Article
Pharmacology & Pharmacy
Nahid S. Awad, Mohamed Haider, Vinod Paul, Nour M. AlSawaftah, Jayalakshmi Jagal, Renu Pasricha, Ghaleb A. Husseini
Summary: The study successfully encapsulated hydrophilic graphene quantum dots in stealth liposomes and triggered their release using low-frequency ultrasound, providing an effective method to deliver QDs to tumor cells while reducing systemic toxicity.
Article
Chemistry, Multidisciplinary
Cheng Lv, Jian Ao, Ji Wang, Man Tang, An-An Liu, Dai-Wen Pang
Summary: A host-cell-assisted strategy is proposed to construct folate-engineered nanocarriers with maintained biofunctions, which can be further multi-functionalized for tumor real-time imaging and therapy. This cell-based strategy facilitates the development and widespread application of bio-nanocarriers in targeted cancer therapy and promotes interdisciplinary studies of nanotechnology, chemistry, and virology.
Article
Chemistry, Multidisciplinary
Ankita Chandra, Preeti Ravindra Bhoge, K. R. Chethan, Chethan D. D. Shanthamurthy, Raghavendra Kikkeri
Summary: In this study, highly fluorescent gold nanoclusters were engineered with sulfated oligo-iduronic acid ligands (I34), which showed strong binding to the HB-EGF receptor over FGF2, and regulated EGF receptor-mediated cancer cell homing in both 2D and 3D cell culture systems. These findings provide a new practical imaging tool for carbohydrate research.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Elzbieta Pedziwiatr-Werbicka, Katarzyna Horodecka, Dzmitry Shcharbin, Maria Bryszewska
Summary: Nanomedicine is a promising alternative to traditional cancer treatment methods, but it does not completely overcome the limitations of oncology. Nanoparticles used in cancer therapy can serve as drug carriers and offer some advantages, but they do not significantly enhance the effectiveness of chemotherapeutic agents.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zihui Liang, Junyi Zhao, Peilin Wang, Yixin Nie, Shuping Xu, Qiang Ma
Summary: In this study, a polarization-resolved ECL sensor based on the surface plasmon coupling effect was constructed for sensitive detection of miRNA-155, which is related to triple-negative breast cancer. The sensing system utilized a gold nanorod vertical array as a surface-enhanced structure, improving the detection sensitivity of the ECL signal.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Dongyoon Kim, Nowras Rahhal, Christoph Rademacher
Summary: Carbohydrates play important roles in cellular interactions and immune system recognition. Nanoparticles coated with carbohydrate structures can be captured by cellular receptors, triggering cellular responses and aiding in the study of carbohydrate-protein interactions.
FRONTIERS IN CHEMISTRY
(2021)
Review
Environmental Sciences
Chanchal Das, Mika Sillanpaa, Shabi Abbas Zaidi, Moonis Ali Khan, Goutam Biswas
Summary: Urbanization and population growth have led to a significant increase in solid waste generation, projected to reach 3.40 billion tons by 2050. Carbon-based quantum dots (Cb-QDs) derived from solid wastes have attracted research interest due to their wide range of applications. This review focuses on the conversion of solid wastes into useful materials for pollution reduction, specifically investigating sustainable synthesis routes of carbon quantum dots (CQDs), graphene quantum dots (GQDs), and graphene oxide quantum dots (GOQDs). The applications of these quantum dots in various fields are also discussed, along with the challenges in implementing existing synthesis methods and future research directions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yoshiki Nakashima, Chika Miyagi-Shiohira, Issei Saitoh, Masami Watanabe, Masayuki Matsushita, Masayoshi Tsukahara, Hirofumi Noguchi
Summary: Human hepatocytes were transformed into induced pluripotent stem cells (iPSCs) using Sendai virus vectors. The iPSCs expressed hepatocyte-specific markers and showed better efficiency in differentiating into hepatocyte-like cells compared to other types of iPSCs.
Article
Chemistry, Analytical
Huijuan Yan, Shuo Yang, Mengxue Liu, Ke Bao, Wu Ren, Fei Lin, Yiqiao Gao, Zhenghui Wang, Shuanghui Liu, Jieli Lv, Ying Zhao
Summary: Targeted imaging using graphene quantum dots (GQDs) as biosensors shows promise for early-stage cancer detection. However, existing GQDs have limitations such as low two-photon absorption and narrow spectral coverage. In this study, a hybrid with high fluorescence and two-photon imaging performance, composed of GQDs and silica nanoparticles (SiO2 NPs), was developed. By further modifying this hybrid with aptamer Sgc8c, it exhibited specific responses to target cells and could be used as a signal-amplifying two-photon nanoprobe for targeted cancer imaging. This signal amplification strategy holds great potential for accurate early tumor diagnosis and broader clinical applications.
Article
Chemistry, Analytical
Zhimin Weng, Zhenglian Li, Yixuan Zhang, Mingying Zhang, Zhongnan Huang, Wei Chen, Huaping Peng
Summary: This study proposes a novel AuNC-based ECL sensing platform and explores the regulation mechanism of electron transfer on ECL. By investigating the ECL quenching effect of OM-AuNCs under the influence of Cu2+, it is found that the ECL intensity of OM-AuNCs is affected by the electron transfer process, enabling sensitive detection of Cu2+ in a low concentration range without the need for amplification techniques. This study enriches the application of ET-mediated ECL and promotes a more rational design of ECL sensors.
ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Felipe Ferreira Lopes, Camila Fabiano de Freitas, Eneida de Paula, Sidney Alves Lourenco, Marcio Florian, Luis Fernando Cabeca
Summary: This work developed hydroxyapatite-coated liposomes for encapsulating drug bupivacaine and quantum dots, serving as a theranostic tool. These systems allow monitoring drug distribution in vivo and modulating drug delivery rate by increasing drug concentration.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Emel Kirbas Cilingir, Meghana Sankaran, Jordan M. Garber, Frederic Anthony Vallejo, Mattia Bartoli, Alberto Tagliaferro, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Summary: Carbon dots (CDs) have gained attention for their biocompatibility and tunable photoluminescence, but further analysis is needed before their use in clinical trials. A new type of carbon nitride dot (CND) has been found to selectively uptake cancer cells due to structural similarities with glutamine. The study investigates the effects of surface structural differences on the cellular uptake of CNDs and finds that the uptake mechanism is linked with ASCT2 and LAT1 transporters. CNDs show promise for selective cancer cell targeting by utilizing highly expressed transporters on cancer cells.
Article
Pharmacology & Pharmacy
Thais da Silva Moreira, Alan Denis Olivindo Silva, Bianca Rodrigues Farias Vasconcelos, Elias da Silva Santos, Ana Carolina Cruz de Sousa, Joao Vito Barroso de Freitas, Yara Santiago de Oliveira, Laura Maria Teodorio Vidal, Fabio de Oliveira Silva Ribeiro, Alyne Rodrigues de Araujo, Jose de Brito Vieira Neto, Claudia do O. Pessoa, Raquel Petrilli, Josimar O. Eloy
Summary: The study aimed to develop pH-sensitive immunoliposomes based on DOPE and CHEMS for selective drug delivery to EGFR-overexpressing cells in the acidic tumor environment. The liposomes showed appropriate characteristics and successful conjugation with anti-EGFR antibody. The results demonstrated high cytotoxicity and cellular internalization in prostate cancer cells.
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, a new approach for synthesizing carbon dots (CDs) with improved electrochemiluminescent (ECL) performance was disclosed. By engineering luminol as molecular emission centers into the CDs, luminescent groups rich in CDs (Lu-CDs) were synthesized. Lu-CDs exhibited significantly stronger ECL intensity and better consistency between ECL and fluorescence emission compared to traditional CDs. Lu-CDs were employed to construct an ECL biosensor for tumor cell analysis, demonstrating wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, luminescent groups rich carbon dots (Lu-CDs) were synthesized by incorporating luminol into the CDs, resulting in a significantly enhanced electrochemiluminescent (ECL) performance. The ECL emission of Lu-CDs showed excellent consistency with its fluorescence emission, unlike other surface state-dominated CDs. Furthermore, Lu-CDs were used to develop an ECL biosensor for tumor cell analysis, demonstrating a wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Ophthalmology
Juan Pena, Nihan Dulger, Tanya Singh, Jing Zhou, Robert Majeska, Stephen Redenti, Maribel Vazquez
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Cell & Tissue Engineering
Ankush Thakur, Shawn Mishra, Juan Pena, Jing Zhou, Stephen Redenti, Robert Majeska, Maribel Vazquez
JOURNAL OF TISSUE ENGINEERING
(2018)
Editorial Material
Ophthalmology
Juan S. Pena, Maribel Vazquez
Article
Chemistry, Analytical
Juan S. Pena, Denise Robles, Stephanie Zhang, Maribel Vazquez
Article
Ophthalmology
Shawn Mishra, Juan S. Pena, Stephen Redenti, Maribel Vazquez
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Cell Biology
Caroline D. Pena, Stephanie Zhang, Robert Majeska, Tadmiri Venkatesh, Maribel Vazquez
Article
Cell & Tissue Engineering
Tanya Singh, Denise Robles, Maribel Vazquez
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Neurosciences
Juan S. Pena, Maribel Vazquez
Review
Chemistry, Analytical
Maribel Vazquez
Article
Chemistry, Analytical
Stephen Ryan Mut, Shawn Mishra, Maribel Vazquez
Summary: Millions of adults worldwide are affected by progressive vision loss. Current cell replacement therapies face a challenge of inability to migrate to targeted areas. A bioengineering system called mu-Eye has been developed to stimulate and examine the migration of retinal stem cells (SCs) within eye facsimiles using external stimuli, showing promising results for promoting migration-targeted strategies for retinal cell replacement therapy.
Article
Engineering, Biomedical
Tanya Singh, Maribel Vazquez
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2019)
Meeting Abstract
Endocrinology & Metabolism
Sean Mccutcheon, Robert Majeska, David Spray, Maribel Vazquez, Mitchell Schaffler
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Chemistry, Analytical
Shawn Mishra, Maribel Vazquez
Article
Engineering, Biomedical
Maribel Vazquez, Otto Marte, Joseph Barba, Karen Hubbard
ANNALS OF BIOMEDICAL ENGINEERING
(2017)
Article
Engineering, Biomedical
Sean McCutcheon, Robert Majeska, Mitchell Schaffler, Maribel Vazquez
BIOMEDICAL MICRODEVICES
(2017)