Article
Cell Biology
Bani Ahluwalia, Cristina Iribarren, Maria K. Magnusson, Johanna Sundin, Egbert Clevers, Otto Savolainen, Alastair B. Ross, Hans Tornblom, Magnus Simren, Lena Ohman
Summary: In this study, a distinct fecal microbiota and metabolite profile associated with bowel habits was found in patients with IBS, with metabolites being the main driver of this separation. Additionally, the intestinal microenvironment profile differed between IBS patients with constipation or diarrhea, but no clustering was detected in subgroups based on symptom severity or anxiety levels. Ingenuity pathway analysis predicted altered amino acid metabolism and several cellular and molecular functions in IBS patients.
Article
Nutrition & Dietetics
Annamaria Altomare, Federica Del Chierico, Giulia Rocchi, Sara Emerenziani, Chiara Nuglio, Lorenza Putignani, Silvia Angeletti, Alessandra Lo Presti, Massimo Ciccozzi, Alessandra Russo, Silvia Cocca, Mentore Ribolsi, Maurizio Muscaritoli, Michele Cicala, Michele Pier Luca Guarino
Summary: This study revealed an association between nutrient intake, adherence to Mediterranean diet, IBS symptoms, and gut microbiota in IBS patients. Lower adherence to Mediterranean diet was correlated with severe abdominal pain and higher flatulence in IBS patients, indicating a potential connection between dietary patterns and gut microbial biomarkers in IBS.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Cell Biology
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Joerg-Dieter Schulzke, Roland Buecker
Summary: This study investigated the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type irritable bowel syndrome (IBS-M). The findings showed that in IBS-M, chloride secretion was reduced and antigen permeability was increased, which contributed to a low-grade inflammation in the colon mucosa.
Article
Gastroenterology & Hepatology
David J. Kearney, Kendra J. Kamp, Meghan Storms, Tracy L. Simpson
Summary: This study described the prevalence of irritable bowel syndrome (IBS) and other gastrointestinal symptoms in veterans with posttraumatic stress disorder (PTSD) and found a relationship between PTSD severity and gastrointestinal symptoms.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenzhao Bao, Li Qi, Yin Bao, Sai Wang, Wei Li
Summary: This study, using Mendelian Randomization design, found that genetic susceptibility to insomnia can increase the risk of irritable bowel syndrome (IBS). Improving sleep quality, especially targeting insomnia, can help to prevent IBS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Gastroenterology & Hepatology
Colleen H. Parker, Bruce D. Naliboff, Wendy Shih, Angela P. Presson, Lisa Kilpatrick, Arpana Gupta, Cathy Liu, Laurie A. Keefer, Jenny S. Sauk, Robert Hirten, Bruce E. Sands, Lin Chang
Summary: The study found that resilience is lower in patients with Irritable Bowel Syndrome (IBS) compared to the general population, leading to more severe symptoms. The impact of global mental health on resilience is more significant in IBS compared to the general population, and early adverse life events also decrease the ability to bounce back from adversity. While resilience in IBS is lower than the general US population, it is comparable to other chronic gastrointestinal conditions.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Primary Health Care
Esmee M. Hogervorst, Ilse N. Ganzevoort, Marjolein Y. Berger, Gea A. Holtman
Summary: In primary care, there are differences in the prognosis and treatment of children with IBS compared to other diagnostic subgroups. Children with IBS are more commonly referred to secondary care, use more laxatives, and have a higher risk of developing chronic diarrhea and low physical health-related quality of life (HRQoL) during 1 year.
