran Xu, Hangzhe Xu, Jianru Li, Guangyu Ying, Chi Gu, Gao Chen, Lin Wang
Summary: The study found that after SAH, MCs were activated/degranulated, and administration of the MC stabilizer cromolyn helped improve neurologic outcomes and reduce brain edema. Cromolyn significantly inhibited the neuroinflammatory response and alleviated neuronal damage after SAH. However, pharmacological activation of MCs actually worsened brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Rosa Molfetta, Rossella Paolini
Summary: Mast cells are tissue-resident sentinels involved in various physiological and pathological processes. They are frequently observed in tumor microenvironments, but their role in tumor initiation and growth is still controversial.
Review
Medicine, General & Internal
Katarzyna Tomaszewska, Aleksandra Slodka, Bartlomiej Tarkowski, Anna Zalewska-Janowska
Summary: Urticaria is a condition characterized by itchy wheals and angioedema. The pathophysiology of chronic spontaneous urticaria (CSU) is not well understood, but there are immunological and non-immunological abnormalities that result in clinical symptoms. Latest hypotheses suggest that Mast cells (MCs) activated by autoantibodies mediate the vasoactive and neurospecific effect in CSU. Psychological stress is seen as a triggering and modulating factor in CSU, but the mechanistic background is not fully elucidated. This review highlights the neuro-immuno-psychological aspects of CSU, suggesting the use of psychological tools and non-invasive interventions to reduce psychological stress.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Nehla Zerarka-Chabane, Fatima Laraba-Djebari, Djelila Hammoudi-Triki
Summary: The study found that Aah scorpion venom induced inflammatory cell infiltration, resulting in severe imbalance of redox status and gastrointestinal tissue damage. Mast cells play a crucial role in gastrointestinal disorders, and inhibition of MCs can reduce reactive oxygen species generation and facilitate tissue repair.
Article
Cell Biology
Darine W. El-Naccache, Fei Chen, Mark J. Palma, Alexander Lemenze, Matthew A. Fischer, Wenhui Wu, Pankaj K. Mishra, Holger K. Eltzschig, Simon C. Robson, Francesco Di Virgilio, George S. Yap, Karen L. Edelblum, Gyorgy Hasko, William C. Gause
Summary: Intestinal nematode parasites can cause tissue damage and promote host protective type 2 immunity by crossing the epithelial barrier and releasing danger-associated molecular patterns. The A2B adenosine receptor on intestinal epithelial cells plays an important role in this process. Blocking this receptor inhibits the host protective memory response to the parasite, affecting granuloma development at the host-parasite interface.
Article
Biochemistry & Molecular Biology
Yi-Ting Chen, Tzu-Ting Tseng, Hung-Pei Tsai, Ming-Yii Huang
Summary: Arylquin 1 exhibits anticancer effects in colorectal cancer cells by inhibiting cell proliferation, migration, and invasion, and inducing apoptosis. It increases the phosphorylation levels of ERK, JNK, and p38, which are related to key signaling proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Cindy Zolotoff, Clementine Puech, Frederic Roche, Nathalie Perek
Summary: Patients with obstructive sleep apnea/hypopnea (OSA) are at high risk of cerebrovascular diseases leading to cognitive impairment. Intermittent hypoxia (IH) and higher thrombin concentrations can increase blood-brain barrier (BBB) permeability, while lower concentration of thrombin associated with IH may have a protective effect on BBB. Thrombin and PARs could be potential targets for preventing BBB opening in OSA.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Dasiel O. Borroto-Escuela, Ramon Fores, Mariana Pita, Miguel A. Barbancho, Pablo Zamorano-Gonzalez, Natalia Garcia Casares, Kjell Fuxe, Manuel Narvaez
Summary: This study assesses the effects of GALR2 and NPYY1R agonists coadministration on sustained memory and hippocampal cell proliferation, suggesting the potential therapeutic benefits for dementia conditions and memory deficits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
John W. Wiley, Gerald A. Higgins, Shuangsong Hong
Summary: This study examined the cellular mechanisms underlying how chronic stress induces visceral hypersensitivity by analyzing gene expression changes in colon epithelial cells from a rat model. The findings suggest that chronic stress alters gene expression and dysregulates biological processes related to inflammation/immune response, tissue morphogenesis and development, and chromatin assembly. It also implicates epigenetic regulation of chromatin remodeling in this process and highlights the role of super enhancers in chronic stress-associated intestinal barrier dysfunction.
