Letter
Gastroenterology & Hepatology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This article is connected to the papers of Marasco et al. To access these papers, visit and
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Irina Midenfjord, Cecilia Grinsvall, Peter Koj, Ida Carnerup, Hans Tornblom, Magnus Simren
Summary: Central sensitization was common in IBS and associated with GI symptom severity, but with stronger associations in chronic pain disorders and IBD. This suggests that other mechanisms may play a significant role in determining GI symptom severity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, General & Internal
Grace L. Burns, Nicholas J. Talley, Simon Keely
Summary: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by chronic abdominal pain and altered defaecation. Research has found that small intestinal mechanosensation, altered barrier functions, and microbial imbalance are associated with IBS. The current literature suggests that the pathogenesis of IBS may involve dysfunction of the entire intestinal tract.
Letter
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This article is connected to Marasco et al papers. To view these articles, visit and...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini
Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Review
Nutrition & Dietetics
Jongsung Hahn, Jeongwon Choi, Min Jung Chang
Summary: This meta-analysis revealed that a low fermentable oligo-, di-, monosaccharides, and polyols diet (LFD) has a moderate reduction effect on the symptom severity and a slight improvement effect on the quality of life of irritable bowel syndrome (IBS) patients, as well as a significant improvement in stool habits.
Article
Gastroenterology & Hepatology
Colleen H. Parker, Bruce D. Naliboff, Wendy Shih, Angela P. Presson, Lisa Kilpatrick, Arpana Gupta, Cathy Liu, Laurie A. Keefer, Jenny S. Sauk, Robert Hirten, Bruce E. Sands, Lin Chang
Summary: The study found that resilience is lower in patients with Irritable Bowel Syndrome (IBS) compared to the general population, leading to more severe symptoms. The impact of global mental health on resilience is more significant in IBS compared to the general population, and early adverse life events also decrease the ability to bounce back from adversity. While resilience in IBS is lower than the general US population, it is comparable to other chronic gastrointestinal conditions.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Zulun Zhang, Qianqian Li, Sheng Zhang, Yujie Liu, Gaochen Lu, Quan Wen, Bota Cui, Fuquan Zhang, Faming Zhang
Summary: This study aimed to evaluate the efficacy of washed microbiota transplantation (WMT) on sleep disturbances, and psychological and gastrointestinal symptoms among patients with irritable bowel syndrome (IBS). The results showed significant improvements in sleep quality, anxiety, depression, gastrointestinal symptoms, and IBS severity after WMT. Baseline sleep duration scores were identified as an independent predictive factor for sleep improvement.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Integrative & Complementary Medicine
Si-qi Tang, Yun-liang Wang, Zi-ye Xie, Yang Zhang, Yi Guo, Kang-li Gao, Tang-you Mao, Chun-e Xie, Jun-xiang Li, Xiao-yan Gao
Summary: This study revealed through serum metabolomics that different TCM syndrome types in IBS-D may exhibit distinct metabolic patterns, with glycerophospholipid metabolism being a significant pathway affected differently among the three TCM syndromes.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Gastroenterology & Hepatology
Heidi M. Staudacher, Sophie Mahoney, Kim Canale, Rachelle S. Opie, Amy Loughman, Daniel So, Lauren Beswick, Chris Hair, Felice N. Jacka
Summary: A Mediterranean diet is feasible and effective in improving gastrointestinal and psychological symptoms in patients with IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Joost P. Algera, Stine Storsrud, Annika Lindstrom, Magnus Simren, Hans Tornblom
Summary: This study found a significant variation in gluten intake among IBS patients, with those experiencing more severe GI symptoms consuming lower levels of gluten. There was no significant association observed between fructan intake and GI symptoms.
CLINICAL NUTRITION
(2021)