Review
Medicine, General & Internal
Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini
Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Zulun Zhang, Qianqian Li, Sheng Zhang, Yujie Liu, Gaochen Lu, Quan Wen, Bota Cui, Fuquan Zhang, Faming Zhang
Summary: This study aimed to evaluate the efficacy of washed microbiota transplantation (WMT) on sleep disturbances, and psychological and gastrointestinal symptoms among patients with irritable bowel syndrome (IBS). The results showed significant improvements in sleep quality, anxiety, depression, gastrointestinal symptoms, and IBS severity after WMT. Baseline sleep duration scores were identified as an independent predictive factor for sleep improvement.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Imran Aziz, Magnus Simren
Summary: Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by symptoms of recurrent abdominal pain and changes in bowel habits. Diagnosis is made by identifying characteristic symptoms and excluding organic gastrointestinal diseases.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Joost P. Algera, Stine Storsrud, Annika Lindstrom, Magnus Simren, Hans Tornblom
Summary: This study found a significant variation in gluten intake among IBS patients, with those experiencing more severe GI symptoms consuming lower levels of gluten. There was no significant association observed between fructan intake and GI symptoms.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Heidi M. Staudacher, Sophie Mahoney, Kim Canale, Rachelle S. Opie, Amy Loughman, Daniel So, Lauren Beswick, Chris Hair, Felice N. Jacka
Summary: A Mediterranean diet is feasible and effective in improving gastrointestinal and psychological symptoms in patients with IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pediatrics
Ying Huang, Serene Yaling Tan, Panam Parikh, Vanitha Buthmanaban, Shaman Rajindrajith, Marc Alexander Benninga
Summary: The study aimed to assess the prevalence of functional gastrointestinal disorders (FGIDs) in infants and young children in China. According to the Rome IV criteria, the prevalence of having a FGID in Chinese infants and young children is 27.3%. Infantile regurgitation was the most common FGID in Chinese infants, while functional constipation was most prevalent among young Chinese children.
Review
Gastroenterology & Hepatology
Hasitha Liyanarachchi, Shaman Rajindrajith, Chandrani Kuruppu, Prasad Chathurangana, Randula Ranawaka, Niranga M. Devanarayana, Marc A. Benninga
Summary: This study systematically reviewed the association between constipation and stressful events, finding that childhood constipation is associated with stressors related to home, school, child maltreatment, and war/civil unrest.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pediatrics
Robyn Rexwinkel, Vera W. A. van Berge Henegouwen, Maartje M. J. Singendonk, Usha Krishnan, Yvan VandenPlas, Caterina Strisciuglio, Rachel Rosen, Arnaud Lalanne, Shaman Rajindrajith, Marc A. Benninga, Merit M. Tabbers
Summary: The study aims to develop a core outcome set for clinical studies assessing gastroesophageal reflux disease (GERD) in children. Through the use of Delphi technique and OMERACT 2.0 recommendations, healthcare professionals, parents, and children identified a total of 9 important outcome measures, including adequate relief, evidence of esophagitis, feeding difficulties, heartburn, hematemesis, regurgitation, sleeping difficulties, vomiting, and adverse events. This core outcome set facilitates comparison between studies and provides recommendations for improving treatment of GERD in children.
JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Manori Vijaya Kumari, Lakmali Amarasiri, Shaman Rajindrajith, Niranga Manjuri Devanarayana
Summary: Gastric motility was impaired in children with asthma, FAPDs, and both disorders, with the motility index showing positive correlation with lung function parameters, suggesting a potential pathophysiological mechanism involving smooth muscle activity in the airways and gastrointestinal wall.
Article
Pediatrics
Loo Wee Chia, Thi Viet Ha Nguyen, Van Nha Phan, Thi Thao Nguyen Luu, Gia Khanh Nguyen, Serene Yaling Tan, Shaman Rajindrajith, Marc Alexander Benninga
Summary: This study assessed the prevalence of functional gastrointestinal disorders (FGIDs) in healthy Vietnamese infants and young children. The results showed a relatively low prevalence of FGIDs, with infantile regurgitation being the most common disorder among infants and functional constipation being the most prevalent among young children.