Article
Neurosciences
Tongyu Zhang, Lei Huang, Jianhua Peng, John H. Zhang, Hongqi Zhang
Summary: The study demonstrated that LJ529 attenuated mast cell-related inflammation in a SAH rat model by modulating the A3R-PKC epsilon-ALDH2 pathway, improving both short-term and long-term neurological functions. Treatment with LJ529 resulted in alleviation of mast cell degranulation and inflammation.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Tongqian Wu, Shirong Yan, Yu-Wen Yeh, Yu Fang, Zou Xiang
Summary: This study found that mast cells expressing only FcγRIIB or FcγRIIIA undergo caspase-independent apoptosis in response to IgG immune complex treatment. Lower frequencies of connective tissue mast cells (CTMC) were recorded in mice lacking either FcγRIIB or FcγRIIIA compared with wild-type mice, especially in aged mice. This suggests that FcγR-mediated mast cell apoptosis may explain the more robust persistence of CTMC compared to mucosal mast cells (MMC). The results were replicated in a mast cell engraftment model, ruling out possible confounding effects of mast cell recruitment or FcγR expression by other cells on mast cell number regulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Roberta Fusco, Rosalba Siracusa, Marika Cordaro, Ramona D'Amico, Francesco Macri, Emanuela Raffone, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The study investigated the beneficial effects of fisetin, a naturally occurring polyphenol, on endometriosis. Fisetin treatment reduced the size and volume of endometriotic implants, as well as histological alterations and inflammatory responses. It also decreased markers of oxidative stress and increased apoptosis in endometrial lesions. Fisetin may represent a potential therapeutic strategy for endometriosis by targeting inflammatory pathways and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sun Min Lee, Nayoung Kim, Hyuk Yoon, Yong Sung Kim, Soo In Choi, Ji Hyun Park, Dong Ho Lee
Summary: Changes in the gut microbiota composition in IBS patients lead to alterations in bacterial functions, such as bile acid transformation and the induction of inflammation, which is a known pathophysiological mechanism of IBS.
Article
Multidisciplinary Sciences
Hye-Kyung Jung, Chung Hyun Tae, Hye-Ah Lee, Hyuk Lee, Kee Don Choi, Jun Chul Park, Joong Goo Kwon, Yoon Jin Choi, Su Jin Hong, Jaekyu Sung, Woo Chul Chung, Ki Bae Kim, Seung Young Kim, Kyung Ho Song, Kyung Sik Park, Seong Woo Jeon, Byung-Wook Kim, Han Seung Ryu, Ok-Jae Lee, Gwang Ho Baik, Yong Sung Kim, Hwoon-Yong Jung
Article
Multidisciplinary Sciences
Chung Hyun Tae, Ki-Nam Shim, Byung-Wook Kim, Jie-Hyun Kim, Su Jin Hong, Gwang Ho Baik, Hyun Joo Song, Yong Sung Kim, Seung-Ho Jang, Hye-Kyung Jung
SCIENTIFIC REPORTS
(2020)
Article
Gastroenterology & Hepatology
Yong Sung Kim, Joonki Lee, Aesun Shin, Jung Min Lee, Jong Heon Park, Hwoon-Yong Jung
Summary: In Korea, the incidence of peptic ulcer bleeding (PUB) has decreased over the past decade in a sex-specific manner, with higher rates in men than women and differences in age groups; H. pylori infection rate has increased while exposure to drugs increasing the risk of PUB has not significantly changed.