Article
Gastroenterology & Hepatology
James Guoxian Huang, Yoko Kin Yoke Wong, Kee Seang Chew, Pornthep Tanpowpong, Karen Sophia Calixto Mercado, Almida Reodica, Shaman Rajindrajith, Kai-Chi Chang, Yen-Hsuan Ni, Suporn Treepongkaruna, Way-Seah Lee, Marion Margaret Aw
Summary: This study found a high incidence of early-onset IBD and an over-representation of Indian ethnicity among pediatric patients with inflammatory bowel disease in Asia. South Asian CD patients were more likely to have symptomatic perianal disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Veerle Huizer, Naveen Wijekoon, Danielle Roorda, Jaap Oosterlaan, Marc A. Benninga, L. W. Ernest van Heurn, Shaman Rajindrajith, Joep P. M. Derikx
Summary: This systematic review and meta-analysis found no evidence for impaired generic health-related quality of life (HRQoL) in patients with Hirschsprung disease (HD) compared to healthy controls. There were also no moderating effects of sex, parental proxy, or self-report on generic HRQoL.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Multidisciplinary Sciences
Shaman Rajindrajith, Damitha Gunawardane, Chandrani Kuruppu, Samath D. Dharmaratne, Nipul K. Gunawardena, Niranga M. Devanarayana
Summary: This systematic review and meta-analysis revealed that aerophagia is prevalent worldwide, with a prevalence rate of 3.66%. The highest prevalence of aerophagia in children was found in Asia.
Review
Endocrinology & Metabolism
Sumudu Nimali Seneviratne, Shaman Rajindrajith
Summary: The prevalence of obesity and type 2 diabetes mellitus has been rapidly increasing, and current prevention efforts are not successful. Fetal programming provides a new concept for lifelong prevention of obesity and type 2 diabetes mellitus. The World Health Organization now advocates a life-course approach to prevent/control obesity, starting with pre-conceptional and antenatal maternal health. This review summarizes current data on fetal programming of obesity and type 2 diabetes mellitus, including potential causative factors, mechanisms, and interventions to reduce its impact.
WORLD JOURNAL OF DIABETES
(2022)
Article
Multidisciplinary Sciences
Amaranath Karunanayake, Niranga Manjuri Devanarayana, Shaman Rajindrajith
Summary: This study aimed to investigate the adverse early life events (ELE) associated with functional abdominal pain disorders (FAPDs) in children. The results of the survey showed that having family members with abdominal pain, chronic pain, prenatal complications, and undergoing interventional deliveries were identified as potential risk factors for the development of FAPDs. Additionally, prolonged breastfeeding and normal vaginal delivery were found to reduce the prevalence of FAPDs in children.
Article
Medicine, General & Internal
Hashan Pathiraja, Dhammike Rasnayake, Thilini Muthukumarana, Channa de Silva, Wasantha Sathkorala, Sandini Gunaratne, Shaman Rajindrajith, Sachith Mettananda
Summary: This case report presents a rare occurrence of a large cystic lymphangioma originating from the pericardium. It highlights the importance of prompt imaging in situations of diagnostic uncertainty to arrive at an accurate diagnosis that can be lifesaving.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Review
Pediatrics
Shaman Rajindrajith, Wathsala Hathagoda, Niranga Manjuri Devanarayana
Summary: Functional diarrhea is a disease that has received attention from pediatricians worldwide. It is believed to primarily occur in younger children, but recent studies have shown its prevalence in all age groups. Despite being known for a long time, the pathophysiological mechanisms and treatment options are not well-explored. This article reviews the available literature on functional diarrhea and highlights the need for a fresh perspective on this disease.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Shaman Rajindrajith, Niranga Manjuri Devanarayana, Nikhil Thapar, Marc Alexander Benninga
Summary: Many common misconceptions and beliefs about childhood constipation continue to hinder its rational management. The prevalence of chronic constipation is around 9.5% in children worldwide, with a higher proportion in non-Western countries. There are misunderstandings about its cause, with many clinicians believing it is due to organic pathology when it is mostly functional. There is evidence that constipation has significant physical and psychological consequences with long-term implications. Ineffective management strategies and fear of long-term medication use further complicate treatment.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Gastroenterology & Hepatology
Shaman Rajindrajith, Wathsala Hathagoda, Eranga Ganewatte, Niranga Manjuri Devanarayana, Nikhil Thapar, Marc Benninga
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Madunil A. Niriella, Suresh Venkateswaran, Shaman Rajindrajith, Kuleesha Kodisinghe, Arjuna P. De Silva, Hithanadura J. De Silva, Nirmani Yasara, Sachith Mettananda, Ranjit S. Pelia, Kyle Gettler, David J. Cutler, Judy H. Cho, Subra Kugathasan