Article
Biochemistry & Molecular Biology
Yunna Lee, Elise L. Ma, Marisa Patel, Gayoung Kim, Cody Howe, Charalabos Pothoulakis, Yong Sung Kim, Eunok Im, Sang Hoon Rhee
Summary: CRHR1 deficiency exerts tumor-suppressing effects in Apcmin/+ mice, while CRHR2 deficiency exacerbates tumorigenicity. CRHR1 deficiency inhibits the expression of tumor-promoting cyclooxygenase 2 and upregulates tumor-suppressing phospholipase A2 in Apcmin/+ mice, but CRHR2 deficiency does not change these expressions. Deficiency of CRHR2 worsens tumorigenesis in both Apcmin/+ and AOM/DSS-treated mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Tadayuki Oshima, Kewin T. H. Siah, Yong Sung Kim, Tanisa Patcharatrakul, Chien-Lin Chen, Sanjiv Mahadeva, Hyojin Park, Min-Hu Chen, Ching-Liang Lu, Xiaohua Hou, Duc T. Quach, Ari F. Syam, M. Masudur Rahman, Yinglian Xiao, Liu Jinsong, Andrew S. B. Chua, Hiroto Miwa
Summary: Gastroparesis is identified as an understudied subject in Asia. The survey shows that many doctors in Asia lack knowledge of the definition and diagnostic tests for gastroparesis. The main reasons for lack of interest in diagnosing gastroparesis are the lack of reliable diagnostic tests and effective treatment.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Soo In Choi, Joo Hee Son, Nayoung Kim, Yong Sung Kim, Ryoung Hee Nam, Ji Hyun Park, Chin-Hee Song, Jeong Eun Yu, Dong Ho Lee, Kichul Yoon, Huitae Min, Yeon-Ran Kim, Yeong-Jae Seok
Summary: This study compared gut microbiota in cecal contents of rats at different ages and found significant changes in certain bacterial families and increased levels of butyrate in 31-week-old rats. The study also revealed a positive relationship between butyrate concentration and the expression of inflammation related genes in aging rats.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Sabrina Xin Zi Quek, Evelyn Xiu Ling Loo, Alla Demutska, Chun En Chua, Guan Sen Kew, Scott Wong, Hui Xing Lau, En Xian Sarah Low, Tze Liang Loh, Ooi Shien Lung, Emily C. W. Hung, M. Masudur Rahman, Uday C. Ghoshal, Sunny H. Wong, Cynthia K. Y. Cheung, Ari F. Syam, Niandi Tan, Yinglian Xiao, Jin-Song Liu, Fang Lu, Chien-Lin Chen, Yeong Yeh Lee, Ruter M. Maralit, Yong-Sung Kim, Tadayuki Oshima, Hiroto Miwa, Junxiong Pang, Kewin Tien Ho Siah
Summary: The study revealed that respondents with self-reported IBS had poorer emotional, social, and psychological well-being compared to non-IBS respondents, and were less compliant to social distancing measures. Those willing to adhere to social distancing indefinitely had a higher proportion of no change in IBS symptoms.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Woori Na, Yeji Lee, Hyeji Kim, Yong Sung Kim, Cheongmin Sohn
Summary: The study found that approximately 21.7% of Korean adults aged 20 to 40 had IBS, and the dietary intake and food consumption habits of these patients differed from those of non-IBS subjects. Increased intake of high-fat and high-gluten foods may lead to more IBS symptoms in Korean adults in their 20s to 40s.
Article
Multidisciplinary Sciences
Shimoni Urvish Shah, Evelyn Xiu Ling Loo, Chun En Chua, Guan Sen Kew, Alla Demutska, Sabrina Quek, Scott Wong, Hui Xing Lau, En Xian Sarah Low, Tze Liang Loh, Ooi Shien Lung, Emily C. W. Hung, M. Masudur Rahman, Uday C. Ghoshal, Sunny H. Wong, Cynthia K. Y. Cheung, Ari F. Syam, Niandi Tan, Yinglian Xiao, Jin-Song Liu, Fang Lu, Chien-Lin Chen, Yeong Yeh Lee, Ruter M. Maralit, Yong-Sung Kim, Tadayuki Oshima, Hiroto Miwa, Kewin Tien Ho Siah, Junxiong Pang
Summary: The study found that healthcare professionals had more positive knowledge and attitudes towards personal hygiene and social distancing measures, leading to higher compliance. HCPs with high compliance were more likely to have better emotional, social, and psychological well-being.
Article
Medicine, General & Internal
Chun En Chua, Guan Sen Kew, Alla Demutska, Sabrina Quek, Evelyn Xiu Ling Loo, Hao Gui, Scott Wong, Hui Xing Lau, En Xian Sarah Low, Tze Liang Loh, Shien Lung Ooi, Emily C. W. Hung, M. Masudur Rahman, Uday Ghoshal, Hei Wong, Cynthia K. Y. Cheung, Ari F. Syam, Niandi Tan, Yinglian Xiao, Jin-Song Liu, Fang Lu, Chien-Lin Chen, Yeong Yeh Lee, Ruter M. Maralit, Yong-Sung Kim, Tadayuki Oshima, Hiroto Miwa, Junxiong Pang, Kewin Tien Ho Siah
Summary: This study aimed to describe and correlate the level of knowledge and attitude with the level of compliance with personal hygiene and physical distancing practices among Asian countries in the early phase of the pandemic. Factors such as high psychological well-being and safe distancing practices were found to be associated with high compliance behavior during the early phase of the pandemic in Asia.
Article
Biochemistry & Molecular Biology
Se Eun Ha, Brian G. Jorgensen, Lai Wei, Byungchang Jin, Min-Seob Kim, Sandra M. Poudrier, Rajan Singh, Allison Bartlett, Hannah Zogg, Sei Kim, Gain Baek, Masaaki Kurahashi, Moon-Young Lee, Yong-Sung Kim, Suck-Chei Choi, Kent C. Sasse, Samuel J. S. Rubin, Andres Gottfried-Blackmore, Laren Becker, Aida Habtezion, Kenton M. Sanders, Seungil Ro
Summary: ADAMDEC1 is selectively expressed in PDGFR alpha(+) cells in the colonic mucosa and may serve as a diagnostic and therapeutic target for intestinal inflammation and Crohn's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Seung-Ho Jang, Suck-Chei Choi, Yong-Sung Kim, Han-Seung Ryu, Sang-Yeol Lee, Won-Myong Bahk
Summary: This study aimed to investigate the differences in psychological characteristics and factors influencing quality of life (QOL) based on the anatomical location of functional gastrointestinal disorders (FGIDs). The study found that the lower gastrointestinal disorder (LGID) group had higher scores in 'emotional depression' and lower QOL compared to the upper gastrointestinal disorder (UGID) group. Significant differences were also observed in resilience, social support, and childhood trauma. These findings highlight the importance of personalized psychological interventions for effective treatment of FGIDs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Ayoung Lee, Ju Yup Lee, Sung Won Jung, Seung Yong Shin, Han Seung Ryu, Seung-Ho Jang, Joong Goo Kwon, Yong Sung Kim
Summary: Research has shown a functional relationship between the brain and the gastrointestinal (GI) tract. The brain influences the composition and function of the gut microbiota, while gut microbiota plays a crucial role in brain and enteric nervous system development and function. This brain-gut-microbiota axis is important in the pathophysiology of GI diseases.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Moon Young Lee, Eui Joong Kim, Aesun Shin, Yong Sung Kim
Summary: Gender medicine aims to analyze research results systematically according to sex and gender to address the lack of reflection of gender differences in biomedical research. However, researchers still face challenges in applying gender medicine to their studies. To conduct rigorous gender medicine research, using correct terminology, conducting thorough literature reviews, appropriate statistical analysis and cautious interpretation of results are necessary.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2021)